| C024566 | 1,1,1-trichloroethane | "1,1,1-trichloroethane results in decreased expression of OPRM1 mRNA" | 25270620 |
| C500851 | 14-benzyloxy-4,5-epoxy-3-hydroxy-17-methylmorphinan-6-one | "14-benzyloxy-4,5-epoxy-3-hydroxy-17-methylmorphinan-6-one inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 15857143 |
| C081949 | 14-methoxymetopon | 14-methoxymetopon binds to and results in increased activity of OPRM1 protein | 19800397 |
| C081949 | 14-methoxymetopon | "14-methoxymetopon inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| C081949 | 14-methoxymetopon | 14-methoxymetopon binds to and results in increased activity of OPRM1 protein | 19800397 |
| C081949 | 14-methoxymetopon | "14-methoxymetopon inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 15857143|1980039 |
| C081949 | 14-methoxymetopon | 14-methoxymetopon binds to and results in increased activity of OPRM1 protein | 21235243 |
| C547349 | 14-O-methyloxymorphone | 14-O-methyloxymorphone binds to and results in increased activity of OPRM1 protein | 19800397 |
| C547349 | 14-O-methyloxymorphone | "14-O-methyloxymorphone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| C547349 | 14-O-methyloxymorphone | 14-O-methyloxymorphone binds to and results in increased activity of OPRM1 protein | 19800397 |
| C547349 | 14-O-methyloxymorphone | "14-O-methyloxymorphone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 15857143|1980039 |
| C478565 | 14-phenylpropoxymetopon | 14-phenylpropoxymetopon binds to OPRM1 protein | 21235243 |
| C507634 | 1,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamido)hexane | "1,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamido)hexane binds to and results in increased activity of OPRM1 protein" | 17142049 |
| C507634 | 1,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamido)hexane | "1,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamido)hexane metabolite binds to and results in increased activity of OPRM1 protein" | 17142049 |
| C029790 | 2,2',3',4,4',5-hexachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of OPRM1 mRNA" | 25510870 |
| C081766 | 2,4,4'-trichlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of OPRM1 mRNA" | 25510870 |
| C014024 | 2,4,5,2',4',5'-hexachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of OPRM1 mRNA" | 25510870 |
| C009828 | 2,4,5,2',5'-pentachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of OPRM1 mRNA" | 25510870 |
| C009407 | 2,5,2',5'-tetrachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of OPRM1 mRNA" | 25510870 |
| C017487 | 2-mercaptoacetate | OPRM1 exon affects the susceptibility to 2-mercaptoacetate | 10802031 |
| C507635 | 3,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamidopropyl)-2(1H)-pyrazinone | "3,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamidopropyl)-2(1H)-pyrazinone binds to and results in increased activity of OPRM1 protein" | 17142049 |
| C507635 | 3,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamidopropyl)-2(1H)-pyrazinone | "3,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamidopropyl)-2(1H)-pyrazinone metabolite binds to and results in increased activity of OPRM1 protein" | 17142049 |
| C586842 | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine binds to OPRM1 protein | 23300227 |
| C586842 | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine | "((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine inhibits the reaction [[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein]" | 23300227 |
| C586842 | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine binds to OPRM1 protein | 23300227 |
| C586842 | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine | [OPRM1 protein co-treated with ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine] results in increased activity of ARRB2 protein | 23300227 |
| C586842 | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine binds to OPRM1 protein | 23300227 |
| C586842 | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine | ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine binds to and results in increased activity of OPRM1 protein | 24063433|2755670 |
| C000595015 | 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine | "6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of OPRM1 mRNA" | 28073004 |
| C023833 | 6 alpha-naloxol | 6 alpha-naloxol binds to and results in decreased activity of OPRM1 protein | 11413242 |
| C010410 | 6 beta-hydroxynaltrexone | 6 beta-hydroxynaltrexone binds to and results in decreased activity of OPRM1 protein | 11413242 |
| C023834 | 6 beta-naloxol | 6 beta-naloxol binds to and results in decreased activity of OPRM1 protein | 11413242 |
| C077358 | 7-benzylidenenaltrexone | [7-benzylidenenaltrexone binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| C077358 | 7-benzylidenenaltrexone | [7-benzylidenenaltrexone binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP | 11413242 |
| C077358 | 7-benzylidenenaltrexone | 7-benzylidenenaltrexone binds to and results in decreased activity of OPRM1 protein | 11413242 |
| C482678 | 7-hydroxymitragynine | "7-hydroxymitragynine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]" | 27192616 |
| C482678 | 7-hydroxymitragynine | 7-hydroxymitragynine binds to and results in increased activity of OPRM1 protein | 27192616 |
| C482678 | 7-hydroxymitragynine | 7-hydroxymitragynine binds to OPRM1 protein | 27192616 |
| C502982 | 9-(benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho(2,1-c)pyran-7-carboxylic acid methyl ester | "9-(benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho(2,1-c)pyran-7-carboxylic acid methyl ester binds to and results in increased activity of OPRM1 protein" | 27556704 |
| D000157 | Aconitine | OPRM1 protein affects the susceptibility to Aconitine | 16995444 |
| D000242 | Cyclic AMP | [7-benzylidenenaltrexone binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP | 11413242 |
| D000242 | Cyclic AMP | [chlornaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP | 11413242 |
| D000242 | Cyclic AMP | [clocinnamox binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP | 11413242 |
| D000242 | Cyclic AMP | [nalmefene binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP | 11413242 |
| D000242 | Cyclic AMP | [[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP | 11413242 |
| D000242 | Cyclic AMP | [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP | 11413242 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased methylation of OPRM1 gene | 27153756 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine inhibits the reaction [[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein]" | 23300227 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "7-hydroxymitragynine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]" | 27192616 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Buprenorphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 21866885 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein" | 21866885|2195833 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- results in increased activity of OPRM1 protein" | 26476280 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- results in increased phosphorylation of OPRM1 protein" | 23300227 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "mitragynine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]" | 27192616 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]" | 27192616 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein" | 23300227|2719261 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "14-methoxymetopon inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "14-O-methyloxymorphone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "ADORA2A protein affects the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate)]" | 14756803 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein" | 27192616 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein" | 14756803|1689360 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate)" | 14756803 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "mitragynine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]" | 27192616 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "mitragynine pseudoindoxyl inhibits the reaction [[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein]" | 27556704 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "OPRM1 gene mutant form inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 16893609|1689360 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein" | 27556704 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Oxymorphone affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "14-benzyloxy-4,5-epoxy-3-hydroxy-17-methylmorphinan-6-one inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 15857143 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "14-methoxymetopon inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 15857143|1980039 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "14-O-methyloxymorphone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 15857143|1980039 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Cadmium inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Cannabidiol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]" | 16489449 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Copper inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "CTAP octapeptide inhibits the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein] which results in increased susceptibility to Cocaine]" | 19279569 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Dronabinol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]" | 16489449 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein" | 1528399|16489449 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein] which results in increased susceptibility to Cocaine" | 19279569 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein" | 10891866|1199125 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Mercury inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "[Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" | 8987795 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]" | 16489449 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "OPRM1 results in increased susceptibility to Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" | 8987795 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Oxymorphone affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Zinc inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Zinc inhibits the reaction [Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]]" | 2162496 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]]" | 2162496 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]]" | 12031848 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]]" | 12031848 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]" | 12031848 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]]" | 12031848 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein" | 10078993|1053412 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein" | 24345467 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]" | 23818586 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- results in increased activity of OPRM1 protein" | 24345467 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 24345467 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "Morphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 24345467 |
| D020875 | Enkephalin, Ala(2)-MePhe(4)-Gly(5)- | "tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]]" | 23818586 |
| D015760 | Alfentanil | Alfentanil binds to and results in increased activity of OPRM1 protein | 11240593 |
| D000535 | Aluminum | [APP protein modified form binds to Aluminum] which results in decreased expression of OPRM1 mRNA | 21298039 |
| C419502 | alvimopan | alvimopan binds to and results in decreased activity of OPRM1 protein | 18313920 |
| C419502 | alvimopan | alvimopan binds to OPRM1 protein | 17340127 |
| C419502 | alvimopan | alvimopan metabolite binds to OPRM1 protein | 17340127 |
| D005680 | gamma-Aminobutyric Acid | OPRM1 protein mutant form results in decreased secretion of gamma-Aminobutyric Acid | 20203187 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of OPRM1 mRNA | 16483693 |
| D003913 | Dextroamphetamine | Dextroamphetamine affects the expression of OPRM1 mRNA | 12629526 |
| C032739 | aroclor 1221 | aroclor 1221 inhibits the reaction [aroclor 1221 results in decreased expression of OPRM1 mRNA] | 26620572 |
| C032739 | aroclor 1221 | aroclor 1221 results in decreased expression of OPRM1 mRNA | 26620572 |
| C032739 | aroclor 1221 | aroclor 1221 results in increased expression of OPRM1 mRNA | 26620572 |
| D001464 | Barium | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]]" | 12031848 |
| D001464 | Barium | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]" | 12031848 |
| D001464 | Barium | "omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]]" | 12031848 |
| D001464 | Barium | OPRM1 protein affects the reaction [Potassium results in increased transport of Barium] | 12031848 |
| D001464 | Barium | OPRM1 protein affects the transport of Barium | 12031848 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of OPRM1 mRNA | 19428949 |
| C024524 | beta-funaltrexamine | [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Nicotine | 15778877 |
| C024524 | beta-funaltrexamine | "[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]" | 8884884 |
| C024524 | beta-funaltrexamine | [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid] | 8884884 |
| C024524 | beta-funaltrexamine | [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine | 8884884 |
| C024524 | beta-funaltrexamine | beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein | 12937158|1577887 |
| C035438 | beta-naltrexamine | beta-naltrexamine binds to and results in decreased activity of OPRM1 protein | 11413242 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of OPRM1 mRNA | 25181051 |
| D002047 | Buprenorphine | Buprenorphine binds to and affects the activity of OPRM1 protein | 21866885 |
| D002047 | Buprenorphine | Buprenorphine binds to and results in increased activity of OPRM1 protein | 16010532 |
| D002047 | Buprenorphine | "Buprenorphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 21866885 |
| D002047 | Buprenorphine | Buprenorphine binds to OPRM1 protein | 7562497 |
| D002047 | Buprenorphine | Buprenorphine binds to and affects the activity of OPRM1 protein | 10862807 |
| D002047 | Buprenorphine | Buprenorphine binds to and results in increased activity of OPRM1 protein | 15966752|1640165 |
