Gene info: ID 4891

Gene: SLC11A2

GENE ID: 4891

Synonyms: AHMIO1|DCT1|DMT1|NRAMP2

Description: solute carrier family 11 member 2

Gene type: protein-coding

Location: 12q13.12

dbXrefs: Ensembl:ENSG00000110911 MIM:600523 Vega:OTTHUMG00000169493 UniprotKB:P49281

RefSeq: NG_021139.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.036e-1 (AD) 5.482e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg22789605	chr12:51419164	SLC11A2		6.300e-13	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NUP133	0.933
MON2	0.919
CREBZF	0.91
TUBGCP3	0.908
SCARB2	0.907
FBXO38	0.907
UBA6	0.9
CDC23	0.899
C5orf15	0.899
PEX1	0.899

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.57
OR4F29	-0.531
MTRNR2L6	-0.377
MTRNR2L9	-0.366
MTRNR2L10	-0.341
OR4F16	-0.305
MTRNR2L2	-0.289
TTLL10	-0.284
MTRNR2L8	-0.275
NKX6-1	-0.271

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB06796	Mangafodipir	Small Molecule	155319-91-8	Approved\|Investigational\|Withdrawn	Transporter
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Transporter

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of SLC11A2 mRNA"	19162173
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC11A2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC11A2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of SLC11A2 mRNA	21420995
D020106	Acrylamide	Acrylamide results in increased expression of SLC11A2 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SLC11A2 mRNA	19770486
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of SLC11A2 mRNA"	20224926
D000438	Alcohols	Alcohols results in increased expression of SLC11A2 mRNA	24025710
D000447	Aldehydes	SLC11A2 protein inhibits the reaction [Ozone results in increased abundance of Aldehydes]	16905637
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SLC11A2 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SLC11A2 mRNA	24449571
D001151	Arsenic	Arsenic affects the expression of SLC11A2 mRNA	18414638
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of SLC11A2 mRNA"	16272461
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of SLC11A2 protein"	16272461
D001205	Ascorbic Acid	Ascorbic Acid results in decreased expression of SLC11A2 protein	18815723
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of SLC11A2 protein	18815723
C017049	bathophenanthroline disulfonic acid	bathophenanthroline disulfonic acid inhibits the reaction [Hydrogen Peroxide results in increased expression of SLC11A2 protein]	20096349
C017049	bathophenanthroline disulfonic acid	bathophenanthroline disulfonic acid inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]	20096349
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SLC11A2 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SLC11A2 mRNA	19770486
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [PRKN protein results in decreased expression of SLC11A2 protein alternative form]	20089134
C038328	BEP protocol	BEP protocol results in increased expression of SLC11A2 mRNA	18987330
D004958	Estradiol	Copper promotes the reaction [Estradiol results in increased expression of SLC11A2 mRNA]	19685012
D004958	Estradiol	Estradiol inhibits the reaction [Copper results in decreased expression of SLC11A2 protein]	19685012
D004958	Estradiol	Estradiol promotes the reaction [Copper affects the expression of SLC11A2 mRNA]	19685012
D004958	Estradiol	Estradiol results in increased expression of SLC11A2 mRNA	19685012
D004958	Estradiol	Estradiol affects the expression of SLC11A2 mRNA	16684588
C044887	beta-methylcholine	beta-methylcholine affects the expression of SLC11A2 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of SLC11A2 mRNA	21786754
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of SLC11A2 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of SLC11A2 mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of SLC11A2 mRNA	15336504
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of SLC11A2 mRNA	14729362
D002101	Cacodylic Acid	Cacodylic Acid results in decreased expression of SLC11A2 mRNA	17720352
D002104	Cadmium	Cadmium results in decreased expression of SLC11A2 mRNA	11439223
D002104	Cadmium	SLC11A2 affects the transport of Cadmium	11439223
D002104	Cadmium	SLC11A2 protein affects the uptake of Cadmium	28904291
D002104	Cadmium	SLC11A2 protein results in increased uptake of Cadmium	12388109
D002104	Cadmium	Cadmium affects the expression of SLC11A2 mRNA	25294218
D002104	Cadmium	SLC11A2 protein affects the transport of Cadmium	16552559
D002104	Cadmium	SLC11A2 protein affects the uptake of Cadmium	22562489
D019256	Cadmium Chloride	SLC11A2 protein results in increased transport of Cadmium Chloride	22736759
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SLC11A2 mRNA	23503628
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of SLC11A2 mRNA	21540277
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SLC11A2 mRNA	23038010
C037123	cadmium sulfate	cadmium sulfate results in increased expression of SLC11A2 mRNA	23912858
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SLC11A2 mRNA	24763279
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of SLC11A2 mRNA	24418189
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of SLC11A2 mRNA	24418189
