Gene: YBX1

4904
BP-8|CBF-A|CSDA2|CSDB|DBPB|EFI-A|MDR-NF1|NSEP-1|NSEP1|YB-1|YB1
Y-box binding protein 1
protein-coding
1p34.2
Ensembl:ENSG00000065978 MIM:154030 Vega:OTTHUMG00000007523 UniprotKB:P67809
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.968e-1 (AD)  4.674e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC11A0.922
RPS160.907
RPL300.901
TPT10.901
RPL100.901
RPS60.9
RPS130.899
RPS15A0.899
RPS190.894
PTMA0.893

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.669
OR4F5-0.637
ABCC12-0.397
CALHM1-0.394
KCNB2-0.393
SOWAHB-0.384
STYK1-0.383
PPEF1-0.382
MLIP-0.379
PAX7-0.379

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of YBX1 mRNA"19162173
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased phosphorylation of YBX1 protein"27026707
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of YBX1 mRNA12958071
C0293704-toluidine4-toluidine results in increased expression of YBX1 mRNA27638505
D000082AcetaminophenAcetaminophen affects the expression of YBX1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of YBX1 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of YBX1 mRNA16483693
C015001arsenitearsenite affects the localization of YBX1 protein17339575
C004456beauvericinbeauvericin results in decreased expression of YBX1 mRNA29203277
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of YBX1 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of YBX1 mRNA26377693
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of YBX1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of YBX1 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of YBX1 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of YBX1 promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of YBX1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of YBX1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of YBX1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of YBX1 mRNA28628672
C026105butylidenephthalidebutylidenephthalide results in decreased expression of YBX1 protein23770345
D002251Carbon TetrachlorideYBX1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]16012952
C099555CD 437CD 437 results in decreased expression of YBX1 mRNA12958071
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of YBX1 mRNA23650126
C100187chloropicrinchloropicrin results in decreased expression of YBX1 mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of YBX1 mRNA28472532
C031180chrysenechrysene results in increased expression of YBX1 mRNA26377693
D003042CocaineCocaine affects the expression of YBX1 mRNA20187946
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of YBX1 mRNA15467011
D003375CoumestrolCoumestrol results in increased expression of YBX1 mRNA19167446
C030973cupric oxidecupric oxide results in increased expression of YBX1 protein25470785
D003471CuprizoneCuprizone results in increased expression of YBX1 mRNA27523638
C017160cypermethrincypermethrin results in increased expression of YBX1 mRNA22528246
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of YBX1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of YBX1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of YBX1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of YBX1 mRNA17361019
D002945CisplatinCisplatin promotes the reaction [APEX1 protein modified form binds to [YBX1 protein binds to EP300 protein]]20856196
D002945CisplatinCisplatin promotes the reaction [[APEX1 protein modified form promotes the reaction [YBX1 protein binds to EP300 protein]] which binds to ABCB1 promoter]20856196
D002945CisplatinYBX1 protein results in decreased susceptibility to Cisplatin21466612
D002945CisplatinCisplatin results in decreased expression of YBX1 protein22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of YBX1 mRNA26924002
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of YBX1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of YBX1 mRNA]19850644
C024629dimethyl phthalatedimethyl phthalate results in increased expression of YBX1 mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of YBX1 mRNA17108234
D005472FluorouracilFluorouracil promotes the reaction [YBX1 protein binds to MVP promoter]15750632
C492448ICG 001ICG 001 results in increased expression of YBX1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of YBX1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of YBX1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of YBX1 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of YBX1 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of YBX1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of YBX1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of YBX1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of YBX1 mRNA28628672
C410337K 7174K 7174 results in decreased expression of YBX1 mRNA24086573
D007854LeadLead affects the splicing of YBX1 mRNA28903495
D018021Lithium ChlorideLithium Chloride results in decreased expression of YBX1 mRNA23527032
D008627Mercuric ChlorideMercuric Chloride affects the expression of YBX1 mRNA20353558
D008628MercuryMercury results in increased expression of YBX1 mRNA16823088
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of YBX1 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of YBX1 mRNA19564919
D008777MethyltestosteroneMethyltestosterone results in decreased expression of YBX1 mRNA29191790
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of YBX1 protein20553848
C517284monomethyl phthalatemonomethyl phthalate affects the expression of YBX1 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of YBX1 mRNA15674843
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"ILK protein inhibits the reaction [N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased expression of YBX1 mRNA]"21823616
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"ILK protein inhibits the reaction [N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased expression of YBX1 protein]"21823616
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased expression of YBX1 mRNA"21823616
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased expression of YBX1 protein"21823616
D011441PropylthiouracilPropylthiouracil results in increased expression of YBX1 mRNA24780913
C037219quinolinequinoline analog results in decreased expression of YBX1 protein18645022
C059514resveratrolresveratrol results in decreased expression of YBX1 protein25505154
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of YBX1 mRNA19564919
C534628SCH 23390SCH 23390 results in increased expression of YBX1 mRNA19564919
C017947sodium arsenitesodium arsenite results in increased activity of YBX1 protein10411148
C017947sodium arsenitesodium arsenite affects the activity of YBX1 protein10411148
C016104sodium bichromatesodium bichromate results in increased activity of YBX1 protein10411148
C016104sodium bichromatesodium bichromate results in increased activity of YBX1 protein10411148
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of YBX1 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of YBX1 mRNA25613284
D014118Toxins, Biological"Toxins, Biological affects the expression of YBX1 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of YBX1 mRNA17218384
D014241TrichloroethyleneTrichloroethylene results in increased methylation of YBX1 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of YBX1 mRNA19042947
D014520UrethaneUrethane results in increased expression of YBX1 mRNA28818685
D015032ZincZinc deficiency results in increased expression of YBX1 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA18809583  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA18809583  
GO:0003677DNA binding-IDA18809583  
GO:0003677DNA binding-TAS2977358  8188694  
GO:0003682chromatin binding-IEA-  
GO:0003690double-stranded DNA binding-TAS1738588  
GO:0003697single-stranded DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS3174636  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IDA19561594  
GO:0005515protein binding-IPI12674497  15229244  16198352  16797541  17289661  17572683  
17932509  18335541  18809583  18851979  19174163  20856196  
21423216  21849455  22118625  22365833  23986595  24965446  
25497084  
GO:0051020GTPase binding-IPI24337748  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0001701in utero embryonic development-IEA-  
GO:0006355regulation of transcription, DNA-templated-IDA18809583  
GO:0006366transcription by RNA polymerase II-TAS3174636  
GO:0007219Notch signaling pathway-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA18809583  
GO:0051154negative regulation of striated muscle cell differentiation-IEA-  
GO:0051781positive regulation of cell division-IEA-  
GO:0070934CRD-mediated mRNA stabilization-IMP19029303  
GO:1903608protein localization to cytoplasmic stress granule-IMP24965446  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-TAS3174636  
GO:0005654nucleoplasm-TAS-  
GO:0005689U12-type spliceosomal complex-IDA15146077  
GO:0005737cytoplasm-IDA24965446  
GO:0005829cytosol-IDA-  
GO:0010494cytoplasmic stress granule-IDA18335541  
GO:0031965nuclear membrane-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-HDA20458337  
GO:0070937CRD-mediated mRNA stability complex-IDA19029303  
GO:0071204histone pre-mRNA 3'end processing complex-ISS-  
GO:1990904ribonucleoprotein complex-IDA17289661  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72165mRNA Splicing - Minor PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusTAS
R-HSA-9017802Noncanonical activation of NOTCH3TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27033944Long noncoding RNA POU6F2-AS2 is associated with oesophageal squamous cell carcinoma. (2016 Oct)Liu JJ Biochem