Gene: OPRL1

4987
KOR-3|NOCIR|NOP|NOPr|OOR|ORL1
OD related nociceptin receptor 1
protein-coding
20q13.33
Ensembl:ENSG00000125510 MIM:602548 Vega:OTTHUMG00000033027 UniprotKB:P41146
NC_000020.11
PubMed
0   ANCO-SNPs
OD|ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.112e-1 (AD)  6.865e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2B30.909
LRTM20.908
WSCD20.907
CLSTN30.906
MADD0.904
SLC12A50.904
UBE2O0.903
B4GALNT10.902
AACS0.902
CACNA1I0.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.582
REST-0.56
RAI14-0.557
HEY2-0.547
MBNL3-0.547
WWTR1-0.542
COPZ2-0.539
MYL3-0.529
WEE1-0.523
RAB13-0.519

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00921BuprenorphineSmall Molecule52485-79-7Approved|Illicit|InvestigationalTarget
DB01497EtorphineSmall Molecule14521-96-1IllicitTarget
DB05492Epicept NP-1Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0174872-mercaptoacetateOPRL1 exon affects the susceptibility to 2-mercaptoacetate10802031
C1217268-acenaphthen-1-yl-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one"8-acenaphthen-1-yl-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one binds to and results in increased activity of OPRL1 protein"12122313
D000082AcetaminophenAcetaminophen affects the expression of OPRL1 mRNA17562736
D000157AconitineOPRL1 protein affects the susceptibility to Aconitine16995444
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of OPRL1 mRNA21298039
C103505AM 251AM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 mRNA]21603976
C103505AM 251AM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 protein]21603976
D000643Ammonium ChlorideAmmonium Chloride affects the expression of OPRL1 mRNA16483693
D001285AtropineAtropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]12007927
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to OPRL1 promoter]19654925
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of OPRL1 mRNA20404318
C044887beta-methylcholinebeta-methylcholine affects the expression of OPRL1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased methylation of OPRL1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of OPRL1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of OPRL1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of OPRL1 mRNA29097150
D002047BuprenorphineBuprenorphine binds to and results in increased activity of OPRL1 protein10998549
D002211CapsaicinOPRL1 protein promotes the reaction [nociceptin (1-13) amide inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]]17640294
D002509CephaloridineCephaloridine results in increased expression of OPRL1 mRNA18500788
D004390ChlorpyrifosChlorpyrifos results in increased expression of OPRL1 mRNA21356183
C482404cis-1-methyl-7-((4-(2,6-dichlorophenyl)piperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol"cis-1-methyl-7-((4-(2,6-dichlorophenyl)piperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol binds to and affects the activity of OPRL1 protein"21438532
C014347decitabinedecitabine affects the expression of OPRL1 mRNA23300844
D013759DronabinolAM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 mRNA]21603976
D013759DronabinolAM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 protein]21603976
D013759DronabinolDronabinol results in decreased expression of OPRL1 mRNA21603976
D013759DronabinolDronabinol results in decreased expression of OPRL1 protein21603976
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of OPRL1 mRNA15620428
D002945CisplatinCisplatin affects the expression of OPRL1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of OPRL1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of OPRL1 mRNA27392435
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of OPRL1 mRNA16931933
D004041Dietary FatsDietary Fats results in increased expression of OPRL1 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of OPRL1 mRNA15620428
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of OPRL1 mRNA"27840820
D004837EpinephrineOPRL1 protein affects the susceptibility to Epinephrine16995444
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of OPRL1 mRNA12655037|2909715
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of OPRL1 gene16495775
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of OPRL1 mRNA21782745
D006220HaloperidolOPRL1 affects the susceptibility to Haloperidol16237164
C402921J 113397J 113397 binds to and results in decreased activity of OPRL1 protein11027224
C402921J 113397[J 113397 binds to and results in decreased activity of OPRL1 protein] which affects the susceptibility to Morphine11027224
C402921J 113397J 113397 binds to and affects the activity of OPRL1 protein12007927
C402921J 113397J 113397 inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]12007927
C402921J 113397J 113397 binds to and results in decreased activity of OPRL1 protein16237164|1994579
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of OPRL1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of OPRL1 mRNA27392435
D007657Ketone BodiesKetone Bodies results in decreased expression of OPRL1 mRNA16807920
D008694MethamphetamineMethamphetamine results in decreased expression of OPRL1 mRNA21886566
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of OPRL1 mRNA21782745
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of OPRL1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of OPRL1 mRNA19162046
D009020Morphine[J 113397 binds to and results in decreased activity of OPRL1 protein] which affects the susceptibility to Morphine11027224
D009538NicotineOPRL1 protein affects the susceptibility to Nicotine19371589
C096012nociceptinnociceptin binds to OPRL1 protein21866885
C096012nociceptinnociceptin binds to OPRL1 protein20359694
C096012nociceptinnociceptin binds to OPRL1 protein20359694
C439964nociceptin (1-13) amidenociceptin (1-13) amide affects the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]12007927
C439964nociceptin (1-13) amideOPRL1 protein promotes the reaction [nociceptin (1-13) amide inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]]17640294
C114149nociceptin (1-13)-NH2, Phe(1)-psi(CH2-NH)-Gly(2)-"nociceptin (1-13)-NH2, Phe(1)-psi(CH2-NH)-Gly(2)- binds to and results in decreased activity of OPRL1 protein"10794074
C525846nociceptin-amide, Nphe(1)-(pF)Phe(4)-Aib(7)-Arg(14)-Lys(15)-"nociceptin-amide, Nphe(1)-(pF)Phe(4)-Aib(7)-Arg(14)-Lys(15)- binds to and results in increased activity of OPRL1 protein"19945794
C025256nonylphenolnonylphenol results in decreased expression of OPRL1 mRNA15620428
C479838(Nphe(1),Arg(14),Lys(15))N-OFQ NH(2)"(Nphe(1),Arg(14),Lys(15))N-OFQ NH(2) binds to and results in decreased activity of OPRL1 protein"16237164
D016627OxidopamineOxidopamine results in decreased expression of OPRL1 mRNA19162046
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of OPRL1 mRNA16221955
C006253pirinixic acidpirinixic acid results in decreased expression of OPRL1 mRNA20813756
D011441PropylthiouracilPropylthiouracil results in increased expression of OPRL1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of OPRL1 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in increased expression of OPRL1 mRNA27862939
D012999SomanSoman results in decreased expression of OPRL1 mRNA19281266
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of OPRL1 mRNA23537331
D014635Valproic AcidValproic Acid results in increased methylation of OPRL1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of OPRL1 gene25560391
C025643vinclozolinvinclozolin affects the expression of OPRL1 mRNA19015723
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of OPRL1 mRNA16931933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001626nociceptin receptor activity-IBA21873635  
GO:0001626nociceptin receptor activity-IDA10571060  12568343  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IMP8137918  
GO:0004930G-protein coupled receptor activity-IPI10571060  
GO:0005515protein binding-IPI23597562  
GO:0008022protein C-terminus binding-IEA-  
GO:0042277peptide binding-IBA21873635  
GO:0042923neuropeptide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IMP8137918  12568343  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007600sensory perception-TAS7566152  
GO:0019233sensory perception of pain-IBA21873635  
GO:0019233sensory perception of pain-ISS-  
GO:0032355response to estradiol-IEA-  
GO:0035810positive regulation of urine volume-IEA-  
GO:0038003opioid receptor signaling pathway-IDA10571060  
GO:0042755eating behavior-IEA-  
GO:0044849estrous cycle-IEA-  
GO:0045776negative regulation of blood pressure-IEA-  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IPI10571060  
GO:0060454positive regulation of gastric acid secretion-IEA-  
GO:0106072negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway-IEA-  
GO:1901386negative regulation of voltage-gated calcium channel activity-IEA-  
GO:1904058positive regulation of sensory perception of pain-IEA-  
GO:1904059regulation of locomotor rhythm-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA8137918  12568343  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0043005neuron projection-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23799031Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls. (2013)Zhang HPLoS One
18269382Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence. (2008 Mar)Huang JAddict Biol
20032820Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians. (2010 Apr)Briant JAPsychiatr Genet
17910740Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence. (2008 Mar)Xuei XAddict Biol