Gene: NTRK1

4914
MTC|TRK|TRK1|TRKA|Trk-A|p140-TrkA
neurotrophic receptor tyrosine kinase 1
protein-coding
1q23.1
Ensembl:ENSG00000198400 MIM:191315 Vega:OTTHUMG00000041304 UniprotKB:P04629
NG_007493.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.322e-1 (AD)  9.726e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf870.708
PTPN70.686
TBC1D10C0.664
ARHGAP60.638
NSUN70.635
TNFRSF80.627
KCNJ10.609
ABCA130.608
UPK1B0.607
ALPK10.605

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.402
GALNT9-0.388
CPLX3-0.383
KCNC2-0.382
NEUROD2-0.378
PVALB-0.368
KCNJ3-0.363
VIP-0.36
KCNJ6-0.358
MPPED1-0.354

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
DB00619ImatinibSmall Molecule152459-95-5ApprovedTarget
DB08896RegorafenibSmall Molecule755037-03-7ApprovedTarget
ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of NTRK1 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of NTRK1 mRNA]"27071940
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased activity of NTRK1 protein"18754654
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of NTRK1 mRNA"20959002
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NTRK1 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NTRK1 mRNA"20816883
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NTRK1 mRNA"20959002
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTRK1 mRNA"27188386
C5495694-cyano-N-(2-(1-cyclohexen-1-yl)-4-(1-((dimethylamino)acetyl)-4-piperidinyl)phenyl)-1H-imidazole-2-carboxamide4-cyano-N-(2-(1-cyclohexen-1-yl)-4-(1-((dimethylamino)acetyl)-4-piperidinyl)phenyl)-1H-imidazole-2-carboxamide results in decreased activity of NTRK1 protein22039836
C5610525H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one"5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one results in decreased activity of NTRK1 protein"21608528
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTRK1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased phosphorylation of and results in increased activity of NTRK1 protein23472850
D000082AcetaminophenAcetylcysteine inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of NTRK1 protein]23472850
D000082AcetaminophenNGF protein affects the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of NTRK1 protein]23472850
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK1 mRNA25607892
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of NTRK1 protein]23472850
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein]23472850
D000452Aldrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA28263720
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NTRK1 mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK1 mRNA25607892
D001151ArsenicArsenic affects the methylation of NTRK1 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of NTRK116569477
D004958EstradiolEstradiol results in increased expression of NTRK1 protein16436532
C006780bisphenol Abisphenol A affects the expression of NTRK1 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK1 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of NTRK1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NTRK1 gene28505145
D019328Buthionine SulfoximineAcetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein]23472850
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein23472850
D019328Buthionine SulfoximineNGF protein affects the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein]23472850
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK1 mRNA25607892
D002211CapsaicinNTRK1 promotes the reaction [NGF protein results in increased susceptibility to Capsaicin]17324588
D002211CapsaicinNTRK1 protein mutant form affects the reaction [NGF protein results in increased susceptibility to Capsaicin]17324588
D002211CapsaicinCapsaicin results in decreased expression of NTRK1 mRNA8971780|9259450
D002220CarbamazepineCarbamazepine affects the expression of NTRK1 mRNA25979313
C084597chlorcyclizinechlorcyclizine results in increased expression of NTRK1 mRNA21058326
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of NTRK1 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK1 mRNA16934159
D004390ChlorpyrifosChlorpyrifos results in decreased expression of NTRK1 mRNA26552522
D004390ChlorpyrifosChlorpyrifos results in increased expression of NTRK1 mRNA18502319
D007464ClioquinolClioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]25758465
D007464Clioquinoltrichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]]25758465
C551994crizotinibcrizotinib results in decreased activity of NTRK1 protein21812414
D003471CuprizoneCuprizone results in decreased expression of NTRK1 mRNA26577399
D003520CyclophosphamideCyclophosphamide results in increased phosphorylation of and results in increased expression of NTRK1 protein12412144
D016572Cyclosporine[Cyclosporine co-treated with NGF protein] results in decreased expression of NTRK1 mRNA24244623
