Gene: OPRD1

4985
OPRD
OD receptor delta 1
protein-coding
1p35.3
Ensembl:ENSG00000116329 MIM:165195 Vega:OTTHUMG00000003646 UniprotKB:P41143
NC_000001.11
PubMed
0   ANCO-SNPs
OD|CD|AD
24   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.297e-1 (AD)  3.485e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNH10.854
C4orf500.845
MTUS20.836
CACNG20.83
FAM78B0.821
SLC36A10.816
HRH20.815
SYN30.815
LHFPL40.814
GRIN2B0.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.634
YES1-0.611
NXT2-0.595
RAB13-0.587
REST-0.584
MYL3-0.574
APOM-0.572
GNG11-0.571
AGTRAP-0.57
ROM1-0.569

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00193TramadolSmall Molecule27203-92-5Approved|InvestigationalTarget
DB00295MorphineSmall Molecule57-27-2Approved|InvestigationalTarget
DB00318CodeineSmall Molecule76-57-3Approved|IllicitTarget
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
DB00327HydromorphoneSmall Molecule466-99-9Approved|IllicitTarget
DB00333MethadoneSmall Molecule76-99-3ApprovedTarget
DB00497OxycodoneSmall Molecule76-42-6Approved|Illicit|InvestigationalTarget
DB00514DextromethorphanSmall Molecule125-71-3ApprovedTarget
DB00611ButorphanolSmall Molecule42408-82-2Approved|IllicitTarget
DB00647DextropropoxypheneSmall Molecule469-62-5Approved|Illicit|Investigational|WithdrawnTarget
DB00704NaltrexoneSmall Molecule16590-41-3Approved|InvestigationalTarget
DB00708SufentanilSmall Molecule56030-54-7Approved|InvestigationalTarget
DB00813FentanylSmall Molecule437-38-7Approved|Illicit|InvestigationalTarget
DB00836LoperamideSmall Molecule53179-11-6ApprovedTarget
DB00844NalbuphineSmall Molecule20594-83-6ApprovedTarget
DB00854LevorphanolSmall Molecule77-07-6ApprovedTarget
DB00899RemifentanilSmall Molecule132875-61-7ApprovedTarget
DB00921BuprenorphineSmall Molecule52485-79-7Approved|Illicit|InvestigationalTarget
DB00956HydrocodoneSmall Molecule125-29-1Approved|IllicitTarget
DB01081DiphenoxylateSmall Molecule915-30-0Approved|IllicitTarget
DB01183NaloxoneSmall Molecule465-65-6ApprovedTarget
DB01192OxymorphoneSmall Molecule76-41-5Approved|InvestigationalTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
DB014393-MethylthiofentanylSmall Molecule86052-04-2Experimental|IllicitTarget
DB01444DimethylthiambuteneSmall Molecule524-84-5Experimental|IllicitTarget
DB01452HeroinSmall Molecule561-27-3Approved|Illicit|InvestigationalTarget
DB01497EtorphineSmall Molecule14521-96-1IllicitTarget
DB01535CarfentanilSmall Molecule59708-52-0Illicit|InvestigationalTarget
DB01548DiprenorphineSmall Molecule14357-78-9IllicitTarget
DB01565DihydromorphineSmall Molecule509-60-4Experimental|IllicitTarget
DB015713-MethylfentanylSmall Molecule42045-86-3IllicitTarget
DB05050ADL5859Small Molecule-InvestigationalTarget
DB06204TapentadolSmall Molecule175591-23-8ApprovedTarget
DB06230NalmefeneSmall Molecule55096-26-9Approved|Investigational|WithdrawnTarget
DB06274AlvimopanSmall Molecule156053-89-3Approved|InvestigationalTarget
DB06738KetobemidoneSmall Molecule469-79-4Approved|InvestigationalTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTarget
DB09209PholcodineSmall Molecule509-67-1Approved|IllicitTarget
DB09272EluxadolineSmall Molecule864821-90-9Approved|InvestigationalTarget
DB09396Propoxyphene napsylateSmall MoleculeApprovedTarget
DB11130OpiumSmall Molecule8008-60-4Approved|IllicitTarget
DB11691NaldemedineSmall Molecule916072-89-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
C47856514-phenylpropoxymetopon14-phenylpropoxymetopon binds to OPRD1 protein21235243
C5076341,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamido)hexane"1,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamido)hexane metabolite binds to and results in increased activity of OPRD1 protein"17142049
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of OPRD1 mRNA"19114083
C0174872-mercaptoacetateOPRD1 exon affects the susceptibility to 2-mercaptoacetate10802031
C5076353,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamidopropyl)-2(1H)-pyrazinone"3,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamidopropyl)-2(1H)-pyrazinone binds to and results in increased activity of OPRD1 protein"17142049
C1089043-(difluoromethyl)-1-(4-methoxyphenyl)-5-(4-(methylsulfinyl)phenyl)pyrazole[naltrindole binds to and results in decreased activity of OPRD1 protein] which results in decreased susceptibility to 3-(difluoromethyl)-1-(4-methoxyphenyl)-5-(4-(methylsulfinyl)phenyl)pyrazole12962910
C0884644-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide"4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide binds to and results in increased activity of OPRD1 protein"15802193|1591076
