Gene: OPA1

4976
BERHS|MGM1|MTDPS14|NPG|NTG|largeG
OPA1, mitochondrial dynamin like GTPase
protein-coding
3q29
Ensembl:ENSG00000198836 MIM:605290 Vega:OTTHUMG00000149897 UniprotKB:O60313
NG_011605.1
PubMed
0   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.588e-1 (AD)  9.502e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PJA20.974
NAPG0.969
CAND10.968
LRPPRC0.966
CLTC0.964
USP330.963
ATAD10.963
SPIN10.963
SLC25A460.963
ZDHHC170.962

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.611
OR4F29-0.57
CSAG1-0.479
MTRNR2L6-0.383
MTRNR2L10-0.381
MAGEA12-0.367
CNN2-0.362
RUNX3-0.361
MTRNR2L9-0.361
MTRNR2L8-0.355

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 inhibits the reaction [OPA1 protein binds to OPA1 protein]20678484
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form20678484
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 results in increased ubiquitination of OPA1 protein20678484
C47781915-deoxyprostaglandin J2Acetylcysteine inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form]20678484
C47781915-deoxyprostaglandin J2Acetylcysteine inhibits the reaction [15-deoxyprostaglandin J2 results in increased ubiquitination of OPA1 protein]20678484
C47781915-deoxyprostaglandin J2Cycloheximide inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form]20678484
C47781915-deoxyprostaglandin J2Dactinomycin inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form]20678484
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of OPA1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of OPA1 mRNA"18648102
C0423754-diphenylacetoxy-1,1-dimethylpiperidinium"4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of OPA1 protein"27491814
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of OPA1 protein"27491814
D000082AcetaminophenAcetaminophen results in decreased expression of OPA1 mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of OPA1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form]20678484
D000111AcetylcysteineAcetylcysteine inhibits the reaction [15-deoxyprostaglandin J2 results in increased ubiquitination of OPA1 protein]20678484
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of OPA1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of OPA1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of OPA1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OPA1 mRNA20504355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of OPA1 mRNA21715664|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OPA1 mRNA"26238291
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of OPA1 protein alternative form20678484
C006780bisphenol Abisphenol A affects the expression of OPA1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of OPA1 mRNA21786754
C006780bisphenol Abisphenol A results in increased methylation of OPA1 gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of OPA1 protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of OPA1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of OPA1 mRNA26472689
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of OPA1 mRNA20360939
D003474CurcuminCurcumin inhibits the reaction [Cisplatin results in decreased expression of OPA1 protein]28698153
D003513CycloheximideCycloheximide inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form]20678484
D016572CyclosporineCyclosporine results in decreased expression of OPA1 protein23347876
D016572CyclosporineVitamin E inhibits the reaction [Cyclosporine results in decreased expression of OPA1 protein]23347876
D003609DactinomycinDactinomycin inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form]20678484
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of OPA1 mRNA29288687
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of OPA1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of OPA1 protein28698153
D002945CisplatinCurcumin inhibits the reaction [Cisplatin results in decreased expression of OPA1 protein]28698153
D004008DiclofenacDiclofenac results in decreased expression of OPA1 mRNA26934552
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of OPA1 mRNA18313992
D004026DieldrinDieldrin affects the expression of OPA1 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of OPA1 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of OPA1 mRNA]19030233
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of OPA1 mRNA20360939
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of OPA1 mRNA27638505
D004221DisulfiramDisulfiram results in decreased expression of OPA1 mRNA20530235
D007980LevodopaLevodopa inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]25129099
D004317DoxorubicinDoxorubicin results in decreased expression of OPA1 protein26678157
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of OPA1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of OPA1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OPA1 mRNA17942748
C496966Eudragit RSPOEudragit RSPO results in decreased expression of OPA1 mRNA22119964
C496966Eudragit RSPOEudragit RSPO results in decreased expression of OPA1 protein22119964
D005419FlavonoidsFlavonoids results in increased expression of OPA1 mRNA18035473
D005557FormaldehydeFormaldehyde results in decreased expression of OPA1 mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of OPA1 mRNA22634610
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of OPA1 mRNA17183730
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of OPA1 mRNA29288687
D007545IsoproterenolIsoproterenol results in decreased expression of OPA1 protein27491814
C016527isoquercitrinisoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]25129099
C544151jinfukangjinfukang results in decreased expression of OPA1 mRNA27392435
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of OPA1 mRNA29288687
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of OPA1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of OPA1 mRNA"20188158
D016627Oxidopamineisoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]25129099
D016627OxidopamineLevodopa inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]25129099
D016627OxidopamineOxidopamine results in decreased expression of OPA1 mRNA25129099
D016627OxidopamineRutin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]25129099
D019319Okadaic AcidOkadaic Acid results in increased expression of OPA1 protein26732598
D052638Particulate MatterParticulate Matter affects the expression of OPA1 mRNA25560372
D052638Particulate MatterParticulate Matter affects the expression of OPA1 protein25560372
D010433PentylenetetrazolePentylenetetrazole affects the expression of OPA1 mRNA21503142
D010894PiroxicamPiroxicam results in decreased expression of OPA1 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of OPA1 mRNA23557933
C059514resveratrolresveratrol results in decreased expression of OPA1 protein18089832
C059514resveratrolresveratrol inhibits the reaction [Rotenone results in decreased expression of OPA1 mRNA]26770656
C059514resveratrolresveratrol inhibits the reaction [Rotenone results in decreased expression of OPA1 protein]26770656
C059514resveratrolresveratrol promotes the reaction [Rotenone results in decreased expression of OPA1 mRNA]26770656
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of OPA1 mRNA]19030233
C089730rosiglitazonerosiglitazone affects the expression of OPA1 mRNA22013433
D012402RotenoneRotenone results in increased expression of OPA1 protein21223980
D012402Rotenoneresveratrol inhibits the reaction [Rotenone results in decreased expression of OPA1 mRNA]26770656
D012402Rotenoneresveratrol inhibits the reaction [Rotenone results in decreased expression of OPA1 protein]26770656
D012402Rotenoneresveratrol promotes the reaction [Rotenone results in decreased expression of OPA1 mRNA]26770656
D012402RotenoneRotenone results in decreased expression of OPA1 mRNA26770656
D012402RotenoneRotenone results in decreased expression of OPA1 protein26770656
D012402RotenoneRotenone results in increased expression of OPA1 mRNA19013527
D012431RutinRutin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]25129099
D012643SeleniumSelenium results in decreased expression of OPA1 mRNA19244175
D012969Sodium FluorideSodium Fluoride results in decreased expression of OPA1 protein28918527
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of OPA1 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of OPA1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of OPA1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OPA1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of OPA1 mRNA15328365
D013893ThiramThiram results in decreased expression of OPA1 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of OPA1 mRNA28065790
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of OPA1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of OPA1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of OPA1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of OPA1 gene25560391
C025643vinclozolinvinclozolin affects the expression of OPA1 mRNA19015723
D014810Vitamin EVitamin E inhibits the reaction [Cyclosporine results in decreased expression of OPA1 protein]23347876
D015215Zidovudine[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 mRNA28683400
D015215Zidovudine[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 protein28683400
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of OPA1 mRNA18313992

