Gene: OAT

4942
GACR|HOGA|OATASE|OKT
ornithine aminotransferase
protein-coding
10q26.13
Ensembl:ENSG00000065154 MIM:613349 Vega:OTTHUMG00000019213 UniprotKB:P04181
NG_008861.1
PubMed
0   ANCO-SNPs
OD|ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.346e-1 (AD)  4.397e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6AP20.977
RAB2A0.977
OCIAD10.972
NDFIP10.969
ARL8B0.967
RAB6A0.965
PPP2CA0.964
REEP50.964
NARS0.964
UQCRC20.963

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.719
OR4F29-0.671
MTRNR2L6-0.405
MTRNR2L10-0.4
CSAG1-0.393
MTRNR2L9-0.391
KCNJ15-0.37
FOLR3-0.36
MTRNR2L8-0.357
MTRNR2L3-0.355

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of OAT mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of OAT mRNA"28903501
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of OAT mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of OAT mRNA"19114083
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of OAT mRNA"22016648
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of OAT mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of OAT mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"10503888|9581821
C0369892-amino-3,4-dimethylimidazo(4,5-f)quinoline"[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,4-dimethylimidazo(4,5-f)quinoline"10503888|9581821
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"10503888|9581821
C0292162-amino-3-methylimidazo(4,5-f)quinoline"[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline"10503888|9581821
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of OAT mRNA"21346803
C0194992-nitrofluorene2-nitrofluorene results in decreased expression of OAT mRNA14600272|2248451
C0263083,4-dihydrocoumarin"3,4-dihydrocoumarin results in decreased expression of OAT mRNA"22016648
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in decreased expression of OAT protein"22649188
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of OAT mRNA18544908
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of OAT mRNA14610520
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of OAT mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of OAT mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OAT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OAT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OAT mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of OAT mRNA"21346803
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of OAT mRNA14600272|2248451
C0293704-toluidine4-toluidine results in decreased expression of OAT mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OAT mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of OAT mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of OAT mRNA11793227|2142099
D000082AcetaminophenAcetaminophen affects the expression of OAT mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of OAT mRNA11264010|1854490
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of OAT mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of OAT mRNA]17585979
D000082AcetaminophenAcetaminophen affects the expression of OAT mRNA17366322
D000082AcetaminophenAcetaminophen results in decreased expression of OAT mRNA15084756|1720276
D000242Cyclic AMPCyclic AMP results in increased activity of OAT protein2824512
D000242Cyclic AMPCyclic AMP results in increased expression of OAT mRNA2827574
D000242Cyclic AMPDeoxyglucose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPDihydroxyacetone inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPFructose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPFructose inhibits the reaction [Cyclic AMP results in increased expression of OAT mRNA]2827574
D000242Cyclic AMPGalactose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPGlucose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPGlycerol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPInositol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPMannitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPMannose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPRhamnose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPRibose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPSorbitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPSorbose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D000242Cyclic AMPXylitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of OAT mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of OAT mRNA14600272
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of OAT protein26597043
D000638AmiodaroneAmiodarone affects the expression of OAT mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of OAT mRNA16483693
D001414BacitracinBacitracin results in increased expression of OAT mRNA18289764
D001554BenzeneBenzene affects the expression of OAT mRNA15878777
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OAT mRNA18061397
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OAT mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of OAT mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of OAT mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of OAT promoter27312807
C006780bisphenol Abisphenol A affects the expression of OAT mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of OAT mRNA26496021
C013418bromfenacoumbromfenacoum results in increased expression of OAT protein28903499
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of OAT protein24527689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of OAT protein24527689
D019256Cadmium ChlorideCadmium Chloride affects the expression of OAT mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of OAT mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in increased expression of OAT mRNA21297351
D002110CaffeineCaffeine results in increased expression of OAT mRNA11793227
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of OAT mRNA26639393|2733941
D002706ChlordanChlordan results in decreased expression of OAT mRNA23153324
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of OAT mRNA18178546
C100187chloropicrinchloropicrin results in decreased expression of OAT mRNA26352163
D002746ChlorpromazineChlorpromazine affects the expression of OAT mRNA25064622
C019304ciprofibrateciprofibrate results in decreased expression of OAT mRNA12771043
D002994ClofibrateClofibrate affects the expression of OAT mRNA16081524
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of OAT mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of OAT mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of OAT mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of OAT mRNA17602206
C018021cobaltous chloridecobaltous chloride results in increased expression of OAT mRNA17553155
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of OAT mRNA15467011
D003300CopperCopper results in decreased expression of OAT mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of OAT mRNA19549813
D003314Corn OilCorn Oil affects the expression of OAT mRNA16360708
C030123coumarincoumarin results in decreased expression of OAT mRNA18480146
D003474CurcuminCurcumin affects the expression of OAT mRNA18539377
D016572CyclosporineCyclosporine affects the expression of OAT mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of OAT mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of OAT mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of OAT mRNA19770486
D003847DeoxyglucoseDeoxyglucose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of OAT mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of OAT mRNA17361019
D002945CisplatinCisplatin results in decreased expression of OAT mRNA18289764
C000944dicrotophosdicrotophos results in decreased expression of OAT mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of OAT mRNA12771043|2453584
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of OAT mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of OAT mRNA]17942915
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of OAT mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of OAT mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of OAT mRNA19638242
D004098DihydroxyacetoneDihydroxyacetone inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of OAT mRNA27638505
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of OAT mRNA14600272|2538013
D004237DiuronDiuron results in decreased expression of OAT mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of OAT mRNA22016648
C118739entinostatentinostat results in increased expression of OAT mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OAT mRNA"27188386
D000431EthanolEthanol results in increased expression of OAT mRNA16098508
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of OAT mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of OAT mRNA17555576
C504383fenbuconazolefenbuconazole results in increased expression of OAT mRNA15942997
C082360fipronilfipronil results in increased expression of OAT mRNA23962444
D005485FlutamideFlutamide results in decreased expression of OAT mRNA24136188
D005632FructoseFructose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D005632FructoseFructose inhibits the reaction [Cyclic AMP results in increased expression of OAT mRNA]2827574
C056933fumonisin B1fumonisin B1 results in decreased expression of OAT mRNA16221962
C039281furanfuran results in decreased expression of OAT mRNA25539665|2619464
D005690GalactoseGalactose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D005839GentamicinsGentamicins results in decreased expression of OAT mRNA18289764
D005839GentamicinsGentamicins results in decreased expression of OAT protein22061828
D005897GlafenineGlafenine results in decreased expression of OAT mRNA24136188
D005944GlucosamineGlucosamine affects the reaction [IL1B results in decreased expression of OAT mRNA]17109745
D005947GlucoseGlucose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D005990GlycerolGlycerol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of OAT mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of OAT mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of OAT mRNA21396975
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in decreased expression of OAT mRNA"18061397
D007294InositolInositol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of OAT mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of OAT mRNA24796395
D007657Ketone BodiesKetone Bodies results in increased expression of OAT mRNA16807920
D007854LeadLead affects the expression of OAT mRNA28903495
C045463leflunomideleflunomide results in decreased expression of OAT mRNA24136188
D008148LovastatinLovastatin results in decreased expression of OAT mRNA20493250
D008353MannitolMannitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D008358MannoseMannose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D008727MethotrexateMethotrexate affects the expression of OAT mRNA18502557
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of OAT protein26558463
C008493methylselenic acidmethylselenic acid results in increased expression of OAT mRNA18548127
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of OAT mRNA22401849
C500085muraglitazarmuraglitazar results in increased expression of OAT mRNA21515302
D009151Mustard GasMustard Gas results in increased expression of OAT mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of OAT mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of OAT mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of OAT mRNA25380136
C051752nefazodonenefazodone results in decreased expression of OAT mRNA24136188
C012655nimesulidenimesulide results in decreased expression of OAT mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of OAT mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of OAT mRNA19716841
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of OAT protein19716841
C025256nonylphenolnonylphenol results in decreased expression of OAT protein19260726
C025589ochratoxin Aochratoxin A results in increased expression of OAT protein19445961
C025589ochratoxin Aochratoxin A results in decreased expression of OAT mRNA16251485|1841718
C025589ochratoxin Aochratoxin A results in decreased methylation of OAT gene26431795
D009966OrphenadrineOrphenadrine affects the expression of OAT mRNA23665939
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of OAT mRNA"23246600
D017239PaclitaxelPaclitaxel analog results in increased expression of OAT mRNA15585946
D017239PaclitaxelPaclitaxel results in increased expression of OAT mRNA15585946
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OAT mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of OAT mRNA26272509
D010269ParaquatParaquat affects the expression of OAT mRNA25064622
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of OAT protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of OAT mRNA18281256
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of OAT mRNA19162173
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of OAT mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of OAT mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of OAT mRNA19482888
D010634PhenobarbitalPhenobarbital affects the expression of OAT mRNA19162173
D010795Phthalic AcidsPhthalic Acids results in increased expression of OAT mRNA21061450
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of OAT mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of OAT mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of OAT mRNA17426115|2381119
C006253pirinixic acidpirinixic acid results in decreased expression of OAT mRNA17164430|1916217
D010936Plant ExtractsPlant Extracts results in decreased expression of OAT mRNA18061397
D010936Plant ExtractsPlant Extracts results in increased expression of OAT mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of OAT protein18563748
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of OAT mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of OAT mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of OAT mRNA21278054
C010313pseudocumenepseudocumene results in decreased expression of OAT protein17337753
D012210RhamnoseRhamnose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D012266RiboseRibose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
C488333Ro 65-7199Ro 65-7199 affects the expression of OAT mRNA14610520
C089730rosiglitazonerosiglitazone results in increased expression of OAT mRNA21515302
C080703SK&F 83959SK&F 83959 results in decreased expression of OAT protein25852303
C017947sodium arsenitesodium arsenite affects the expression of OAT mRNA29319823
C016104sodium bichromatesodium bichromate results in decreased expression of OAT mRNA24612858
C016104sodium bichromatesodium bichromate results in decreased expression of OAT mRNA25993096
D013012SorbitolSorbitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D013013SorboseSorbose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574
D013013SorboseSorbose results in decreased activity of OAT protein2827574
D013311StreptozocinStreptozocin results in decreased expression of OAT protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in decreased expression of OAT protein]19634143
D012460SulfasalazineSulfasalazine results in increased expression of OAT mRNA22016648
D013605T-2 ToxinT-2 Toxin affects the expression of OAT protein26141394
D013629TamoxifenTamoxifen affects the expression of OAT mRNA17555576
C501413tesaglitazartesaglitazar results in increased expression of OAT mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of OAT mRNA18061397
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of OAT mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of OAT mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of OAT mRNA18796159|2121527
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of OAT mRNA28973375
D013752TetracyclineTetracycline affects the expression of OAT mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of OAT mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of OAT mRNA22378314
D013853ThioacetamideThioacetamide affects the expression of OAT mRNA25064622
D013853ThioacetamideThioacetamide results in increased expression of OAT mRNA11793227
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of OAT mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of OAT mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in decreased expression of OAT mRNA19448997
C012589trichostatin Atrichostatin A results in increased expression of OAT mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of OAT mRNA15901671
D014266TrientineTrientine inhibits the reaction [Streptozocin results in decreased expression of OAT protein]19634143
D014303TrinitrotolueneTrinitrotoluene affects the expression of OAT mRNA21346803
C057693troglitazonetroglitazone results in increased expression of OAT protein18495193
D014415TunicamycinTunicamycin results in decreased expression of OAT mRNA22378314
C022884undecaneundecane results in decreased expression of OAT protein17337753
D014501UraniumUranium affects the expression of OAT mRNA15672453
D017974Uranium CompoundsUranium Compounds results in decreased expression of OAT mRNA19654044
C005460uranyl acetateuranyl acetate affects the expression of OAT mRNA15672453
D014520UrethaneUrethane results in increased expression of OAT mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of OAT mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of OAT mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OAT mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of OAT mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of OAT mRNA23179753|2352703
D014635Valproic AcidValproic Acid results in increased expression of OAT mRNA15901671
D014640VancomycinVancomycin results in decreased expression of OAT mRNA18289764
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of OAT gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of OAT mRNA20044591
C111237vorinostatvorinostat results in increased expression of OAT protein17593366
D014859WarfarinWarfarin results in decreased expression of OAT mRNA20493250
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of OAT mRNA"23246600
D014993XylitolXylitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]2827574

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004587ornithine-oxo-acid transaminase activity-EXP6819292  
GO:0004587ornithine-oxo-acid transaminase activity-IBA21873635  
GO:0030170pyridoxal phosphate binding-IBA21873635  
GO:0042802identical protein binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007601visual perception-TAS2793865  
GO:0008652cellular amino acid biosynthetic process-TAS-  
GO:0010121arginine catabolic process to proline via ornithine-IBA21873635  
GO:0019544arginine catabolic process to glutamate-IBA21873635  
GO:0034214protein hexamerization-IDA9514741  
GO:0055129L-proline biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70614Amino acid synthesis and interconversion (transamination)TAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29359516Seminal SIRT1 expression in infertile oligoasthenoteratozoospermic men with varicocoele. (2018 Mar)Mostafa TAndrology
12620529Weight loss associated with a daily intake of three apples or three pears among overweight women. (2003 Mar)Conceicao de Oliveira MNutrition
3759102Haptoglobin groups and lung cancer. (1986)Beckman GHum Hered
20177974Improved HIV and substance abuse treatment outcomes for released HIV-infected prisoners: the impact of buprenorphine treatment. (2010 Jul)Springer SAJ Urban Health
25997674Risk Factors for Relapse and Higher Costs Among Medicaid Members with Opioid Dependence or Abuse: Opioid Agonists, Comorbidities, and Treatment History. (2015 Oct)Clark REJ Subst Abuse Treat
11921189Characterization of a major aromatic DNA adduct detected in human breast tissues. (2002)Li DEnviron Mol Mutagen
26987797Assessing Differences in the Availability of Opioid Addiction Therapy Options: Rural Versus Urban and American Indian Reservation Versus Nonreservation. (2017 Jan)Hirchak KAJ Rural Health
28629854Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate. (2017 Oct)Sayyed KToxicol In Vitro
7242134Function of the secretory immune system in bronchogenic carcinoma. Immunoglobulin A levels in respiratory secretions. (1981 Jul)Iglehart JDJ Thorac Cardiovasc Surg