Gene: NR4A2

4929
HZF-3|NOT|NURR1|RNR1|TINUR
nuclear receptor subfamily 4 group A member 2
protein-coding
2q24.1
Ensembl:ENSG00000153234 MIM:601828 Vega:OTTHUMG00000131950 UniprotKB:P43354
NG_011821.1
PubMed
0   ANCO-SNPs
OD|ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.993e-1 (AD)  4.884e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NR4A10.699
NR4A30.693
FOSB0.616
SIK10.598
EGR10.585
JUNB0.57
ZNF3310.556
IER20.551
BTG20.542
PPP1R15A0.534

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OXTR-0.238
SIX3-0.235
POU3F4-0.228
RXRG-0.225
SLCO1C1-0.216
TMEM100-0.212
RGS20-0.211
RGR-0.206
FAM181A-0.204
DIO3-0.202

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5348801,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane"1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] affects the localization of and results in decreased expression of NR4A2 protein]"25406165
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NR4A2 mRNA28329830
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NR4A2 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NR4A2 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NR4A2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NR4A2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NR4A2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NR4A2 mRNA"25510870
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]22188298
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NR4A2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NR4A2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of NR4A2 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NR4A2 mRNA"27188386
D000079AcetaldehydeAcetaldehyde results in increased expression of NR4A2 mRNA23416264
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sodium arsenite affects the localization of NR4A2 protein]23283970
D020106AcrylamideAcrylamide affects the expression of NR4A2 mRNA28959563
D020106AcrylamideAcrylamide results in decreased expression of NR4A2 mRNA22197712
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NR4A2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NR4A2 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of NR4A2 mRNA"23195993
D000638AmiodaroneAmiodarone results in increased expression of NR4A2 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NR4A2 mRNA16483693
C530884anacetrapibanacetrapib results in increased expression of NR4A2 protein25617244
D000936Antigen-Antibody ComplexAntigen-Antibody Complex results in increased expression of NR4A2 mRNA25451590
D000936Antigen-Antibody ComplexCyclosporine inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A2 mRNA]25451590
D000936Antigen-Antibody ComplexNR4A2 mRNA promotes the reaction [Antigen-Antibody Complex results in increased expression of TNF mRNA]25451590
D000936Antigen-Antibody Complexshikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A2 mRNA]25451590
D016718Arachidonic AcidArachidonic Acid results in decreased expression of NR4A2 mRNA16704987
D001151ArsenicArsenic results in decreased expression of NR4A2 mRNA16835338
D001151ArsenicArsenic results in decreased expression of NR4A2 mRNA19654921
C006632arsenic trioxidearsenic trioxide results in decreased expression of NR4A2 mRNA26705709
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of NR4A2 mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of NR4A2 mRNA"18687144|2416032
D001280AtrazineAtrazine results in decreased expression of NR4A2 mRNA24552878|2456137
D001280AtrazineAtrazine results in decreased expression of NR4A2 protein24863964|2834157
D001548Benzalkonium CompoundsBenzalkonium Compounds results in increased expression of NR4A2 mRNA25377654
D001554BenzeneBenzene results in increased expression of NR4A2 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NR4A2 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NR4A2 mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NR4A2 mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of NR4A2 mRNA21185374
D004958EstradiolEstradiol results in increased expression of NR4A2 mRNA19153601
C006780bisphenol Abisphenol A affects the methylation of NR4A2 promoter27334623
C006780bisphenol Abisphenol A affects the expression of NR4A2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NR4A2 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of NR4A2 mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of NR4A2 mRNA26079696
D002104CadmiumCadmium results in increased expression of NR4A2 mRNA21694771
C028031cadmium acetatecadmium acetate results in increased expression of NR4A2 mRNA15016657
C028031cadmium acetatecadmium acetate results in increased expression of NR4A2 mRNA15016657
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NR4A2 mRNA26472689
D000001CalcimycinCalcimycin results in increased expression of NR4A2 mRNA25451590
D000001Calcimycinshikonin inhibits the reaction [Calcimycin results in increased expression of NR4A2 mRNA]25451590
C459604candoxincandoxin results in decreased expression of NR4A2 mRNA16309724