D003035	Cobalt	Cobalt inhibits the reaction [SLC11A2 protein results in increased transport of Ferrous Compounds]	22736759
D003035	Cobalt	SLC11A2 protein results in increased transport of Cobalt	22736759
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SLC11A2 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SLC11A2 mRNA	23814049
C018021	cobaltous chloride	Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC11A2 mRNA]	23814049
D003300	Copper	Copper promotes the reaction [Estradiol results in increased expression of SLC11A2 mRNA]	19685012
D003300	Copper	Copper results in decreased expression of SLC11A2 mRNA	12220667\|1968501
D003300	Copper	Copper results in decreased expression of SLC11A2 protein	12220667\|1968501
D003300	Copper	Copper results in increased expression of SLC11A2 protein	26067577
D003300	Copper	Estradiol inhibits the reaction [Copper results in decreased expression of SLC11A2 protein]	19685012
D003300	Copper	Estradiol promotes the reaction [Copper affects the expression of SLC11A2 mRNA]	19685012
D003300	Copper	[SLC11A2 protein co-treated with SLC31A1 protein] affects the uptake of Copper	26067577
D003300	Copper	SLC11A2 protein results in increased transport of Copper	12220667
D003300	Copper	Copper deficiency results in increased expression of SLC11A2 mRNA alternative form	23555700
D003300	Copper	Copper deficiency results in increased expression of SLC11A2 protein	23555700
D003300	Copper	EPAS1 gene mutant form inhibits the reaction [Copper deficiency results in increased expression of SLC11A2 mRNA alternative form]	23555700
D003300	Copper	SLC11A2 mRNA alternative form results in increased uptake of Copper	24327293
D003300	Copper	SLC11A2 protein affects the reaction [manganese chloride results in increased uptake of Copper]	22465424
D003300	Copper	Copper deficiency results in increased expression of SLC11A2 mRNA	17298691\|1982111
D003300	Copper	[Deferoxamine promotes the reaction [Doxorubicin results in increased expression of SLC11A2 protein]] which results in increased uptake of Copper	24089420
D003300	Copper	[[manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper	25575534
D003300	Copper	[[Manganese results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper	25575534
D003300	Copper	SLC11A2 protein affects the transport of Copper	22465424
D019327	Copper Sulfate	"[Copper Sulfate co-treated with Iron, Dietary] results in increased expression of SLC11A2 mRNA"	18987288
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SLC11A2 mRNA	18987288
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SLC11A2 mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SLC11A2 protein	24815816
C029892	cupric chloride	cupric chloride inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	12220667
D003474	Curcumin	Curcumin results in increased expression of SLC11A2 mRNA	24634837
D016572	Cyclosporine	Cyclosporine results in decreased expression of SLC11A2 mRNA	20106945\|2163298
D003676	Deferoxamine	Deferoxamine promotes the reaction [Deferoxamine results in increased expression of SLC11A2 protein]	23764342
D003676	Deferoxamine	[Deferoxamine results in decreased abundance of Iron] which results in increased expression of SLC11A2 mRNA	12393473
D003676	Deferoxamine	Deferoxamine results in increased expression of SLC11A2 protein	23764342
D003676	Deferoxamine	[Deferoxamine results in increased expression of SLC11A2 protein] which results in increased uptake of Manganese	23764342
D003676	Deferoxamine	[Deferoxamine co-treated with Manganese] results in increased expression of SLC11A2	11933051
D003676	Deferoxamine	Deferoxamine promotes the reaction [Doxorubicin results in increased expression of SLC11A2 mRNA]	24089420
D003676	Deferoxamine	Deferoxamine promotes the reaction [Doxorubicin results in increased expression of SLC11A2 protein]	24089420
D003676	Deferoxamine	[Deferoxamine promotes the reaction [Doxorubicin results in increased expression of SLC11A2 protein]] which results in increased uptake of Copper	24089420
D003676	Deferoxamine	Deferoxamine results in decreased expression of SLC11A2 mRNA	24089420
D013759	Dronabinol	Dronabinol inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	16984886
C016366	dibenzothiophene	dibenzothiophene results in increased expression of SLC11A2 mRNA	23656968
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of SLC11A2 mRNA	21266533
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of SLC11A2 mRNA	26924002
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of SLC11A2 mRNA	19061943
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of SLC11A2 protein	19061943
D004052	Diethylnitrosamine	Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC11A2 protein]	19061943
D004110	Diltiazem	Diltiazem inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]	27095094
C024629	dimethyl phthalate	dimethyl phthalate results in decreased expression of SLC11A2 mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of SLC11A2 mRNA	20463971
D007980	Levodopa	Levodopa results in decreased expression of SLC11A2 protein alternative form	19240805
D007980	Levodopa	Levodopa results in increased expression of SLC11A2 protein	19240805
D004317	Doxorubicin	Deferoxamine promotes the reaction [Doxorubicin results in increased expression of SLC11A2 mRNA]	24089420
