Gene: NRTN

4902
NTN
neurturin
protein-coding
19p13.3
Ensembl:ENSG00000171119 MIM:602018 Vega:OTTHUMG00000180555 UniprotKB:Q99748
NG_008202.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.425e-1 (AD)  4.652e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHP20.506
KIAA12100.465
ALX40.463
MFAP20.46
KBTBD130.454
ATP6V1G30.445
CDC20B0.444
OR51E10.439
CLIC60.438
CCL260.431

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ESRP1-0.292
TNNT2-0.258
GP6-0.249
UROC1-0.248
MYBPHL-0.243
SOSTDC1-0.242
SEMA3A-0.242
TBR1-0.242
C3orf35-0.241
TDO2-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NRTN mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NRTN mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRTN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRTN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRTN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRTN mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of NRTN mRNA22634333
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of NRTN mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NRTN mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NRTN protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NRTN mRNA22100608|2715375
D016718Arachidonic AcidArachidonic Acid results in decreased expression of NRTN mRNA16704987
D001151ArsenicArsenic affects the expression of NRTN protein24675094
C006632arsenic trioxidearsenic trioxide results in decreased expression of NRTN mRNA26705709
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NRTN mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of NRTN mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NRTN mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NRTN mRNA21839799
D004958EstradiolEstradiol results in decreased expression of NRTN mRNA20106945
D004958EstradiolEstradiol results in increased expression of NRTN mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of NRTN mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of NRTN mRNA25181051
D002104CadmiumCadmium results in decreased expression of NRTN mRNA24067728
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NRTN mRNA20360939
D002220CarbamazepineCarbamazepine affects the expression of NRTN mRNA22634333
D002330CarmustineCarmustine results in decreased expression of NRTN mRNA15980968
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of NRTN mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of NRTN mRNA24374135
D002922CiguatoxinsCiguatoxins affects the expression of NRTN mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of NRTN mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of NRTN mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NRTN mRNA]17585979
D003042CocaineCocaine affects the expression of NRTN mRNA20187946
D019327Copper SulfateCopper Sulfate results in decreased expression of NRTN mRNA19549813
C030123coumarincoumarin results in increased expression of NRTN mRNA18480146
D016572CyclosporineCyclosporine results in decreased expression of NRTN mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of NRTN mRNA27989131
C014347decitabinedecitabine results in decreased expression of NRTN mRNA19363521
C014347decitabineTP53 protein affects the reaction [decitabine results in decreased expression of NRTN mRNA]19363521
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NRTN mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of NRTN mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of NRTN mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NRTN mRNA20360939
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of NRTN mRNA19371625
D004237DiuronDiuron results in decreased expression of NRTN mRNA21551480
D004237DiuronDiuron results in increased expression of NRTN mRNA25152437
C118739entinostatentinostat results in increased expression of NRTN mRNA27188386
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased methylation of NRTN promoter27415467
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NRTN mRNA18936297
D015025ZearalenoneZearalenone results in increased expression of NRTN mRNA19371625
C039281furanfuran results in decreased expression of NRTN mRNA25539665|2619464
D019833GenisteinGenistein results in increased expression of NRTN mRNA19371625|2301914
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of NRTN mRNA24680724
D017313FenretinideFenretinide results in increased expression of NRTN mRNA28973697
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of NRTN mRNA22563483
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NRTN mRNA27188386|2800136
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of NRTN mRNA24810058
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of NRTN mRNA25729387
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of NRTN mRNA22563483
D010269ParaquatParaquat results in decreased expression of NRTN mRNA22563483
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of NRTN mRNA17616710
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRTN mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NRTN mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of NRTN mRNA23811191
D011441PropylthiouracilPropylthiouracil results in decreased expression of NRTN mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of NRTN mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NRTN mRNA25895662
D012999SomanSoman results in decreased expression of NRTN mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of NRTN mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NRTN mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NRTN mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NRTN mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased expression of NRTN mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of NRTN mRNA25729387
D014212TretinoinTretinoin results in decreased expression of NRTN mRNA20488242
C034613triacsin Ctriacsin C results in decreased expression of NRTN mRNA16704987
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRTN mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of NRTN mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of NRTN mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NRTN mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NRTN mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of NRTN gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NRTN mRNA21427059
D015032ZincZinc deficiency results in decreased expression of NRTN mRNA16140947
D015032ZincZinc inhibits the reaction [Zinc deficiency results in decreased expression of NRTN mRNA]16140947

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005102signaling receptor binding-TAS10829012  
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001755neural crest cell migration-IDA15242795  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IEA-  
GO:0007399nervous system development-TAS9286710  
GO:0007411axon guidance-TAS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0021675nerve development-IEA-  
GO:0031175neuron projection development-IDA15242795  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005622intracellular-IEA-  
GO:0030424axon-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-419037NCAM1 interactionsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-8853659RET signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25975578The RET fusion gene and its correlation with demographic and clinicopathological features of non-small cell lung cancer: a meta-analysis. (2015)Lin CCancer Biol Ther