C4826787-hydroxymitragynine"7-hydroxymitragynine affects the reaction [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein]"27192616
C4826787-hydroxymitragynine7-hydroxymitragynine binds to and affects the activity of OPRD1 protein27192616
C5401659-(8-azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide9-(8-azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide analog binds to and results in increased activity of OPRD1 protein20616206
C5401659-(8-azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide9-(8-azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide binds to and results in increased activity of OPRD1 protein20616206
D000157AconitineOPRD1 protein affects the susceptibility to Aconitine16995444
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein"7562497
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]"2162496
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]"2162496
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Zinc inhibits the reaction [Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]]"2162496
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]]"2162496
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Enkephalin, Ala(2)-MePhe(4)-Gly(5)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]"23818586
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]]"23818586
D000535Aluminum"[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum"7477890
D019804MesalamineMesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 mRNA]24637189
D019804MesalamineMesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 protein]24637189
D000643Ammonium ChlorideAmmonium Chloride affects the expression of OPRD1 mRNA16483693
D003913DextroamphetamineDextroamphetamine affects the expression of OPRD1 mRNA12629526
D001464Barium"Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [OPRD1 protein results in increased transport of Barium]"12031848
D001464BariumOPRD1 protein affects the transport of Barium12031848
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of OPRD1 mRNA20127859
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]21600884
D002047Buprenorphine"Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]"21866885
D002047BuprenorphineBuprenorphine binds to OPRD1 protein7562497
D002077ButorphanolButorphanol affects the activity of OPRD1 protein17909753
D002077ButorphanolButorphanol affects the activity of OPRD1 protein17909753
C083877BW 373U86BW 373U86 binds to and results in increased activity of OPRD1 protein7493622
D002104Cadmium"Cadmium inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein]"2162496
D002185CannabidiolCannabidiol inhibits the reaction [naltrindole binds to and results in decreased activity of OPRD1 protein]16489449
D004390ChlorpyrifosChlorpyrifos results in increased expression of OPRD1 mRNA20682304
D002994ClofibrateClofibrate results in decreased expression of OPRD1 mRNA17585979
D003042CocaineCocaine affects the localization of OPRD1 protein18417105
D003042Cocaine"[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine"19279569
D003042Cocaine"naltrindole inhibits the reaction [[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine]"19279569
D003061CodeineCodeine binds to OPRD1 protein7562497
D003300CopperCopper deficiency results in increased expression of OPRD1 mRNA26033743
D003300Copper"Copper inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein]"2162496
C084603cyclorphancyclorphan binds to and results in increased activity of OPRD1 protein10812979
C583602CYM51010CYM51010 promotes the reaction [[OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate)]23818586
C583602CYM51010CYM51010 results in increased activity of OPRD1 protein23818586
C583602CYM51010Naltrexone inhibits the reaction [CYM51010 promotes the reaction [[OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate)]]23818586
D013759DronabinolDronabinol inhibits the reaction [naltrindole binds to and results in decreased activity of OPRD1 protein]16489449
D013759DronabinolDronabinol results in increased expression of OPRD1 mRNA9771917
D013759DronabinolPertussis Toxin inhibits the reaction [Dronabinol results in increased expression of OPRD1 mRNA]9771917
D013759Dronabinolrimonabant inhibits the reaction [Dronabinol results in increased expression of OPRD1 mRNA]9771917
C060209deltorphin II, Ala(2)-"deltorphin II, Ala(2)- analog binds to and results in increased activity of OPRD1 protein"10753473
C060209deltorphin II, Ala(2)-"deltorphin II, Ala(2)- binds to and results in increased activity of OPRD1 protein"11698066
C060209deltorphin II, Ala(2)-"deltorphin II, Ala(2)- results in increased activity of OPRD1 protein"23818586