D004317	Doxorubicin	Deferoxamine promotes the reaction [Doxorubicin results in increased expression of SLC11A2 protein]	24089420
D004317	Doxorubicin	[Deferoxamine promotes the reaction [Doxorubicin results in increased expression of SLC11A2 protein]] which results in increased uptake of Copper	24089420
D004317	Doxorubicin	Doxorubicin results in decreased expression of SLC11A2 mRNA	19915844
D004317	Doxorubicin	Doxorubicin results in increased expression of SLC11A2 mRNA	24089420
D004317	Doxorubicin	Doxorubicin results in increased expression of SLC11A2 protein	24089420
D004317	Doxorubicin	[Doxorubicin results in increased expression of SLC11A2 protein] which results in increased uptake of Iron	24089420
C042986	ebselen	ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	16984886
D052244	Endocrine Disruptors	Endocrine Disruptors results in increased expression of SLC11A2 mRNA	25198161
D000431	Ethanol	[Ethanol co-treated with Iron] results in increased expression of SLC11A2 mRNA	24569067
D000431	Ethanol	[Ethanol co-treated with Iron] results in increased expression of SLC11A2 protein	24569067
D000431	Ethanol	Ethanol results in increased expression of SLC11A2 mRNA	24569067
D000431	Ethanol	Ethanol results in increased expression of SLC11A2 protein	16737972\|2456906
D000431	Ethanol	HAMP protein inhibits the reaction [Ethanol results in increased expression of SLC11A2 protein]	16737972
D000431	Ethanol	Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 mRNA]	24569067
D000431	Ethanol	Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 protein]	24569067
D000431	Ethanol	Quercetin inhibits the reaction [Ethanol results in increased expression of SLC11A2 mRNA]	24569067
D000431	Ethanol	Quercetin inhibits the reaction [Ethanol results in increased expression of SLC11A2 protein]	24569067
D000431	Ethanol	Vitamin E inhibits the reaction [Ethanol results in increased expression of SLC11A2 protein]	16737972
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of SLC11A2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SLC11A2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC11A2 mRNA	17942748
C574336	excavatolide B	excavatolide B results in decreased expression of SLC11A2 protein	26790859
C013531	ferric ammonium citrate	ferric ammonium citrate results in increased expression of SLC11A2 mRNA	11054110
C024555	ferric chloride	bathophenanthroline disulfonic acid inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]	20096349
C024555	ferric chloride	[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride	20096349
C024555	ferric chloride	Zinc Sulfate inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]	20096349
C024555	ferric chloride	[Zinc Sulfate results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride	20096349
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in decreased expression of SLC11A2 mRNA	11925462
D005296	Ferrous Compounds	Cobalt inhibits the reaction [SLC11A2 protein results in increased transport of Ferrous Compounds]	22736759
D005296	Ferrous Compounds	Manganese inhibits the reaction [SLC11A2 protein results in increased transport of Ferrous Compounds]	22736759
D005296	Ferrous Compounds	SLC11A2 protein results in increased transport of Ferrous Compounds	22736759
D005296	Ferrous Compounds	Zinc inhibits the reaction [SLC11A2 protein results in increased transport of Ferrous Compounds]	22736759
C020748	ferrous sulfate	ferrous sulfate results in decreased expression of SLC11A2 mRNA	10966897
D005485	Flutamide	Flutamide results in increased expression of SLC11A2 mRNA	24136188
D005839	Gentamicins	Gentamicins results in decreased expression of SLC11A2 mRNA	22061828
D005897	Glafenine	Glafenine results in increased expression of SLC11A2 mRNA	24136188
D005947	Glucose	[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 mRNA alternative form	22666436
D005947	Glucose	[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 protein alternative form	22666436
D005947	Glucose	RELA protein modified form promotes the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 mRNA alternative form]	22666436
D005947	Glucose	RELA protein promotes the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 mRNA alternative form]	22666436
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SLC11A2 mRNA	24763279
D017313	Fenretinide	Fenretinide results in increased expression of SLC11A2 mRNA	28973697
D006861	Hydrogen Peroxide	bathophenanthroline disulfonic acid inhibits the reaction [Hydrogen Peroxide results in increased expression of SLC11A2 protein]	20096349
D006861	Hydrogen Peroxide	bathophenanthroline disulfonic acid inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]	20096349
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SLC11A2 protein	20096349
D006861	Hydrogen Peroxide	[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride	20096349
D006861	Hydrogen Peroxide	Zinc Sulfate inhibits the reaction [Hydrogen Peroxide results in increased expression of SLC11A2 protein]	20096349
D006861	Hydrogen Peroxide	Zinc Sulfate inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]	20096349
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC11A2 mRNA	25613284
D007501	Iron	cupric chloride inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	12220667
