Gene: ROR1

4919
NTRKR1|dJ537F10.1
receptor tyrosine kinase like orphan receptor 1
protein-coding
1p31.3
Ensembl:ENSG00000185483 MIM:602336 Vega:OTTHUMG00000009022 UniprotKB:Q01973
NG_032801.2
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.574e-1 (AD)  5.063e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs620019chr1:63775258 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13300480chr1:64485696ROR13.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDE3A0.755
ALX40.746
PCSK50.739
CDC20B0.733
FOXC20.728
CPED10.724
TRABD2B0.713
HIST1H2AH0.709
LTBP10.706
OR51E10.7

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMPX-0.402
CKMT1A-0.394
GPR150-0.381
CACNA1F-0.379
HYAL3-0.371
SLC22A14-0.37
B3GNT4-0.367
DLK2-0.366
MYADML2-0.365
RTBDN-0.363

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ROR1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ROR1 mRNA"25614096
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ROR1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ROR1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ROR1 mRNA24449571
C102351apicidinapicidin inhibits the reaction [Dexamethasone results in increased expression of ROR1 mRNA]23946490
D001151ArsenicArsenic affects the methylation of ROR1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ROR1 mRNA21871943|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ROR1 mRNA19770486|2071347
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ROR1 mRNA27195522
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ROR1 mRNA"19150397
D004958EstradiolEstradiol affects the expression of ROR1 mRNA22574217
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ROR1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ROR1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ROR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ROR1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROR1 mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ROR1 mRNA22079614
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ROR1 mRNA16997883
C018475butyraldehydebutyraldehyde results in decreased expression of ROR1 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ROR1 mRNA17484886
D019327Copper SulfateCopper Sulfate results in decreased expression of ROR1 mRNA19549813
C030973cupric oxidecupric oxide results in decreased expression of ROR1 mRNA22077320
C089595cylindrospermopsincylindrospermopsin results in decreased expression of ROR1 mRNA24921660
D000069439DasatinibDasatinib results in increased expression of ROR1 mRNA20579391
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ROR1 mRNA16997883
D003907DexamethasoneDexamethasone results in increased expression of ROR1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ROR1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ROR1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROR1 mRNA28628672
D003907Dexamethasoneapicidin inhibits the reaction [Dexamethasone results in increased expression of ROR1 mRNA]23946490
D003907DexamethasoneDexamethasone results in increased expression of ROR1 mRNA23946490
D002945CisplatinCisplatin results in decreased expression of ROR1 mRNA19561079
D002117CalcitriolCalcitriol results in decreased expression of ROR1 mRNA16002434
C118739entinostatentinostat results in increased expression of ROR1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ROR1 mRNA23649840
D004397FonofosFonofos results in increased methylation of ROR1 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of ROR1 mRNA23416264|2364984
C029424hydrazinehydrazine results in decreased expression of ROR1 mRNA15282401
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ROR1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ROR1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROR1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ROR1 mRNA16997883
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ROR1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ROR1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROR1 mRNA28628672
D008558MelphalanMelphalan results in decreased expression of ROR1 mRNA22363485
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of ROR1 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ROR1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ROR1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ROR1 mRNA23649840
C029938nickel sulfatenickel sulfate results in decreased expression of ROR1 mRNA22714537
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of ROR1 mRNA"12756304
D010100OxygenOxygen deficiency results in increased expression of ROR1 mRNA26516004
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ROR1 mRNA26272509
D010278ParathionParathion results in increased methylation of ROR1 promoter22847954
D010634PhenobarbitalPhenobarbital affects the expression of ROR1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROR1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ROR1 mRNA26272509
C531249Poly(amidoamine)Poly(amidoamine) analog affects the expression of ROR127193728
D011192Potassium DichromatePotassium Dichromate results in increased expression of ROR1 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of ROR1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ROR1 mRNA27029645
C502851quinocetonequinocetone results in increased expression of ROR1 mRNA27046791
D015474IsotretinoinIsotretinoin results in increased expression of ROR1 mRNA20436886
C009166retinol acetateretinol acetate results in increased expression of ROR1 mRNA16772331
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ROR1 mRNA25895662
C012568terbufosterbufos results in increased methylation of ROR1 promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of ROR1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ROR1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ROR1 mRNA19933214
D014212TretinoinTretinoin results in increased expression of ROR1 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ROR1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of ROR1 mRNA"26179874
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ROR1 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of ROR1 mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ROR1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of ROR1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ROR1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of ROR1 mRNA24896083
D014638VanadatesVanadates results in increased expression of ROR1 mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of ROR1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of ROR1 mRNA26682919
D019287Zinc SulfateZinc Sulfate results in decreased expression of ROR1 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-TAS8875995  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005515protein binding-IPI22439932  
GO:0005524ATP binding-IEA-  
GO:0017147Wnt-protein binding-IBA21873635  
GO:0017147Wnt-protein binding-IPI18287027  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0042813Wnt-activated receptor activity-IMP27162350  
GO:1904929coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway-TAS24431302  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-IBA21873635  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0007605sensory perception of sound-IMP27162350  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0014002astrocyte development-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IMP27162350  
GO:0048839inner ear development-ISS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IMP27162350  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IDA27162350  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS1334494  
GO:0009986cell surface-IEA-  
GO:0030424axon-IBA21873635  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA23382219  
GO:0043679axon terminus-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-5140745WNT5A-dependent internalization of FZD2, FZD5 and ROR2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal