Gene info: ID 4905

Gene: NSF

GENE ID: 4905

Synonyms: SEC18|SKD2

Description: N-ethylmaleimide sensitive factor, vesicle fusing ATPase

Gene type: protein-coding

Location: 17q21.31

dbXrefs: Ensembl:ENSG00000073969 MIM:601633 Vega:OTTHUMG00000134315 UniprotKB:P46459

RefSeq: NC_000017.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.189e-1 (AD) 7.209e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RTN1	0.986
MAP7D2	0.983
SNAP91	0.983
NEFL	0.981
GLRB	0.98
PPP3CB	0.979
SYN2	0.979
SYT1	0.979
INA	0.979
TMEM246	0.979

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSAG1	-0.527
RAI14	-0.518
REST	-0.516
HEY2	-0.508
YES1	-0.506
MYL3	-0.506
CNN2	-0.506
TFPI2	-0.501
RNF135	-0.5
OR4F5	-0.498

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01902	1-Ethyl-Pyrrolidine-2,5-Dione	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NSF mRNA"	25510870
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of NSF mRNA"	23829299
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NSF mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NSF mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NSF mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NSF mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of NSF mRNA"	23829299
C011269	2,5-hexanedione	"2,5-hexanedione results in decreased expression of NSF protein"	19033394
D000082	Acetaminophen	Acetaminophen results in increased expression of NSF mRNA	22230336
D020106	Acrylamide	Acrylamide binds to and affects the metabolism of NSF protein	17698512
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of NSF gene	27153756
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of NSF mRNA"	23195993
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NSF mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of NSF mRNA	24449571
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to NSF promoter]	19654925
C044887	beta-methylcholine	beta-methylcholine affects the expression of NSF mRNA	21179406
C006780	bisphenol A	bisphenol A results in decreased expression of NSF mRNA	25181051
C013418	bromfenacoum	bromfenacoum results in increased expression of NSF protein	28903499
C018475	butyraldehyde	butyraldehyde results in decreased expression of NSF mRNA	26079696
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NSF mRNA"	20230807
D002110	Caffeine	"Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA]"	20230807
C010063	carbonyl sulfide	carbonyl sulfide results in increased expression of NSF mRNA	19395590
D003042	Cocaine	Cocaine results in decreased expression of NSF mRNA	12629581
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of NSF mRNA	19549813
D016578	Crack Cocaine	Crack Cocaine results in increased expression of NSF mRNA	12629581
D016572	Cyclosporine	Cyclosporine results in decreased expression of NSF mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of NSF mRNA	21163907
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of NSF mRNA	21266533
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of NSF mRNA	19041683
C472511	dimethylarsinous acid	dimethylarsinous acid results in decreased expression of NSF mRNA	16507463
D004221	Disulfiram	Disulfiram results in decreased expression of NSF mRNA	20530235
D016291	Dizocilpine Maleate	Dizocilpine Maleate results in increased expression of NSF protein	21297352
D007980	Levodopa	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]	25129099
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NSF mRNA	22079256
D005419	Flavonoids	Flavonoids results in increased expression of NSF mRNA	18035473
D005485	Flutamide	Flutamide results in decreased expression of NSF mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of NSF mRNA	24136188
D006220	Haloperidol	Haloperidol results in decreased expression of NSF mRNA	15860345
D002112	Calcifediol	Calcifediol deficiency results in decreased expression of NSF mRNA	17293106
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NSF mRNA	25613284
C051890	irinotecan	irinotecan analog results in decreased expression of NSF mRNA	18927307
C016527	isoquercitrin	isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]	25129099
C410337	K 7174	K 7174 results in decreased expression of NSF mRNA	24086573
D007649	Ketamine	Ketamine results in increased expression of NSF mRNA	20080153
D048628	Ketolides	Ketolides analog results in decreased expression of NSF mRNA	24967691
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of NSF mRNA	25613284
C025340	manganese chloride	manganese chloride results in decreased expression of NSF mRNA	27913844
C025340	manganese chloride	manganese chloride results in increased methylation of NSF gene	27913844
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of NSF mRNA	20353558
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of NSF protein	27012723
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of NSF protein	26558463
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of NSF protein	26558463
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NSF mRNA"	15329391
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NSF mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NSF mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA]"	20230807
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of NSF mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of NSF mRNA	23195993
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NSF mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA]"	20230807
D016627	Oxidopamine	isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]	25129099
D016627	Oxidopamine	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]	25129099
D016627	Oxidopamine	Oxidopamine results in decreased expression of NSF mRNA	25129099
D016627	Oxidopamine	Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]	25129099
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of NSF mRNA]"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NSF mRNA"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NSF mRNA]"	21673326
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of NSF mRNA	25729387
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NSF mRNA"	25510870
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of NSF protein	19954255
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of NSF mRNA	26794494
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NSF mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of NSF mRNA	22079256
C015586	propiverine	propiverine binds to NSF protein	29273565
D012431	Rutin	Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]	25129099
C010327	salinomycin	salinomycin results in decreased expression of NSF mRNA	19682730
D012524	Sarin	Sarin results in decreased expression of NSF protein	25842371
C080703	SK&F 83959	SK&F 83959 results in decreased expression of NSF protein	25852303
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NSF mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NSF protein	24680724
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NSF protein	19492234
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NSF mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of NSF mRNA	23411599
D013893	Thiram	Thiram results in decreased expression of NSF mRNA	20530235
C009495	titanium dioxide	titanium dioxide results in increased expression of NSF mRNA	23409001
D024505	Tocopherols	Tocopherols results in increased expression of NSF mRNA	17654050
D014050	Toluene	Toluene affects the expression of NSF mRNA	21827849
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of NSF mRNA	25729387
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of NSF mRNA	19042947
D014635	Valproic Acid	Valproic Acid affects the expression of NSF mRNA	25979313
C025643	vinclozolin	vinclozolin affects the expression of NSF mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of NSF mRNA	23034163

