Gene: NRCAM

4897
-
neuronal cell adhesion molecule
protein-coding
7q31.1
Ensembl:ENSG00000091129 MIM:601581 Vega:OTTHUMG00000154973 UniprotKB:Q92823
NG_029898.1
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.373e-1 (AD)  3.676e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25311470chr7:107950866NRCAM5.460e-9Maternal smoking in pregnancy27040690
cg25311470chr7:107950866NRCAM8.250e-10Maternal smoking in pregnancy27040690
cg25311470chr7:107950866NRCAM6.290e-11Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLTC0.948
NARS0.947
MARCH60.946
RAB140.945
ARL8B0.942
NDFIP10.94
LRPPRC0.94
CUL30.938
USP100.937
RANBP90.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.688
OR4F29-0.618
SH2D1A-0.338
CSAG1-0.338
HEY2-0.324
RAI14-0.312
ANXA13-0.309
CXCL3-0.296
CNN2-0.296
TNFRSF13B-0.295

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NRCAM mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NRCAM mRNA"19167446
C0065932-anthramine2-anthramine results in increased expression of NRCAM mRNA23038007
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRCAM mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NRCAM mRNA22484513
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRCAM mRNA"27188386
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NRCAM mRNA25607892
D020106AcrylamideAcrylamide results in decreased expression of NRCAM mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NRCAM gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NRCAM mRNA22484513|2363061
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NRCAM mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NRCAM mRNA25607892
D001151ArsenicArsenic affects the expression of NRCAM protein24675094
D001241AspirinAspirin results in decreased expression of NRCAM mRNA15456535
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NRCAM mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NRCAM mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NRCAM mRNA22316170
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NRCAM mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NRCAM mRNA21569818
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of NRCAM mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of NRCAM mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of NRCAM mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of NRCAM mRNA18007998
C006780bisphenol Abisphenol A affects the expression of NRCAM mRNA21786754
C006780bisphenol Abisphenol A affects the expression of NRCAM mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NRCAM mRNA25607892
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of NRCAM mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of NRCAM mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of NRCAM gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of NRCAM mRNA22079614
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NRCAM mRNA25607892
C018475butyraldehydebutyraldehyde results in decreased expression of NRCAM mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NRCAM promoter22457795
D002737ChloropreneChloroprene results in decreased expression of NRCAM mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of NRCAM mRNA20350560
D004390ChlorpyrifosChlorpyrifos results in decreased expression of NRCAM mRNA17452286|1866822
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NRCAM mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of NRCAM mRNA19320972
D003300CopperCopper deficiency results in increased expression of NRCAM mRNA26033743
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NRCAM mRNA"19167446
D003471CuprizoneCuprizone results in decreased expression of NRCAM mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of NRCAM mRNA20106945
C093628cyproconazolecyproconazole results in increased expression of NRCAM mRNA22045034
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of NRCAM mRNA23640034
C014347decitabinedecitabine affects the expression of NRCAM mRNA17194187
D003907DexamethasoneDexamethasone results in increased expression of NRCAM mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of NRCAM mRNA28628672
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRCAM mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRCAM mRNA25607892
D019422Dietary SucroseDietary Sucrose results in increased expression of NRCAM mRNA26033743
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRCAM mRNA25607892
C118739entinostatentinostat results in decreased expression of NRCAM mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRCAM mRNA"27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NRCAM mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRCAM mRNA25607892
D000431EthanolNRCAM mRNA SNP results in increased susceptibility to Ethanol16123759
D005419FlavonoidsFlavonoids results in increased expression of NRCAM mRNA18035473
C409722hexaconazolehexaconazole results in increased expression of NRCAM mRNA22045034
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of NRCAM mRNA21179406
D007213IndomethacinIndomethacin results in decreased expression of NRCAM mRNA16984733
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of NRCAM mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NRCAM mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of NRCAM mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NRCAM mRNA26752646
D007854LeadLead affects the splicing of NRCAM mRNA28903495