D003634DDT[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA28263720
D003976DiazinonDiazinon results in increased expression of NTRK1 mRNA19130878
D002945CisplatinCisplatin results in increased expression of NTRK1 mRNA27392435
D003632Dichlorodiphenyldichloroethane[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA28263720
D003633Dichlorodiphenyl Dichloroethylene[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA28263720
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NTRK1 mRNA26924002
D004026Dieldrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA28263720
D004026DieldrinDieldrin results in increased expression of NTRK1 mRNA19130878
C024629dimethyl phthalatedimethyl phthalate affects the expression of NTRK1 mRNA26924002
D004147DioxinsDioxins affects the expression of NTRK1 mRNA20463971
C060297echinacosideechinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK1 protein]23189969
C060297echinacosidestaurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK1 protein]]23189969
C060297echinacosideechinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK1 protein]23189969
C060297echinacosideechinacoside results in increased phosphorylation of NTRK1 protein23189969
C060297echinacosidestaurosporine aglycone inhibits the reaction [echinacoside results in increased phosphorylation of NTRK1 protein]23189969
D004732Endrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA28263720
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK1 mRNA25607892
C039281furanfuran results in increased expression of NTRK1 mRNA25539665
D019833GenisteinGenistein results in increased expression of NTRK1 mRNA24967385
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of NTRK1 mRNA22634610
C000606649GW 441756GW 441756 inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NTRK1 protein]26476374
C492448ICG 001ICG 001 results in decreased expression of NTRK1 mRNA26191083
D007649KetamineKetamine results in increased expression of NTRK1 mRNA20080153
D001556Lindane[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA28263720
D008345ManganeseManganese results in decreased expression of NTRK1 protein17029596
C509574MCC-257MCC-257 inhibits the reaction [Methylmercury Compounds results in decreased phosphorylation of NTRK1 protein]25545984
C509574MCC-257MCC-257 inhibits the reaction [staurosporine aglycone results in decreased phosphorylation of NTRK1 protein]25545984
D008767Methylmercury CompoundsG(M1) Ganglioside inhibits the reaction [Methylmercury Compounds results in decreased phosphorylation of NTRK1 protein]25545984
D008767Methylmercury CompoundsMCC-257 inhibits the reaction [Methylmercury Compounds results in decreased phosphorylation of NTRK1 protein]25545984
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased phosphorylation of NTRK1 protein25545984|2696572
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NTRK1 mRNA26924002
D005677G(M1) GangliosideG(M1) Ganglioside inhibits the reaction [Methylmercury Compounds results in decreased phosphorylation of NTRK1 protein]25545984
D005677G(M1) GangliosideG(M1) Ganglioside inhibits the reaction [staurosporine aglycone results in decreased phosphorylation of NTRK1 protein]25545984
C500085muraglitazarmuraglitazar results in increased expression of NTRK1 mRNA21515302
D009532NickelNickel affects the expression of NTRK1 mRNA19130878
D015739NocodazoleNocodazole inhibits the reaction [NGF protein affects the localization of NTRK1 protein]17822405
C025589ochratoxin Aochratoxin A results in increased expression of NTRK1 mRNA23358140
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK1 mRNA25607892
D010100OxygenGW 441756 inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NTRK1 protein]26476374
D010100OxygenNGF protein inhibits the reaction [Quercetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NTRK1 protein]]26476374
D010100OxygenOxygen deficiency results in increased expression of NTRK1 mRNA26476374
D010100OxygenOxygen deficiency results in increased phosphorylation of NTRK1 protein26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of NTRK1 mRNA]26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NTRK1 protein]26476374
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of NTRK1 mRNA18636392
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NTRK1 protein26879310
C545373ponatinibponatinib results in decreased activity of NTRK1 protein19878872
D011192Potassium DichromatePotassium Dichromate results in decreased expression of NTRK1 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of NTRK1 mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of NTRK1 protein16436532
D011374Progesterone[VIP protein results in increased secretion of Progesterone] which results in decreased expression of NTRK1 mRNA20150881
D011441PropylthiouracilPropylthiouracil results in decreased expression of NTRK1 mRNA24780913
