Gene: ORC5

5001
ORC5L|ORC5P|ORC5T|PPP1R117
origin recognition complex subunit 5
protein-coding
7q22.1-q22.2
Ensembl:ENSG00000164815 MIM:602331 Vega:OTTHUMG00000157275 UniprotKB:O43913
NG_029899.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.956e-1 (AD)  4.241e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6949887chr7:104196893 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10260238chr7:104196532 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2385134chr7:104169681 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LZTFL10.95
GPRASP20.95
RMND10.949
CUL20.949
ATP6V1C10.946
BTBD100.945
VPS350.945
VPS33A0.944
MRPS300.943
C10orf880.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.479
OR4F5-0.455
MYL3-0.451
HEY2-0.45
RAI14-0.448
MAGEA12-0.442
YES1-0.436
RAB13-0.424
ASB4-0.422
CNN2-0.411

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ORC5 mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of ORC5 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ORC5 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ORC5 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ORC5 mRNA"19150397
D004958EstradiolEstradiol affects the expression of ORC5 mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of ORC5 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ORC5 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of ORC5 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of ORC5 mRNA25181051
C054133casticincasticin results in decreased expression of ORC5 mRNA28444820
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ORC5 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of ORC5 mRNA28302478
D004026DieldrinDieldrin results in increased expression of ORC5 mRNA23041725
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ORC5 mRNA20227414
D018120FinasterideFinasteride results in increased expression of ORC5 mRNA24136188
D005485FlutamideFlutamide results in increased expression of ORC5 mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ORC5 mRNA20044591
C544151jinfukangjinfukang results in decreased expression of ORC5 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ORC5 mRNA26011545
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ORC5 mRNA25729387
D052638Particulate MatterParticulate Matter results in increased expression of ORC5 mRNA24769257
D010705PhosgenePhosgene affects the expression of ORC5 mRNA16300373
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ORC5 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ORC5 mRNA18301758
D010936Plant ExtractsPlant Extracts results in increased expression of ORC5 mRNA23557933
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ORC5 mRNA21427059
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ORC5 mRNA18495758
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ORC5 mRNA22574217
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of ORC5 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ORC5 mRNA19770486
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ORC5 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ORC5 mRNA21934132
D014520UrethaneUrethane results in decreased expression of ORC5 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of ORC5 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of ORC5 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of ORC5 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ORC5 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ORC5 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-TAS9765232  
GO:0003674molecular_function-ND-  
GO:0003688DNA replication origin binding-IBA21873635  
GO:0003688DNA replication origin binding-TAS9765232  
GO:0005515protein binding-IPI15232106  16549788  17716973  22398447  26496610  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-TAS-  
GO:0006260DNA replication-NAS9765232  
GO:0006260DNA replication-TAS-  
GO:0006270DNA replication initiation-IBA21873635  
GO:0006270DNA replication initiation-TAS9765232  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000808origin recognition complex-IDA17716973  
GO:0005634nucleus-IDA-  
GO:0005634nucleus-NAS9765232  
GO:0005654nucleoplasm-TAS-  
GO:0005664nuclear origin of replication recognition complex-IBA21873635  
GO:0005664nuclear origin of replication recognition complex-IDA20932478  
GO:0005664nuclear origin of replication recognition complex-NAS9765232  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa04110Cell cycle
Reactome ID Reactome Term Evidence
R-HSA-113507E2F-enabled inhibition of pre-replication complex formationIEA
R-HSA-113510E2F mediated regulation of DNA replicationIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-176187Activation of ATR in response to replication stressTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-453279Mitotic G1-G1/S phasesIEA
R-HSA-68616Assembly of the ORC complex at the origin of replicationTAS
R-HSA-68689CDC6 association with the ORC:origin complexTAS
R-HSA-68827CDT1 association with the CDC6:ORC:origin complexTAS
R-HSA-68867Assembly of the pre-replicative complexTAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-68949Orc1 removal from chromatinTAS
R-HSA-68962Activation of the pre-replicative complexTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69206G1/S TransitionIEA
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-69306DNA ReplicationTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal