Gene: DDR2

4921
MIG20a|NTRKR3|TKT|TYRO10
discoidin domain receptor tyrosine kinase 2
protein-coding
1q23.3
Ensembl:ENSG00000162733 MIM:191311 Vega:OTTHUMG00000034423 UniprotKB:Q16832
NG_016290.2
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.199e-1 (AD)  1.371e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNG120.872
PDLIM50.841
MAML20.831
YAP10.829
LPP0.827
ARHGAP310.818
PRKD30.818
EPS80.818
SNTB10.814
ARHGAP420.812

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADTRP-0.567
GALNT14-0.54
KCNB2-0.534
BCL11A-0.532
ABCC12-0.529
RHO-0.519
CALHM1-0.517
CACNA1F-0.511
NRG1-0.508
OVOL2-0.508

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08896RegorafenibSmall Molecule755037-03-7ApprovedTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DDR2 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DDR2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DDR2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DDR2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DDR2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DDR2 mRNA"25510870
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of DDR2 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDR2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDR2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDR2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of DDR2 mRNA"19561079
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of DDR2 mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDR2 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of DDR2 mRNA28959563
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDR2 mRNA]29094188
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DDR2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DDR2 mRNA24449571
D000068180AripiprazoleAripiprazole results in decreased expression of DDR2 mRNA17868501
D001280AtrazineAtrazine results in increased expression of DDR2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DDR2 mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DDR2 mRNA22300585
C044887beta-methylcholinebeta-methylcholine affects the expression of DDR2 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of DDR2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of DDR2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DDR2 gene28505145
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDR2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of DDR2 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of DDR2 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of DDR2 mRNA19320972
D003042CocaineCocaine results in decreased expression of DDR2 mRNA17898221
D003471CuprizoneCuprizone results in increased expression of DDR2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of DDR2 mRNA20106945
D003561CytarabineCytarabine results in decreased expression of DDR2 mRNA21198554
D013759DronabinolDronabinol results in increased expression of DDR2 mRNA16616335
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DDR2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DDR2 mRNA27392435
D004237DiuronDiuron results in decreased expression of DDR2 mRNA25152437
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DDR2 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DDR2 mRNA23649840
C540355fenamidonefenamidone results in increased expression of DDR2 mRNA27029645
C039281furanfuran results in increased expression of DDR2 mRNA27387713
C001277geldanamycingeldanamycin results in increased expression of DDR2 mRNA26705709
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of DDR2 mRNA22467014
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DDR2 mRNA21179406
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of DDR2 mRNA12419474
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DDR2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of DDR2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DDR2 mRNA24796395
C008261lead acetatelead acetate results in increased expression of DDR2 mRNA22641619
D008094LithiumLithium results in decreased expression of DDR2 mRNA21092101
C042720mercuric bromidemercuric bromide results in increased expression of DDR2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDR2 mRNA"27188386
D008748Methylcholanthrenealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDR2 mRNA]29094188
D008748MethylcholanthreneMethylcholanthrene results in increased expression of DDR2 mRNA29094188
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DDR2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DDR2 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of DDR2 mRNA24810058
D015735MifepristoneMifepristone results in decreased expression of DDR2 mRNA25972201
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DDR2 mRNA"28673683
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DDR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DDR2 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of DDR2 mRNA19812364
C028007nickel monoxidenickel monoxide results in decreased expression of DDR2 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of DDR2 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of DDR2 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DDR2 mRNA"25510870
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of DDR2 mRNA18593933
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDR2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DDR2 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of DDR2 mRNA12832660
C545373ponatinibponatinib results in decreased activity of DDR2 protein19878872
D011192Potassium DichromatePotassium Dichromate results in increased expression of DDR2 mRNA23608068
D011441PropylthiouracilPropylthiouracil affects the expression of DDR2 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of DDR2 mRNA27029645
C059514resveratrolresveratrol results in decreased expression of DDR2 mRNA25667456
C009277sodium arsenatesodium arsenate results in decreased expression of DDR2 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of DDR2 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of DDR2 mRNA22714537
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of DDR2 mRNA22467014
D013629TamoxifenTamoxifen affects the expression of DDR2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DDR2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DDR2 mRNA15034205
D019284ThapsigarginThapsigargin results in increased expression of DDR2 protein24648495
C009495titanium dioxidetitanium dioxide results in increased expression of DDR2 mRNA19695317
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in increased expression of DDR2 mRNA23825117
C009495titanium dioxidetitanium dioxide results in decreased expression of DDR2 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of DDR2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of DDR2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of DDR2 mRNA21934132
D014635Valproic AcidValproic Acid affects the expression of DDR2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DDR2 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DDR2 gene25560391
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in increased expression of DDR2 mRNA23825117
D014800VitalliumVitallium analog results in increased expression of DDR2 mRNA23825117
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in decreased expression of DDR2 mRNA20370541
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of DDR2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IDA20004161  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005515protein binding-IPI11884411  17703188  22939624  
GO:0005518collagen binding-IBA21873635  
GO:0005518collagen binding-IDA20004161  
GO:0005524ATP binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0038062protein tyrosine kinase collagen receptor activity-IBA21873635  
GO:0038062protein tyrosine kinase collagen receptor activity-IDA9659899  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-IEA-  
GO:0003416endochondral bone growth-ISS-  
GO:0007155cell adhesion-TAS9659899  
GO:0007165signal transduction-TAS9659899  
GO:0007275multicellular organism development-IBA21873635  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010715regulation of extracellular matrix disassembly-TAS16626936  
GO:0010763positive regulation of fibroblast migration-ISS-  
GO:0010763positive regulation of fibroblast migration-TAS16626936  
GO:0018108peptidyl-tyrosine phosphorylation-IDA20004161  
GO:0030154cell differentiation-IBA21873635  
GO:0030198extracellular matrix organization-TAS-  
GO:0030199collagen fibril organization-ISS-  
GO:0030500regulation of bone mineralization-IMP20564243  
GO:0031214biomineral tissue development-ISS-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0035988chondrocyte proliferation-ISS-  
GO:0035988chondrocyte proliferation-TAS16626936  
GO:0038063collagen-activated tyrosine kinase receptor signaling pathway-IDA16186108  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0045669positive regulation of osteoblast differentiation-IMP20564243  
GO:0045860positive regulation of protein kinase activity-IMP20564243  
GO:0046777protein autophosphorylation-IDA16186108  
GO:0048146positive regulation of fibroblast proliferation-ISS-  
GO:0051091positive regulation of DNA-binding transcription factor activity-IMP20564243  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0090091positive regulation of extracellular matrix disassembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0015629actin cytoskeleton-IDA-  
GO:0016324apical plasma membrane-IEA-  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26860843Sensitive methods for screening of the MEK1 gene mutations in patients with central nervous system metastases of non-small cell lung cancer. (2016 Oct)Nicos MClin Transl Oncol
22768234Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status. (2012)An SJPLoS One
24163741Molecular biology of lung cancer. (2013 Oct)Cooper WAJ Thorac Dis
29302581Novel Genetic Associations Between Lung Cancer and Indoor Radon Exposure. (2017 Dec)Choi JRJ Cancer Prev
29216386An exome-wide association study identifies new susceptibility loci for age of smoking initiation in African- and European-American populations. (2017 Dec 5)Jiang KNicotine Tob Res
26599269Mutation Profiling of Lung Cancers with Long-Term Response to Gefitinib Therapy. (2015)Gautschi OOncol Res Treat
26923333Screening for major driver oncogene alterations in adenosquamous lung carcinoma using PCR coupled with next-generation and Sanger sequencing methods. (2016 Feb 29)Shi XSci Rep