D011794QuercetinNGF protein inhibits the reaction [Quercetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NTRK1 protein]]26476374
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of NTRK1 mRNA]26476374
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NTRK1 protein]26476374
C089730rosiglitazonerosiglitazone results in increased expression of NTRK1 mRNA21515302
D012402Rotenoneechinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK1 protein]23189969
D012402RotenoneRotenone results in decreased phosphorylation of NTRK1 protein23189969
D012402Rotenonestaurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK1 protein]]23189969
D012402Rotenoneechinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK1 protein]23189969
D012402RotenoneRotenone results in decreased phosphorylation of NTRK1 protein23189969
D017975Ruthenium CompoundsRuthenium Compounds results in decreased activity of NTRK1 protein16858717
D019821Simvastatin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA28263720
C017947sodium arsenitesodium arsenite results in increased phosphorylation of and results in increased activity of NTRK1 protein23472850
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK1 protein]]23189969
C049985staurosporine aglyconeG(M1) Ganglioside inhibits the reaction [staurosporine aglycone results in decreased phosphorylation of NTRK1 protein]25545984
C049985staurosporine aglyconeMCC-257 inhibits the reaction [staurosporine aglycone results in decreased phosphorylation of NTRK1 protein]25545984
C049985staurosporine aglyconestaurosporine aglycone binds to and results in decreased activity of NTRK1 protein20658530
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [echinacoside results in increased phosphorylation of NTRK1 protein]23189969
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [NTRK1 protein results in increased expression of NGF mRNA]20658530
C049985staurosporine aglyconestaurosporine aglycone results in decreased activity of NTRK1 protein15973493
C049985staurosporine aglyconestaurosporine aglycone results in decreased phosphorylation of NTRK1 protein25545984
D013629TamoxifenTamoxifen results in increased expression of NTRK1 mRNA25123088
C501413tesaglitazartesaglitazar results in increased expression of NTRK1 mRNA21515302
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of NTRK1 protein27239688
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NTRK1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NTRK1 mRNA20959002
D013849Thimerosal[Thimerosal co-treated with NGF protein] results in decreased phosphorylation of NTRK1 protein15843506
D014050TolueneToluene results in decreased expression of NTRK1 mRNA17481687
D014050TolueneToluene results in increased expression of NTRK1 mRNA19932712
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK1 mRNA17085092
D014212TretinoinTretinoin results in decreased expression of NTRK1 mRNA23724009
D014212TretinoinTretinoin affects the expression of NTRK1 mRNA16211290
D014212TretinoinTretinoin results in increased expression of NTRK1 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased methylation of NTRK1 gene27618143
C012589trichostatin Atrichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]]25758465
C001899triptolidetriptolide results in decreased expression of NTRK1 mRNA23639586
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NTRK1 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NTRK1 mRNA"26552522
C057693troglitazonetroglitazone results in increased expression of NTRK1 mRNA21515302
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTRK1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NTRK1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NTRK1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of NTRK1 mRNA10689198
D024483Vitamin K 3Vitamin K 3 analog results in increased phosphorylation of NTRK1 protein19273458
C111237vorinostatvorinostat results in increased expression of NTRK1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IDA2927393  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IDA15488758  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IMP1281417  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005004GPI-linked ephrin receptor activity-IEA-  
GO:0005030neurotrophin receptor activity-IBA21873635  
GO:0005166neurotrophin p75 receptor binding-IEA-  
GO:0005515protein binding-IPI10490030  12237455  14985763  15488758  17389358  21102451  
21364532  21570973  27445338  
GO:0005524ATP binding-IEA-  
GO:0010465nerve growth factor receptor activity-IDA15488758  
GO:0010465nerve growth factor receptor activity-IMP1281417  
GO:0019900kinase binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0042803protein homodimerization activity-IDA1281417  17196528  
GO:0043121neurotrophin binding-IBA21873635  
GO:0043121neurotrophin binding-TAS9290260  
GO:0048406nerve growth factor binding-IDA1281417  15488758  17196528  
GO ID GO Term Qualifier Evidence PubMed
GO:0000186activation of MAPKK activity-TAS-  
GO:0001934positive regulation of protein phosphorylation-TAS19036963  
GO:0006468protein phosphorylation-IDA15488758  
GO:0007275multicellular organism development-IBA21873635  
GO:0007411axon guidance-IEA-  
GO:0007568aging-IEA-  
GO:0007611learning or memory-IEA-  
GO:0007623circadian rhythm-IEA-  
GO:0008285negative regulation of cell proliferation-IDA15488758  
GO:0009314response to radiation-IEA-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010623programmed cell death involved in cell development-ISS-  
GO:0010976positive regulation of neuron projection development-IDA15488758  
GO:0018108peptidyl-tyrosine phosphorylation-IDA2927393  
GO:0021553olfactory nerve development-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030183B cell differentiation-IEA-  
GO:0031667response to nutrient levels-IEA-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0038083peptidyl-tyrosine autophosphorylation-IMP1281417  
GO:0038180nerve growth factor signaling pathway-IMP1281417  
GO:0042490mechanoreceptor differentiation-IEA-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043066negative regulation of apoptotic process-TAS22635104  
GO:0043068positive regulation of programmed cell death-ISS-  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0043547positive regulation of GTPase activity-IDA15488758  
GO:0046579positive regulation of Ras protein signal transduction-IDA15488758  
GO:0046777protein autophosphorylation-IDA15488758  
GO:0048011neurotrophin TRK receptor signaling pathway-IDA15488758  
GO:0048011neurotrophin TRK receptor signaling pathway-TAS-  
GO:0048013ephrin receptor signaling pathway-IEA-  
GO:0048015phosphatidylinositol-mediated signaling-TAS-  
GO:0048485sympathetic nervous system development-ISS-  
GO:0048678response to axon injury-IEA-  
GO:0050965detection of temperature stimulus involved in sensory perception of pain-IEA-  
GO:0050966detection of mechanical stimulus involved in sensory perception of pain-IEA-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA15488758  
GO:0051599response to hydrostatic pressure-IEA-  
GO:0051602response to electrical stimulus-IEA-  
GO:0051965positive regulation of synapse assembly-IEA-  
GO:0051968positive regulation of synaptic transmission, glutamatergic-IEA-  
GO:0060009Sertoli cell development-IEA-  
GO:0060385axonogenesis involved in innervation-ISS-  
GO:0061368behavioral response to formalin induced pain-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA15488758  
GO:0071316cellular response to nicotine-IEA-  
GO:1904646cellular response to amyloid-betaNOTIDA11927634  
GO:1990090cellular response to nerve growth factor stimulus-IBA21873635  
GO:1990090cellular response to nerve growth factor stimulus-IMP1281417  
GO:1990090cellular response to nerve growth factor stimulus-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005768endosome-TAS-  
GO:0005769early endosome-ISS-  
GO:0005770late endosome-ISS-  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA1281417  2927393  15488758  
GO:0009986cell surface-IEA-  
GO:0030424axon-IBA21873635  
GO:0030424axon-IEA-  
GO:0030425dendrite-IEA-  
GO:0031901early endosome membrane-IEA-  
GO:0031902late endosome membrane-IEA-  
GO:0032991protein-containing complex-ISS-  
GO:0043025neuronal cell body-IEA-  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04144Endocytosis
hsa04210Apoptosis
hsa04722Neurotrophin signaling pathway
hsa05200Pathways in cancer
hsa05216Thyroid cancer
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-167021PLC-gamma1 signallingIEA
R-HSA-167044Signalling to RASIEA
R-HSA-169893Prolonged ERK activation eventsTAS
R-HSA-169893Prolonged ERK activation eventsIEA
R-HSA-170968Frs2-mediated activationTAS
R-HSA-170968Frs2-mediated activationIEA
R-HSA-170984ARMS-mediated activationTAS
R-HSA-170984ARMS-mediated activationIEA
R-HSA-177504Retrograde neurotrophin signallingIEA
R-HSA-177504Retrograde neurotrophin signallingTAS
R-HSA-187015Activation of TRKA receptorsTAS
R-HSA-187015Activation of TRKA receptorsIEA
R-HSA-187024NGF-independant TRKA activationIEA
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-187042TRKA activation by NGFTAS
R-HSA-187042TRKA activation by NGFIEA
R-HSA-187687Signalling to ERKsTAS
R-HSA-187687Signalling to ERKsIEA
R-HSA-187706Signalling to p38 via RIT and RINIEA
R-HSA-198203PI3K/AKT activationTAS
R-HSA-198203PI3K/AKT activationIEA
R-HSA-198745Signalling to STAT3IEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25870798Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer. (2015 Apr)Kohno TTransl Lung Cancer Res
26200269Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung. (2015 Aug)Shim HSJ Thorac Oncol