Gene info: ID 4922

Gene: NTS

GENE ID: 4922

Synonyms: NMN-125|NN|NT|NT/N|NTS1

Description: neurotensin

Gene type: protein-coding

Location: 12q21.31

dbXrefs: Ensembl:ENSG00000133636 MIM:162650 Vega:OTTHUMG00000169832 UniprotKB:P30990

RefSeq: NG_047010.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 8

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.628e-2 (AD) 1.864e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OTP	0.98
FOXB1	0.977
LHX5	0.974
HMX2	0.971
SIM1	0.97
C22orf42	0.966
HCRT	0.962
SIX6	0.949
FEZF1	0.946
HMX3	0.938

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MGLL	-0.369
LZTS1	-0.35
TNFRSF25	-0.333
KCNH3	-0.329
TNNT2	-0.328
MLLT6	-0.322
SOHLH1	-0.321
SLC17A7	-0.317
LENG8	-0.317
SHANK3	-0.316

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]"	15177934
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]"	15177934
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]"	15177934
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]"	15177934
C465664	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
C465664	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
C465664	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide results in increased activity of NTS protein	18313772
C465664	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide	Tetradecanoylphorbol Acetate inhibits the reaction [2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide results in increased activity of NTS protein]	18313772
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	15177934
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]	15177934
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	15177934
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	15177934
C088860	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]"	15177934
C088860	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]"	15177934
C088860	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]"	15177934
C088860	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]"	15177934
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA"	27188386
C081320	8-(3-chlorostyryl)caffeine	8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]	10199625
D000082	Acetaminophen	Acetaminophen affects the expression of NTS mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of NTS mRNA	21641981
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of NTS mRNA	19770486
D000452	Aldrin	Aldrin results in increased expression of NTS mRNA	18579281
D013196	Dihydrotestosterone	Dihydrotestosterone affects the expression of NTS mRNA	17094431
D005680	gamma-Aminobutyric Acid	NTS protein inhibits the reaction [Cocaine results in decreased secretion of gamma-Aminobutyric Acid]	18252810
D005680	gamma-Aminobutyric Acid	NTS protein results in increased secretion of gamma-Aminobutyric Acid	18252810
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NTS mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of NTS mRNA	11120399
D000661	Amphetamine	Amphetamine results in increased expression of NTS mRNA	14698760
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of NTS mRNA	26705709
C015001	arsenite	arsenite results in decreased expression of NTS mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of NTS mRNA]	18929588
D001280	Atrazine	Atrazine results in decreased expression of NTS mRNA	25929836
D001374	Azacitidine	Azacitidine results in decreased expression of NTS mRNA	20823114
C080985	batimastat	batimastat inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	15247267
C080985	batimastat	batimastat inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	15247267
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NTS mRNA	19770486\|2373587
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NTS mRNA	21839799
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NTS mRNA	20823114
D004958	Estradiol	Estradiol results in increased expression of NTS mRNA	21795739
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased expression of NTS mRNA]	21795739
D004958	Estradiol	Estradiol results in increased expression of NTS mRNA	20068009
C053541	bicalutamide	NTS protein results in decreased susceptibility to bicalutamide	17044078
C088060	bisindolylmaleimide	bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	15177934
C088060	bisindolylmaleimide	bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]	15177934
C088060	bisindolylmaleimide	bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	15177934
C088060	bisindolylmaleimide	bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	15177934
C070515	bisindolylmaleimide I	bisindolylmaleimide I affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in increased activity of NTS protein	18313772
C070515	bisindolylmaleimide I	Sucrose promotes the reaction [bisindolylmaleimide I results in increased activity of NTS protein]	18313772
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in increased activity of NTS protein	18313772
C006780	bisphenol A	bisphenol A results in decreased expression of NTS mRNA	25181051
C016299	chelerythrine	chelerythrine results in increased activity of NTS protein	18313772
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of NTS mRNA	20682304
D002857	Chromium	NTS protein results in increased transport of Chromium	11208724
D003024	Clozapine	Clozapine results in increased expression of NTS mRNA	12887421
C018021	cobaltous chloride	cobaltous chloride inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]	12064480
C018021	cobaltous chloride	cobaltous chloride results in decreased susceptibility to NTS protein	12064480
D003042	Cocaine	Cocaine results in increased expression of NTS mRNA	11120399
D003042	Cocaine	DRD3 protein affects the reaction [Cocaine results in increased expression of NTS mRNA]	11120399
D003042	Cocaine	Cocaine results in increased expression of NTS mRNA	27899881
D003042	Cocaine	NTS protein inhibits the reaction [Cocaine results in decreased secretion of gamma-Aminobutyric Acid]	18252810
D003078	Colchicine	Colchicine results in increased expression of NTS mRNA	1850078
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of NTS mRNA	20971185
D003471	Cuprizone	Cuprizone results in decreased expression of NTS mRNA	26577399
D018750	6-Cyano-7-nitroquinoxaline-2,3-dione	"6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]"	12064480
D018750	6-Cyano-7-nitroquinoxaline-2,3-dione	"6-Cyano-7-nitroquinoxaline-2,3-dione results in decreased susceptibility to NTS protein"	12064480
D016572	Cyclosporine	Cyclosporine results in increased expression of NTS mRNA	20106945
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone affects the expression of NTS mRNA	17094431
C103490	dexloxiglumide	dexloxiglumide inhibits the reaction [osteum results in increased secretion of NTS protein]	18303078
D003976	Diazinon	Diazinon results in decreased expression of NTS mRNA	29108742
D003976	Diazinon	Diazinon results in increased expression of NTS mRNA	20682304