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-NAS11017080  
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-IDA20185555  27667664  
GO:0003924GTPase activity-TAS11017080  
GO:0005515protein binding-IPI17353931  20436456  21081504  21150319  21364629  24282027  
24344202  28746876  
GO:0005525GTP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0019900kinase binding-IEA-  
GO:0070300phosphatidic acid binding-IDA20185555  
GO:1901612cardiolipin binding-IDA20185555  
GO ID GO Term Qualifier Evidence PubMed
GO:0000002mitochondrial genome maintenance-IMP18158317  
GO:0000266mitochondrial fission-IBA21873635  
GO:0000266mitochondrial fission-TAS12509422  
GO:0003374dynamin family protein polymerization involved in mitochondrial fission-IBA21873635  
GO:0006915apoptotic process-IEA-  
GO:0007005mitochondrion organization-IMP21149567  
GO:0007005mitochondrion organization-NAS11017080  
GO:0007007inner mitochondrial membrane organization-IDA12509422  
GO:0007601visual perception-IMP11017080  
GO:0008053mitochondrial fusion-IDA17545159  
GO:0008053mitochondrial fusion-IMP20185555  20436456  
GO:0008053mitochondrial fusion-TAS12509422  
GO:0010636positive regulation of mitochondrial fusion-IEA-  
GO:0014042positive regulation of neuron maturation-IEA-  
GO:0014850response to muscle activity-IEA-  
GO:0019896axonal transport of mitochondrion-TAS11017080  
GO:0036444calcium import into the mitochondrion-IEA-  
GO:0043066negative regulation of apoptotic process-IDA12509422  
GO:0046039GTP metabolic process-IDA20185555  
GO:0048285organelle fission-IBA21873635  
GO:0048312intracellular distribution of mitochondria-IEA-  
GO:0051259protein complex oligomerization-IDA20185555  
GO:0051602response to electrical stimulus-IEA-  
GO:0060041retina development in camera-type eye-IEA-  
GO:0061003positive regulation of dendritic spine morphogenesis-IEA-  
GO:0061025membrane fusion-IBA21873635  
GO:0070584mitochondrion morphogenesis-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:0090102cochlea development-IEA-  
GO:0090201negative regulation of release of cytochrome c from mitochondria-IMP21149567  
GO:0090398cellular senescence-IDA17545159  
GO:0097749membrane tubulation-IDA20185555  
GO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-IGI23453807  
GO:1904643response to curcumin-IEA-  
GO:1905232cellular response to L-glutamate-IEA-  
GO:2001275positive regulation of glucose import in response to insulin stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA17545159  
GO:0005741mitochondrial outer membrane-IDA12504110  
GO:0005743mitochondrial inner membrane-ISS-  
GO:0005743mitochondrial inner membrane-NAS20436456  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005758mitochondrial intermembrane space-IDA17008324  
GO:0005758mitochondrial intermembrane space-ISS11847212  
GO:0005829cytosol-IDA-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0030061mitochondrial crista-IDA12504110  
GO:0030425dendrite-ISS11847212  
GO:0031314extrinsic component of mitochondrial inner membrane-IEA-  
GO:0031966mitochondrial membrane-IBA21873635  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-169911Regulation of ApoptosisTAS
R-HSA-5357801Programmed Cell DeathTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24088173Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells. (2013 Oct 2)Hoffmann RFRespir Res
21892625Spinocerebellar ataxia: a rational approach to aetiological diagnosis. (2012 Mar)Degardin ACerebellum
21112411Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies. (2011 Mar)Yu-Wai-Man PProg Retin Eye Res
20301426Optic Atrophy Type 1 (1993)Delettre-Cribaillet C-
19915464Genetically determined optic neuropathies. (2010 Feb)Milea DCurr Opin Neurol