D007501	Iron	[Deferoxamine results in decreased abundance of Iron] which results in increased expression of SLC11A2 mRNA	12393473
D007501	Iron	Dronabinol inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	16984886
D007501	Iron	ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	16984886
D007501	Iron	[HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron	16841247
D007501	Iron	Iron results in decreased expression of SLC11A2 protein	18815723
D007501	Iron	Iron results in increased expression of SLC11A2 mRNA	11439223
D007501	Iron	Iron results in increased expression of SLC11A2 protein	18815723
D007501	Iron	prolinedithiocarbamate inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	16984886
D007501	Iron	SLC11A2 gene SNP affects the abundance of Iron	25483413
D007501	Iron	SLC11A2 protein alternative form results in increased uptake of Iron	22666436
D007501	Iron	SLC11A2 protein results in increased uptake of Iron	12220667\|1238810
D007501	Iron	[Ethanol co-treated with Iron] results in increased expression of SLC11A2 mRNA	24569067
D007501	Iron	[Ethanol co-treated with Iron] results in increased expression of SLC11A2 protein	24569067
D007501	Iron	Iron deficiency results in increased expression of SLC11A2 mRNA	18648087\|2377659
D007501	Iron	Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC11A2 protein]	19061943
D007501	Iron	Iron results in increased expression of SLC11A2 mRNA	16648237\|2456906
D007501	Iron	Iron results in increased expression of SLC11A2 protein	24569067
D007501	Iron	Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 mRNA]	24569067
D007501	Iron	Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 protein]	24569067
D007501	Iron	Quercetin inhibits the reaction [Iron results in increased expression of SLC11A2 mRNA]	24569067
D007501	Iron	Quercetin inhibits the reaction [Iron results in increased expression of SLC11A2 protein]	24569067
D007501	Iron	SLC11A2 gene mutant form results in decreased transport of Iron	17116712
D007501	Iron	SLC11A2 protein affects the metabolism of Iron	17194590
D007501	Iron	[Doxorubicin results in increased expression of SLC11A2 protein] which results in increased uptake of Iron	24089420
D007501	Iron	Iron deficiency results in increased expression of SLC11A2 mRNA	16629162\|1982111
D007501	Iron	Iron deficiency results in increased expression of SLC11A2 protein	15157939\|1706037
D007501	Iron	Iron inhibits the reaction [SLC11A2 protein results in increased uptake of Manganese]	17116743
D007501	Iron	Iron inhibits the reaction [SLC11A2 protein results in increased uptake of manganese chloride]	17116743
D007501	Iron	Iron results in decreased expression of SLC11A2 protein	17116743
D007501	Iron	Iron results in increased expression of SLC11A2 mRNA	15908475
D007501	Iron	Iron results in increased expression of SLC11A2 protein	15908475
D007501	Iron	Manganese promotes the reaction [SLC11A2 protein results in increased transport of Iron]	18849539
D007501	Iron	Metals promotes the reaction [SLC11A2 protein results in increased transport of Iron]	15908475
D007501	Iron	Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]	16908409
D007501	Iron	SLC11A2 gene mutant form results in decreased uptake of Iron	17116712
D007501	Iron	SLC11A2 protein affects the metabolism of Iron	17194590
D007501	Iron	SLC11A2 protein affects the reaction [Manganese results in increased transport of Iron]	18849539
D007501	Iron	SLC11A2 protein mutant form results in decreased uptake of Iron	17116743
D007501	Iron	SLC11A2 protein results in increased transport of Iron	18849539
D007501	Iron	SLC11A2 affects the transport of Iron	11439223
D007501	Iron	SLC11A2 protein results in increased import of Iron	20105537
D007501	Iron	SLC11A2 protein results in increased transport of Iron	11933051
D007501	Iron	SLC11A2 protein results in increased uptake of Iron	16039939
D007505	Iron-Dextran Complex	Diltiazem inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]	27095094
D007505	Iron-Dextran Complex	Iron-Dextran Complex results in increased expression of SLC11A2 protein	27095094
D007505	Iron-Dextran Complex	Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]	27095094
D007505	Iron-Dextran Complex	Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]	27095094
D019266	Iron, Dietary	"Iron, Dietary results in decreased expression of SLC11A2 protein"	20105537
D019266	Iron, Dietary	"[Iron, Dietary results in decreased expression of SLC11A2 protein] which results in decreased transport of Manganese"	20105537
D019266	Iron, Dietary	"[Iron, Dietary results in decreased expression of SLC11A2 protein] which results in decreased uptake of Iron, Dietary"	20105537
D019266	Iron, Dietary	"[Copper Sulfate co-treated with Iron, Dietary] results in increased expression of SLC11A2 mRNA"	18987288
D019266	Iron, Dietary	"Iron, Dietary results in increased expression of SLC11A2 mRNA"	18987288
D019266	Iron, Dietary	"Iron, Dietary affects the expression of SLC11A2 mRNA"	15637178
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of SLC11A2 protein	17337753
C410337	K 7174	K 7174 results in decreased expression of SLC11A2 mRNA	24086573
D007608	Kainic Acid	Kainic Acid results in increased expression of SLC11A2	16552559