C016366	dibenzothiophene	dibenzothiophene results in decreased expression of NTS mRNA	23656968
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NTS mRNA	20823114
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in decreased expression of NTS mRNA	26924002
D004026	Dieldrin	Dieldrin results in increased expression of NTS mRNA	20682304
D004041	Dietary Fats	Dietary Fats results in increased transport of NTS protein	11208724
D015102	3,4-Dihydroxyphenylacetic Acid	"NTS protein results in increased abundance of 3,4-Dihydroxyphenylacetic Acid"	6682440
C024629	dimethyl phthalate	dimethyl phthalate results in decreased expression of NTS mRNA	26924002
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]	12064480
D016291	Dizocilpine Maleate	Dizocilpine Maleate results in decreased susceptibility to NTS protein	12064480
D004298	Dopamine	NTS protein results in increased secretion of Dopamine	12064480
D004298	Dopamine	[NTS protein results in increased secretion of Dopamine] which results in increased activity of DRD1 protein	12064480
D004298	Dopamine	[[NTS protein results in increased secretion of Dopamine] which results in increased activity of DRD1 protein] which results in increased phosphorylation of PPP1R1B protein	12064480
D004298	Dopamine	[NTS protein results in increased secretion of Dopamine] which results in increased phosphorylation of GRIA1 protein	12064480
D004298	Dopamine	PPP1R1B protein affects the reaction [[NTS protein results in increased secretion of Dopamine] which results in increased phosphorylation of GRIA1 protein]	12064480
C108024	emamectin benzoate	emamectin benzoate affects the activity of NTS protein	23611293
D000431	Ethanol	NTS protein results in increased susceptibility to Ethanol	11602683
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of NTS gene	16495775
D005223	Fats	Fats results in increased secretion of NTS protein	18303078
D005223	Fats	orlistat inhibits the reaction [Fats results in increased secretion of NTS protein]	18303078
D005472	Fluorouracil	NTS protein affects the susceptibility to Fluorouracil	16217747
D005947	Glucose	NTS protein results in increased transport of Glucose	11208724
C081021	Go 6976	Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
C081021	Go 6976	Go 6976 promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
C081021	Go 6976	Go 6976 results in increased activity of NTS protein	18313772
C081021	Go 6976	Tetradecanoylphorbol Acetate inhibits the reaction [Go 6976 results in increased activity of NTS protein]	18313772
D006220	Haloperidol	Haloperidol results in increased expression of NTS mRNA	11120399\|1460326
D006220	Haloperidol	SLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA]	14698760
D006220	Haloperidol	8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]	10199625
D006220	Haloperidol	Haloperidol results in increased expression of NTS mRNA	10199625\|1160268
D006220	Haloperidol	Haloperidol results in increased expression of NTS protein	11602683
D006220	Haloperidol	Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]	10199625
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde affects the expression of NTS mRNA	22302311
D006719	Homovanillic Acid	NTS protein results in increased abundance of Homovanillic Acid	6682440
D007295	Inositol Phosphates	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
D007295	Inositol Phosphates	bisindolylmaleimide I affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
D007295	Inositol Phosphates	Go 6976 promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
D007295	Inositol Phosphates	NTS protein results in increased chemical synthesis of Inositol Phosphates	18313772
D007295	Inositol Phosphates	PRKCD protein promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
D007295	Inositol Phosphates	PRKCE protein promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
D007295	Inositol Phosphates	Ro 31-8220 affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
D007295	Inositol Phosphates	rottlerin affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
D007295	Inositol Phosphates	Staurosporine promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
D007295	Inositol Phosphates	Tetradecanoylphorbol Acetate inhibits the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
C094211	JTP 4819	JTP 4819 results in decreased degradation of NTS protein	7562510
D008353	Mannitol	NTS protein results in increased transport of Mannitol	11208724
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NTS mRNA	20823114
C042720	mercuric bromide	mercuric bromide results in increased expression of NTS mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA"	27188386
D008694	Methamphetamine	Methamphetamine results in increased expression of NTS mRNA	19564919
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of NTS mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NTS mRNA"	15661373
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of NTS mRNA	22108045
C517284	monomethyl phthalate	monomethyl phthalate results in decreased expression of NTS mRNA	26924002
D009532	Nickel	Nickel results in increased expression of NTS mRNA	20682304
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of NTS mRNA	20971185
D019319	Okadaic Acid	Okadaic Acid promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
D019319	Okadaic Acid	Okadaic Acid results in decreased activity of NTS protein	18313772
D000069463	Olive Oil	Olive Oil results in increased secretion of NTS protein	18303078
D000069463	Olive Oil	orlistat inhibits the reaction [Olive Oil results in increased secretion of NTS protein]	18303078
C055122	orlistat	orlistat inhibits the reaction [Fats results in increased secretion of NTS protein]	18303078
C055122	orlistat	orlistat inhibits the reaction [Olive Oil results in increased secretion of NTS protein]	18303078
C013173	osteum	dexloxiglumide inhibits the reaction [osteum results in increased secretion of NTS protein]	18303078
C013173	osteum	osteum results in increased secretion of NTS protein	18303078
D010100	Oxygen	Oxygen deficiency results in decreased expression of NTS mRNA	24236059
D052638	Particulate Matter	Particulate Matter results in decreased expression of NTS mRNA	22178795
D010476	Perfume	Perfume results in increased expression of NTS mRNA	24768652
D010656	Phenylephrine	NTS protein results in decreased susceptibility to Phenylephrine	2326505
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA"	27188386
C008890	phosphoramidon	phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	15177934
C008890	phosphoramidon	phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]	15177934
C008890	phosphoramidon	phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	15177934
C008890	phosphoramidon	phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	15177934
D009764	o-Phthalaldehyde	o-Phthalaldehyde affects the expression of NTS mRNA	22302311
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NTS mRNA	19710929
