Gene: OPRK1

4986
K-OR-1|KOR|KOR-1|OPRK
OD receptor kappa 1
protein-coding
8q11.23
Ensembl:ENSG00000082556 MIM:165196 Vega:OTTHUMG00000164276 UniprotKB:P41145
NC_000008.11
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
27   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.265e-1 (AD)  3.979e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPHA70.808
DACH10.807
SEMA3A0.798
PEG100.784
SYNPR0.775
MCTP10.761
CXXC40.754
VAT1L0.749
PPP1R9A0.743
CHN20.742

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAPKAPK3-0.416
FZD10-0.416
MSX1-0.404
FOXL1-0.398
TBX2-0.391
ASB4-0.391
S100A14-0.389
MTRNR2L8-0.386
C1QTNF1-0.375
HES1-0.375

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00193TramadolSmall Molecule27203-92-5Approved|InvestigationalTarget
DB00295MorphineSmall Molecule57-27-2Approved|InvestigationalTarget
DB00318CodeineSmall Molecule76-57-3Approved|IllicitTarget
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
DB00327HydromorphoneSmall Molecule466-99-9Approved|IllicitTarget
DB00370MirtazapineSmall Molecule85650-52-8ApprovedTarget
DB00396ProgesteroneSmall Molecule57-83-0ApprovedTarget
DB00454PethidineSmall Molecule57-42-1ApprovedTarget
DB00497OxycodoneSmall Molecule76-42-6Approved|Illicit|InvestigationalTarget
DB00514DextromethorphanSmall Molecule125-71-3ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00611ButorphanolSmall Molecule42408-82-2Approved|IllicitTarget
DB00647DextropropoxypheneSmall Molecule469-62-5Approved|Illicit|Investigational|WithdrawnTarget
DB00652PentazocineSmall Molecule359-83-1ApprovedTarget
DB00704NaltrexoneSmall Molecule16590-41-3Approved|InvestigationalTarget
DB00708SufentanilSmall Molecule56030-54-7Approved|InvestigationalTarget
DB00813FentanylSmall Molecule437-38-7Approved|Illicit|InvestigationalTarget
DB00825MentholSmall Molecule2216-51-5ApprovedTarget
DB00836LoperamideSmall Molecule53179-11-6ApprovedTarget
DB00844NalbuphineSmall Molecule20594-83-6ApprovedTarget
DB00854LevorphanolSmall Molecule77-07-6ApprovedTarget
DB00899RemifentanilSmall Molecule132875-61-7ApprovedTarget
DB00921BuprenorphineSmall Molecule52485-79-7Approved|Illicit|InvestigationalTarget
DB01183NaloxoneSmall Molecule465-65-6ApprovedTarget
DB01209DezocineSmall Molecule53648-55-8Approved|InvestigationalTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
DB014393-MethylthiofentanylSmall Molecule86052-04-2Experimental|IllicitTarget
DB01452HeroinSmall Molecule561-27-3Approved|Illicit|InvestigationalTarget
DB01497EtorphineSmall Molecule14521-96-1IllicitTarget
DB01535CarfentanilSmall Molecule59708-52-0Illicit|InvestigationalTarget
DB01548DiprenorphineSmall Molecule14357-78-9IllicitTarget
DB01565DihydromorphineSmall Molecule509-60-4Experimental|IllicitTarget
DB015713-MethylfentanylSmall Molecule42045-86-3IllicitTarget
DB05046V1003Small Molecule-InvestigationalTarget
DB05104AsimadolineSmall Molecule153205-46-0InvestigationalTarget
DB05155CR665Small MoleculeInvestigationalTarget
DB05443ADL 10-0101Small Molecule-InvestigationalTarget
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalTarget
DB06204TapentadolSmall Molecule175591-23-8ApprovedTarget
DB06230NalmefeneSmall Molecule55096-26-9Approved|Investigational|WithdrawnTarget
DB06274AlvimopanSmall Molecule156053-89-3Approved|InvestigationalTarget
DB06738KetobemidoneSmall Molecule469-79-4Approved|InvestigationalTarget
DB06800MethylnaltrexoneSmall Molecule916055-93-1ApprovedTarget
DB09209PholcodineSmall Molecule509-67-1Approved|IllicitTarget
DB09272EluxadolineSmall Molecule864821-90-9Approved|InvestigationalTarget
DB09396Propoxyphene napsylateSmall MoleculeApprovedTarget
DB11130OpiumSmall Molecule8008-60-4Approved|IllicitTarget
DB11691NaldemedineSmall Molecule916072-89-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
C47856514-phenylpropoxymetopon14-phenylpropoxymetopon binds to OPRK1 protein21235243
C49914817,17'-bis(cyclopropylmethyl)-6,6',7,7'-tetrahydro-4,5-4',5'-diepoxy-6,6'-(benzylimino)(7,7'-bimorphinan)-3,3',14,14'-tetrol"17,17'-bis(cyclopropylmethyl)-6,6',7,7'-tetrahydro-4,5-4',5'-diepoxy-6,6'-(benzylimino)(7,7'-bimorphinan)-3,3',14,14'-tetrol binds to and results in decreased activity of OPRK1 protein"20232057
C57330122-thiocyanatosalvinorin A22-thiocyanatosalvinorin A binds to and results in increased activity of OPRK1 protein27556704
C0174872-mercaptoacetateOPRK1 exon affects the susceptibility to 2-mercaptoacetate10802031
C5704023-chloro-4-(4-((2-(3-pyridyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide3-chloro-4-(4-((2-(3-pyridyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide binds to OPRK1 protein21958337
C5704033-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide binds to and results in decreased activity of OPRK1 protein21958337
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OPRK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OPRK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA"27188386
C5033166'-guanidinonaltrindole6'-guanidinonaltrindole binds to and results in increased activity of OPRK1 protein27556704
C4826787-hydroxymitragynine7-hydroxymitragynine binds to OPRK1 protein27192616
C4826787-hydroxymitragynine"7-hydroxymitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]"27192616
C4826787-hydroxymitragynine7-hydroxymitragynine binds to OPRK1 protein27192616
C4338147-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl)methyl)-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide"7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl)methyl)-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide binds to and results in decreased activity of OPRK1 protein"20232057
C5514547-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-2-methylbutyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride"7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-2-methylbutyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride results in decreased activity of OPRK1 protein"20372878
C042552acenaphtheneacenaphthene analog binds to OPRK1 protein1846919
D000081AcetamidesAcetamides analog binds to OPRK1 protein16263278
D020106AcrylamideAcrylamide results in decreased expression of OPRK1 mRNA22197712
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of OPRK1 gene27153756
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein"7562497
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein]"2162496
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein]"2162496
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of OPRK1 mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of OPRK1 mRNA16483693
C470200arodynarodyn binds to and results in decreased activity of OPRK1 protein17568579
D001464Barium"3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer inhibits the reaction [OPRK1 protein results in increased transport of Barium]"12031848
D001464BariumOPRK1 protein affects the transport of Barium12031848
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OPRK1 mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OPRK1 mRNA21839799
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of OPRK1 mRNA20660070
C006780bisphenol Abisphenol A results in decreased expression of OPRK1 mRNA25181051
C027248bremazocinebremazocine binds to OPRK1 protein10087027
C027248bremazocinebremazocine binds to and results in increased activity of OPRK1 protein8968362
D002047BuprenorphineBuprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]21866885
D002047BuprenorphineBuprenorphine binds to OPRK1 protein7562497
D002047BuprenorphineBuprenorphine binds to and results in decreased activity of OPRK1 protein10630350|1086280
D002077ButorphanolButorphanol affects the activity of OPRK1 protein17909753
D002077ButorphanolButorphanol affects the activity of OPRK1 protein17909753
D002077ButorphanolButorphanol binds to and results in increased activity of OPRK1 protein11561074
D002077ButorphanolButorphanol metabolite binds to and affects the activity of OPRK1 protein8267194
D002104CadmiumCadmium inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein]2162496
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of OPRK1 promoter22457795
D002713ChlorineChlorine results in decreased expression of OPRK1 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of OPRK1 mRNA18636392
D003042CocaineCocaine affects the reaction [enadoline binds to OPRK1 protein]17621646
D003042CocaineCocaine results in increased expression of OPRK1 protein17621646
D003042Cocaine[U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine]11113311
D003042CocaineCocaine results in increased activity of OPRK1 protein17532787
