Gene: NTSR1

4923
NTR
neurotensin receptor 1
protein-coding
20q13.33
Ensembl:ENSG00000101188 MIM:162651 Vega:OTTHUMG00000032932 UniprotKB:P30989
NC_000020.11
PubMed
0   ANCO-SNPs
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.768e-1 (AD)  1.608e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DOK40.733
CELF50.732
XKR70.728
LHFPL50.719
MCHR10.717
DRD50.715
GABRA50.71
EFNB30.707
TENM30.706
SLC8A20.706

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARD3B-0.51
ASB4-0.489
CHST14-0.485
REST-0.484
COPZ2-0.482
AGTRAP-0.475
RBPMS-0.472
MBNL3-0.472
OLAH-0.471
HEY2-0.465

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTSR1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTSR1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTSR1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTSR1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTSR1 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NTSR1 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of NTSR1 mRNA25064622
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NTSR1 mRNA23630614
D000638AmiodaroneAmiodarone affects the expression of NTSR1 mRNA25064622
C006632arsenic trioxidearsenic trioxide results in decreased expression of NTSR1 mRNA25258189
C006780bisphenol Abisphenol A results in decreased expression of NTSR1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of NTSR1 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of NTSR1 mRNA26191083
D002746ChlorpromazineChlorpromazine affects the expression of NTSR1 mRNA25064622
D003300CopperCopper deficiency results in increased expression of NTSR1 mRNA26033743
D016572CyclosporineCyclosporine affects the expression of NTSR1 mRNA25064622
D003976DiazinonDiazinon results in increased methylation of NTSR1 gene22964155
D004041Dietary FatsDietary Fats results in decreased expression of NTSR1 mRNA18721800
D019422Dietary SucroseDietary Sucrose results in increased expression of NTSR1 mRNA26033743
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NTSR1 mRNA22129741
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NTSR1 mRNA25064622
D005472FluorouracilFluorouracil results in decreased expression of NTSR1 protein15352031
D005472FluorouracilNTSR1 protein affects the susceptibility to Fluorouracil15352031
D004397FonofosFonofos results in increased methylation of NTSR1 promoter22847954
C412815GW 4064GW 4064 results in decreased expression of NTSR1 mRNA26655953
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NTSR1 mRNA22129741
D007529IsoflavonesIsoflavones affects the expression of NTSR1 mRNA16365062
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NTSR1 mRNA21385734
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NTSR1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of NTSR1 mRNA24810058
D009020MorphineNTSR1 protein affects the susceptibility to Morphine20727387
D009496NeurotensinNeurotensin binds to NTSR1 protein19874804
C407426neurotensin 69Lneurotensin 69L binds to NTSR1 protein19874804
D009538NicotineNicotine results in increased expression of NTSR1 mRNA23825647
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of NTSR1 mRNA24888373
D010269ParaquatParaquat affects the expression of NTSR1 mRNA25064622
D010278ParathionParathion results in increased methylation of NTSR1 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTSR1 mRNA"25510870
D010622PhencyclidineNTSR1 gene affects the reaction [Phencyclidine results in decreased expression of DRD1 protein]20659557
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of NTSR1 mRNA24888373
D011441PropylthiouracilPropylthiouracil results in increased expression of NTSR1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NTSR1 mRNA25895662
D012999SomanSoman results in increased expression of NTSR1 mRNA19281266
C114947SR 142948SR 142948 binds to and results in decreased activity of NTSR1 protein12064480
C079087SR 48692SR 48692 binds to and results in decreased activity of NTSR1 protein12064480
C012568terbufosterbufos results in increased methylation of NTSR1 promoter22847954
D013739TestosteroneTestosterone results in decreased expression of NTSR1 mRNA19693291
D013752TetracyclineTetracycline affects the expression of NTSR1 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of NTSR1 mRNA25064622
C024746tobacco tartobacco tar results in increased expression of NTSR1 mRNA19559774
D014302Trinitrobenzenesulfonic AcidNTSR1 protein affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VEGFA mRNA]25307345
D014302Trinitrobenzenesulfonic AcidNTSR1 protein results in increased susceptibility to Trinitrobenzenesulfonic Acid25307345
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of NTSR1 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of NTSR1 mRNA25064622
D014635Valproic AcidValproic Acid results in increased methylation of NTSR1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS8381365  
GO:0005515protein binding-IPI17620610  23597562  
GO:0016492G-protein coupled neurotensin receptor activity-IDA21725197  
GO:0016492G-protein coupled neurotensin receptor activity-IMP8381365  
GO:0042802identical protein binding-IPI17620610  
GO:0042803protein homodimerization activity-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0047485protein N-terminus binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001659temperature homeostasis-IEA-  
GO:0003085negative regulation of systemic arterial blood pressure-IEA-  
GO:0003254regulation of membrane depolarization-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IDA21725197  
GO:0007268chemical synaptic transmission-TAS9763490  
GO:0007612learning-IEA-  
GO:0008344adult locomotory behavior-IEA-  
GO:0014049positive regulation of glutamate secretion-IEA-  
GO:0014054positive regulation of gamma-aminobutyric acid secretion-IEA-  
GO:0033993response to lipid-IEA-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043066negative regulation of apoptotic process-IMP21725197  
GO:0043576regulation of respiratory gaseous exchange-IEA-  
GO:0050965detection of temperature stimulus involved in sensory perception of pain-IEA-  
GO:0051280negative regulation of release of sequestered calcium ion into cytosol-IEA-  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-IEA-  
GO:0051930regulation of sensory perception of pain-IEA-  
GO:0060732positive regulation of inositol phosphate biosynthetic process-IEA-  
GO:0070779D-aspartate import across plasma membrane-IEA-  
GO:0071545inositol phosphate catabolic process-IEA-  
GO:0090238positive regulation of arachidonic acid secretion-IEA-  
GO:0097151positive regulation of inhibitory postsynaptic potential-IEA-  
GO:0098712L-glutamate import across plasma membrane-IEA-  
GO:0098900regulation of action potential-IEA-  
GO:2001259positive regulation of cation channel activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IMP8381365  
GO:0009898cytoplasmic side of plasma membrane-IEA-  
GO:0009986cell surface-IEA-  
GO:0032280symmetric synapse-IEA-  
GO:0043195terminal bouton-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0043198dendritic shaft-IEA-  
GO:0043204perikaryon-IEA-  
GO:0045121membrane raft-IDA21725197  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25657825Identification and validation of the methylation biomarkers of non-small cell lung cancer (NSCLC). (2015)Guo SClin Epigenetics
26384852Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry. (2015 Nov)Levran OCNS Neurosci Ther