Gene: NUCB2

4925
HEL-S-109|NEFA
nucleobindin 2
protein-coding
11p15.1
Ensembl:ENSG00000070081 MIM:608020 Vega:OTTHUMG00000166050 UniprotKB:P80303
NC_000011.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.778e-1 (AD)  7.464e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF3H0.842
NPM10.839
HNRNPR0.838
EIF3E0.83
RBMX0.824
UBE2J10.822
UBE2A0.82
SMARCE10.818
C11orf580.816
FNDC3A0.809

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.606
OR4F29-0.599
EPPIN-0.211
MMP23B-0.185
MBD3L3-0.181
PTGDR2-0.174
RAX2-0.165
ARGFX-0.153
NANOS2-0.152
TBX5-0.146

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTarget
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of NUCB2 mRNA"26377693
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [troglitazone results in increased stability of NUCB2 mRNA]20427483
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NUCB2 mRNA"19114083
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of NUCB2 mRNA"17547211
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NUCB2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NUCB2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCB2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of NUCB2 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCB2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NUCB2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of NUCB2 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of NUCB2 mRNA28959563
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of NUCB2 protein26072098
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NUCB2 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of NUCB2 mRNA17547211
C547126AZM551248AZM551248 results in increased expression of NUCB2 mRNA22323515
C487081belinostatbelinostat results in decreased expression of NUCB2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCB2 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NUCB2 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of NUCB2 mRNA28476547
D004958EstradiolEstradiol results in decreased expression of NUCB2 protein28476547
C006780bisphenol Abisphenol A results in decreased expression of NUCB2 mRNA28476547
C006780bisphenol Abisphenol A results in decreased expression of NUCB2 protein28476547
C006780bisphenol Abisphenol A results in increased expression of NUCB2 mRNA25181051
D001761BleomycinBleomycin results in increased expression of NUCB2 protein25933445
D002065BuspironeBuspirone results in decreased expression of NUCB2 mRNA24136188
D002104CadmiumCadmium results in decreased expression of NUCB2 mRNA17547211
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NUCB2 mRNA17547211
D019256Cadmium ChlorideCadmium Chloride affects the expression of NUCB2 mRNA22110744
D002118CalciumKT 5720 inhibits the reaction [NUCB2 protein results in increased import of Calcium]17627999
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of NUCB2 mRNA25270620|2733941
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NUCB2 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NUCB2 gene20938992
D002857ChromiumChromium results in decreased expression of NUCB2 mRNA17547211
D002922CiguatoxinsCiguatoxins affects the expression of NUCB2 mRNA18353800
D003300CopperCopper results in increased expression of NUCB2 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of NUCB2 mRNA19549813
D016572CyclosporineCyclosporine affects the expression of NUCB2 mRNA25224403
D016572CyclosporineCyclosporine results in increased expression of NUCB2 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of NUCB2 mRNA19770486|2522440
D013759DronabinolDronabinol results in increased expression of NUCB2 mRNA18454173
D003907DexamethasoneDexamethasone results in decreased expression of NUCB2 mRNA25047013
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of NUCB2 mRNA28962523
C000944dicrotophosdicrotophos results in decreased expression of NUCB2 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NUCB2 mRNA26924002
D004041Dietary FatsDietary Fats affects the expression of NUCB2 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of NUCB2 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of NUCB2 protein16400681
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NUCB2 mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of NUCB2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of NUCB2 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NUCB2 mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of NUCB2 mRNA17547211
C024629dimethyl phthalatedimethyl phthalate affects the expression of NUCB2 mRNA26924002
C118739entinostatentinostat results in decreased expression of NUCB2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCB2 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NUCB2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NUCB2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NUCB2 mRNA23550701
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of NUCB2 mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of NUCB2 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of NUCB2 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NUCB2 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NUCB2 gene20938992
D005897GlafenineGlafenine results in increased expression of NUCB2 mRNA24136188
D005944GlucosamineGlucosamine results in decreased expression of NUCB2 mRNA17178593
D005947GlucoseGlucose results in decreased expression of NUCB2 mRNA17178593
D017313FenretinideFenretinide results in increased expression of NUCB2 mRNA16671099
D017313FenretinideFenretinide results in decreased expression of NUCB2 mRNA28973697
D017313FenretinideFenretinide results in increased expression of NUCB2 mRNA28973697
D007545IsoproterenolIsoproterenol results in increased expression of NUCB2 mRNA21823215
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NUCB2 mRNA23086925|2675264
C410337K 7174K 7174 results in increased expression of NUCB2 mRNA24086573
C057416KT 5720KT 5720 inhibits the reaction [NUCB2 protein results in increased import of Calcium]17627999
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NUCB2 mRNA"24972896
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NUCB2 mRNA"21782869
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NUCB2 protein"21782869
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NUCB2 mRNA27339419
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NUCB2 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NUCB2 gene20938992
D008731MethoxychlorMethoxychlor results in increased methylation of NUCB2 gene23303685
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NUCB2 mRNA23649840
D015741MetriboloneMetribolone results in increased expression of NUCB2 mRNA17010196
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NUCB2 mRNA26924002
C051752nefazodonenefazodone results in decreased expression of NUCB2 mRNA24136188
C022838nickel chloridenickel chloride results in decreased expression of NUCB2 mRNA17547211
C022838nickel chloridenickel chloride affects the expression of NUCB2 mRNA22110744
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of NUCB2 mRNA17616710
D010100OxygenOxygen deficiency results in decreased expression of NUCB2 mRNA26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in decreased expression of NUCB2 mRNA]26476374
D000073878Palm OilPalm Oil affects the expression of NUCB2 mRNA19680557
D000073878Palm OilPalm Oil results in increased expression of NUCB2 mRNA18042831
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NUCB2 mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of NUCB2 mRNA23091169
C060836pioglitazonepioglitazone results in increased stability of NUCB2 mRNA20427483
C006253pirinixic acidpirinixic acid results in decreased expression of NUCB2 mRNA20813756|2381119
D011192Potassium DichromatePotassium Dichromate results in decreased expression of NUCB2 mRNA17547211
D011374ProgesteroneProgesterone results in decreased expression of NUCB2 mRNA23018184
D011441PropylthiouracilPropylthiouracil results in increased expression of NUCB2 mRNA24780913
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in decreased expression of NUCB2 mRNA]26476374
C059514resveratrolresveratrol results in increased expression of NUCB2 mRNA23419489
C017947sodium arsenitesodium arsenite results in decreased expression of NUCB2 mRNA28595984
D012969Sodium FluorideSodium Fluoride results in decreased expression of NUCB2 protein28918527
C013698tallowtallow affects the expression of NUCB2 mRNA19680557
D013629TamoxifenTamoxifen results in increased expression of NUCB2 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of NUCB2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of NUCB2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NUCB2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NUCB2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NUCB2 mRNA21215274
D019284ThapsigarginThapsigargin results in increased expression of NUCB2 mRNA22378314
C009495titanium dioxidetitanium dioxide results in increased expression of NUCB2 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of NUCB2 mRNA15894607
D014241TrichloroethyleneTrichloroethylene results in decreased expression of NUCB2 mRNA25549359|2897337
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCB2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of NUCB2 mRNA26272509
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of NUCB2 mRNA17982090
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NUCB2 mRNA"26179874
C057693troglitazone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [troglitazone results in increased stability of NUCB2 mRNA]20427483
C057693troglitazonetroglitazone results in increased stability of and results in increased expression of NUCB2 mRNA20427483
D014415TunicamycinTunicamycin results in increased expression of NUCB2 mRNA22378314
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of NUCB2 mRNA15885361
D014635Valproic AcidValproic Acid results in increased expression of NUCB2 mRNA23179753|2718838
D014640VancomycinVancomycin results in decreased expression of NUCB2 mRNA18930951
C025643vinclozolinvinclozolin affects the expression of NUCB2 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI21988832  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA16502470  
GO:0005635nuclear envelope-IEA-  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IDA15308636  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-TAS7811391  
GO:0005886plasma membrane-TAS7811391  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28529367Serum NUCB2/nesfatin-1 levels in different stages of alcohol dependence: Is there a relationship with craving? (2017 Jan-Mar)Umut GIndian J Psychiatry