D007854	Lead	SLC11A2 gene SNP affects the abundance of Lead	25483413
D007854	Lead	SLC11A2 protein results in increased transport of Lead	19913089
D007854	Lead	SLC11A2 protein affects the transport of Lead	16552559
C008261	lead acetate	lead acetate results in decreased expression of SLC11A2 mRNA	23219683
C008261	lead acetate	lead acetate results in decreased expression of SLC11A2 protein	23219683
C008261	lead acetate	lead acetate results in increased expression of SLC11A2 mRNA	23219683
C008261	lead acetate	lead acetate results in increased expression of SLC11A2 protein	23219683
C029891	lead chloride	lead chloride results in increased expression of SLC11A2 mRNA	23503628
D001556	Lindane	Lindane results in increased expression of SLC11A2 mRNA	17785943
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC11A2 mRNA"	18930950
D008070	Lipopolysaccharides	[Lipopolysaccharides results in increased expression of SLC11A2 mRNA] which results in decreased uptake of Zinc	19306086
D008070	Lipopolysaccharides	IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of SLC11A2 mRNA]	11054110
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SLC11A2 mRNA	11054110\|1664823
D008070	Lipopolysaccharides	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of SLC11A2 gene	21212295
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC11A2 mRNA	26378955
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC11A2 mRNA	21641980\|2308674
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC11A2 mRNA	26378955
D008345	Manganese	"[Iron, Dietary results in decreased expression of SLC11A2 protein] which results in decreased transport of Manganese"	20105537
D008345	Manganese	[Deferoxamine results in increased expression of SLC11A2 protein] which results in increased uptake of Manganese	23764342
D008345	Manganese	Manganese inhibits the reaction [SLC11A2 protein results in increased transport of Ferrous Compounds]	22736759
D008345	Manganese	Manganese results in increased expression of SLC11A2 mRNA	17175027
D008345	Manganese	SLC11A2 results in increased uptake of Manganese	25772431
D008345	Manganese	[Deferoxamine co-treated with Manganese] results in increased expression of SLC11A2	11933051
D008345	Manganese	Iron inhibits the reaction [SLC11A2 protein results in increased uptake of Manganese]	17116743
D008345	Manganese	[manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese	25575534
D008345	Manganese	[[manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper	25575534
D008345	Manganese	Manganese promotes the reaction [SLC11A2 protein results in increased transport of Iron]	18849539
D008345	Manganese	Manganese results in increased expression of SLC11A2 mRNA	16729984\|1884953
D008345	Manganese	Manganese results in increased expression of SLC11A2 protein	16705042\|1672998
D008345	Manganese	[Manganese results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese	25575534
D008345	Manganese	[[Manganese results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper	25575534
D008345	Manganese	Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA]	16729984
D008345	Manganese	SLC11A2 protein affects the reaction [Manganese results in increased transport of Iron]	18849539
D008345	Manganese	SLC11A2 protein mutant form results in decreased metabolism of Manganese	17116743
D008345	Manganese	SLC11A2 protein mutant form results in decreased uptake of Manganese	17116743
D008345	Manganese	SLC11A2 protein results in increased abundance of Manganese	25575534
D008345	Manganese	SLC11A2 protein results in increased transport of Manganese	11933051\|2010553
D008345	Manganese	SLC11A2 results in increased transport of Manganese	17615110
C025340	manganese chloride	manganese chloride results in increased expression of SLC11A2 mRNA	17175027
C025340	manganese chloride	SLC11A2 protein results in increased transport of manganese chloride	22736759
C025340	manganese chloride	manganese chloride results in increased expression of SLC11A2 mRNA	22465424
C025340	manganese chloride	SLC11A2 protein affects the reaction [manganese chloride results in increased uptake of Copper]	22465424
C025340	manganese chloride	Iron inhibits the reaction [SLC11A2 protein results in increased uptake of manganese chloride]	17116743
C025340	manganese chloride	manganese chloride affects the expression of SLC11A2 mRNA	20635692
C025340	manganese chloride	manganese chloride results in increased expression of SLC11A2 mRNA	25575534
C025340	manganese chloride	manganese chloride results in increased expression of SLC11A2 protein	25575534
C025340	manganese chloride	[manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese	25575534
C025340	manganese chloride	[[manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper	25575534
C025340	manganese chloride	SLC11A2 protein mutant form results in decreased uptake of manganese chloride	17116743
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of SLC11A2 mRNA	20353558
D008628	Mercury	[HAMP protein results in decreased expression of SLC11A2 mRNA] which results in decreased uptake of Mercury	25772431
D008628	Mercury	Mercury results in decreased expression of SLC11A2 mRNA	25772431
D008628	Mercury	SLC11A2 mRNA results in increased uptake of Mercury	25772431
D008628	Mercury	SLC11A2 results in increased uptake of Mercury	25772431