C060209deltorphin II, Ala(2)-"deltorphin II, Ala(2)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]"23818586
C060209deltorphin II, Ala(2)-"phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide promotes the reaction [deltorphin II, Ala(2)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]]"23818586
C044130dextrallorphandextrallorphan binds to OPRD1 protein7562497
C044130dextrallorphan[dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
C044130dextrallorphan[dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D003917DextrorphanDextrorphan binds to OPRD1 protein7562497
D003917Dextrorphan[Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D003917Dextrorphan[Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of OPRD1 mRNA15620428
D019422Dietary SucroseDietary Sucrose results in increased expression of OPRD1 mRNA26033743
C569763Dmt-NMe-Ala-Aba-Gly-NH2Dmt-NMe-Ala-Aba-Gly-NH2 binds to OPRD1 protein21978284
C569763Dmt-NMe-Ala-Aba-Gly-NH2[Dmt-NMe-Ala-Aba-Gly-NH2 binds to OPRD1 protein] which results in increased phosphorylation of MAPK1 protein21978284
C569763Dmt-NMe-Ala-Aba-Gly-NH2[Dmt-NMe-Ala-Aba-Gly-NH2 binds to OPRD1 protein] which results in increased phosphorylation of MAPK3 protein21978284
D004399DynorphinsDynorphins results in increased activity of OPRD1 protein26476280
C583636eluxadolineOPRD1 protein affects the susceptibility to eluxadoline25261794
C105293endomorphin 1endomorphin 1 metabolite binds to and results in decreased activity of OPRD1 protein17142049
C105294endomorphin 2endomorphin 2 metabolite binds to and results in decreased activity of OPRD1 protein17142049
C040996enkephalin-Leu, Ala(2)-Arg(6)-"enkephalin-Leu, Ala(2)-Arg(6)- binds to and results in increased activity of OPRD1 protein"23651617
D004743Enkephalin, Leucine"Enkephalin, Leucine results in increased activity of OPRD1 protein"26476280
D004744Enkephalin, Methionine"Enkephalin, Methionine results in increased activity of OPRD1 protein"24345467
C034318enkephalin, Ser(2), Leu(5), Thr(6)-"Cadmium inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein]"2162496
C034318enkephalin, Ser(2), Leu(5), Thr(6)-"Copper inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein]"2162496
C034318enkephalin, Ser(2), Leu(5), Thr(6)-"enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein"2162496
C034318enkephalin, Ser(2), Leu(5), Thr(6)-"Mercury inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein]"2162496
C034318enkephalin, Ser(2), Leu(5), Thr(6)-"enkephalin, Ser(2), Leu(5), Thr(6)- binds to and results in increased activity of OPRD1 protein"2557556|3015659
D004837EpinephrineOPRD1 protein affects the susceptibility to Epinephrine16995444
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of OPRD1 mRNA15212814
C069837fullerene C60fullerene C60 results in decreased expression of OPRD1 mRNA19167457
D016244Guanosine 5'-O-(3-Thiotriphosphate)CYM51010 promotes the reaction [[OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate)]23818586
D016244Guanosine 5'-O-(3-Thiotriphosphate)Naltrexone inhibits the reaction [CYM51010 promotes the reaction [[OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate)]]23818586
D016244Guanosine 5'-O-(3-Thiotriphosphate)[OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate)23818586
D012701Serotonin[dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Levallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Levorphanol binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in decreased expression of OPRD1 mRNA17183730
D006853HydrocodoneHydrocodone binds to OPRD1 protein7562497
C036405ICI 154129ICI 154129 binds to and results in decreased activity of OPRD1 protein3015659
C008261lead acetatelead acetate results in decreased expression of OPRD1 mRNA21891863
D016308Enkephalin, Leucine-2-Alanine"Enkephalin, Leucine-2-Alanine binds to and results in increased activity of OPRD1 protein"14988739|3015659
D007977LevallorphanLevallorphan binds to OPRD1 protein7562497
D007977Levallorphan[Levallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D007977Levallorphan[Levallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D007981LevorphanolLevorphanol binds to OPRD1 protein7562497
D007981Levorphanol[Levorphanol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D007981Levorphanol[Levorphanol binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of OPRD1 mRNA18977430
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of OPRD1 mRNA18977430
D008139LoperamideOPRD1 protein affects the susceptibility to Loperamide25261794
D008274Magnesium"Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]"2162496
D008274Magnesium"Zinc inhibits the reaction [Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]]"2162496