C058229	polydatin	polydatin binds to NTS protein	16249055
D059808	Polyphenols	Polyphenols binds to NTS protein	16249055
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased expression of NTS mRNA]	21795739
D011441	Propylthiouracil	Propylthiouracil results in increased expression of NTS mRNA	24780913
D011794	Quercetin	Quercetin results in increased activity of NTS protein	18313772
D020891	Raclopride	NTS protein promotes the reaction [Raclopride results in increased phosphorylation of PPP1R1B protein]	12064480
D020891	Raclopride	[SCH 23390 co-treated with Raclopride] inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]	12064480
D012110	Reserpine	Reserpine results in increased expression of NTS mRNA	1850078
C059514	resveratrol	resveratrol binds to NTS protein	16249055
C064758	Ro 31-8220	Ro 31-8220 affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
C064758	Ro 31-8220	Ro 31-8220 results in increased activity of NTS protein	18313772
C064758	Ro 31-8220	Tetradecanoylphorbol Acetate inhibits the reaction [Ro 31-8220 results in increased activity of NTS protein]	18313772
D012402	Rotenone	Rotenone results in decreased expression of NTS mRNA	19013527
C085746	rottlerin	rottlerin affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
C085746	rottlerin	rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	15177934
C085746	rottlerin	rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]	15177934
C085746	rottlerin	rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	15177934
C085746	rottlerin	rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	15177934
C085746	rottlerin	rottlerin results in increased activity of NTS protein	18313772
C534628	SCH 23390	[SCH 23390 co-treated with Raclopride] inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]	12064480
C534628	SCH 23390	SCH 23390 inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]	12064480
C534628	SCH 23390	SCH 23390 results in decreased susceptibility to NTS protein	12064480
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of NTS mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of NTS mRNA	23221170
C114947	SR 142948	SR 142948 inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]	12064480
C114947	SR 142948	SR 142948 results in decreased susceptibility to NTS protein	12064480
C079087	SR 48692	SR 48692 binds to and results in decreased activity of NTS protein	17276509
D019311	Staurosporine	Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	15177934
D019311	Staurosporine	Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]	15177934
D019311	Staurosporine	Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	15177934
D019311	Staurosporine	Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	15177934
D019311	Staurosporine	Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
D019311	Staurosporine	Staurosporine promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
D019311	Staurosporine	Staurosporine results in increased activity of NTS protein	18313772
D019311	Staurosporine	Tetradecanoylphorbol Acetate inhibits the reaction [Staurosporine results in increased activity of NTS protein]	18313772
D013395	Sucrose	Sucrose promotes the reaction [bisindolylmaleimide I results in increased activity of NTS protein]	18313772
D013395	Sucrose	Sucrose promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
D013395	Sucrose	Sucrose results in decreased activity of NTS protein	18313772
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NTS mRNA	15977195
D013755	Tetradecanoylphorbol Acetate	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
D013755	Tetradecanoylphorbol Acetate	bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
D013755	Tetradecanoylphorbol Acetate	Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
D013755	Tetradecanoylphorbol Acetate	Okadaic Acid promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
D013755	Tetradecanoylphorbol Acetate	Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
D013755	Tetradecanoylphorbol Acetate	Sucrose promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]	18313772
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide results in increased activity of NTS protein]	18313772
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [Go 6976 results in increased activity of NTS protein]	18313772
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [Ro 31-8220 results in increased activity of NTS protein]	18313772
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [Staurosporine results in increased activity of NTS protein]	18313772
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased activity of NTS protein	18313772
D013779	Tetrodotoxin	Tetrodotoxin inhibits the reaction [NTS protein results in increased phosphorylation of PPP1R1B protein]	12064480
D013779	Tetrodotoxin	Tetrodotoxin results in decreased susceptibility to NTS protein	12064480
D013806	Theophylline	Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]	10199625
C012589	trichostatin A	trichostatin A results in increased expression of NTS mRNA	24935251
C015559	trimellitic anhydride	trimellitic anhydride affects the expression of NTS mRNA	22302311
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of NTS mRNA	19042947
D014302	Trinitrobenzenesulfonic Acid	NTS protein promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VWF protein]	25307345
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NTS mRNA"	26179874
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [NTS protein results in increased expression of CXCL8 mRNA]	15247267
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	15177934
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]	15177934
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	15177934\|1524726
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	15177934\|1524726
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [NTS protein results in increased secretion of CXCL8 protein]	15247267
C113580	U 0126	U 0126 inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	15177934
C113580	U 0126	U 0126 inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]	15177934
C113580	U 0126	U 0126 inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	15177934
C113580	U 0126	U 0126 inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	15177934
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTS mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of NTS mRNA	19101580\|2317975
D014635	Valproic Acid	Valproic Acid affects the expression of NTS mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of NTS gene	25560391
C009687	wortmannin	wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	15177934
C009687	wortmannin	wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]	15177934
C009687	wortmannin	wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	15177934
C009687	wortmannin	wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	15177934