D003061CodeineCodeine binds to OPRK1 protein7562497
D003300CopperCopper inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein]2162496
D003496CyclazocineCyclazocine binds to and results in increased activity of OPRK1 protein8968362|9788768
D003513CycloheximideCycloheximide results in increased expression of OPRK1 mRNA19684285
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of OPRK1 mRNA19684285
C084603cyclorphancyclorphan binds to OPRK1 protein21351746
C084603cyclorphancyclorphan analog binds to and results in increased activity of OPRK1 protein10812979
C084603cyclorphancyclorphan binds to and results in increased activity of OPRK1 protein10812979
C084603cyclorphancyclorphan analog binds to OPRK1 protein10812979
C084603cyclorphancyclorphan binds to OPRK1 protein10812979
D013759DronabinolOPRK1 affects the reaction [KCNIP3 affects the susceptibility to Dronabinol]15182311
D013759DronabinolOPRK1 affects the susceptibility to Dronabinol11826143
C044130dextrallorphandextrallorphan binds to OPRK1 protein7562497
C044130dextrallorphan[dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
C044130dextrallorphan[dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D003917DextrorphanDextrorphan binds to OPRK1 protein7562497
D003917Dextrorphan[Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D003917Dextrorphan[Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of OPRK1 mRNA21266533
D0199003,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer"3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein"27192616
D0199003,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer"7-hydroxymitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]"27192616
D0199003,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer"mitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]"27192616
D0199003,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer"3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to OPRK1 protein"10087027
D0199003,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer"3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein"18385270
D0199003,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer"[3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein] which results in increased phosphorylation of STAT3 protein"18385270
D0199003,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer"3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer inhibits the reaction [OPRK1 protein results in increased transport of Barium]"12031848
D0199003,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer"3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein"11698066|1295748
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of OPRK1 mRNA26924002
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of OPRK1 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of OPRK1 mRNA26924002
D004298Dopamine[U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine]11113311
C502814dynorphin A-(1-11)-NH2, Nalpha-benzylTyr(1)-cyclo(Asp(5)-Dap(8))-"dynorphin A-(1-11)-NH2, Nalpha-benzylTyr(1)-cyclo(Asp(5)-Dap(8))- results in decreased activity of OPRK1 protein"19841255
C502814dynorphin A-(1-11)-NH2, Nalpha-benzylTyr(1)-cyclo(Asp(5)-Dap(8))-"dynorphin A-(1-11)-NH2, Nalpha-benzylTyr(1)-cyclo(Asp(5)-Dap(8))- binds to and results in decreased activity of OPRK1 protein"19841255
D004399DynorphinsDynorphins results in increased activity of OPRK1 protein26476280
D004399DynorphinsDynorphins binds to OPRK1 protein10087027
D004399DynorphinsDynorphins analog binds to OPRK1 protein11270320
D004399DynorphinsDynorphins binds to and results in increased activity of OPRK1 protein11676193
D004399Dynorphinsnorbinaltorphimine inhibits the reaction [Dynorphins binds to and results in increased activity of OPRK1 protein]11676193
D004399DynorphinsDynorphins binds to and results in increased activity of OPRK1 protein10940359
C061285E 2078E 2078 binds to and results in decreased activity of OPRK1 protein1976830
C067110enadolineCocaine affects the reaction [enadoline binds to OPRK1 protein]17621646
C067110enadolineenadoline binds to OPRK1 protein17621646
C067110enadolineenadoline binds to and results in increased activity of OPRK1 protein10602339|1156107
C118739entinostatentinostat results in decreased expression of OPRK1 mRNA27188386
