Gene: ODF2

4957
CT134|ODF2/1|ODF2/2|ODF84
outer dense fiber of sperm tails 2
protein-coding
9q34.11
Ensembl:ENSG00000136811 MIM:602015 Vega:OTTHUMG00000020748 UniprotKB:Q5BJF6
NG_029568.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.972e-1 (AD)  7.419e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HKR10.898
GGA20.891
CLK20.891
NSMAF0.891
ASXL10.89
GTF3C20.885
MAN2C10.883
HDAC30.883
GIT20.882
SEC16A0.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.604
OR4F29-0.553
KLRC2-0.27
TRDN-0.243
LRAT-0.236
PDE11A-0.236
DIAPH3-0.225
MTRNR2L9-0.219
NCBP2L-0.216
CARD17-0.214

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ODF2 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ODF2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ODF2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ODF2 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of ODF2 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of ODF2 mRNA17562736
C014949acetylhydrazineacetylhydrazine results in decreased expression of ODF2 mRNA15282401
D020106AcrylamideAcrylamide results in increased expression of ODF2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ODF2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ODF2 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ODF2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ODF2 mRNA24449571
C015001arsenitearsenite results in increased expression of ODF2 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in increased expression of ODF2 mRNA]18929588
D001280AtrazineAtrazine results in increased expression of ODF2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ODF2 mRNA20504355|2156981
C006780bisphenol Abisphenol A results in decreased expression of ODF2 mRNA23798566
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ODF2 mRNA28628672
C018475butyraldehydebutyraldehyde results in increased expression of ODF2 mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of ODF2 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of ODF2 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ODF2 mRNA23650126
D002922CiguatoxinsCiguatoxins affects the expression of ODF2 mRNA18353800
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ODF2 mRNA"19167446
D016572CyclosporineCyclosporine results in increased expression of ODF2 mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ODF2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ODF2 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of ODF2 mRNA28302478
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ODF2 protein20932895
D004317DoxorubicinDoxorubicin results in increased oxidation of ODF2 protein28818578
D005419FlavonoidsFlavonoids results in decreased expression of ODF2 mRNA18035473
D005839GentamicinsGentamicins results in decreased expression of ODF2 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ODF2 mRNA20044591
C016517indole-3-carbinolindole-3-carbinol affects the expression of ODF2 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ODF2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ODF2 mRNA28628672
D007854LeadLead affects the expression of ODF2 mRNA28903495
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ODF2 mRNA"26251327
D008777MethyltestosteroneMethyltestosterone results in increased expression of ODF2 mRNA29191790
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of ODF2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ODF2 mRNA"25620056
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ODF2 mRNA25729387
C006253pirinixic acidpirinixic acid results in decreased expression of ODF2 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of ODF2 mRNA19162173
D010936Plant ExtractsPlant Extracts results in increased expression of ODF2 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ODF2 mRNA23608068
D011192Potassium DichromatePotassium Dichromate results in increased expression of ODF2 protein18563748
D012402RotenoneRotenone results in increased expression of ODF2 mRNA27900601
D012969Sodium FluorideSodium Fluoride results in decreased expression of ODF2 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ODF2 mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ODF2 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ODF2 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ODF2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ODF2 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of ODF2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of ODF2 gene29154799
C025643vinclozolinvinclozolin results in increased expression of ODF2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-TAS10072582  
GO:0005515protein binding-IPI16980960  23355646  28422092  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0007275multicellular organism development-IEA-  
GO:0007286spermatid development-IEA-  
GO:0008104protein localization-IMP23213374  28422092  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0010457centriole-centriole cohesion-IGI23213374  
GO:0044782cilium organization-IGI23400999  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IEA-  
GO:0001520outer dense fiber-IEA-  
GO:0005634nucleus-HDA21630459  
GO:0005813centrosome-IDA21399614  24157919  
GO:0005814centriole-IDA24421332  
GO:0005829cytosol-TAS-  
GO:0005874microtubule-IEA-  
GO:0097539ciliary transition fiber-IEA-  
GO:0120103centriolar subdistal appendage-IDA23213374  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8854518AURKA Activation by TPX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25269568Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility. (2014 Dec)Sobinoff APHum Reprod