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	17620610

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	NAS	8954810
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0050880	regulation of blood vessel size	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0030133	transport vesicle	-	IEA	-
GO:0043679	axon terminus	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21822476	Modulation of tyrosine hydroxylase, neuropeptide y, glutamate, and substance p in Ganglia and brain areas involved in cardiovascular control after chronic exposure to nicotine. (2011)	Ferrari MF	Int J Hypertens
24059101	[Effects of intrauterine cigarette smoking exposure on expression of 3-mercaptopyruvate sulfurtransferase in medulla oblongata of neonatal rats]. (2013 Jul)	Nie LH	Sichuan Da Xue Xue Bao Yi Xue Ban
28506824	Hypoxia and nicotine effects on Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the developing piglet brainstem. (2017 Sep)	Huang J	Neurotoxicology
29407532	The involvement of CRF1 receptor within the basolateral amygdala and dentate gyrus in the naloxone-induced conditioned place aversion in morphine-dependent mice. (2018 Jun 8)	Valero E	Prog Neuropsychopharmacol Biol Psychiatry
28760662	Acute ethanol modulation of neurocircuit function in the nucleus of the tractus solitarius. (2018 Apr)	Aimino MA	Brain Res Bull
20363096	Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis. (2010 Jul)	Gao W	Biomed Pharmacother
12900720	[Early effects of cigarette smoking in hypertensive and normotensive subjects. An ambulatory blood pressure and thermographic study]. (2003 Aug)	Di Carlo A	Minerva Cardioangiol
25050821	Cocaine self-administration and extinction alter medullary noradrenergic and limbic forebrain cFos responses to acute, noncontingent cocaine injections in adult rats. (2014 Dec 5)	Buffalari DM	Neuroscience