D008670	Metals	Metals inhibits the reaction [SLC11A2 protein results in increased transport of Vanadium]	15908475
D008670	Metals	Metals promotes the reaction [SLC11A2 protein results in increased transport of Iron]	15908475
D008670	Metals	SLC11A2 protein results in increased transport of Metals	15908475
D008701	Methapyrilene	Methapyrilene results in increased expression of SLC11A2 mRNA	28935588
D008746	Methylazoxymethanol Acetate	Methylazoxymethanol Acetate results in increased expression of SLC11A2 mRNA	28349193
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SLC11A2 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of SLC11A2 mRNA	26011545
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of SLC11A2 mRNA	26924002
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SLC11A2 mRNA"	29244179
D009532	Nickel	SLC11A2 protein results in increased transport of Nickel	22736759
D009532	Nickel	SLC11A2 protein results in increased uptake of Nickel	16039939
D009553	Nimodipine	Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]	27095094
D009569	Nitric Oxide	Nitric Oxide affects the expression of SLC11A2 protein alternative form	16232120
D009569	Nitric Oxide	Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]	16908409
D009599	Nitroprusside	[Nitroprusside results in increased abundance of nitrosonium ion] which results in decreased expression of SLC11A2 mRNA	12393473
C504137	nitrosonium ion	[Nitroprusside results in increased abundance of nitrosonium ion] which results in decreased expression of SLC11A2 mRNA	12393473
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC11A2 mRNA"	19083439
C025589	ochratoxin A	ochratoxin A results in decreased expression of SLC11A2 mRNA	19287073\|2212462
C025589	ochratoxin A	ochratoxin A results in decreased expression of SLC11A2 mRNA	22124623
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC11A2 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of SLC11A2 mRNA	25729387
D010100	Oxygen	[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 mRNA alternative form	22666436
D010100	Oxygen	[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 protein alternative form	22666436
D010100	Oxygen	RELA protein modified form promotes the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 mRNA alternative form]	22666436
D010100	Oxygen	RELA protein promotes the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 mRNA alternative form]	22666436
D010126	Ozone	SLC11A2 protein inhibits the reaction [Ozone results in increased abundance of Aldehydes]	16905637
D010126	Ozone	SLC11A2 protein inhibits the reaction [Ozone results in increased secretion of CXCL15 protein]	16905637
D010634	Phenobarbital	Phenobarbital results in decreased methylation of SLC11A2 gene	19233941
D010634	Phenobarbital	Phenobarbital results in decreased methylation of SLC11A2 promoter	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of SLC11A2 mRNA	19482888
C006253	pirinixic acid	pirinixic acid results in decreased expression of SLC11A2 mRNA	23811191
D010936	Plant Extracts	Plant Extracts results in increased expression of SLC11A2 mRNA	23557933
D008926	Plicamycin	Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC11A2 mRNA]	23814049
D008926	Plicamycin	Plicamycin results in decreased expression of SLC11A2 mRNA	23814049
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of SLC11A2 mRNA	28903501
D011374	Progesterone	Progesterone results in increased expression of SLC11A2 mRNA	19690047
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]	16984886
D011794	Quercetin	Quercetin results in decreased expression of SLC11A2 mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 mRNA]	24569067
D011794	Quercetin	Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 protein]	24569067
D011794	Quercetin	Quercetin inhibits the reaction [Ethanol results in increased expression of SLC11A2 mRNA]	24569067
D011794	Quercetin	Quercetin inhibits the reaction [Ethanol results in increased expression of SLC11A2 protein]	24569067
D011794	Quercetin	Quercetin inhibits the reaction [Iron results in increased expression of SLC11A2 mRNA]	24569067
D011794	Quercetin	Quercetin inhibits the reaction [Iron results in increased expression of SLC11A2 protein]	24569067
D011794	Quercetin	Quercetin results in decreased expression of SLC11A2 mRNA	25058155
D015474	Isotretinoin	Isotretinoin results in decreased expression of SLC11A2 mRNA	20436886
D012643	Selenium	[Selenium co-treated with Vitamin E] results in decreased expression of SLC11A2 mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SLC11A2 mRNA	23221170
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SLC11A2 mRNA	22431001
C016104	sodium bichromate	sodium bichromate results in decreased expression of SLC11A2 mRNA	22561333
C016104	sodium bichromate	sodium bichromate results in increased expression of SLC11A2 mRNA	22561333
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC11A2 mRNA	26378955
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC11A2 mRNA	21641980\|2308674
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC11A2 mRNA	26378955
D013629	Tamoxifen	Tamoxifen affects the expression of SLC11A2 mRNA	17555576
