Gene: SLC22A18

5002
BWR1A|BWSCR1A|HET|IMPT1|ITM|ORCTL2|SLC22A1L|TSSC5|p45-BWR1A
solute carrier family 22 member 18
protein-coding
11p15.4
Ensembl:ENSG00000110628 MIM:602631 Vega:OTTHUMG00000010037 UniprotKB:Q96BI1
NG_011512.1
PubMed
0   ANCO-SNPs
AD
1   
8.508e-1 (AD)  4.984e-1 (ND)   (Frontal_Cortex)
3.344e-1 (AD)  1.980e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMYD20.768
GTPBP30.766
SERPINF10.765
SEPT60.765
TM6SF10.763
SLC22A18AS0.759
AHNAK20.752
TOX20.748
RTBDN0.748
RAB370.744

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.438
LRAT-0.433
MYOM1-0.418
ASB4-0.406
PHEX-0.403
C4orf19-0.401
HVCN1-0.401
PDLIM3-0.399
AKR1C3-0.388
GNG12-0.382

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of SLC22A18 mRNA14583596
D000082AcetaminophenAcetaminophen results in decreased expression of SLC22A18 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SLC22A18 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC22A18 mRNA27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC22A18 mRNA24449571
D001151ArsenicArsenic affects the methylation of SLC22A18 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of SLC22A18 mRNA15725085
D001379AzathioprineAzathioprine results in increased expression of SLC22A18 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC22A18 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC22A18 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SLC22A18 mRNA"20382639
C006780bisphenol Abisphenol A results in increased expression of SLC22A18 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of SLC22A18 mRNA21636974
C006780bisphenol Abisphenol A results in increased methylation of SLC22A18 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SLC22A18 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC22A18 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SLC22A18 mRNA15336504
C584509C646 compoundC646 compound results in increased expression of SLC22A18 mRNA26191083
D002994ClofibrateClofibrate results in decreased expression of SLC22A18 mRNA17585979
D019327Copper SulfateCopper Sulfate results in increased expression of SLC22A18 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of SLC22A18 mRNA17211630
D003471CuprizoneCuprizone results in increased expression of SLC22A18 mRNA26577399
D016572CyclosporineCyclosporine affects the expression of SLC22A18 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of SLC22A18 mRNA21632981|2556210
C014347decitabinedecitabine affects the expression of SLC22A18 mRNA23300844
D003976DiazinonDiazinon results in increased methylation of SLC22A18 gene22964155
C016366dibenzothiophenedibenzothiophene results in increased expression of SLC22A18 mRNA23656968
D002945CisplatinCisplatin affects the expression of SLC22A18 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SLC22A18 mRNA27392435
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of SLC22A18 gene23968726
D002117CalcitriolCalcitriol results in increased expression of SLC22A18 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SLC22A18 mRNA21592394
D004237DiuronDiuron results in increased expression of SLC22A18 mRNA21551480
D005047EtoposideSLC22A18 protein affects the susceptibility to Etoposide16217747
D005485FlutamideFlutamide results in decreased expression of SLC22A18 mRNA24793618
D005557FormaldehydeFormaldehyde results in increased expression of SLC22A18 mRNA18045764
C056933fumonisin B1fumonisin B1 results in increased expression of SLC22A18 mRNA16221962
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SLC22A18 mRNA20044591
D007052IbuprofenIbuprofen results in increased expression of SLC22A18 mRNA28201806
D007213IndomethacinIndomethacin results in increased expression of SLC22A18 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SLC22A18 mRNA27392435
C544151jinfukangjinfukang results in increased expression of SLC22A18 mRNA27392435
C410337K 7174K 7174 results in increased expression of SLC22A18 mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC22A18 mRNA"24972896
C059539midostaurinmidostaurin results in increased expression of SLC22A18 mRNA20980353
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SLC22A18 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC22A18 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC22A18 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of SLC22A18 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SLC22A18 mRNA25729387
D017239PaclitaxelSLC22A18 protein results in decreased susceptibility to Paclitaxel16734730
D010416PentachlorophenolPentachlorophenol results in increased expression of SLC22A18 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of SLC22A18 mRNA23091169
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of SLC22A18 gene23968726
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC22A18 mRNA19710929
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SLC22A18 mRNA19162173
C012526quercitrinquercitrin results in decreased expression of SLC22A18 mRNA25193878
D015474IsotretinoinIsotretinoin results in decreased expression of SLC22A18 mRNA20436886
D012643SeleniumSelenium results in increased expression of SLC22A18 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC22A18 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of SLC22A18 mRNA23922661
C016104sodium bichromatesodium bichromate affects the expression of SLC22A18 mRNA22110744
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SLC22A18 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SLC22A18 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC22A18 mRNA22298810
C009495titanium dioxidetitanium dioxide affects the expression of SLC22A18 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC22A18 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SLC22A18 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SLC22A18 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of SLC22A18 mRNA23830798
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SLC22A18 mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of SLC22A18 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC22A18 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC22A18 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of SLC22A18 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SLC22A18 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLC22A18 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of SLC22A18 gene29154799
D014640VancomycinVancomycin results in increased expression of SLC22A18 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC22A18 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC22A18 mRNA26682919
D015215ZidovudineZidovudine results in increased expression of SLC22A18 mRNA24292225
C074508zinc methioninezinc methionine results in increased expression of SLC22A18 mRNA15936645

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015238drug transmembrane transporter activity-IDA9744804  
GO:0015293symporter activity-IEA-  
GO:0015307drug:proton antiporter activity-TAS-  
GO:0031625ubiquitin protein ligase binding-IPI16314844  
GO ID GO Term Qualifier Evidence PubMed
GO:0006855drug transmembrane transport-IEA-  
GO:0007588excretion-NAS9744804  
GO:0015695organic cation transport-NAS9744804  
GO:0015893drug transport-IDA9744804  
GO:0046618drug export-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IDA16314844  
GO:0005737cytoplasm-IDA16314844  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-NAS9499412  9751628  
GO:0016324apical plasma membrane-IDA9744804  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-549127Organic cation transportTAS
R-HSA-549132Organic cation/anion/zwitterion transportTAS
R-HSA-5619066Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res