D004837EpinephrineOPRK1 protein affects the susceptibility to Epinephrine16995444
D000431EthanolEthanol results in decreased expression of OPRK1 mRNA17934066
D000431Ethanolfomepizole inhibits the reaction [Ethanol results in decreased expression of OPRK1 mRNA]17934066
D016314EthylketocyclazocineCadmium inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein]2162496
D016314EthylketocyclazocineCopper inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein]2162496
D016314EthylketocyclazocineEthylketocyclazocine binds to OPRK1 protein2162496
D016314EthylketocyclazocineMercury inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein]2162496
D016314EthylketocyclazocineEthylketocyclazocine binds to and results in increased activity of OPRK1 protein226904|2558758|3
C067749fedotozinefedotozine binds to and results in increased activity of OPRK1 protein8968362
C010238fomepizolefomepizole inhibits the reaction [Ethanol results in decreased expression of OPRK1 mRNA]17934066
C106014geduningedunin results in decreased expression of OPRK1 mRNA17010675
C071609GR 89696GR 89696 binds to and results in decreased activity of OPRK1 protein21958337
C000611307GUM1 compoundGUM1 compound results in increased activity of OPRK1 protein26476280
D012701Serotonin[dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Levallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Levorphanol binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D012701Serotonin[Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D006853HydrocodoneHydrocodone binds to OPRK1 protein7562497
C058468ICI 199441ICI 199441 analog binds to and results in increased activity of OPRK1 protein15863335
C058468ICI 199441ICI 199441 binds to and results in increased activity of OPRK1 protein15863335
C012395ketazocineketazocine binds to and results in increased activity of OPRK1 protein226904
D007977LevallorphanLevallorphan binds to OPRK1 protein7562497
D007977Levallorphan[Levallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D007977Levallorphan[Levallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D007981LevorphanolLevorphanol binds to OPRK1 protein7562497
D007981Levorphanol[Levorphanol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D007981Levorphanol[Levorphanol binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of OPRK1 mRNA18977430
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of OPRK1 mRNA18977430
D008274Magnesium"Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein]"2162496
D008345Manganese"Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein]"2162496
D008614MeperidineMeperidine binds to OPRK1 protein8267194
D008627Mercuric ChlorideMercuric Chloride affects the expression of OPRK1 mRNA20353558
D008628MercuryMercury inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein]2162496
D008691MethadoneMethadone binds to OPRK1 protein7562497
D008691Methadone[Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D008691Methadone[Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D008692Methadyl AcetateMethadyl Acetate binds to OPRK1 protein7562497
D008692Methadyl Acetate[Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D008692Methadyl Acetate[Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D003915DextromethorphanDextromethorphan binds to OPRK1 protein7562497
D003915Dextromethorphan[Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D003915Dextromethorphan[Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D008727MethotrexateMethotrexate results in increased expression of OPRK1 mRNA17400583
D007050IbogaineIbogaine binds to OPRK1 protein9668680
C533093methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate"methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate binds to and results in increased activity of OPRK1 protein"24345467
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of OPRK1 protein"28790194
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of OPRK1 mRNA28001369
C001801mitragyninemitragynine binds to OPRK1 protein27192616
C001801mitragynine"mitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]"27192616
C001801mitragyninemitragynine binds to OPRK1 protein27192616
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of OPRK1 mRNA26924002
D009020MorphineMorphine results in increased activity of OPRK1 protein26476280