D008345Manganese"Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]"2162496
D008345Manganese"Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]]"2162496
D008628Mercury"Mercury inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein]"2162496
D008691MethadoneMethadone binds to OPRD1 protein7562497
D008691Methadone[Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D008691Methadone[Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D008692Methadyl AcetateMethadyl Acetate binds to OPRD1 protein7562497
D008692Methadyl Acetate[Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D008692Methadyl Acetate[Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D003915DextromethorphanDextromethorphan binds to OPRD1 protein7562497
D003915Dextromethorphan[Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D003915Dextromethorphan[Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
C587452methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate"methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- binds to OPRD1 protein]"24345467
C587452methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate"methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate results in increased activity of OPRD1 protein"24345467
C028208metkephamidmetkephamid binds to and results in increased activity of OPRD1 protein2981652
C001801mitragyninemitragynine binds to OPRD1 protein27192616
C121049mitragynine pseudoindoxylmitragynine pseudoindoxyl binds to and results in decreased activity of OPRD1 protein27556704
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]21600884
D009020MorphineMorphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]21600884
D009020MorphineOPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]21600884
D009020MorphineOPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]21600884
D009020MorphineOPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]21600884
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]21600884
D009020Morphinebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]21600884
D009020MorphineMorphine binds to OPRD1 protein7562497
D009020MorphineMorphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]21600884
D009020MorphineMorphine results in increased expression of OPRD1 protein21600884
D009270NaloxoneNaloxone binds to OPRD1 protein7562497
D009271NaltrexoneNaltrexone binds to OPRD1 protein7562497
D009271NaltrexoneNaltrexone inhibits the reaction [CYM51010 promotes the reaction [[OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate)]]23818586
C055382naltrindole[naltrindole binds to and results in decreased activity of OPRD1 protein] which results in increased susceptibility to Nicotine15778877
C055382naltrindoleCannabidiol inhibits the reaction [naltrindole binds to and results in decreased activity of OPRD1 protein]16489449
C055382naltrindoleDronabinol inhibits the reaction [naltrindole binds to and results in decreased activity of OPRD1 protein]16489449
C055382naltrindolenaltrindole binds to and results in decreased activity of OPRD1 protein16489449
C055382naltrindole[naltrindole binds to and results in decreased activity of OPRD1 protein] which results in decreased susceptibility to 3-(difluoromethyl)-1-(4-methoxyphenyl)-5-(4-(methylsulfinyl)phenyl)pyrazole12962910
C055382naltrindole"naltrindole inhibits the reaction [[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine]"19279569
C055382naltrindolenaltrindole binds to and results in decreased activity of OPRD1 protein11520128|1296291
C028007nickel monoxidenickel monoxide results in decreased expression of OPRD1 mRNA19167457
D009538Nicotine[naltrindole binds to and results in decreased activity of OPRD1 protein] which results in increased susceptibility to Nicotine15778877
C040643N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine"N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine binds to and results in decreased activity of OPRD1 protein"9162281
C040643N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine"N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine binds to and results in decreased activity of OPRD1 protein"8113989
C415566N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide"N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide binds to and results in increased activity of OPRD1 protein"18539914
C025256nonylphenolnonylphenol results in decreased expression of OPRD1 mRNA15620428
D009638Norepinephrine[dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Levallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Levorphanol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D010098OxycodoneOxycodone binds to OPRD1 protein7562497