| D002047 | Buprenorphine | Buprenorphine binds to OPRM1 protein | 15897523 |
| D020001 | 1-Butanol | [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] | 14720217 |
| D002077 | Butorphanol | Butorphanol affects the activity of OPRM1 protein | 17909753 |
| D002077 | Butorphanol | Butorphanol affects the activity of OPRM1 protein | 17909753 |
| D002077 | Butorphanol | Butorphanol affects the activity of OPRM1 protein | 17909753 |
| D002077 | Butorphanol | Butorphanol binds to and results in increased activity of OPRM1 protein | 11561074 |
| D002104 | Cadmium | "Cadmium inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| D002118 | Calcium | [Tetradecanoylphorbol Acetate co-treated with Calcium] inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| C058819 | calphostin C | calphostin C inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCA protein]] | 18652891 |
| C058819 | calphostin C | calphostin C inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| C061465 | calphostin complex | calphostin complex inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]] | 21235400 |
| D002185 | Cannabidiol | "Cannabidiol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]" | 16489449 |
| D002211 | Capsaicin | Capsaicin inhibits the reaction [carfentanil binds to OPRM1 protein] | 12406535 |
| C017114 | carfentanil | Capsaicin inhibits the reaction [carfentanil binds to OPRM1 protein] | 12406535 |
| C017114 | carfentanil | Cocaine affects the reaction [carfentanil binds to OPRM1 protein] | 15953495 |
| C017114 | carfentanil | carfentanil binds to and results in increased activity of OPRM1 protein | 12406535|1876291 |
| C017114 | carfentanil | carfentanil binds to OPRM1 protein | 15953495 |
| D002395 | Catecholamines | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]]" | 12031848 |
| D002395 | Catecholamines | OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines] | 12031848 |
| C017120 | chlornaltrexamine | [chlornaltrexamine binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| C017120 | chlornaltrexamine | [chlornaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP | 11413242 |
| C017120 | chlornaltrexamine | chlornaltrexamine binds to and results in decreased activity of OPRM1 protein | 11413242 |
| C076806 | clocinnamox | [clocinnamox binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| C076806 | clocinnamox | [clocinnamox binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP | 11413242 |
| C076806 | clocinnamox | clocinnamox binds to and results in decreased activity of OPRM1 protein | 11413242 |
| D003000 | Clonidine | [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine | 8987795 |
| D003000 | Clonidine | OPRM1 results in increased susceptibility to Clonidine | 8987795 |
| C007095 | cobaltiprotoporphyrin | cobaltiprotoporphyrin affects the expression of OPRM1 | 23358127 |
| D003042 | Cocaine | Cocaine results in increased expression of OPRM1 mRNA | 23226419 |
| D003042 | Cocaine | Cocaine affects the reaction [carfentanil binds to OPRM1 protein] | 15953495 |
| D003042 | Cocaine | OPRM1 gene SNP results in increased susceptibility to Cocaine | 12815747 |
| D003042 | Cocaine | Cocaine results in decreased expression of OPRM1 mRNA | 10081923 |
| D003042 | Cocaine | Cocaine results in increased activity of OPRM1 protein | 17532787 |
| D003042 | Cocaine | OPRM1 gene mutant form results in decreased susceptibility to Cocaine | 16893609 |
| D003042 | Cocaine | OPRM1 mutant form results in decreased susceptibility to Cocaine | 15664692 |
| D003042 | Cocaine | OPRM1 protein affects the susceptibility to Cocaine | 10803207 |
| D003042 | Cocaine | PDYN protein affects the reaction [Cocaine results in increased activity of OPRM1 protein] | 17532787 |
| D003042 | Cocaine | Cocaine affects the expression of OPRM1 mRNA | 15950784|1899054 |
| D003042 | Cocaine | Cocaine affects the expression of OPRM1 protein | 10891866 |
| D003042 | Cocaine | Cocaine results in decreased expression of OPRM1 mRNA | 12128154 |
| D003042 | Cocaine | [CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [POMC protein results in increased susceptibility to Cocaine] | 19279569 |
| D003042 | Cocaine | "CTAP octapeptide inhibits the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein] which results in increased susceptibility to Cocaine]" | 19279569 |
| D003042 | Cocaine | "[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein] which results in increased susceptibility to Cocaine" | 19279569 |
| D003061 | Codeine | Codeine binds to OPRM1 protein | 7562497 |
| C009862 | connective tissue-activating peptide | connective tissue-activating peptide binds to and results in decreased activity of OPRM1 protein | 16954126 |
| D003300 | Copper | Copper deficiency results in increased expression of OPRM1 mRNA | 26033743 |
| D003300 | Copper | "Copper inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| C529311 | CTAP octapeptide | CTAP octapeptide binds to and results in decreased activity of OPRM1 protein | 22258905 |
| C529311 | CTAP octapeptide | [CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [POMC protein results in increased susceptibility to Cocaine] | 19279569 |
| C529311 | CTAP octapeptide | [CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Methamphetamine | 20298714 |
| C529311 | CTAP octapeptide | "CTAP octapeptide inhibits the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein] which results in increased susceptibility to Cocaine]" | 19279569 |
| C529311 | CTAP octapeptide | CTAP octapeptide binds to and results in decreased activity of OPRM1 protein | 17687547|1927956 |
| D003496 | Cyclazocine | Cyclazocine binds to and results in decreased activity of OPRM1 protein | 9788768 |
| D003513 | Cycloheximide | Cycloheximide inhibits the reaction [Dronabinol results in increased expression of OPRM1 mRNA] | 16434616 |
| C084603 | cyclorphan | cyclorphan binds to OPRM1 protein | 21351746 |
| C084603 | cyclorphan | cyclorphan analog binds to and results in increased activity of OPRM1 protein | 10812979 |
| C084603 | cyclorphan | cyclorphan binds to and results in decreased activity of OPRM1 protein | 10812979 |
| C583602 | CYM51010 | CYM51010 promotes the reaction [[OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate)] | 23818586 |
| C583602 | CYM51010 | CYM51010 results in increased activity of OPRM1 protein | 23818586 |
| C583602 | CYM51010 | Naltrexone inhibits the reaction [CYM51010 promotes the reaction [[OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate)]] | 23818586 |
| C058450 | cyprodime | [cyprodime binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Phenytoin | 7870991 |
| C058450 | cyprodime | cyprodime binds to and results in decreased activity of OPRM1 protein | 11520128|7870991 |
| C014347 | decitabine | decitabine results in increased expression of OPRM1 mRNA | 22262103 |
| C014347 | decitabine | decitabine affects the methylation of OPRM1 promoter | 17452465 |
| C014347 | decitabine | [decitabine affects the methylation of OPRM1 promoter] which affects the expression of OPRM1 mRNA | 17452465|1745246 |
| D013759 | Dronabinol | Cycloheximide inhibits the reaction [Dronabinol results in increased expression of OPRM1 mRNA] | 16434616 |
| D013759 | Dronabinol | Dronabinol results in increased expression of OPRM1 mRNA | 16434616 |