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of SLC11A2 mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC11A2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC11A2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of SLC11A2 gene	21212295
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLC11A2 mRNA	19465110\|2821309
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SLC11A2 mRNA	17942748\|1977048
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC11A2 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC11A2 mRNA	25613284
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC11A2 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of SLC11A2 mRNA	25729387
D014204	Trenbolone Acetate	Trenbolone Acetate results in decreased expression of SLC11A2 mRNA	25198161
D014212	Tretinoin	Tretinoin affects the expression of SLC11A2 mRNA alternative form	16232120
D014212	Tretinoin	Tretinoin affects the expression of SLC11A2 protein alternative form	16232120
D014212	Tretinoin	Tretinoin affects the reaction [RELA protein binds to SLC11A2 promoter]	16232120
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of SLC11A2 gene	27618143
C012589	trichostatin A	trichostatin A results in decreased expression of SLC11A2 mRNA	24935251
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC11A2 mRNA"	18930950
C022884	undecane	undecane results in decreased expression of SLC11A2 protein	17337753
D014501	Uranium	Uranium results in decreased expression of SLC11A2 protein	18375546
D014501	Uranium	Uranium results in increased expression of SLC11A2 mRNA	18375546
D014520	Urethane	Urethane results in decreased expression of SLC11A2 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC11A2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of SLC11A2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of SLC11A2 mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid affects the expression of SLC11A2 mRNA	17292431
D014639	Vanadium	Metals inhibits the reaction [SLC11A2 protein results in increased transport of Vanadium]	15908475
D014639	Vanadium	Vanadium results in decreased expression of SLC11A2 mRNA	15908475
D014639	Vanadium	Vanadium results in decreased expression of SLC11A2 protein	15908475
C581824	vanadium dioxide	SLC11A2 protein results in increased transport of vanadium dioxide	22736759
C066075	vanadium pentoxide	vanadium pentoxide results in increased expression of SLC11A2 protein	19646462
D014700	Verapamil	Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]	27095094
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in decreased expression of SLC11A2 mRNA	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of SLC11A2 mRNA	19244175
D014810	Vitamin E	Vitamin E inhibits the reaction [Ethanol results in increased expression of SLC11A2 protein]	16737972
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of SLC11A2 mRNA"	25198161
D015032	Zinc	[IFNG protein results in increased expression of SLC11A2 mRNA] which results in decreased uptake of Zinc	19306086
D015032	Zinc	[Lipopolysaccharides results in increased expression of SLC11A2 mRNA] which results in decreased uptake of Zinc	19306086
D015032	Zinc	[TNF protein results in increased expression of SLC11A2 mRNA] which results in decreased uptake of Zinc	19306086
D015032	Zinc	Zinc inhibits the reaction [SLC11A2 protein results in increased transport of Ferrous Compounds]	22736759
D015032	Zinc	Zinc deficiency results in decreased expression of SLC11A2 mRNA	18073202
D015032	Zinc	Zinc results in increased expression of SLC11A2 mRNA	16614402
D015032	Zinc	Zinc results in increased expression of SLC11A2 protein	16614402
C016837	zinc chloride	SLC11A2 protein results in increased transport of zinc chloride	22736759
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of SLC11A2 mRNA	23912858
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [Hydrogen Peroxide results in increased expression of SLC11A2 protein]	20096349
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]	20096349
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of SLC11A2 mRNA	19306086
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of SLC11A2 protein	19306086\|2009634
D019287	Zinc Sulfate	[Zinc Sulfate results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride	20096349
C088658	zoledronic acid	zoledronic acid results in increased expression of SLC11A2 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005375	copper ion transmembrane transporter activity	-	IDA	12734107
GO:0005381	iron ion transmembrane transporter activity	-	TAS	-
GO:0005384	manganese ion transmembrane transporter activity	-	IDA	17293870
GO:0005515	protein binding	-	IPI	15880641 18776082 19706893 27462458
GO:0015086	cadmium ion transmembrane transporter activity	-	IDA	12662899
GO:0015087	cobalt ion transmembrane transporter activity	-	IEA	-
GO:0015093	ferrous iron transmembrane transporter activity	-	IDA	12734107 17293870
GO:0015093	ferrous iron transmembrane transporter activity	-	IMP	25491917
GO:0015093	ferrous iron transmembrane transporter activity	-	NAS	9990067
GO:0015094	lead ion transmembrane transporter activity	-	IDA	12127992
GO:0015295	solute:proton symporter activity	-	IDA	17109629
GO:0046870	cadmium ion binding	-	IDA	25326704
GO:0046915	transition metal ion transmembrane transporter activity	-	IDA	25326704

