Gene: ATP2B1

490
PMCA1|PMCA1kb
ATPase plasma membrane Ca2+ transporting 1
protein-coding
12q21.33
Ensembl:ENSG00000070961 MIM:108731 Vega:OTTHUMG00000169946 UniprotKB:P20020
NG_029485.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.626e-1 (AD)  4.083e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00508575chr12:90050967ATP2B13.050e-8Maternal smoking in pregnancy27040690
cg00508575chr12:90050967ATP2B14.640e-9Maternal smoking in pregnancy27040690
cg00508575chr12:90050967ATP2B12.390e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCN2A0.976
GABRB30.972
CNKSR20.968
ST8SIA30.968
GRIA20.968
SSX2IP0.964
PDP10.964
SLC9A60.964
NCEH10.961
RBFOX10.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.534
OR4F5-0.524
TFPI2-0.516
CNN2-0.509
MYL3-0.493
RUNX3-0.49
WWTR1-0.483
HEY2-0.482
RAI14-0.481
OR4F29-0.478

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0630871,24-dihydroxyvitamin D2"1,24-dihydroxyvitamin D2 results in increased expression of ATP2B1 mRNA"10927029
C0238501 alpha,24-dihydroxyvitamin D3"1 alpha,24-dihydroxyvitamin D3 results in increased expression of ATP2B1 mRNA"10927029
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of ATP2B1 mRNA"23829299
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of ATP2B1 protein"21673325
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ATP2B1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ATP2B1 mRNA"19167446
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ATP2B1 mRNA"17547211
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ATP2B1 mRNA"21346803
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of ATP2B1 mRNA17011747
D000082AcetaminophenAcetaminophen results in increased expression of ATP2B1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of ATP2B1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ATP2B1 mRNA19770486
C068073Am 580Am 580 results in decreased expression of ATP2B1 mRNA16982809
D000965AntimonyAntimony results in decreased expression of ATP2B1 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of ATP2B1 mRNA17547211
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ATP2B1 mRNA24449571
D001151ArsenicArsenic results in decreased expression of ATP2B1 mRNA19654921
C006632arsenic trioxidearsenic trioxide results in decreased expression of ATP2B1 mRNA12852829|1754721
C015001arsenitearsenite affects the expression of ATP2B1 mRNA22959463
D001280AtrazineAtrazine results in decreased expression of ATP2B1 mRNA26476475
D001280Atrazinelycopene inhibits the reaction [Atrazine results in decreased expression of ATP2B1 mRNA]26476475
D001374AzacitidineAzacitidine results in decreased expression of ATP2B1 mRNA20823114
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATP2B1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ATP2B1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATP2B1 mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATP2B1 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATP2B1 mRNA"19150397|2038263
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of ATP2B1 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ATP2B1 mRNA20823114
D004958EstradiolEstradiol results in decreased expression of ATP2B1 mRNA21185374|2475840
C006780bisphenol Abisphenol A results in decreased expression of ATP2B1 mRNA27690074
C006780bisphenol Abisphenol A results in decreased expression of ATP2B1 protein27690074
C006780bisphenol Abisphenol A results in increased expression of ATP2B1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ATP2B1 mRNA15336504
D002104CadmiumCadmium results in decreased expression of ATP2B1 mRNA17547211
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ATP2B1 mRNA17547211
D002118CalciumCalcium affects the expression of ATP2B1 mRNA16490722
D002118CalciumATP2B1 protein results in increased export of Calcium16452157
D002118Calciumcaloxin 1b1 inhibits the reaction [ATP2B1 protein results in increased export of Calcium]16452157
C510327caloxin 1b1caloxin 1b1 inhibits the reaction [ATP2B1 protein results in increased export of Calcium]16452157
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ATP2B1 mRNA23650126
D002857ChromiumChromium results in decreased expression of ATP2B1 mRNA17547211
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ATP2B1 mRNA28472532
D060729Coal AshCoal Ash results in decreased expression of ATP2B1 mRNA19000753
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ATP2B1 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of ATP2B1 mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of ATP2B1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ATP2B1 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of ATP2B1 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of ATP2B1 mRNA21865292
D003976DiazinonDiazinon results in increased expression of ATP2B1 mRNA29108742
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ATP2B1 mRNA21266533
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ATP2B1 mRNA20823114
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ATP2B1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ATP2B1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ATP2B1 mRNA27594783
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ATP2B1 mRNA17011747
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ATP2B1 mRNA17011747
D002117CalcitriolCalcitriol results in increased expression of ATP2B1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ATP2B1 mRNA21592394
D002117CalcitriolCalcitriol results in increased expression of ATP2B1 mRNA10927029
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ATP2B1 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ATP2B1 mRNA17547211
D004221DisulfiramDisulfiram results in decreased expression of ATP2B1 mRNA15003327
D004237DiuronDiuron results in decreased expression of ATP2B1 mRNA25152437
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATP2B1 mRNA22079256
D000431EthanolEthanol affects the expression of ATP2B1 mRNA11772933
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ATP2B1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ATP2B1 mRNA27690074
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ATP2B1 protein27690074
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ATP2B1 mRNA15834898|1755790
D005839GentamicinsGentamicins results in increased expression of ATP2B1 mRNA22061828
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA19695318
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATP2B1 mRNA25613284
C051890irinotecanirinotecan affects the expression of ATP2B1 mRNA20097248
D007529IsoflavonesIsoflavones results in increased expression of ATP2B1 mRNA17374662
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ATP2B1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ATP2B1 mRNA27392435
C410337K 7174K 7174 results in increased expression of ATP2B1 mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of ATP2B1 mRNA"24972896
C015329lycopenelycopene inhibits the reaction [Atrazine results in decreased expression of ATP2B1 mRNA]26476475
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ATP2B1 mRNA21641980
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ATP2B1 mRNA20823114
D008558MelphalanMelphalan results in decreased expression of ATP2B1 mRNA22363485
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ATP2B1 protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ATP2B1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ATP2B1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ATP2B1 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ATP2B1 mRNA24810058
C111654NPS R-467NPS R-467 results in decreased expression of ATP2B1 mRNA16164647
C474055octylphenoloctylphenol results in decreased expression of ATP2B1 mRNA27690074
C474055octylphenoloctylphenol results in decreased expression of ATP2B1 protein27690074
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ATP2B1 mRNA25729387
D010634PhenobarbitalPhenobarbital affects the expression of ATP2B1 mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of ATP2B1 mRNA23091169
C004479pimagedinepimagedine results in decreased expression of ATP2B1 mRNA15003327
D010936Plant ExtractsPlant Extracts results in increased expression of ATP2B1 mRNA22222932|2355793
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA19695318
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATP2B1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ATP2B1 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ATP2B1 mRNA17547211
D011441PropylthiouracilPropylthiouracil results in decreased expression of ATP2B1 mRNA24780913
C089730rosiglitazonerosiglitazone results in decreased expression of ATP2B1 mRNA16982809
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of ATP2B1 mRNA"24160326
C009277sodium arsenatesodium arsenate results in decreased expression of ATP2B1 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of ATP2B1 mRNA21795629
D012999SomanSoman results in decreased expression of ATP2B1 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ATP2B1 mRNA21641980
C061133tamibarotenetamibarotene affects the expression of ATP2B1 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of ATP2B1 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ATP2B1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ATP2B1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of ATP2B1 mRNA20090667
C004648testosterone enanthatetestosterone enanthate affects the expression of ATP2B1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ATP2B1 mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ATP2B1 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ATP2B1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATP2B1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATP2B1 mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of ATP2B1 protein20109541
C009495titanium dioxidetitanium dioxide results in decreased expression of ATP2B1 mRNA23131501
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ATP2B1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ATP2B1 mRNA15498508
C012589trichostatin Atrichostatin A results in decreased expression of ATP2B1 mRNA24935251
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ATP2B1 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of ATP2B1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ATP2B1 mRNA23179753|2519280
D014639VanadiumVanadium results in increased expression of ATP2B1 mRNA19000753
C025643vinclozolinvinclozolin affects the expression of ATP2B1 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of ATP2B1 mRNA20566332
D015034Zinc OxideZinc Oxide analog results in decreased expression of ATP2B1 mRNA24060544
D015034Zinc OxideZinc Oxide analog results in decreased expression of ATP2B1 protein24060544