| D013759 | Dronabinol | GATA3 affects the reaction [Dronabinol results in increased expression of OPRM1 mRNA] | 16434616 |
| D013759 | Dronabinol | IL4 protein mutant form inhibits the reaction [Dronabinol results in increased expression of OPRM1 mRNA] | 16434616 |
| D013759 | Dronabinol | iodopravadoline inhibits the reaction [Dronabinol results in increased expression of OPRM1 mRNA] | 16434616 |
| D013759 | Dronabinol | STAT5A affects the reaction [Dronabinol results in increased expression of OPRM1 mRNA] | 16434616 |
| D013759 | Dronabinol | STAT6 affects the reaction [Dronabinol results in increased expression of OPRM1 mRNA] | 16434616 |
| D013759 | Dronabinol | OPRM1 affects the susceptibility to Dronabinol | 11826143 |
| D013759 | Dronabinol | Dronabinol promotes the reaction [Guanosine Triphosphate binds to OPRM1 protein] | 16823391 |
| D013759 | Dronabinol | "Dronabinol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]" | 16489449 |
| D013759 | Dronabinol | Dronabinol results in increased activity of OPRM1 protein | 10101241 |
| C060209 | deltorphin II, Ala(2)- | "deltorphin II, Ala(2)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]" | 23818586 |
| C060209 | deltorphin II, Ala(2)- | "phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide promotes the reaction [deltorphin II, Ala(2)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]]" | 23818586 |
| C030058 | dermorphin | dermorphin binds to and results in increased activity of OPRM1 protein | 21870874 |
| C044130 | dextrallorphan | dextrallorphan binds to OPRM1 protein | 7562497 |
| C044130 | dextrallorphan | [dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| C044130 | dextrallorphan | [dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D003917 | Dextrorphan | Dextrorphan binds to OPRM1 protein | 7562497 |
| D003917 | Dextrorphan | [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D003917 | Dextrorphan | [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D004041 | Dietary Fats | Dietary Fats results in increased expression of OPRM1 mRNA | 18721800 |
| D019422 | Dietary Sucrose | Dietary Sucrose results in increased expression of OPRM1 mRNA | 26033743 |
| D015102 | 3,4-Dihydroxyphenylacetic Acid | "[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]" | 8884884 |
| D004147 | Dioxins | Dioxins affects the expression of OPRM1 mRNA | 20463971 |
| D016291 | Dizocilpine Maleate | Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]] | 18652891 |
| D016291 | Dizocilpine Maleate | Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| C569763 | Dmt-NMe-Ala-Aba-Gly-NH2 | Dmt-NMe-Ala-Aba-Gly-NH2 binds to OPRM1 protein | 21978284 |
| C569763 | Dmt-NMe-Ala-Aba-Gly-NH2 | [Dmt-NMe-Ala-Aba-Gly-NH2 binds to OPRM1 protein] which results in increased phosphorylation of MAPK1 protein | 21978284 |
| C569763 | Dmt-NMe-Ala-Aba-Gly-NH2 | [Dmt-NMe-Ala-Aba-Gly-NH2 binds to OPRM1 protein] which results in increased phosphorylation of MAPK3 protein | 21978284 |
| D007980 | Levodopa | "[Levodopa co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased activity of OPRM1 protein" | 15802193 |
| D004399 | Dynorphins | Dynorphins results in increased activity of OPRM1 protein | 26476280 |
| D004399 | Dynorphins | Dynorphins analog binds to OPRM1 protein | 11270320 |
| C105293 | endomorphin 1 | endomorphin 1 binds to and results in increased activity of OPRM1 protein | 17142049 |
| C105293 | endomorphin 1 | endomorphin 1 metabolite binds to and results in decreased activity of OPRM1 protein | 17142049 |
| C105293 | endomorphin 1 | endomorphin 1 affects the activity of OPRM1 protein | 11726782 |
| C105293 | endomorphin 1 | [naloxonazine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to endomorphin 1 | 11726782 |
| C105293 | endomorphin 1 | endomorphin 1 binds to and results in increased activity of OPRM1 protein | 10988119 |
| C105294 | endomorphin 2 | endomorphin 2 binds to and results in increased activity of OPRM1 protein | 17142049 |
| C105294 | endomorphin 2 | endomorphin 2 metabolite binds to and results in decreased activity of OPRM1 protein | 17142049 |
| C105294 | endomorphin 2 | [OPRM1 protein co-treated with endomorphin 2] results in increased activity of ARRB2 protein | 27556704 |
| C105294 | endomorphin 2 | endomorphin 2 binds to and results in increased activity of OPRM1 protein | 10988119 |
| D004743 | Enkephalin, Leucine | "Enkephalin, Leucine results in increased activity of OPRM1 protein" | 26476280 |
| D004837 | Epinephrine | OPRM1 protein affects the susceptibility to Epinephrine | 16995444 |
| D004967 | Estrogens | ESR1 affects the reaction [Estrogens affects the localization of OPRM1 protein] | 12605406 |
| D004967 | Estrogens | Estrogens affects the localization of OPRM1 protein | 12605406 |
| D000431 | Ethanol | OPRM1 gene SNP results in increased susceptibility to Ethanol | 12815747 |
| D000431 | Ethanol | OPRM1 protein affects the susceptibility to Ethanol | 17339526 |
| D000431 | Ethanol | OPRM1 protein affects the susceptibility to Ethanol | 10803207 |
| D005038 | Ethylnitrosourea | Ethylnitrosourea results in increased mutagenesis of OPRM1 gene | 16495775 |
| C084835 | etonitazene | etonitazene results in increased phosphorylation of OPRM1 protein | 21957251 |
| D005283 | Fentanyl | Fentanyl results in increased phosphorylation of OPRM1 protein | 23300227 |
| D005283 | Fentanyl | Fentanyl results in increased phosphorylation of OPRM1 protein | 17240843|2195725 |
| D005283 | Fentanyl | Fentanyl binds to and results in increased activity of OPRM1 protein | 16099308|1611303 |
| D005283 | Fentanyl | Fentanyl binds to OPRM1 protein | 8267194 |
| C061872 | FK 409 | FK 409 promotes the reaction [OPRM1 protein binds to PRKCG protein] | 18652891|2123540 |
| C061872 | FK 409 | FK 409 promotes the reaction [OPRM1 protein binds to RAF1 protein] | 21235400 |
| C061872 | FK 409 | FK 409 promotes the reaction [OPRM1 protein binds to RGS17 protein] | 18652891 |
| C061872 | FK 409 | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to PRKCG protein]]" | 21235400 |
| C061872 | FK 409 | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to RAF1 protein]]" | 21235400 |
| D005473 | Fluoxetine | Fluoxetine inhibits the reaction [Methamphetamine results in decreased expression of OPRM1 mRNA] | 21886566 |
| D005473 | Fluoxetine | Fluoxetine inhibits the reaction [Methamphetamine results in decreased expression of OPRM1 protein] | 21886566 |
| D005473 | Fluoxetine | Fluoxetine results in increased expression of OPRM1 protein | 16484055 |
| C039281 | furan | furan results in decreased expression of OPRM1 mRNA | 26194646 |
| D016244 | Guanosine 5'-O-(3-Thiotriphosphate) | [7-benzylidenenaltrexone binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| D016244 | Guanosine 5'-O-(3-Thiotriphosphate) | [chlornaltrexamine binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| D016244 | Guanosine 5'-O-(3-Thiotriphosphate) | [clocinnamox binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| D016244 | Guanosine 5'-O-(3-Thiotriphosphate) | "ADORA2A protein affects the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate)]" | 14756803 |
| D016244 | Guanosine 5'-O-(3-Thiotriphosphate) | "[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate)" | 14756803 |
| D016244 | Guanosine 5'-O-(3-Thiotriphosphate) | CYM51010 promotes the reaction [[OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate)] | 23818586 |
| D016244 | Guanosine 5'-O-(3-Thiotriphosphate) | [nalmefene binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| D016244 | Guanosine 5'-O-(3-Thiotriphosphate) | [[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| D016244 | Guanosine 5'-O-(3-Thiotriphosphate) | [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| D016244 | Guanosine 5'-O-(3-Thiotriphosphate) | Naltrexone inhibits the reaction [CYM51010 promotes the reaction [[OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate)]] | 23818586 |
| D016244 | Guanosine 5'-O-(3-Thiotriphosphate) | [OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate) | 23818586 |
| D006160 | Guanosine Triphosphate | Dronabinol promotes the reaction [Guanosine Triphosphate binds to OPRM1 protein] | 16823391 |
| D006160 | Guanosine Triphosphate | Guanosine Triphosphate binds to OPRM1 protein | 16823391 |
| C000611307 | GUM1 compound | GUM1 compound results in increased activity of OPRM1 protein | 26476280 |
| D006220 | Haloperidol | OPRM1 protein inhibits the reaction [Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]] | 20184921 |
| D003932 | Heroin | Heroin binds to and results in increased activity of OPRM1 protein | 18597954 |
| D006719 | Homovanillic Acid | [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid] | 8884884 |
| D017313 | Fenretinide | Fenretinide results in decreased expression of OPRM1 mRNA | 28973697 |
| D012701 | Serotonin | [dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D012701 | Serotonin | [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D012701 | Serotonin | [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D012701 | Serotonin | [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D012701 | Serotonin | [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D012701 | Serotonin | [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D012701 | Serotonin | [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D012701 | Serotonin | [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D012701 | Serotonin | [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D006853 | Hydrocodone | Hydrocodone binds to OPRM1 protein | 7562497 |
| D006853 | Hydrocodone | Hydrocodone binds to and results in increased activity of OPRM1 protein | 15893155 |
| C094023 | iodopravadoline | iodopravadoline inhibits the reaction [Dronabinol results in increased expression of OPRM1 mRNA] | 16434616 |
| D015759 | Ionomycin | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OPRM1 mRNA | 25613284 |
| D007531 | Isoflurophate | OPRM1 affects the susceptibility to Isoflurophate | 15378609|1580040 |
| C402944 | JHW 015 | JHW 015 results in increased expression of OPRM1 mRNA | 16434616 |
| C008261 | lead acetate | lead acetate results in decreased expression of OPRM1 mRNA | 21891863 |
| D007977 | Levallorphan | Levallorphan binds to OPRM1 protein | 7562497 |
| D007977 | Levallorphan | [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D007977 | Levallorphan | [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D007981 | Levorphanol | Levorphanol binds to OPRM1 protein | 7562497 |
| D007981 | Levorphanol | [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D007981 | Levorphanol | [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in increased expression of OPRM1 mRNA | 18977430 |
| D018021 | Lithium Chloride | Lithium Chloride results in decreased expression of OPRM1 protein | 17919468 |
| D008139 | Loperamide | Loperamide binds to and results in increased activity of OPRM1 protein | 20604828 |
| D008274 | Magnesium | "Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| D008274 | Magnesium | "Zinc inhibits the reaction [Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]]" | 2162496 |
| D008345 | Manganese | "Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| D008345 | Manganese | "Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]]" | 2162496 |
| D008614 | Meperidine | Meperidine binds to OPRM1 protein | 8267194 |
| D008628 | Mercury | "Mercury inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| D008691 | Methadone | Methadone binds to OPRM1 protein | 7562497 |
| D008691 | Methadone | [Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D008691 | Methadone | [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D008691 | Methadone | Methadone binds to and results in increased activity of OPRM1 protein | 10215673|1859795 |
| D008692 | Methadyl Acetate | Methadyl Acetate binds to OPRM1 protein | 7562497 |
| D008692 | Methadyl Acetate | [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D008692 | Methadyl Acetate | [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D008692 | Methadyl Acetate | Methadyl Acetate binds to and results in increased activity of OPRM1 protein | 10215673|1086280 |
| D008694 | Methamphetamine | OPRM1 gene SNP results in increased susceptibility to Methamphetamine | 16402083 |
| D008694 | Methamphetamine | Fluoxetine inhibits the reaction [Methamphetamine results in decreased expression of OPRM1 mRNA] | 21886566 |
| D008694 | Methamphetamine | Fluoxetine inhibits the reaction [Methamphetamine results in decreased expression of OPRM1 protein] | 21886566 |
| D008694 | Methamphetamine | Methamphetamine results in decreased expression of OPRM1 mRNA | 21886566 |
| D008694 | Methamphetamine | Methamphetamine results in decreased expression of OPRM1 protein | 21886566 |
| D008694 | Methamphetamine | OPRM1 protein affects the susceptibility to [Methamphetamine results in decreased expression of TH mRNA] | 22329540 |
| D008694 | Methamphetamine | OPRM1 protein affects the susceptibility to [Methamphetamine results in decreased expression of TH protein] | 22329540 |
| D008694 | Methamphetamine | OPRM1 protein inhibits the reaction [Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]] | 20184921 |
| D008694 | Methamphetamine | [CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Methamphetamine | 20298714 |
| D008694 | Methamphetamine | Methamphetamine results in increased expression of OPRM1 mRNA | 15644446 |
| D003915 | Dextromethorphan | Dextromethorphan binds to OPRM1 protein | 7562497 |
| D003915 | Dextromethorphan | [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D003915 | Dextromethorphan | [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D008727 | Methotrexate | Methotrexate results in increased expression of OPRM1 mRNA | 24449571 |
| C533093 | methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate | "methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate binds to and results in increased activity of OPRM1 protein" | 24345467 |
| C587452 | methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate | "methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 24345467 |
| C587452 | methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate | "methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate results in increased activity of OPRM1 protein" | 24345467 |
| C445068 | methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate | "methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of OPRM1 protein" | 28790194 |
| C004925 | methylmercuric chloride | methylmercuric chloride results in decreased expression of OPRM1 mRNA | 23103053 |
| C032257 | methylnaltrexone | methylnaltrexone binds to OPRM1 protein | 17340127 |
