Gene: NTRK3

4916
GP145-TrkC|TRKC|gp145(trkC)
neurotrophic receptor tyrosine kinase 3
protein-coding
15q25.3
Ensembl:ENSG00000140538 MIM:191316 Vega:OTTHUMG00000148677 UniprotKB:Q16288
NG_029619.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.005e-1 (AD)  1.992e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17755717chr15:88081865 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRP10.852
MAP3K50.831
PRKCA0.829
SUFU0.813
MINK10.807
TMEM1640.799
PLXNB20.799
ELMO20.799
ARID1A0.797
MAPK40.797

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.591
OR4F29-0.53
CTNNA3-0.371
CETP-0.368
OR6C74-0.342
MUSK-0.298
C17orf112-0.294
WDR72-0.277
SLCO1A2-0.276
C5orf64-0.275

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of NTRK3 mRNA"20406850
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of NTRK3 mRNA"20206263
D000082AcetaminophenAcetaminophen results in decreased expression of NTRK3 mRNA26690555
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK3 mRNA25607892
D000638AmiodaroneAmiodarone results in increased expression of NTRK3 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NTRK3 mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK3 mRNA25607892
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NTRK3 mRNA24449571
D001151ArsenicArsenic affects the methylation of NTRK3 gene25304211
C015001arsenitearsenite results in increased methylation of NTRK3 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of NTRK3 mRNA"18687144
D001280AtrazineAtrazine results in increased expression of NTRK3 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of NTRK3 mRNA22323515
C487081belinostatbelinostat results in increased expression of NTRK3 mRNA27188386
D001548Benzalkonium CompoundsNTRK3 SNP affects the susceptibility to Benzalkonium Compounds27206134
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NTRK3 mRNA22178795|2231617
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of NTRK3 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NTRK3 mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of NTRK3 mRNA20660070
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of NTRK3 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK3 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of NTRK3 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of NTRK3 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of NTRK3 mRNA25181051
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK3 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of NTRK3 mRNA25607892
C018475butyraldehydebutyraldehyde results in decreased expression of NTRK3 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NTRK3 mRNA12160620
C119032CFM 1CFM 1 results in increased expression of NTRK3 protein23826121
D004390ChlorpyrifosChlorpyrifos results in decreased expression of NTRK3 mRNA18502319
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NTRK3 gene20938992
D003345CorticosteroneCorticosterone results in increased expression of NTRK3 mRNA18363858
D003471CuprizoneCuprizone results in decreased expression of NTRK3 mRNA26577399
D003976DiazinonDiazinon affects the expression of NTRK3 mRNA18502319
D003976DiazinonDiazinon results in decreased expression of NTRK3 mRNA19130878
D002945CisplatinCisplatin results in decreased expression of NTRK3 mRNA21151649
D004026DieldrinDieldrin results in decreased expression of NTRK3 mRNA19130878
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of NTRK3 mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of NTRK3 promoter25374375
D002117CalcitriolCalcitriol results in decreased expression of NTRK3 mRNA16002434
D004391DustDust results in decreased expression of NTRK3 mRNA17805423
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK3 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of NTRK3 mRNA25607892
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of NTRK3 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NTRK3 gene20938992
D004397FonofosFonofos results in increased methylation of NTRK3 promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of NTRK3 mRNA19167457
D017313FenretinideFenretinide results in increased expression of NTRK3 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NTRK3 mRNA25961927
D008628MercuryMercury results in increased expression of NTRK3 mRNA19937285
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NTRK3 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NTRK3 mRNA28001369
D009532NickelNickel results in decreased expression of NTRK3 mRNA24768652|2558310
D009532NickelNickel results in decreased expression of NTRK3 mRNA19130878
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK3 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of NTRK3 mRNA25607892
D010278ParathionParathion results in increased methylation of NTRK3 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of NTRK3 mRNA22178795
D010424PentobarbitalPentobarbital results in decreased expression of NTRK3 mRNA9191102
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of NTRK3 mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of NTRK3 promoter25374375
D010634PhenobarbitalPhenobarbital results in decreased expression of NTRK3 mRNA19162173
D010862PilocarpinePilocarpine results in increased expression of NTRK3 mRNA8635431
D010862PilocarpineScopolamine Hydrobromide inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA]8635431
D059808PolyphenolsPolyphenols results in decreased expression of NTRK3 mRNA16293270
C545373ponatinibponatinib results in decreased activity of NTRK3 protein19878872
D011192Potassium DichromatePotassium Dichromate results in increased expression of NTRK3 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of NTRK3 mRNA20660070
C059514resveratrolresveratrol results in decreased expression of NTRK3 mRNA25888808
D012524SarinSarin results in increased expression of NTRK3 mRNA19522546
D012601Scopolamine HydrobromideScopolamine Hydrobromide inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA]8635431
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NTRK3 mRNA23806026|2589566
C012568terbufosterbufos results in increased methylation of NTRK3 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NTRK3 mRNA20055451
D013849ThimerosalThimerosal results in decreased expression of NTRK3 mRNA24675092
C009495titanium dioxidetitanium dioxide affects the expression of NTRK3 mRNA17656681
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of NTRK3 gene26756918
D014212Tretinoin[NTF3 protein co-treated with Tretinoin] results in increased expression of NTRK3 mRNA16996685
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK3 mRNA17085092
C046488trimethyltintrimethyltin results in decreased expression of NTRK3 mRNA24002884
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NTRK3 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of NTRK3 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NTRK3 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of NTRK3 mRNA25423262

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002039p53 binding-IPI23027130  
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005004GPI-linked ephrin receptor activity-IEA-  
GO:0005030neurotrophin receptor activity-IBA21873635  
GO:0005030neurotrophin receptor activity-IDA23027130  
GO:0005515protein binding-IPI21102451  
GO:0005524ATP binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0043121neurotrophin binding-IBA21873635  
GO:0043121neurotrophin binding-TAS7806211  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IDA23027130  
GO:0001764neuron migration-IEA-  
GO:0001933negative regulation of protein phosphorylation-IDA23027130  
GO:0001934positive regulation of protein phosphorylation-TAS19036963  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IDA23027130  
GO:0007275multicellular organism development-IBA21873635  
GO:0007507heart development-IMP25196463  
GO:0007623circadian rhythm-IEA-  
GO:0008284positive regulation of cell proliferation-IDA23027130  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010628positive regulation of gene expression-IDA23027130  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0019056modulation by virus of host transcription-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030335positive regulation of cell migration-IDA23027130  
GO:0032148activation of protein kinase B activity-IDA23027130  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IDA23027130  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0038179neurotrophin signaling pathway-IEA-  
GO:0042490mechanoreceptor differentiation-IEA-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0045471response to ethanol-IEA-  
GO:0046777protein autophosphorylation-IEA-  
GO:0048013ephrin receptor signaling pathway-IEA-  
GO:0048665neuron fate specification-IEA-  
GO:0048678response to axon injury-IEA-  
GO:0048691positive regulation of axon extension involved in regeneration-IEA-  
GO:0048712negative regulation of astrocyte differentiation-IEA-  
GO:0050927positive regulation of positive chemotaxis-IDA23027130  
GO:0051412response to corticosterone-IEA-  
GO:0051965positive regulation of synapse assembly-IEA-  
GO:0060548negative regulation of cell death-IEA-  
GO:0070306lens fiber cell differentiation-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071300cellular response to retinoic acid-IEA-  
GO:0090102cochlea development-IEA-  
GO:0090630activation of GTPase activity-IDA23027130  
GO:1990090cellular response to nerve growth factor stimulus-IBA21873635  
GO:2000251positive regulation of actin cytoskeleton reorganization-IDA23027130  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0030424axon-IBA21873635  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04722Neurotrophin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-388844Receptor-type tyrosine-protein phosphatasesTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal