Gene: OAZ1

4946
AZ1|AZI|OAZ
ornithine decarboxylase antizyme 1
protein-coding
19p13.3
Ensembl:ENSG00000104904 MIM:601579 Vega:OTTHUMG00000178459 UniprotKB:P54368
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
3.748e-1 (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13437554chr19:2272716OAZ1Gene body1.871e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SSU720.971
NGRN0.966
BRK10.961
ATP6V1F0.959
CFL10.959
CHMP4B0.958
GAPDH0.958
RAD23A0.955
MLF20.954
COPS60.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.897
OR4F29-0.87
IL18RAP-0.237
KCNJ15-0.229
CXCR2-0.221
VNN3-0.22
KLRB1-0.218
MMP9-0.213
CXCR1-0.212
VNN2-0.203

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00129OrnithineSmall Molecule70-26-8Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of OAZ1 mRNA"19417177
D000082AcetaminophenAcetaminophen affects the expression of OAZ1 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of OAZ1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OAZ1 mRNA20127859|2719552
C095105bexarotenebexarotene results in increased expression of OAZ1 mRNA16648578
C006780bisphenol Abisphenol A affects the expression of OAZ1 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of OAZ1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of OAZ1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of OAZ1 mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of OAZ1 mRNA18804290
D002101Cacodylic AcidCacodylic Acid results in decreased expression of OAZ1 mRNA17441966
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of OAZ1 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of OAZ1 promoter22457795
C073316carvacrolcarvacrol results in decreased expression of OAZ1 mRNA20008804
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of OAZ1 mRNA18804290
C100187chloropicrinchloropicrin results in decreased expression of OAZ1 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OAZ1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of OAZ1 mRNA17553155
D003300CopperCopper affects the expression of OAZ1 mRNA18522721
C009160cyclonitecyclonite affects the expression of OAZ1 mRNA19417177
D004147DioxinsDioxins affects the expression of OAZ1 mRNA20463971
D004317DoxorubicinOAZ1 protein affects the susceptibility to Doxorubicin16217747
D000431EthanolEthanol affects the expression of OAZ1 mRNA24355176
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of OAZ1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OAZ1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of OAZ1 mRNA23550701
C082360fipronilfipronil results in decreased expression of OAZ1 mRNA23962444
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OAZ1 gene20938992
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of OAZ1 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OAZ1 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of OAZ1 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OAZ1 gene20938992
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of OAZ1 mRNA18804290
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of OAZ1 mRNA"20188158
D015741MetriboloneMetribolone affects the splicing of OAZ1 mRNA17010196
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of OAZ1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of OAZ1 mRNA"25620056
C049032pinosylvinpinosylvin results in decreased expression of OAZ1 mRNA23333577
D012643SeleniumSelenium results in increased expression of OAZ1 mRNA19244175
C009277sodium arsenatesodium arsenate results in increased expression of OAZ1 mRNA23922661
D012999SomanSoman results in increased expression of OAZ1 mRNA19281266
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of OAZ1 mRNA26496021
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OAZ1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of OAZ1 mRNA19465110|2135428
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OAZ1 mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in decreased expression of OAZ1 mRNA28973375
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of OAZ1 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of OAZ1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of OAZ1 gene25560391
D014747VinblastineOAZ1 protein affects the susceptibility to Vinblastine16217747
D024483Vitamin K 3Vitamin K 3 affects the expression of OAZ1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17900240  
GO:0008073ornithine decarboxylase inhibitor activity-IBA21873635  
GO:0008073ornithine decarboxylase inhibitor activity-IDA17900240  
GO:0008073ornithine decarboxylase inhibitor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006521regulation of cellular amino acid metabolic process-TAS-  
GO:0006596polyamine biosynthetic process-IEA-  
GO:0043086negative regulation of catalytic activity-IEA-  
GO:0045732positive regulation of protein catabolic process-IBA21873635  
GO:0045732positive regulation of protein catabolic process-IDA17900240  
GO:0045732positive regulation of protein catabolic process-ISS-  
GO:0090316positive regulation of intracellular protein transport-ISS-  
GO:1902268negative regulation of polyamine transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-350562Regulation of ornithine decarboxylase (ODC)TAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15623624Salivary transcriptome diagnostics for oral cancer detection. (2004 Dec 15)Li YClin Cancer Res