| C032257 | methylnaltrexone | methylnaltrexone binds to and results in decreased activity of OPRM1 protein | 18183536 |
| D015632 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | "[Levodopa co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased activity of OPRM1 protein" | 15802193 |
| C001801 | mitragynine | "mitragynine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]" | 27192616 |
| C001801 | mitragynine | mitragynine binds to and results in increased activity of OPRM1 protein | 27192616 |
| C001801 | mitragynine | mitragynine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA] | 23608241 |
| C001801 | mitragynine | mitragynine binds to OPRM1 protein | 27192616 |
| C001801 | mitragynine | "mitragynine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]" | 27192616 |
| C121049 | mitragynine pseudoindoxyl | mitragynine pseudoindoxyl binds to and results in increased activity of OPRM1 protein | 27556704 |
| C121049 | mitragynine pseudoindoxyl | "mitragynine pseudoindoxyl inhibits the reaction [[OPRM1 protein co-treated with Enkephalin, Ala(2)-MePhe(4)-Gly(5)-] results in increased activity of ARRB2 protein]" | 27556704 |
| C121049 | mitragynine pseudoindoxyl | OPRM1 exon mutant form results in decreased susceptibility to mitragynine pseudoindoxyl | 27556704 |
| C028889 | morphiceptin | morphiceptin binds to and results in increased activity of OPRM1 protein | 8383026 |
| C028889 | morphiceptin | morphiceptin binds to and results in increased activity of OPRM1 protein | 2557556|3015659| |
| D009020 | Morphine | [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine | 21127283 |
| D009020 | Morphine | Morphine affects the activity of OPRM1 protein | 11106302 |
| D009020 | Morphine | Morphine binds to and results in increased activity of OPRM1 protein | 17656655 |
| D009020 | Morphine | Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA] | 23608241 |
| D009020 | Morphine | Morphine results in increased activity of OPRM1 protein | 26476280 |
| D009020 | Morphine | Morphine results in increased phosphorylation of OPRM1 protein | 23300227 |
| D009020 | Morphine | [[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP | 11413242 |
| D009020 | Morphine | Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]] | 23608241 |
| D009020 | Morphine | [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP | 11413242 |
| D009020 | Morphine | OPRM1 affects the susceptibility to Morphine | 23748253 |
| D009020 | Morphine | OPRM1 exon SNP results in decreased susceptibility to Morphine | 15504181 |
| D009020 | Morphine | OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein] | 20564181 |
| D009020 | Morphine | OPRM1 protein affects the susceptibility to Morphine | 22258905 |
| D009020 | Morphine | [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein | 23300227 |
| D009020 | Morphine | Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]] | 18652891 |
| D009020 | Morphine | Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| D009020 | Morphine | HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]] | 21235400 |
| D009020 | Morphine | HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]] | 21235400 |
| D009020 | Morphine | HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]] | 21235400 |
| D009020 | Morphine | HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]] | 18652891 |
| D009020 | Morphine | HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]] | 18652891 |
| D009020 | Morphine | HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| D009020 | Morphine | HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein] | 18652891 |
| D009020 | Morphine | "Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| D009020 | Morphine | Morphine binds to and affects the activity of OPRM1 protein | 19800397 |
| D009020 | Morphine | Morphine binds to and results in increased activity of OPRM1 protein | 11272841|1260540 |
| D009020 | Morphine | Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein] | 21235400 |
| D009020 | Morphine | Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein] | 21235400 |
| D009020 | Morphine | Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein] | 18652891 |
| D009020 | Morphine | Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein] | 18652891 |
| D009020 | Morphine | Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein] | 18652891|2123540 |
| D009020 | Morphine | Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein] | 21235400 |
| D009020 | Morphine | Morphine results in decreased expression of OPRM1 mRNA | 26877219 |
| D009020 | Morphine | Morphine results in increased activity of OPRM1 protein | 17996026 |
| D009020 | Morphine | [Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein | 17996026 |
| D009020 | Morphine | Morphine results in increased expression of OPRM1 protein | 21957251 |
| D009020 | Morphine | Morphine results in increased phosphorylation of OPRM1 protein | 18652891|2195725 |
| D009020 | Morphine | Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein] | 21957251 |
| D009020 | Morphine | OPRM1 affects the activity of Morphine | 12213227 |
| D009020 | Morphine | OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG] | 11590188 |
| D009020 | Morphine | OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2] | 11590188 |
| D009020 | Morphine | OPRM1 protein affects the susceptibility to Morphine | 10803207 |
| D009020 | Morphine | [phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine | 17996026 |
| D009020 | Morphine | Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| D009020 | Morphine | valyl-prolyl-aspartyl-prolyl-arginine inhibits the reaction [Morphine results in increased activity of OPRM1 protein] | 11272841 |
| D009020 | Morphine | [Zymosan co-treated with Morphine] results in increased expression of OPRM1 mRNA | 15979727 |
| D009020 | Morphine | "[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]" | 8884884 |
| D009020 | Morphine | [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid] | 8884884 |
| D009020 | Morphine | [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine | 8884884 |
| D009020 | Morphine | "Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| D009020 | Morphine | Morphine binds to and affects the activity of OPRM1 protein | 19800397 |
| D009020 | Morphine | Morphine binds to OPRM1 protein | 7562497 |
| D009020 | Morphine | [naloxonazine binds to and results in decreased activity of OPRM1 protein] which affects the susceptibility to Morphine | 9264103 |
| D009020 | Morphine | [naloxonazine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine | 8884884 |
| D009020 | Morphine | [Morphine affects the activity of OPRM1 protein] which results in decreased susceptibility to OXT protein | 9151298 |
| D009020 | Morphine | Morphine binds to and results in increased activity of OPRM1 protein | 10319781|1646444 |
| D009020 | Morphine | Morphine binds to OPRM1 protein | 12350293 |
| D009020 | Morphine | "Morphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 24345467 |
| D009020 | Morphine | [[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| D009020 | Morphine | [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| C440388 | N-(3-iodoprop-(2)-enyl) | N-(3-iodoprop-(2)-enyl) binds to OPRM1 protein | 11591513 |
| C048599 | N(6)-cyclopentyladenosine | [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to N(6)-cyclopentyladenosine | 8987795 |
| D009266 | Nalbuphine | Nalbuphine binds to and results in decreased activity of OPRM1 protein | 15810761 |
| D009266 | Nalbuphine | Nalbuphine binds to and results in increased activity of OPRM1 protein | 16517095 |
| C038981 | nalmefene | nalmefene binds to and results in decreased activity of OPRM1 protein | 9862779 |
| C038981 | nalmefene | [nalmefene binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP | 11413242 |
| C038981 | nalmefene | nalmefene binds to and results in decreased activity of OPRM1 protein | 11413242 |
| C038981 | nalmefene | [nalmefene binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| C034643 | naloxonazine | naloxonazine binds to and results in decreased activity of OPRM1 protein | 11726782 |
| C034643 | naloxonazine | [naloxonazine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to endomorphin 1 | 11726782 |
| C034643 | naloxonazine | [naloxonazine binds to and results in decreased activity of OPRM1 protein] which affects the susceptibility to Morphine | 9264103 |
| C034643 | naloxonazine | [naloxonazine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine | 8884884 |
| C034643 | naloxonazine | naloxonazine binds to and results in decreased activity of OPRM1 protein | 10802031|8884884 |
| D009270 | Naloxone | [[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP | 11413242 |
| D009270 | Naloxone | "Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]" | 27192616 |
| D009270 | Naloxone | Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]] | 23608241 |
| D009270 | Naloxone | Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein] | 21957251 |
| D009270 | Naloxone | "Cannabidiol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]" | 16489449 |
| D009270 | Naloxone | "Dronabinol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]" | 16489449 |
| D009270 | Naloxone | Naloxone binds to and results in decreased activity of OPRM1 protein | 1528399|1654493| |
| D009270 | Naloxone | [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine | 8987795 |
| D009270 | Naloxone | "[Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" | 8987795 |
| D009270 | Naloxone | [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to N(6)-cyclopentyladenosine | 8987795 |
| D009270 | Naloxone | Naloxone binds to OPRM1 protein | 7562497 |
| D009270 | Naloxone | "Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]" | 16489449 |
| D009270 | Naloxone | Naloxone binds to and results in decreased activity of OPRM1 protein | 10988119|1141324 |
| D009270 | Naloxone | [[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| D009270 | Naloxone | Naloxone binds to OPRM1 protein | 12350293|1893114 |
| D009270 | Naloxone | Naloxone results in decreased activity of OPRM1 protein | 10070497 |
| D009271 | Naltrexone | [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP | 11413242 |
| D009271 | Naltrexone | OPRM1 affects the susceptibility to Naltrexone | 18250251 |
| D009271 | Naltrexone | Naltrexone binds to OPRM1 protein | 7562497 |
| D009271 | Naltrexone | Naltrexone binds to and results in decreased activity of OPRM1 protein | 11413242|1640165 |
| D009271 | Naltrexone | [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) | 11413242 |
| D009271 | Naltrexone | Naltrexone inhibits the reaction [CYM51010 promotes the reaction [[OPRD1 protein binds to OPRM1 protein] which binds to Guanosine 5'-O-(3-Thiotriphosphate)]] | 23818586 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon analog results in decreased expression of OPRM1 mRNA" | 25554681 |
| D009538 | Nicotine | [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Nicotine | 15778877 |
| D026423 | S-Nitroso-N-Acetylpenicillamine | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]" | 18652891 |
| D026423 | S-Nitroso-N-Acetylpenicillamine | S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein] | 18652891 |
| D026423 | S-Nitroso-N-Acetylpenicillamine | S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein] | 18652891|2123540 |
| D026423 | S-Nitroso-N-Acetylpenicillamine | S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RAF1 protein] | 21235400 |
| D026423 | S-Nitroso-N-Acetylpenicillamine | S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RGS17 protein] | 18652891 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to PRKCG protein]]" | 21235400 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to RAF1 protein]]" | 21235400 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]" | 18652891 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]" | 18652891 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]" | 21235400 |
| C044387 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]]" | 21235400 |
| C025256 | nonylphenol | nonylphenol results in increased expression of OPRM1 mRNA | 15620428 |
| D009638 | Norepinephrine | [dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D009638 | Norepinephrine | [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D009638 | Norepinephrine | [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D009638 | Norepinephrine | [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D009638 | Norepinephrine | [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D009638 | Norepinephrine | [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D009638 | Norepinephrine | [Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D009638 | Norepinephrine | [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D009638 | Norepinephrine | [Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| C440369 | N-propargyl | N-propargyl binds to OPRM1 protein | 11591513 |
| D020866 | omega-Conotoxin GVIA | "omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]]" | 12031848 |
| D010098 | Oxycodone | Oxycodone binds to OPRM1 protein | 7562497 |
| D010111 | Oxymorphone | "Oxymorphone affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| D010111 | Oxymorphone | Oxymorphone binds to and affects the activity of OPRM1 protein | 19800397 |
| D010111 | Oxymorphone | "Oxymorphone affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 19800397 |
| D010111 | Oxymorphone | Oxymorphone binds to and results in increased activity of OPRM1 protein | 16343768|1759530 |
| D010269 | Paraquat | Paraquat results in decreased expression of OPRM1 mRNA | 26498265 |
| C580857 | paynantheine | paynantheine binds to OPRM1 protein | 27192616 |
| C410127 | PCB 180 | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of OPRM1 mRNA" | 25510870 |
| D020881 | Enkephalin, D-Penicillamine (2,5)- | "Enkephalin, D-Penicillamine (2,5)- binds to OPRM1 protein" | 7562497 |
| D010423 | Pentazocine | Pentazocine binds to and results in decreased activity of OPRM1 protein | 3744788 |
| C049352 | phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide | [phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine | 17996026 |
| C049352 | phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide | phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide binds to and results in decreased activity of OPRM1 protein | 17996026|9396060 |
| C049352 | phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide | "phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide promotes the reaction [deltorphin II, Ala(2)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]]" | 23818586 |