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006783	heme biosynthetic process	-	IEA	-
GO:0006824	cobalt ion transport	-	IEA	-
GO:0006825	copper ion transport	-	IDA	12734107
GO:0006828	manganese ion transport	-	IDA	17293870
GO:0006879	cellular iron ion homeostasis	-	TAS	-
GO:0007611	learning or memory	-	IEA	-
GO:0010039	response to iron ion	-	IEP	12734107 17109629
GO:0015684	ferrous iron transport	-	IDA	12734107 17293870
GO:0015692	lead ion transport	-	IDA	12127992
GO:0035434	copper ion transmembrane transport	-	IEA	-
GO:0048813	dendrite morphogenesis	-	IEA	-
GO:0048821	erythrocyte development	-	IEA	-
GO:0060586	multicellular organismal iron ion homeostasis	-	IMP	15459009
GO:0070574	cadmium ion transmembrane transport	-	IDA	12662899 25326704
GO:0070627	ferrous iron import	-	NAS	9990067
GO:0071421	manganese ion transmembrane transport	-	IEA	-
GO:1902600	proton transmembrane transport	-	IEA	-
GO:1903874	ferrous iron transmembrane transport	-	IDA	17293870

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	15880641
GO:0005737	cytoplasm	-	IDA	11891802
GO:0005739	mitochondrion	-	IDA	-
GO:0005741	mitochondrial outer membrane	-	IEA	-
GO:0005765	lysosomal membrane	-	HDA	17897319
GO:0005765	lysosomal membrane	-	IDA	10751401
GO:0005769	early endosome	-	IDA	15880641 25491917
GO:0005773	vacuole	-	IMP	17932044
GO:0005886	plasma membrane	-	IMP	11891802 17932044
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IDA	25491917
GO:0005887	integral component of plasma membrane	-	IMP	25326704
GO:0009986	cell surface	-	IEA	-
GO:0016020	membrane	-	HDA	19946888
GO:0016324	apical plasma membrane	-	IDA	15880641
GO:0031410	cytoplasmic vesicle	-	IDA	15880641
GO:0031526	brush border membrane	-	ISS	-
GO:0031902	late endosome membrane	-	IDA	10751401
GO:0045177	apical part of cell	-	IDA	15880641
GO:0045178	basal part of cell	-	IDA	15880641
GO:0048471	perinuclear region of cytoplasm	-	IDA	10751401
GO:0055037	recycling endosome	-	IDA	15880641
GO:0070826	paraferritin complex	-	IDA	11842004
GO:1903561	extracellular vesicle	-	IDA	27462458

KEGG ID	KEGG Term
hsa04142	Lysosome

Reactome ID	Reactome Term	Evidence
R-HSA-1643685	Disease	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425366	Transport of bile salts and organic acids, metal ions and amine compounds	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS
R-HSA-425410	Metal ion SLC transporters	TAS
R-HSA-5619048	Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)	TAS
R-HSA-5619102	SLC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-917937	Iron uptake and transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23565323	Genotype and age at Parkinson disease diagnosis. (2013)	Searles Nielsen S	Int J Mol Epidemiol Genet