Gene: NRDC

4898
NRD1|hNRD1|hNRD2
nardilysin convertase
protein-coding
1p32.3
Ensembl:ENSG00000078618 MIM:602651 Vega:OTTHUMG00000008278 UniprotKB:O43847
NG_029171.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.620e-3 (AD)  6.894e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2842576chr1:51858556 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1417364chr1:51797410 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1004815chr1:51793053 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of NRDC mRNA21420995
C044887beta-methylcholinebeta-methylcholine affects the expression of NRDC mRNA21179406
C025703bleomycetinbleomycetin results in decreased expression of NRDC mRNA21040473
C018021cobaltous chloridecobaltous chloride results in increased expression of NRDC mRNA19320972
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NRDC protein23301498
D005557FormaldehydeFormaldehyde results in decreased expression of NRDC mRNA20655997
C492448ICG 001ICG 001 results in decreased expression of NRDC mRNA26191083
D014635Valproic AcidValproic Acid affects the expression of NRDC mRNA25979313

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-NAS9581555  
GO:0005515protein binding-IPI18355445  22653443  
GO:0046872metal ion binding-IEA-  
GO:0048408epidermal growth factor binding-TAS12463163  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-NAS9581555  
GO:0007528neuromuscular junction development-TAS9479496  
GO:0008283cell proliferation-TAS12463163  
GO:0016477cell migration-TAS15544571  
GO:0051044positive regulation of membrane protein ectodomain proteolysis-IDA18355445  
GO:0052548regulation of endopeptidase activity-IDA18355445  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA28017472  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS12463163  
GO:0009986cell surface-TAS12463163  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal