Gene: CRNN

49860
C1orf10|DRC1|PDRC1|SEP53
cornulin
protein-coding
1q21.3
Ensembl:ENSG00000143536 MIM:611312 Vega:OTTHUMG00000012383 UniprotKB:Q9UBG3
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.595e-1 (AD)  2.111e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPRR30.905
MUC210.898
KRT40.892
KRT130.891
TMPRSS11B0.858
SPRR1A0.857
SPINK50.826
SPRR2A0.823
KRT6A0.809
SPRR1B0.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF534-0.257
GSTCD-0.254
SKA1-0.253
ZNF43-0.246
HELLS-0.244
SP4-0.24
RMI1-0.234
FAM161A-0.228
ZNF100-0.225
RNF180-0.222

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of CRNN mRNA22230336
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CRNN mRNA"25351596
C006780bisphenol Abisphenol A results in decreased expression of CRNN mRNA25181051
D008727MethotrexateMethotrexate results in increased expression of CRNN mRNA24449571
D010936Plant ExtractsPlant Extracts results in decreased expression of CRNN mRNA23557933
D012969Sodium FluorideSodium Fluoride results in increased expression of CRNN mRNA27257137
D014635Valproic AcidValproic Acid results in decreased methylation of CRNN gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-NAS11056050  
GO:0046914transition metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009408response to heat-IDA11606197  
GO:0098609cell-cell adhesion-IDA2631556  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS14967811  
GO:0016020membrane-IDA2980212  
GO:0070062extracellular exosome-HDA19056867  19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28620964Does gene expression in laryngeal subsites differ between patients with laryngopharyngeal reflux and controls? (2018 Feb)Wood JMClin Otolaryngol