D002330CarmustineCarmustine affects the expression of NR4A2 mRNA19174181
C068623carnosolcarnosol results in increased expression of NR4A2 protein17047462
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NR4A2 gene20938992
D003024ClozapineClozapine results in increased expression of NR4A2 mRNA17266109
C018021cobaltous chloridecobaltous chloride results in increased expression of NR4A2 mRNA19376846
D003042CocaineCocaine results in decreased expression of NR4A2 protein15094491
D005576ColforsinColforsin results in increased expression of NR4A2 protein19732956
D005576ColforsinNR4A2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]19822197
D019327Copper SulfateCopper Sulfate results in increased expression of NR4A2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NR4A2 mRNA"19167446
D003471CuprizoneCuprizone results in decreased expression of NR4A2 mRNA26577399
D003474CurcuminCurcumin results in decreased expression of NR4A2 mRNA17999991
D016572CyclosporineCyclosporine inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A2 mRNA]25451590
C411602dalcetrapibdalcetrapib results in increased expression of NR4A2 protein25617244
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of NR4A2 mRNA23914054
D003703DemecolcineDemecolcine results in increased expression of NR4A2 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NR4A2 mRNA21266533
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased activity of NR4A2 protein27589886
C089799diheptyl phthalatediheptyl phthalate results in decreased expression of NR4A2 mRNA22112501
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of NR4A2 mRNA"23811387
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of NR4A2 mRNA22079256
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]"22188298
D005419FlavonoidsFlavonoids results in decreased expression of NR4A2 mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NR4A2 mRNA28329830
D005473FluoxetineFluoxetine results in decreased expression of NR4A2 mRNA20857517
D005485FlutamideFlutamide results in increased expression of NR4A2 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NR4A2 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of NR4A2 mRNA17938736|2065599
C004312glycidolglycidol results in decreased expression of NR4A2 mRNA24915197
C120099GW 1929GW 1929 affects the localization of NR4A2 protein27435855
C120099GW 1929[GW 1929 co-treated with Mercaptopurine] results in increased expression of NR4A2 mRNA27435855
C120099GW 1929[GW 1929 co-treated with Mercaptopurine] results in increased expression of NR4A2 protein27435855
D003932HeroinHeroin results in decreased expression of NR4A2 mRNA25643298
C475919hydroxytamoxifenGPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of NR4A2 mRNA]19153601
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of NR4A2 mRNA19153601
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NR4A2 mRNA25613284
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of NR4A2 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NR4A2 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of NR4A2 mRNA26254443
D007608Kainic AcidKainic Acid results in increased expression of NR4A2 protein24813937
D007608Kainic AcidKainic Acid results in increased expression of NR4A2 mRNA19700661
D007649KetamineKetamine results in decreased expression of NR4A2 mRNA20080153
C031895lead chromatelead chromate results in increased expression of NR4A2 mRNA23584427
C038753leptomycin Bleptomycin B inhibits the reaction [sodium arsenite affects the localization of NR4A2 protein]23283970
D001556LindaneLindane results in increased expression of NR4A2 mRNA8737662
D008094LithiumLithium results in increased expression of NR4A2 mRNA21092101
D018021Lithium ChlorideCTNNB1 protein affects the reaction [Lithium Chloride results in increased expression of NR4A2 mRNA]27045591
D018021Lithium ChlorideLithium Chloride inhibits the reaction [Rotenone results in decreased expression of NR4A2 protein]27045591
D018021Lithium ChlorideLithium Chloride promotes the reaction [CTNNB1 protein binds to NR4A2 promoter]27045591
D018021Lithium ChlorideLithium Chloride promotes the reaction [CTNNB1 protein binds to NR4A2 protein]27045591
D018021Lithium ChlorideLithium Chloride results in increased expression of NR4A2 mRNA27045591
D018021Lithium ChlorideLithium Chloride results in increased expression of NR4A2 protein27045591
D008154LucanthoneLucanthone results in increased expression of NR4A2 mRNA21148553
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of NR4A2 mRNA20843944
D015122Mercaptopurine[GW 1929 co-treated with Mercaptopurine] results in increased expression of NR4A2 mRNA27435855
D015122Mercaptopurine[GW 1929 co-treated with Mercaptopurine] results in increased expression of NR4A2 protein27435855
D015122MercaptopurineMercaptopurine results in increased expression of and affects the localization of NR4A2 protein27435855
D015122MercaptopurineMercaptopurine results in increased expression of NR4A2 mRNA27435855
D008694MethamphetamineNR4A2 protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]21151937
D008694MethamphetamineNR4A2 protein affects the reaction [Methamphetamine results in decreased expression of TH protein]21151937
D008694MethamphetamineNR4A2 protein affects the susceptibility to Methamphetamine21151937
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of NR4A2 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of NR4A2 mRNA19564919
D008713MethimazoleMethimazole results in increased expression of NR4A2 mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NR4A2 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of NR4A219732956
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NR4A2 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride affects the expression of NR4A2 mRNA21613230
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NR4A2 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of NR4A2 mRNA26558463
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] affects the localization of and results in decreased expression of NR4A2 protein]"25406165
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] affects the localization of and results in decreased expression of NR4A2 protein"25406165
D008942MitoxantroneNR4A2 protein affects the susceptibility to Mitoxantrone16217747
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of NR4A2 mRNA19822197
C002373monobutyryl cyclic AMPCREM protein inhibits the reaction [monobutyryl cyclic AMP results in increased expression of NR4A2 mRNA]25381014
C002373monobutyryl cyclic AMPmonobutyryl cyclic AMP results in increased expression of NR4A2 mRNA25381014
D009020MorphineBDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]25643298
D009020MorphineNR4A2 protein affects the susceptibility to Morphine25643298
D009020MorphineMorphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]25643298
D009020MorphineMorphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]25643298
D009020MorphineMorphine results in decreased expression of NR4A2 mRNA25643298
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA]22188298
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]22188298
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NR4A2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NR4A2 mRNA"25554681
D009281NaphthalenesNaphthalenes results in increased expression of NR4A2 protein17337753
C495860naphthol AS-E phosphatenaphthol AS-E phosphate results in increased expression of NR4A2 mRNA25150140
D009285NaphthoquinonesNaphthoquinones results in increased expression of NR4A2 mRNA23811387
D009532NickelNickel results in increased expression of NR4A2 mRNA23195993
C029938nickel sulfatenickel sulfate results in increased expression of NR4A2 mRNA16780908
C024713n-tetradecanen-tetradecane results in increased expression of NR4A2 protein17337753
C507134ON 01910ON 01910 results in increased expression of NR4A2 mRNA22351695
C084656paricalcitol[Phosphorus co-treated with paricalcitol] affects the expression of NR4A2 mRNA17715259
D052638Particulate MatterParticulate Matter results in decreased expression of NR4A2 mRNA22178795
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NR4A2 mRNA"25510870
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of NR4A2 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of NR4A2 mRNA19095052
D010433PentylenetetrazolePentylenetetrazole results in increased expression of NR4A2 mRNA8164692
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of NR4A2 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of NR4A2 mRNA19429403
D026023PermethrinPermethrin affects the expression of NR4A2 mRNA23566817
D026023PermethrinPermethrin results in decreased expression of NR4A225048945
D026023PermethrinPermethrin results in decreased expression of NR4A2 mRNA22056222|2317453
D026023PermethrinPermethrin results in decreased expression of NR4A2 protein22056222|2317453
D026023PermethrinPermethrin results in increased expression of NR4A2 protein23566817
D015232Dinoprostone3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]22188298
D015232Dinoprostone[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA22188298
D015232Dinoprostone[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein22188298
D015232Dinoprostone"exoenzyme C3, Clostridium botulinum inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]"22188298
D015232DinoprostoneN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA]22188298
D015232DinoprostoneN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]22188298
D015232DinoprostoneDinoprostone results in increased expression of NR4A216293616
D010622PhencyclidinePhencyclidine results in increased expression of NR4A2 mRNA17266109
D010758Phosphorus[Phosphorus co-treated with paricalcitol] affects the expression of NR4A2 mRNA17715259
C014153pirimiphos methylpirimiphos methyl results in increased activity of NR4A2 protein20143881
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NR4A2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of NR4A2 mRNA18301758|2081375
D010938Plant OilsPlant Oils results in increased expression of NR4A2 mRNA23370395
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of NR4A2 mRNA21334430
D011189Potassium ChloridePotassium Chloride results in increased expression of NR4A2 mRNA8737662
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of NR4A2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of NR4A2 mRNA22079256
D044945ProanthocyanidinsProanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of NR4A2 mRNA]26802905
D011339Probenecid"1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] affects the localization of and results in decreased expression of NR4A2 protein]"25406165
D011339Probenecid"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] affects the localization of and results in decreased expression of NR4A2 protein"25406165
C005556propionaldehydepropionaldehyde results in decreased expression of NR4A2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of NR4A2 mRNA22504374
C010313pseudocumenepseudocumene results in increased expression of NR4A2 protein17337753
C502851quinocetoneProanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of NR4A2 mRNA]26802905
C502851quinocetonequinocetone metabolite results in decreased expression of NR4A2 mRNA26802905
C502851quinocetonequinocetone results in decreased expression of NR4A2 mRNA27046791
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of NR4A2 mRNA27634759
D012402RotenoneLithium Chloride inhibits the reaction [Rotenone results in decreased expression of NR4A2 protein]27045591
D012402RotenoneRotenone results in decreased expression of NR4A2 mRNA19013527
D012402RotenoneRotenone results in decreased expression of NR4A2 protein27045591
C417521SB 216763CTNNB1 protein affects the reaction [SB 216763 results in increased expression of NR4A2 mRNA]27045591
C417521SB 216763SB 216763 promotes the reaction [CTNNB1 protein binds to NR4A2 promoter]27045591
C417521SB 216763SB 216763 promotes the reaction [CTNNB1 protein binds to NR4A2 protein]27045591
C417521SB 216763SB 216763 results in increased expression of NR4A2 mRNA27045591
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of NR4A2 mRNA19564919
C534628SCH 23390SCH 23390 results in increased expression of NR4A2 mRNA19564919
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of NR4A2 mRNA"24160326
C016101shikoninshikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of NR4A2 mRNA]25451590
C016101shikoninshikonin inhibits the reaction [Calcimycin results in increased expression of NR4A2 mRNA]25451590
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NR4A2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NR4A2 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of NR4A2 mRNA19073995
D012834SilverSilver affects the expression of NR4A2 mRNA27131904
D012839SimazineSimazine affects the expression of NR4A2 mRNA27513680
C017947sodium arseniteleptomycin B inhibits the reaction [sodium arsenite affects the localization of NR4A2 protein]23283970
C017947sodium arsenitesodium arsenite affects the localization of NR4A2 protein23283970
C017947sodium arsenite[sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of DDC mRNA]23283970
C017947sodium arsenite[sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of SLC18A2 mRNA]23283970
C017947sodium arsenite[sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of TH mRNA]23283970
C017947sodium arsenitesodium arsenite results in decreased expression of NR4A2 mRNA18812580
C017947sodium arseniteAcetylcysteine inhibits the reaction [sodium arsenite affects the localization of NR4A2 protein]23283970
C017947sodium arsenitesodium arsenite affects the localization of NR4A2 protein23283970
C016104sodium bichromatesodium bichromate results in increased expression of NR4A2 mRNA27859739
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of NR4A2 mRNA25377654
D012969Sodium FluorideSodium Fluoride results in decreased expression of NR4A2 mRNA27862939
D018038Sodium SeleniteSodium Selenite results in increased expression of NR4A2 mRNA18175754
D012999SomanSoman results in decreased expression of NR4A2 mRNA19281266
D012999SomanSoman results in increased expression of NR4A2 mRNA19281266
D053260SootSoot results in decreased expression of NR4A2 mRNA26551751
D020058StyreneStyrene results in decreased expression of NR4A2 mRNA28951217
D013629TamoxifenTamoxifen results in increased expression of NR4A2 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NR4A2 mRNA21570461|2405805
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NR4A2 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NR4A2 mRNA25613284
D013792ThalidomideThalidomide analog results in increased expression of NR4A2 mRNA20525221
D019284ThapsigarginThapsigargin results in increased expression of NR4A2 mRNA21694771
D013849ThimerosalThimerosal results in increased expression of NR4A2 mRNA16870260
C009495titanium dioxidetitanium dioxide results in increased expression of NR4A2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NR4A2 mRNA28065790