| D010672 | Phenytoin | [cyprodime binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Phenytoin | 7870991 |
| D010712 | Phosphatidic Acids | [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] | 14720217 |
| D010852 | Picrotoxin | Picrotoxin results in increased expression of OPRM1 mRNA | 15170462 |
| D010862 | Pilocarpine | Pilocarpine results in decreased expression of OPRM1 protein | 17919468 |
| D011188 | Potassium | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]]" | 12031848 |
| D011188 | Potassium | "Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]]" | 12031848 |
| D011188 | Potassium | OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines] | 12031848 |
| D011188 | Potassium | OPRM1 protein affects the reaction [Potassium results in increased transport of Barium] | 12031848 |
| D011431 | Dextropropoxyphene | Dextropropoxyphene binds to OPRM1 protein | 7562497 |
| D011431 | Dextropropoxyphene | [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D011431 | Dextropropoxyphene | [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| C017947 | sodium arsenite | sodium arsenite affects the methylation of OPRM1 gene | 28589171 |
| C580856 | speciogynine | speciogynine binds to OPRM1 protein | 27192616 |
| C580856 | speciogynine | speciogynine binds to OPRM1 protein | 27192616 |
| D012460 | Sulfasalazine | Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNA] | 11901219 |
| D012460 | Sulfasalazine | Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA] | 11901219 |
| C523979 | tapentadol | tapentadol binds to and results in increased activity of OPRM1 protein | 17656655 |
| C523979 | tapentadol | tapentadol binds to OPRM1 protein | 17656655 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of OPRM1 mRNA | 19465110 |
| D013755 | Tetradecanoylphorbol Acetate | Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNA] | 11901219 |
| D013755 | Tetradecanoylphorbol Acetate | Tetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNA | 11901219 |
| D013755 | Tetradecanoylphorbol Acetate | [Tetradecanoylphorbol Acetate co-treated with Calcium] inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| D013755 | Tetradecanoylphorbol Acetate | Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| D013755 | Tetradecanoylphorbol Acetate | Tetradecanoylphorbol Acetate inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| D013755 | Tetradecanoylphorbol Acetate | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OPRM1 mRNA | 25613284 |
| C050504 | tianeptine | tianeptine binds to and results in increased activity of OPRM1 protein | 27192616 |
| D014147 | Tramadol | Tramadol binds to OPRM1 protein | 7562497 |
| D014147 | Tramadol | [Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine | 7562497 |
| D014147 | Tramadol | [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin | 7562497 |
| D014212 | Tretinoin | mitragynine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA] | 23608241 |
| D014212 | Tretinoin | Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA] | 23608241 |
| D014212 | Tretinoin | Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]] | 23608241 |
| D014212 | Tretinoin | Tretinoin results in increased expression of OPRM1 mRNA | 23608241 |
| D014227 | Triazines | Triazines analog binds to OPRM1 protein | 12350293 |
| C447082 | tricarbonyldichlororuthenium (II) dimer | tricarbonyldichlororuthenium (II) dimer affects the expression of OPRM1 | 23358127 |
| C012589 | trichostatin A | trichostatin A affects the expression of OPRM1 mRNA | 17452465 |
| C111212 | TRK 820 | TRK 820 binds to OPRM1 protein | 22742909 |
| C111212 | TRK 820 | TRK 820 metabolite binds to OPRM1 protein | 22742909 |
| C059393 | tyrosyl-arginyl-phenylalanyl-glycinamide | tyrosyl-arginyl-phenylalanyl-glycinamide binds to and results in increased activity of OPRM1 protein | 21870874 |
| C092721 | tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine | "tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- results in increased activity of [OPRD1 protein binds to OPRM1 protein]]" | 23818586 |
| C045444 | U 69593 | U 69593 binds to OPRM1 protein | 7562497 |
| D014635 | Valproic Acid | Valproic Acid results in decreased methylation of OPRM1 gene | 29154799 |
| D014635 | Valproic Acid | Valproic Acid affects the expression of OPRM1 mRNA | 17452465 |
| C107385 | valyl-prolyl-aspartyl-prolyl-arginine | valyl-prolyl-aspartyl-prolyl-arginine inhibits the reaction [Morphine results in increased activity of OPRM1 protein] | 11272841 |
| D001335 | Vehicle Emissions | Vehicle Emissions affects the methylation of OPRM1 gene | 25560391 |
| D014801 | Vitamin A | Vitamin A affects the expression of OPRM1 mRNA | 17289162 |
| D014801 | Vitamin A | Vitamin A affects the expression of OPRM1 protein | 17289162 |
| D015032 | Zinc | calphostin C inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCA protein]] | 18652891 |
| D015032 | Zinc | calphostin C inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| D015032 | Zinc | calphostin complex inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]] | 21235400 |
| D015032 | Zinc | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]" | 18652891 |
| D015032 | Zinc | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]" | 21235400 |
| D015032 | Zinc | "N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]]" | 21235400 |
| D015032 | Zinc | RGS17 protein affects the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| D015032 | Zinc | [Tetradecanoylphorbol Acetate co-treated with Calcium] inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| D015032 | Zinc | Tetradecanoylphorbol Acetate inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 18652891 |
| D015032 | Zinc | Zinc inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]] | 21235400 |
| D015032 | Zinc | Zinc inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]] | 21235400 |
| D015032 | Zinc | Zinc promotes the reaction [OPRM1 protein binds to MAPK1 protein] | 21235400 |
| D015032 | Zinc | Zinc promotes the reaction [OPRM1 protein binds to MAPK3 protein] | 21235400 |
| D015032 | Zinc | Zinc promotes the reaction [OPRM1 protein binds to PRKCA protein] | 18652891 |
| D015032 | Zinc | Zinc promotes the reaction [OPRM1 protein binds to PRKCB protein] | 18652891 |
| D015032 | Zinc | Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein] | 18652891|2123540 |
| D015032 | Zinc | Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein] | 21235400 |
| D015032 | Zinc | Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein] | 21235400 |
| D015032 | Zinc | Zinc promotes the reaction [OPRM1 protein binds to RGS17 protein] | 18652891 |
| D015032 | Zinc | "Zinc inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]" | 2162496 |
| D015032 | Zinc | "Zinc inhibits the reaction [Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]]" | 2162496 |
| D015032 | Zinc | "Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]]" | 2162496 |
| D015054 | Zymosan | Zymosan results in increased expression of OPRM1 mRNA | 18977430 |
| D015054 | Zymosan | [Zymosan co-treated with Morphine] results in increased expression of OPRM1 mRNA | 15979727 |
| D015054 | Zymosan | Zymosan results in increased expression of OPRM1 mRNA | 15979727 |