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005388calcium-transporting ATPase activity-IBA21873635  
GO:0005388calcium-transporting ATPase activity-TAS-  
GO:0005515protein binding-IPI18029012  22084111  
GO:0005516calmodulin binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0015085calcium ion transmembrane transporter activity-IDA18029012  
GO:0019829cation-transporting ATPase activity-IBA21873635  
GO:0030165PDZ domain binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003407neural retina development-IEA-  
GO:0006874cellular calcium ion homeostasis-IBA21873635  
GO:0007420brain development-IEA-  
GO:0007568aging-IEA-  
GO:0009409response to cold-IEA-  
GO:0034220ion transmembrane transport-TAS-  
GO:0051480regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0051480regulation of cytosolic calcium ion concentration-IDA18029012  
GO:0070588calcium ion transmembrane transport-IEA-  
GO:0071305cellular response to vitamin D-IEA-  
GO:0071386cellular response to corticosterone stimulus-IEA-  
GO:0099132ATP hydrolysis coupled cation transmembrane transport-IEA-  
GO:1903779regulation of cardiac conduction-TAS-  
GO:1990034calcium ion export across plasma membrane-IDA18029012  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005886plasma membrane-IDA18029012  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8396145  
GO:0009898cytoplasmic side of plasma membrane-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0032591dendritic spine membrane-IEA-  
GO:0032809neuronal cell body membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0045121membrane raft-IEA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04970Salivary secretion
hsa04972Pancreatic secretion
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418359Reduction of cytosolic Ca++ levelsTAS
R-HSA-418360Platelet calcium homeostasisTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-936837Ion transport by P-type ATPasesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24142389Male-specific genetic effect on hypertension and metabolic disorders. (2014 Mar)Heo SGHum Genet
25059375[Association between polymorphism of ATP2B1 gene, its interaction with smoking and essential hypertension -a case-control study]. (2014 May)Song JZhonghua Liu Xing Bing Xue Za Zhi