Gene: OAS3

4940
p100|p100OAS
2'-5'-oligoadenylate synthetase 3
protein-coding
12q24.13
Ensembl:ENSG00000111331 MIM:603351 Vega:OTTHUMG00000169795 UniprotKB:Q9Y6K5
NC_000012.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.908e-1 (AD)  2.062e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2072134chr12:112971371 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OAS20.939
IFIH10.921
OAS10.905
USP180.902
IFI44L0.886
DDX580.876
MX20.86
OASL0.859
RSAD20.856
SAMD9L0.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN1-0.224
CHST8-0.218
MYADML2-0.215
C19orf73-0.208
ALG1L-0.201
BRDT-0.197
TTC9B-0.196
SPEF1-0.196
PRSS56-0.189
RHO-0.183

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0700461,2-dioleoyloxy-3-(trimethylammonium)propane"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of OAS3 mRNA"22129739
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of OAS3 mRNA"23146750
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of OAS3 mRNA"28712647
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of OAS3 mRNA"23146750
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of OAS3 mRNA19191707
D000082AcetaminophenAcetaminophen results in decreased expression of OAS3 mRNA21420995
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of OAS3 mRNA"23195993
D017639Asbestos, Amosite"Asbestos, Amosite results in decreased expression of OAS3 mRNA"23917077
D001379AzathioprineAzathioprine results in decreased expression of OAS3 mRNA19192274
C547126AZM551248AZM551248 results in decreased expression of OAS3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OAS3 mRNA22228805
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of OAS3 mRNA19619570
D004958EstradiolEstradiol results in increased expression of OAS3 mRNA19619570|2118537
C006780bisphenol Abisphenol A affects the expression of OAS3 mRNA25181051
C518299BIX 01294BIX 01294 promotes the reaction [IFNA2 protein alternative form results in increased expression of OAS3 mRNA]25079219
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of OAS3 mRNA15336504
D000074262Canola OilCanola Oil metabolite results in decreased expression of OAS3 mRNA27363782
D002784Cholesterol"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of OAS3 mRNA"22129739
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of OAS3 mRNA20971185
D019327Copper SulfateCopper Sulfate affects the expression of OAS3 mRNA19549813
D016572CyclosporineCyclosporine affects the expression of OAS3 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of OAS3 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of OAS3 mRNA22147139
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of OAS3 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of OAS3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of OAS3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of OAS3 mRNA21151649
C000944dicrotophosdicrotophos results in increased expression of OAS3 mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of OAS3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of OAS3 mRNA21592394
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OAS3 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of OAS3 mRNA27392435
C544151jinfukangjinfukang results in increased expression of OAS3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of OAS3 mRNA23086925|2479639
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of OAS3 mRNA25890327|2658214
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of OAS3 mRNA26378955
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of OAS3 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of OAS3 mRNA26378955
D008775MethylprednisoloneMethylprednisolone results in decreased expression of OAS3 mRNA19192274
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of OAS3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of OAS3 mRNA"25554681
D009532NickelNickel results in decreased expression of OAS3 mRNA23195993
D009532NickelNickel results in increased expression of OAS3 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of OAS3 mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of OAS3 mRNA20971185
D010100OxygenOxygen deficiency results in decreased expression of OAS3 mRNA26516004
D010416PentachlorophenolPentachlorophenol results in increased expression of OAS3 mRNA23892564
D010936Plant ExtractsPlant Extracts results in increased expression of OAS3 mRNA21297082
D011794QuercetinQuercetin results in increased expression of OAS3 mRNA21632981
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of OAS3 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide results in increased expression of OAS3 mRNA22300531|2535159
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of OAS3 mRNA26378955
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of OAS3 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of OAS3 mRNA26378955
D013629TamoxifenTamoxifen results in increased expression of OAS3 mRNA19155303
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of OAS3 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of OAS3 mRNA21592394
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of OAS3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of OAS3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of OAS3 mRNA20106945|2163298
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OAS3 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of OAS3 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of OAS3 mRNA"26179874
C561310UNC 0638UNC 0638 promotes the reaction [IFNA2 protein alternative form results in increased expression of OAS3 mRNA]25079219
D014520UrethaneUrethane results in decreased expression of OAS3 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of OAS3 mRNA29154799
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS3 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00017302'-5'-oligoadenylate synthetase activity-IBA21873635  
GO:00017302'-5'-oligoadenylate synthetase activity-IDA9880533  
GO:0003725double-stranded RNA binding-IBA21873635  
GO:0003725double-stranded RNA binding-IDA9880533  
GO:0005515protein binding-IPI21903422  
GO:0005524ATP binding-IDA9880533  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-TAS2440675  
GO:0009615response to virus-IDA19056102  
GO:0045071negative regulation of viral genome replication-IDA19056102  19923450  
GO:0051607defense response to virus-IDA19923450  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0060700regulation of ribonuclease activity-IBA21873635  
GO:0060700regulation of ribonuclease activity-IDA19923450  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA23580065  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA9880533  19923450  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016020membrane-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-TAS2440675  
KEGG ID KEGG Term
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24142389Male-specific genetic effect on hypertension and metabolic disorders. (2014 Mar)Heo SGHum Genet
21270382Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (2011 Apr)Baik IAm J Clin Nutr