Gene: NTHL1

4913
FAP3|NTH1|OCTS3|hNTH1
nth like DNA glycosylase 1
protein-coding
16p13.3
Ensembl:ENSG00000065057 MIM:602656 Vega:OTTHUMG00000128744 UniprotKB:P78549
NG_008412.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.208e-1 (AD)  5.435e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01815912chr16:2089851NTHL12.510e-9Maternal smoking in pregnancy27040690
cg01815912chr16:2089851NTHL11.400e-9Maternal smoking in pregnancy27040690
cg04119529chr16:2094667NTHL14.500e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXOSC50.919
HSPBP10.91
LAGE30.909
PIN10.897
NDUFA110.897
ABHD14A0.896
PSMG30.896
MRPS340.896
MRPL280.892
TWF20.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.581
OR4F29-0.548
KCNJ15-0.487
IL18RAP-0.481
FCGR3B-0.479
VNN2-0.473
CXCR2-0.472
ITGA1-0.471
NEDD4-0.47
CXCR1-0.461

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NTHL1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of NTHL1 mRNA25704631|2906747
D000082AcetaminophenAcetaminophen affects the expression of NTHL1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of NTHL1 mRNA]16137721
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NTHL1 mRNA22100608
C023650anilineaniline results in increased expression of and results in increased activity of NTHL1 protein23352893
C023650anilineaniline results in increased expression of NTHL1 mRNA23352893
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NTHL1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NTHL1 mRNA22228805
D004958EstradiolEstradiol affects the expression of NTHL1 mRNA16684588
C044887beta-methylcholinebeta-methylcholine affects the expression of NTHL1 mRNA21179406
D001629BezafibrateBezafibrate results in increased expression of NTHL1 mRNA15447978
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTHL1 mRNA28628672
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTHL1 mRNA28628672
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNA12634122
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NTHL1 promoter22457795
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNA12634122
C018021cobaltous chloridecobaltous chloride results in decreased expression of NTHL1 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in decreased expression of NTHL1 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of NTHL1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of NTHL1 mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of NTHL1 mRNA21878529
D016572CyclosporineCyclosporine results in decreased expression of NTHL1 mRNA20106945|2556210
D003609DactinomycinDactinomycin results in decreased expression of NTHL1 mRNA21527772
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTHL1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTHL1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NTHL1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NTHL1 mRNA27392435
D002945CisplatinFolic Acid affects the reaction [Cisplatin affects the expression of NTHL1 mRNA]16898872
D004391DustDust results in decreased expression of NTHL1 mRNA17805423
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NTHL1 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NTHL1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of NTHL1 mRNA23649840
D005485FlutamideFlutamide results in increased expression of NTHL1 mRNA19442681
D005492Folic AcidFolic Acid affects the reaction [Cisplatin affects the expression of NTHL1 mRNA]16898872
D005557FormaldehydeFormaldehyde results in decreased expression of NTHL1 mRNA23649840
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTHL1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTHL1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTHL1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTHL1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NTHL1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of NTHL1 mRNA27392435
C410337K 7174K 7174 results in decreased expression of NTHL1 mRNA24086573
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNA12634122
D008694MethamphetamineMethamphetamine results in decreased expression of NTHL1 mRNA19564919
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NTHL1 mRNA21527772|2364984
D008825MiconazoleMiconazole results in increased expression of NTHL1 mRNA22262564
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of NTHL1 mRNA20971185
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NTHL1 mRNA19710929
C547185riccardin Driccardin D results in decreased expression of NTHL1 mRNA24069304
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNA12634122
C017947sodium arsenitesodium arsenite results in decreased expression of NTHL1 mRNA21776218
C017947sodium arsenitesodium arsenite results in increased expression of NTHL1 mRNA12634122
C016104sodium bichromatesodium bichromate results in increased expression of NTHL1 mRNA22155349
D012999SomanSoman results in increased expression of NTHL1 mRNA19281266
D053260SootSoot results in increased expression of NTHL1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NTHL1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NTHL1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NTHL1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NTHL1 mRNA21215274
D014028Tobacco Smoke PollutionAcetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of NTHL1 mRNA]16137721
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NTHL1 mRNA16137721
D014212TretinoinTretinoin results in decreased expression of NTHL1 mRNA16140955|2372400
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NTHL1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of NTHL1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of NTHL1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000703oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity-IBA21873635  
GO:0000703oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity-TAS-  
GO:0003690double-stranded DNA binding-IDA15358233  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-IBA21873635  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-IDA8990169  
GO:0004519endonuclease activity-TAS9831664  
GO:0005515protein binding-IPI15358233  
GO:0008534oxidized purine nucleobase lesion DNA N-glycosylase activity-TAS-  
GO:0019104DNA N-glycosylase activity-IDA10882850  
GO:0046872metal ion binding-IEA-  
GO:00515394 iron, 4 sulfur cluster binding-IEA-  
GO:0140078class I DNA-(apurinic or apyrimidinic site) endonuclease activity-IDA8990169  
GO ID GO Term Qualifier Evidence PubMed
GO:0006285base-excision repair, AP site formation-IBA21873635  
GO:0006285base-excision repair, AP site formation-IDA15358233  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-IBA21873635  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-IDA8990169  
GO:0045008depyrimidination-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12531031  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-110328Recognition and association of DNA glycosylase with site containing an affected pyrimidineTAS
R-HSA-110329Cleavage of the damaged pyrimidine TAS
R-HSA-110357Displacement of DNA glycosylase by APEX1TAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73928DepyrimidinationTAS
R-HSA-73929Base-Excision Repair, AP Site FormationTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23951112Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk. (2013)Corral RPLoS One