D009020MorphineMorphine affects the activity of OPRK1 protein18385270
D009020MorphineMorphine inhibits the reaction [Zymosan results in decreased expression of OPRK1 mRNA]15979727
D009020MorphineMorphine binds to OPRK1 protein7562497
D009020MorphineMorphine results in increased expression of OPRK1 mRNA22661197
C027247MR 2266MR 2266 binds to and results in decreased activity of OPRK1 protein1654493|8490741
C027247MR 2266MR 2266 binds to and results in decreased activity of OPRK1 protein8113989
C551455N-(1-((4-(3-carbamoylphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-2-methylpropyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide"N-(1-((4-(3-carbamoylphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-2-methylpropyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide results in decreased activity of OPRK1 protein"20372878
C440388N-(3-iodoprop-(2)-enyl)N-(3-iodoprop-(2)-enyl) binds to OPRK1 protein11591513
D009266NalbuphineNalbuphine binds to and results in increased activity of OPRK1 protein15810761|1651709
C038981nalmefenenalmefene binds to and results in decreased activity of OPRK1 protein9862779
D009270NaloxoneNaloxone binds to OPRK1 protein7562497
D009270NaloxoneNaloxone binds to and results in decreased activity of OPRK1 protein8267194
D009270NaloxoneNaloxone binds to OPRK1 protein3744788
C058380naloxone benzoylhydrazonenaloxone benzoylhydrazone binds to and results in increased activity of OPRK1 protein11676193
C058380naloxone benzoylhydrazonenorbinaltorphimine inhibits the reaction [naloxone benzoylhydrazone binds to and results in increased activity of OPRK1 protein]11676193
D009271NaltrexoneNaltrexone binds to OPRK1 protein7562497
D009538NicotineNicotine results in decreased expression of OPRK1 mRNA18247414
C051844norbinaltorphiminenorbinaltorphimine binds to and results in decreased activity of OPRK1 protein18385270
C051844norbinaltorphiminenorbinaltorphimine binds to and results in decreased activity of OPRK1 protein15456805
C051844norbinaltorphiminenorbinaltorphimine inhibits the reaction [Dynorphins binds to and results in increased activity of OPRK1 protein]11676193
C051844norbinaltorphiminenorbinaltorphimine inhibits the reaction [naloxone benzoylhydrazone binds to and results in increased activity of OPRK1 protein]11676193
C051844norbinaltorphiminenorbinaltorphimine binds to and results in decreased activity of OPRK1 protein10802031|1094035
D009638Norepinephrine[dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Levallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Levorphanol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D009638Norepinephrine[PDYN protein affects the activity of OPRK1 protein] which results in decreased secretion of Norepinephrine2987744
C094385noribogainenoribogaine binds to OPRK1 protein9668680
C440369N-propargylN-propargyl binds to OPRK1 protein11591513
D010098OxycodoneOxycodone binds to OPRK1 protein7562497
D010126OzoneOzone results in increased expression of OPRK1 mRNA12763052
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of OPRK1 mRNA18636392
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of OPRK1 mRNA26272509
C580857paynantheinepaynantheine binds to OPRK1 protein27192616
C054718PD 117302PD 117302 analog binds to OPRK1 protein1846919
C054718PD 117302PD 117302 binds to and results in increased activity of OPRK1 protein1846919|7894264|
D020881Enkephalin, D-Penicillamine (2,5)-"Enkephalin, D-Penicillamine (2,5)- binds to OPRK1 protein"7562497
D010423PentazocinePentazocine binds to and results in increased activity of OPRK1 protein3744788
D010433PentylenetetrazoleOPRK1 gene results in decreased susceptibility to Pentylenetetrazole17126860
D010852PicrotoxinPicrotoxin results in increased expression of OPRK1 mRNA15170462
D010862PilocarpineOPRK1 protein results in decreased susceptibility to Pilocarpine7894264
D010936Plant ExtractsPlant Extracts results in increased activity of OPRK1 protein9162281
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of OPRK1 mRNA20660070
D011431DextropropoxypheneDextropropoxyphene binds to OPRK1 protein7562497
D011431Dextropropoxyphene[Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D011431Dextropropoxyphene[Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D011441PropylthiouracilPropylthiouracil results in increased expression of OPRK1 mRNA24780913
