Gene: WEE2

494551
WEE1B
WEE1 homolog 2
protein-coding
7q34
Ensembl:ENSG00000214102 MIM:614084 Vega:OTTHUMG00000157536 UniprotKB:P0C1S8
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.772e-1 (AD)  1.573e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDNF0.482
PLEKHG40.467
HESX10.453
C11orf650.447
CCT6B0.441
APOM0.439
ENPP70.426
CLEC4D0.414
DMGDH0.413
EXOSC80.408

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNK12-0.305
SLC22A13-0.292
XKR6-0.272
OVOL3-0.256
SLC35G6-0.247
DLX3-0.245
KLRG1-0.239
OPRD1-0.237
ADRA2C-0.233
KCNG1-0.232

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of WEE2 mRNA"25614096
D000082AcetaminophenAcetaminophen results in decreased expression of WEE2 mRNA26690555
D001280AtrazineAtrazine results in increased expression of WEE2 mRNA25929836
C006780bisphenol Abisphenol A results in increased expression of WEE2 mRNA29027980
C006780bisphenol Abisphenol A affects the expression of WEE2 mRNA27561114
C006780bisphenol Abisphenol A results in decreased expression of WEE2 mRNA25181051
C045463leflunomideleflunomide results in increased expression of WEE2 mRNA28988120
D010416PentachlorophenolPentachlorophenol results in increased expression of WEE2 mRNA24642059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of WEE2 gene25560391
D015032ZincZinc results in decreased expression of WEE2 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004672protein kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000278mitotic cell cycle-IEA-  
GO:0007093mitotic cell cycle checkpoint-IBA21873635  
GO:0007143female meiotic nuclear division-ISS-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0035038female pronucleus assembly-ISS-  
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity-IEA-  
GO:0060631regulation of meiosis I-IBA21873635  
GO:0060631regulation of meiosis I-ISS-  
GO:1900194negative regulation of oocyte maturation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa04110Cell cycle
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29040583Taste receptor polymorphisms and male infertility. (2017 Nov 1)Gentiluomo MHum Reprod