D010269ParaquatParaquat results in decreased expression of OPRD1 mRNA26498265
D020881Enkephalin, D-Penicillamine (2,5)-"7-hydroxymitragynine affects the reaction [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein]"27192616
D020881Enkephalin, D-Penicillamine (2,5)-"Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]"21866885
D020881Enkephalin, D-Penicillamine (2,5)-"Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein"21866885
D020881Enkephalin, D-Penicillamine (2,5)-"Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein"27192616
D020881Enkephalin, D-Penicillamine (2,5)-"[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum"7477890
D020881Enkephalin, D-Penicillamine (2,5)-"[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine"19279569
D020881Enkephalin, D-Penicillamine (2,5)-"Enkephalin, D-Penicillamine (2,5)- binds to OPRD1 protein"7562497
D020881Enkephalin, D-Penicillamine (2,5)-"Enkephalin, D-Penicillamine (2,5)- results in increased expression of OPRD1 mRNA"9302088
D020881Enkephalin, D-Penicillamine (2,5)-"naltrindole inhibits the reaction [[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine]"19279569
D020881Enkephalin, D-Penicillamine (2,5)-"Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [OPRD1 protein results in increased transport of Barium]"12031848
D020881Enkephalin, D-Penicillamine (2,5)-"Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein"19279569|2010815
D020881Enkephalin, D-Penicillamine (2,5)-"Enkephalin, D-Penicillamine (2,5)- binds to OPRD1 protein"24345467
D020881Enkephalin, D-Penicillamine (2,5)-"methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- binds to OPRD1 protein]"24345467
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [Dronabinol results in increased expression of OPRD1 mRNA]9771917
C049352phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide"phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide promotes the reaction [deltorphin II, Ala(2)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]]"23818586
D010936Plant ExtractsPlant Extracts results in decreased expression of OPRD1 mRNA23557933
D011431DextropropoxypheneDextropropoxyphene binds to OPRD1 protein7562497
D011431Dextropropoxyphene[Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D011431Dextropropoxyphene[Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
C000594493qingre zaoshi liangxue fangqingre zaoshi liangxue fang inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 mRNA]24637189
C000594493qingre zaoshi liangxue fangqingre zaoshi liangxue fang inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 protein]24637189
C089032rimonabantrimonabant inhibits the reaction [Dronabinol results in increased expression of OPRD1 mRNA]9771917
C523979tapentadoltapentadol binds to OPRD1 protein17656655
D014147TramadolTramadol binds to OPRD1 protein7562497
D014147Tramadol[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine7562497
D014147Tramadol[Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin7562497
D014302Trinitrobenzenesulfonic AcidMesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 mRNA]24637189
D014302Trinitrobenzenesulfonic AcidMesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 protein]24637189
D014302Trinitrobenzenesulfonic Acidqingre zaoshi liangxue fang inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 mRNA]24637189
D014302Trinitrobenzenesulfonic Acidqingre zaoshi liangxue fang inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 protein]24637189
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of OPRD1 mRNA24637189
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of OPRD1 protein24637189
C111212TRK 820TRK 820 binds to OPRD1 protein22742909
C111212TRK 820TRK 820 metabolite binds to OPRD1 protein22742909
C092721tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine"tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]]"23818586
C045444U 69593U 69593 binds to OPRD1 protein7562497
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in decreased expression of OPRD1 mRNA17183730
D014635Valproic AcidValproic Acid results in increased methylation of OPRD1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of OPRD1 mRNA17963808
D015032Zinc"Zinc inhibits the reaction [Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]]"2162496
D015032Zinc"Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]]"2162496
D015054ZymosanZymosan results in increased expression of OPRD1 mRNA18977430

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004985opioid receptor activity-IDA22184124  
GO:0005515protein binding-IPI15086532  20528919  