C098221RP 60180RP 60180 binds to and results in increased activity of OPRK1 protein9197945
C090499salvinorin Asalvinorin A binds to and results in increased activity of OPRK1 protein19747933
C051272spiradolinespiradoline binds to and results in increased activity of OPRK1 protein17702903|1974793
C523979tapentadoltapentadol binds to OPRK1 protein17656655
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of OPRK1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of OPRK1 mRNA19684285
D013876ThiophenesThiophenes analog binds to OPRK1 protein1846919
C035470tifluadomtifluadom binds to and results in increased activity of OPRK1 protein2558758|8968362
D014147TramadolTramadol binds to OPRK1 protein7562497
D014147Tramadol[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine7562497
D014147Tramadol[Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin7562497
D014212TretinoinTretinoin results in decreased expression of OPRK1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of OPRK1 mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of OPRK1 mRNA24935251
C050414tripterinetripterine results in decreased expression of OPRK1 mRNA17010675
C111212TRK 820TRK 820 binds to OPRK1 protein22742909
C111212TRK 820TRK 820 metabolite binds to OPRK1 protein22742909
C111212TRK 820TRK 820 binds to and results in increased activity of OPRK1 protein16919318|1968673
C045444U 69593Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]21866885
C045444U 69593U 69593 binds to and results in increased activity of OPRK1 protein21958337
C045444U 69593U 69593 binds to OPRK1 protein21866885
C045444U 69593U 69593 binds to and results in increased activity of OPRK1 protein15456805
C045444U 69593[U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine]11113311
C045444U 69593U 69593 binds to OPRK1 protein7562497
C045444U 69593U 69593 binds to and results in increased activity of OPRK1 protein10435406|1095812
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OPRK1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of OPRK1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of OPRK1 mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in increased expression of OPRK1 mRNA23179753|2493525
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OPRK1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of OPRK1 mRNA26272509|2718838
D015054ZymosanZymosan results in decreased expression of OPRK1 mRNA18977430
D015054ZymosanMorphine inhibits the reaction [Zymosan results in decreased expression of OPRK1 mRNA]15979727
D015054ZymosanZymosan results in decreased expression of OPRK1 mRNA15979727

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004985opioid receptor activity-IDA22437504  
GO:0005515protein binding-IPI16431922  
GO:0033612receptor serine/threonine kinase binding-IEA-  
GO:0038048dynorphin receptor activity-IBA21873635  
GO:0038048dynorphin receptor activity-IDA8755601  
GO:0038048dynorphin receptor activity-IMP7624359  
GO:0042277peptide binding-IBA21873635  
GO:0042923neuropeptide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-IDA8755601  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-TAS7624359  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-ISS-  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007268chemical synaptic transmission-TAS7624359  
GO:0007600sensory perception-TAS7624359  
GO:0007626locomotory behavior-ISS-  
GO:0009314response to radiation-IEA-  
GO:0019233sensory perception of pain-IBA21873635  
GO:0019233sensory perception of pain-ISS-  
GO:0031635adenylate cyclase-inhibiting opioid receptor signaling pathway-IDA22437504  
GO:0032868response to insulin-IEA-  
GO:0033603positive regulation of dopamine secretion-IEA-  
GO:0033685negative regulation of luteinizing hormone secretion-IEA-  
GO:0038003opioid receptor signaling pathway-IBA21873635  
GO:0038003opioid receptor signaling pathway-IDA8755601  
GO:0040017positive regulation of locomotion-IEA-  
GO:0042711maternal behavior-IEA-  
GO:0042755eating behavior-IEA-  
GO:0043278response to morphine-IEA-  
GO:0043627response to estrogen-IEA-  
GO:0044849estrous cycle-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0046877regulation of saliva secretion-ISS-  
GO:0048148behavioral response to cocaine-IEA-  
GO:0050951sensory perception of temperature stimulus-IEA-  
GO:0051607defense response to virus-IDA8755601  
GO:0051930regulation of sensory perception of pain-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:1900745positive regulation of p38MAPK cascade-IEA-  
GO:1901381positive regulation of potassium ion transmembrane transport-IEA-  
GO:1903937response to acrylamide-IEA-  
GO:1904000positive regulation of eating behavior-IEA-  
GO:1990708conditioned place preference-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IMP7624359  
GO:0016021integral component of membrane-IDA22437504  
GO:0030425dendrite-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043204perikaryon-IEA-  
GO:0043679axon terminus-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22954510Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. (2012 Dec)Ashenhurst JRPharmacol Biochem Behav
23101464Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states. (2013 Jun)Karpyak VMInt J Neuropsychopharmacol
16961766The genetics of alcoholism: identifying specific genes through family studies. (2006 Sep)Edenberg HJAddict Biol
25655461Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)Manzardo AMGene
24035285Opioid system genes in alcoholism: a case-control study in Croatian population. (2013 Oct)Cupic BNeuropeptides
17374034Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. (2007 Apr)Gelernter JAlcohol Clin Exp Res
28300812[A pharmacogenetic analysis of dopaminergic and opioidergic genes in opioid addicts treated with the combination of naltrexone and guanfacine]. (2016)Kibitov capital A, Cyrilliccapital O, CyrillicZh Nevrol Psikhiatr Im S S Korsakova
28656735An analysis of genetic association in opioid dependence susceptibility. (2018 Feb)Nagaya DJ Clin Pharm Ther
26288297[Stabilization of remission in patients with opioid dependence with naltrexone implant: a pharmacogenetic approach]. (2015)Krupitsky capital IE, Cyrilliccapital EM, CyrillicZh Nevrol Psikhiatr Im S S Korsakova
26692286Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms. (2016 Jan)Jones JDAm J Addict
16924269Association of the kappa-opioid system with alcohol dependence. (2006 Nov)Xuei XMol Psychiatry
17373729Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction. (2007 Sep 5)Gerra GAm J Med Genet B Neuropsychiatr Genet
25823631The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. (2015 Jan)Bauer IEAm J Addict
25177835A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence. (2014 Oct)Faisal MComput Biol Med
17622222The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. (2008 May)Zhang HMol Psychiatry
24479196Optimization and characterization of an opioid kappa receptor (OPRK1) antagonist (2010)Guerrero M-
18537939Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers. (2008 Jul)Arias AJAlcohol Clin Exp Res
18319328A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence. (2008 Jun 15)Edenberg HJHum Mol Genet
25418439The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. (2014 Nov 21)Bauer IEAm J Addict
19393386[Treatment of a serious autistic disorder in a child with Naltrexone in an oral suspension form]. (2009 Apr)Desjardins SEncephale
15608558Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. (2004 Dec)Yuferov VPharmacogenetics
22197712Neurobehavioral and transcriptional effects of acrylamide in juvenile rats. (2012 Mar)Seale SMPharmacol Biochem Behav
23995774The kappa-opioid receptor gene as a predictor of response in a cocaine vaccine clinical trial. (2013 Dec)Nielsen DAPsychiatr Genet
17503481The opioid system in alcohol and drug dependence: family-based association study. (2007 Oct 5)Xuei XAm J Med Genet B Neuropsychiatr Genet
28786760Association of OPRK1 gene polymorphisms with opioid dependence in addicted men undergoing methadone treatment in an Iranian population. (2017 Oct-Dec)Albonaim AJ Addict Dis
24533225Analyzing Interaction of mu-, delta- and kappa-opioid Receptor Gene Variants on Alcohol or Drug Dependence Using a Pattern Discovery-based Method. (2013 May 14)Li ZJ Addict Res Ther
23962922A variant on the kappa opioid receptor gene (OPRK1) is associated with stress response and related drug craving, limbic brain activation and cocaine relapse risk. (2013 Aug 20)Xu KTransl Psychiatry