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000149	SNARE binding	-	ISS	-
GO:0005515	protein binding	-	IPI	15322554 16417406 16724110 20562859
GO:0005524	ATP binding	-	IEA	-
GO:0016887	ATPase activity	-	IBA	21873635
GO:0016887	ATPase activity	-	ISS	-
GO:0016887	ATPase activity	-	TAS	-
GO:0017075	syntaxin-1 binding	-	ISS	-
GO:0017137	Rab GTPase binding	-	ISS	-
GO:0019901	protein kinase binding	-	ISS	-
GO:0030165	PDZ domain binding	-	IPI	15613468
GO:0035255	ionotropic glutamate receptor binding	-	IPI	12130635
GO:0042623	ATPase activity, coupled	-	IEA	-
GO:0044877	protein-containing complex binding	-	IDA	15613468
GO:0044877	protein-containing complex binding	-	ISS	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001921	positive regulation of receptor recycling	-	IDA	15613468
GO:0006813	potassium ion transport	-	IEA	-
GO:0006886	intracellular protein transport	-	IMP	22045810
GO:0006887	exocytosis	-	TAS	15613468
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	-
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	-
GO:0006891	intra-Golgi vesicle-mediated transport	-	IBA	21873635
GO:0016192	vesicle-mediated transport	-	ISS	-
GO:0017157	regulation of exocytosis	-	ISS	-
GO:0035494	SNARE complex disassembly	-	ISS	-
GO:0043001	Golgi to plasma membrane protein transport	-	IBA	21873635
GO:0045026	plasma membrane fusion	-	TAS	15613468
GO:0045732	positive regulation of protein catabolic process	-	IMP	22045810
GO:0048208	COPII vesicle coating	-	TAS	-
GO:0048211	Golgi vesicle docking	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	IEA	-
GO:0005765	lysosomal membrane	-	HDA	17897319
GO:0005795	Golgi stack	-	IBA	21873635
GO:0005795	Golgi stack	-	ISS	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	15613468
GO:0014069	postsynaptic density	-	ISS	-
GO:0043198	dendritic shaft	-	ISS	-
GO:0043209	myelin sheath	-	IEA	-

KEGG ID	KEGG Term
hsa04962	Vasopressin-regulated water reabsorption

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-199977	ER to Golgi Anterograde Transport	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-204005	COPII-mediated vesicle transport	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-399719	Trafficking of AMPA receptors	TAS
R-HSA-399721	Glutamate binding, activation of AMPA receptors and synaptic plasticity	TAS
R-HSA-416993	Trafficking of GluR2-containing AMPA receptors	TAS
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6807878	COPI-mediated anterograde transport	TAS
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	TAS
R-HSA-6811438	Intra-Golgi traffic	TAS
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	TAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	TAS
R-HSA-8856688	Golgi-to-ER retrograde transport	TAS
R-HSA-948021	Transport to the Golgi and subsequent modification	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
9269360	Smoking in the Singapore Armed Forces. (1997 Feb)	Lim MK	Singapore Med J
15140344	Recalculation of cardiovascular risk score as a surrogate marker of change in clinical care of diabetes patients: the Alphabet POEM project (Practice Of Evidence-based Medicine). (2004 May)	Lee JD	Curr Med Res Opin
21426264	Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)	Fernandez-Castillo N	World J Biol Psychiatry
27498889	A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence. (2016 Aug 8)	Cabana-Dominguez J	Sci Rep