C052342topiramatetopiramate results in decreased expression of NR4A2 mRNA16979414
C483909torcetrapibtorcetrapib results in increased expression of NR4A2 mRNA19164467|2322803
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NR4A2 mRNA17085092
C034613triacsin Ctriacsin C results in decreased expression of NR4A2 mRNA16704987
C012589trichostatin Atrichostatin A results in increased expression of NR4A2 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of NR4A2 mRNA28973697
C022884undecaneundecane results in increased expression of NR4A2 protein17337753
D014520UrethaneUrethane results in decreased expression of NR4A2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NR4A2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of NR4A2 mRNA27188386
D014635Valproic AcidValproic Acid results in increased expression of NR4A2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid promotes the reaction [NR4A2 protein binds to SLC6A3 promoter]28743636
D014635Valproic AcidValproic Acid results in increased expression of NR4A2 mRNA28743636
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NR4A2 gene25560391
C025643vinclozolinvinclozolin affects the expression of NR4A2 mRNA19015723
D014807Vitamin DVitamin D deficiency results in decreased expression of NR4A2 mRNA28365874
D014807Vitamin DVitamin D deficiency results in decreased expression of NR4A2 protein28365874
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of NR4A2 mRNA18593933
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NR4A2 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0003677DNA binding-TAS16243425  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0004879nuclear receptor activity-TAS16243425  
GO:0005515protein binding-IPI20195357  
GO:0008013beta-catenin binding-TAS22988876  24115276  
GO:0008270zinc ion binding-IEA-  
GO:0035259glucocorticoid receptor binding-IBA21873635  
GO:0035259glucocorticoid receptor binding-IEA-  
GO:0042803protein homodimerization activity-TAS16243425  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0046965retinoid X receptor binding-TAS16243425  
GO:0046982protein heterodimerization activity-ISS-  
GO:0046982protein heterodimerization activity-TAS16243425  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP18463503  
GO:0000122negative regulation of transcription by RNA polymerase II-TAS22988876  
GO:0001666response to hypoxia-IEA-  
GO:0001764neuron migration-TAS16243425  
GO:0001975response to amphetamine-IEA-  
GO:0006351transcription, DNA-templated-IDA17184956  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007165signal transduction-NAS7877627  
GO:0008344adult locomotory behavior-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0021952central nervous system projection neuron axonogenesis-IEA-  
GO:0021953central nervous system neuron differentiation-IBA21873635  
GO:0021986habenula development-IEA-  
GO:0030522intracellular receptor signaling pathway-IEA-  
GO:0031668cellular response to extracellular stimulus-IDA7877627  
GO:0034599cellular response to oxidative stress-IEA-  
GO:0042053regulation of dopamine metabolic process-IEA-  
GO:0042416dopamine biosynthetic process-IEA-  
GO:0042551neuron maturation-IEA-  
GO:0043085positive regulation of catalytic activity-IEA-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0043576regulation of respiratory gaseous exchange-IEA-  
GO:0045444fat cell differentiation-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS24115276  
GO:0051866general adaptation syndrome-IEA-  
GO:0060070canonical Wnt signaling pathway-TAS24115276  
GO:0071376cellular response to corticotropin-releasing hormone stimulus-IBA21873635  
GO:0071376cellular response to corticotropin-releasing hormone stimulus-ISS-  
GO:0071542dopaminergic neuron differentiation-IBA21873635  
GO:0071542dopaminergic neuron differentiation-ISS-  
GO:1904948midbrain dopaminergic neuron differentiation-TAS16243425  22988876  24115276  24431302  
GO:2001234negative regulation of apoptotic signaling pathway-IMP19429166  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA17184956  24399192  
GO:0005634nucleus-TAS16243425  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22197712Neurobehavioral and transcriptional effects of acrylamide in juvenile rats. (2012 Mar)Seale SMPharmacol Biochem Behav
21289608Prenatal exposure to nicotine impairs performance of the 5-choice serial reaction time task in adult rats. (2011 Apr)Schneider TNeuropsychopharmacology
19494806Dopamine genes and nicotine dependence in treatment-seeking and community smokers. (2009 Sep)Bergen AWNeuropsychopharmacology
20560679Response to methadone maintenance treatment is associated with the MYOCD and GRM6 genes. (2010 Jun 1)Fonseca FMol Diagn Ther
20659174Replicated association of the NR4A3 gene with smoking behaviour in schizophrenia and in bipolar disorder. (2010 Nov)Novak GGenes Brain Behav
27629278Evaluation of a Novel Difficulty of Smoking Cessation Phenotype Based on Number of Quit Attempts. (2017 Apr 1)Stevens VLNicotine Tob Res