Gene: SIX6

4990
MCOPCT2|ODRMD|OPTX2|Six9
SIX homeobox 6
protein-coding
14q23.1
Ensembl:ENSG00000184302 MIM:606326 Vega:OTTHUMG00000152339 UniprotKB:O95475
NG_008203.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.090e-1 (AD)  9.230e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIM10.98
FOXB10.971
OTP0.969
HMX20.966
LHX50.965
HMX30.952
C22orf420.951
NTS0.949
HCRT0.944
FEZF10.933

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LZTS1-0.378
MGLL-0.375
KCNH3-0.373
ANKRD24-0.367
SOHLH1-0.362
CABP1-0.357
SLC17A7-0.355
GABRD-0.35
MGAT5B-0.348
TNNT2-0.346

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SIX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SIX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIX6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SIX6 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SIX6 gene27153756
C004984apocarotenalapocarotenal results in increased expression of SIX6 mRNA17034753
C015001arsenitearsenite results in increased methylation of SIX6 promoter23974009
D019207beta Carotenebeta Carotene results in increased expression of SIX6 mRNA17034753
C006780bisphenol Abisphenol A affects the methylation of SIX6 promoter27334623
C006780bisphenol Abisphenol A affects the expression of SIX6 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SIX6 mRNA18804290
C018475butyraldehydebutyraldehyde results in increased expression of SIX6 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the expression of SIX6 mRNA18804290
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SIX6 mRNA26272509
C118739entinostatentinostat results in decreased expression of SIX6 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIX6 mRNA"27188386
D004397FonofosFonofos results in increased methylation of SIX6 promoter22847954
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SIX6 mRNA"27188386
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of SIX6 mRNA18804290
C028007nickel monoxidenickel monoxide results in decreased expression of SIX6 mRNA19167457
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIX6 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of SIX6 mRNA26272509
D010278ParathionParathion results in increased methylation of SIX6 promoter22847954
C012568terbufosterbufos results in increased methylation of SIX6 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SIX6 mRNA24058054
D013849ThimerosalThimerosal results in increased expression of SIX6 mRNA24675092
D014212TretinoinTretinoin results in decreased expression of SIX6 mRNA21934132|2372400
C012589trichostatin Atrichostatin A results in decreased expression of SIX6 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of SIX6 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased expression of SIX6 mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-IBA21873635  
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001654eye development-IBA21873635  
GO:0001654eye development-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007601visual perception-TAS10512683  
GO:0009887animal organ morphogenesis-TAS10512683  
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048856anatomical structure development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005667transcription factor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23599765Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer. (2013 Apr)Zhao YOncol Lett