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRCAM mRNA25607892
D018021Lithium ChlorideLithium Chloride results in decreased expression of NRCAM mRNA26272751
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NRCAM protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NRCAM mRNA28001369
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of NRCAM mRNA22401849
D009020MorphineMorphine results in increased expression of NRCAM mRNA16123759
D009020MorphineMorphine results in increased expression of NRCAM mRNA alternative form16123759
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of NRCAM mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NRCAM mRNA"25554681
D009532NickelNickel results in increased expression of NRCAM mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of NRCAM mRNA19167457
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of NRCAM mRNA19716841
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NRCAM mRNA25607892
C506614PD 0325901PD 0325901 results in decreased expression of NRCAM mRNA25119042
D010672PhenytoinPhenytoin results in decreased expression of NRCAM mRNA26272751
C006253pirinixic acidpirinixic acid results in increased expression of NRCAM mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in decreased expression of NRCAM mRNA23608068
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRCAM mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRCAM mRNA25607892
D011441PropylthiouracilPropylthiouracil results in increased expression of NRCAM mRNA24780913
C043680ptaquilosideptaquiloside results in decreased expression of NRCAM mRNA23274088
D012524SarinSarin results in decreased expression of NRCAM mRNA19522546
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of NRCAM mRNA"21514415
D017632Asbestos, Serpentine"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of NRCAM mRNA]"21514415
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of NRCAM protein25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of NRCAM mRNA25351596
D012906SmokeSmoke affects the expression of NRCAM mRNA23693141
C017947sodium arsenitesodium arsenite results in increased expression of NRCAM mRNA21503876
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of NRCAM mRNA26496021
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of NRCAM mRNA25172293
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NRCAM mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of NRCAM mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NRCAM mRNA20133372
C024746tobacco tartobacco tar results in decreased expression of NRCAM mRNA19559774
D014212TretinoinTretinoin results in decreased expression of NRCAM mRNA21934132|2372400
D014212TretinoinTretinoin results in decreased expression of NRCAM mRNA26272751
C012589trichostatin Atrichostatin A results in decreased expression of NRCAM mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of NRCAM mRNA24935251
D014415TunicamycinTunicamycin results in increased expression of NRCAM mRNA22378314
D014520UrethaneUrethane results in decreased expression of NRCAM mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NRCAM mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NRCAM mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased expression of NRCAM mRNA26272751
D014635Valproic AcidValproic Acid results in increased expression of NRCAM mRNA22045034
D014639VanadiumVanadium results in decreased expression of NRCAM mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NRCAM gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRCAM mRNA25607892
C025643vinclozolinvinclozolin results in decreased expression of NRCAM mRNA23034163
D015034Zinc OxideZinc Oxide analog results in decreased expression of NRCAM mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of NRCAM mRNA27215404
C088658zoledronic acidzoledronic acid results in increased expression of NRCAM mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23897819  
GO:0030506ankyrin binding-IDA14602817  
GO:0086080protein binding involved in heterotypic cell-cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEP11866539  
GO:0001764neuron migration-NAS11483367  
GO:0007409axonogenesis-NAS8812479  
GO:0007413axonal fasciculation-NAS8812479  
GO:0007416synapse assembly-TAS8812479  
GO:0007417central nervous system development-NAS8812479  
GO:0008104protein localization-IEA-  
GO:0019227neuronal action potential propagation-IEA-  
GO:0030516regulation of axon extension-NAS8812479  
GO:0031290retinal ganglion cell axon guidance-IEA-  
GO:0034113heterotypic cell-cell adhesion-IEA-  
GO:0045162clustering of voltage-gated sodium channels-IDA14602817  
GO:0045666positive regulation of neuron differentiation-NAS8812479  
GO:0098609cell-cell adhesion-NAS8812479  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS8812479  
GO:0009897external side of plasma membrane-NAS8812479  
GO:0043005neuron projection-NAS8812479  
GO:0043194axon initial segment-ISS-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-373760L1CAM interactionsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS
R-HSA-445095Interaction between L1 and AnkyrinsIEA
R-HSA-447038NrCAM interactionsIEA
R-HSA-447043Neurofascin interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22780223NrCAM-regulating neural systems and addiction-related behaviors. (2014 May)Ishiguro HAddict Biol
18361428Association of PTPRB gene polymorphism with drug addiction. (2008 Oct 5)Ishiguro HAm J Med Genet B Neuropsychiatr Genet