GO:0033612receptor serine/threonine kinase binding-IEA-  
GO:0038046enkephalin receptor activity-IBA21873635  
GO:0038046enkephalin receptor activity-IMP9548483  
GO:0042277peptide binding-IBA21873635  
GO:0042923neuropeptide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000060protein import into nucleus, translocation-IDA16325578  
GO:0006955immune response-TAS9548483  
GO:0007186G-protein coupled receptor signaling pathway-IDA16325578  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-TAS7808419  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IEA-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-ISS-  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0008344adult locomotory behavior-IEA-  
GO:0010629negative regulation of gene expression-IDA24613828  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032460negative regulation of protein oligomerization-IDA24613828  
GO:0032793positive regulation of CREB transcription factor activity-IC24613828  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IDA24613828  
GO:0038003opioid receptor signaling pathway-IBA21873635  
GO:0038003opioid receptor signaling pathway-IMP9548483  
GO:0042755eating behavior-IEA-  
GO:0051881regulation of mitochondrial membrane potential-IDA24613828  
GO:0051924regulation of calcium ion transport-IEA-  
GO:0051930regulation of sensory perception of pain-IEA-  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO:0071456cellular response to hypoxia-IDA24613828  
GO:0097237cellular response to toxic substance-IDA24613828  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS7808419  
GO:0031226intrinsic component of plasma membrane-IDA22184124  
GO:0031982vesicle-IEA-  
GO:0032590dendrite membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043679axon terminus-IEA-  
GO:0045121membrane raft-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19183129Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? (2009 Apr)Hansell NKAlcohol Clin Exp Res
22954510Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. (2012 Dec)Ashenhurst JRPharmacol Biochem Behav
17622222The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. (2008 May)Zhang HMol Psychiatry
25655461Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)Manzardo AMGene
28632076Association of OPRD1 Gene Variants with Opioid Dependence in Addicted Male Individuals Undergoing Methadone Treatment in the North of Iran. (2017 Jul-Aug)Sharafshah AJ Psychoactive Drugs
17374034Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. (2007 Apr)Gelernter JAlcohol Clin Exp Res
28656735An analysis of genetic association in opioid dependence susceptibility. (2018 Feb)Nagaya DJ Clin Pharm Ther
26692286Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms. (2016 Jan)Jones JDAm J Addict
24086514Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study. (2013)Beer BPLoS One
24126707Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females. (2014 Jun)Clarke TKPharmacogenomics J
25823631The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. (2015 Jan)Bauer IEAm J Addict
27449273A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment. (2016 Sep 1)Crist RCDrug Alcohol Depend
23612435An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans. (2013 Sep)Crist RCNeuropsychopharmacology
12116270Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample. (2002 Jun 1)Xu KAm J Med Genet
22795689Case-control association analysis of polymorphisms in the delta-opioid receptor, OPRD1, with cocaine and opioid addicted populations. (2013 Jan 1)Crist RCDrug Alcohol Depend
24479196Optimization and characterization of an opioid kappa receptor (OPRK1) antagonist (2010)Guerrero M-
18537939Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers. (2008 Jul)Arias AJAlcohol Clin Exp Res
25418439The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. (2014 Nov 21)Bauer IEAm J Addict
10982041Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. (2000 Jul)Gelernter JHum Genet
19393386[Treatment of a serious autistic disorder in a child with Naltrexone in an oral suspension form]. (2009 Apr)Desjardins SEncephale
29781244OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients. (2018 May 20)Muriel JAnn N Y Acad Sci
17503481The opioid system in alcohol and drug dependence: family-based association study. (2007 Oct 5)Xuei XAm J Med Genet B Neuropsychiatr Genet
24533225Analyzing Interaction of mu-, delta- and kappa-opioid Receptor Gene Variants on Alcohol or Drug Dependence Using a Pattern Discovery-based Method. (2013 May 14)Li ZJ Addict Res Ther
20300121Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region. (2010 May)Zhang HJ Hum Genet