Gene: NVL

4931
NVL2
nuclear VCP-like
protein-coding
1q42.11
Ensembl:ENSG00000143748 MIM:602426 Vega:OTTHUMG00000037536 UniprotKB:O15381
NG_029641.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.350e-1 (AD)  4.008e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KDM4C0.874
U2SURP0.869
TMEM2600.869
COG30.868
DMTF10.867
METTL30.864
RBM50.863
CNOT100.86
ALG130.857
USP480.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.49
OR4F29-0.478
MTRNR2L6-0.31
MTRNR2L9-0.304
MTRNR2L10-0.298
OR4F16-0.27
TRDN-0.247
C8orf74-0.246
MTRNR2L8-0.235
RSPO1-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NVL mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NVL mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NVL gene27153756
D001151ArsenicArsenic affects the methylation of NVL gene25304211
D001280AtrazineAtrazine results in increased expression of NVL mRNA25929836
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of NVL mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of NVL mRNA24758408
C006780bisphenol Abisphenol A results in decreased expression of NVL mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of NVL mRNA25181051
D000068579CelecoxibCelecoxib results in decreased expression of NVL mRNA28201806
D016572CyclosporineCyclosporine results in increased expression of NVL mRNA20106945
D004041Dietary FatsDietary Fats results in increased expression of NVL mRNA18042831
D004147DioxinsDioxins affects the expression of NVL mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NVL protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NVL mRNA17606305
D007854LeadLead affects the expression of NVL mRNA28903495
C045463leflunomideleflunomide results in increased expression of NVL mRNA28988120
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of NVL mRNA24525745
D008727MethotrexateMethotrexate affects the expression of NVL mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NVL mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NVL mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NVL mRNA"20188158
D000073878Palm OilPalm Oil results in increased expression of NVL mRNA18042831
D011192Potassium DichromatePotassium Dichromate results in decreased expression of NVL mRNA23608068
C059514resveratrolresveratrol results in decreased expression of NVL protein25505154
C017947sodium arsenitesodium arsenite affects the methylation of NVL gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of NVL protein21925251
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NVL mRNA23152189
D013853ThioacetamideThioacetamide results in increased expression of NVL mRNA23411599
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NVL gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0005515protein binding-IPI15469983  16782053  22226966  
GO:0005524ATP binding-IMP22226966  
GO:0016887ATPase activity-IBA21873635  
GO:1990275preribosome binding-IBA21873635  
GO:1990275preribosome binding-IDA16782053  
GO ID GO Term Qualifier Evidence PubMed
GO:0042254ribosome biogenesis-IBA21873635  
GO:0042254ribosome biogenesis-IMP15469983  16782053  
GO:0051973positive regulation of telomerase activity-IBA21873635  
GO:0051973positive regulation of telomerase activity-IMP22226966  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16782053  
GO:0005654nucleoplasm-IDA15469983  
GO:0005697telomerase holoenzyme complex-IDA22226966  
GO:0005730nucleolus-IDA15469983  22226966  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa03008Ribosome biogenesis in eukaryotes
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19214408Treatment of chronic CAD--do the guidelines (ESC, AHA) reflect daily practice? (2009 Feb)Tillmanns HHerz