Gene info: ID 5009

Gene: OTC

GENE ID: 5009

Synonyms: OCTD

Description: ornithine carbamoyltransferase

Gene type: protein-coding

Location: Xp11.4

dbXrefs: Ensembl:ENSG00000036473 MIM:300461 Vega:OTTHUMG00000022727 UniprotKB:P00480

RefSeq: NG_008471.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CC2D2A	0.394
TMEM99	0.366
KDM1B	0.359
PCDHGA2	0.358
NT5C2	0.356
MORN5	0.356
ZNF117	0.352
ANKRD45	0.347
MKLN1	0.345
LRBA	0.345

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ALPP	-0.265
HUS1B	-0.241
PTH2	-0.234
FCAMR	-0.227
RLN3	-0.226
BLID	-0.224
LRRC37A	-0.222
FOXE3	-0.221
SPATA32	-0.213
PRPH	-0.212

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB12001	Abemaciclib	Small Molecule	1231929-97-7	Approved\|Investigational	Transporter
DB00997	Doxorubicin	Small Molecule	23214-92-8	Approved\|Investigational	Transporter
DB09154	Sodium Citrate	Small Molecule	68-04-2	Approved\|Investigational	Transporter

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of OTC mRNA"	21354444
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of OTC mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of OTC mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of OTC mRNA"	20959002
D000082	Acetaminophen	Acetaminophen results in decreased expression of OTC mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of OTC mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of OTC protein	11752693
D000082	Acetaminophen	Acetaminophen results in decreased expression of OTC mRNA	17522070\|8878780
D000082	Acetaminophen	Acetaminophen results in increased expression of OTC protein	16687475
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of OTC protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of OTC mRNA	22100608\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of OTC gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of OTC mRNA	19770486
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in increased expression of OTC protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of OTC protein	26597043
D000638	Amiodarone	Amiodarone affects the expression of OTC mRNA	19483382
D000641	Ammonia	OTC protein affects the metabolism of Ammonia	16677864
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of OTC mRNA	16483693
D064751	Ammonium Compounds	OTC gene mutant form results in increased abundance of Ammonium Compounds	3374991
D064751	Ammonium Compounds	Sodium Benzoate affects the reaction [OTC gene mutant form results in increased abundance of Ammonium Compounds]	3374991
C025657	arsenic acid	OTC protein results in increased reduction of arsenic acid	19248796
D001241	Aspirin	Aspirin results in decreased expression of OTC protein	8295421
D001553	Benzbromarone	Benzbromarone affects the expression of OTC mRNA	19483382
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of OTC mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of OTC mRNA	21871943
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of OTC mRNA	19770486
D004958	Estradiol	Estradiol results in decreased expression of OTC mRNA	20106945
D004958	Estradiol	Estradiol promotes the reaction [PRL protein results in increased activity of OTC protein]	3097147
C006780	bisphenol A	bisphenol A results in decreased expression of OTC mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of OTC mRNA	26794494
D000001	Calcimycin	[Calcimycin co-treated with Cyclosporine] results in decreased activity of OTC protein	3097147
D000001	Calcimycin	[Calcimycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [PRL protein results in increased activity of OTC protein]	3097147
D000001	Calcimycin	Calcimycin promotes the reaction [PRL protein results in increased activity of OTC protein]	3097147
D000001	Calcimycin	Calcimycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D000001	Calcimycin	Cyclosporine inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
D000001	Calcimycin	Cyclosporine inhibits the reaction [Calcimycin promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
D000001	Calcimycin	Cyclosporine inhibits the reaction [Calcimycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]]	3097147
D000001	Calcimycin	didemnins inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
D000001	Calcimycin	didemnins inhibits the reaction [Calcimycin promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
D000001	Calcimycin	didemnins inhibits the reaction [Calcimycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]]	3097147
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of OTC mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of OTC mRNA	15963342
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of OTC mRNA	17522070
D002725	Chloroform	Chloroform results in decreased expression of OTC mRNA	17522070
D002994	Clofibrate	Clofibrate affects the expression of OTC mRNA	19483382
D016572	Cyclosporine	Cyclosporine results in decreased expression of OTC mRNA	20106945\|2383089
D016572	Cyclosporine	Cyclosporine results in decreased expression of OTC mRNA	19770486\|2330838
D016572	Cyclosporine	Cyclosporine results in increased expression of OTC protein	23308384\|2504735
D016572	Cyclosporine	[Calcimycin co-treated with Cyclosporine] results in decreased activity of OTC protein	3097147
D016572	Cyclosporine	Cyclosporine inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
D016572	Cyclosporine	Cyclosporine inhibits the reaction [Calcimycin promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
D016572	Cyclosporine	Cyclosporine inhibits the reaction [Calcimycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]]	3097147
D016572	Cyclosporine	Cyclosporine inhibits the reaction [PRL protein results in increased activity of OTC protein]	3097147
D016572	Cyclosporine	Cyclosporine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
D016572	Cyclosporine	Cyclosporine promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D016572	Cyclosporine	[didemnins co-treated with Cyclosporine] results in decreased activity of OTC protein	3097147
D003907	Dexamethasone	Dexamethasone results in decreased expression of OTC mRNA	17522070
C000944	dicrotophos	dicrotophos results in decreased expression of OTC mRNA	28302478
C030051	didemnins	[didemnins co-treated with Cyclosporine] results in decreased activity of OTC protein	3097147
C030051	didemnins	didemnins inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
C030051	didemnins	didemnins inhibits the reaction [Calcimycin promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
C030051	didemnins	didemnins inhibits the reaction [Calcimycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]]	3097147
C030051	didemnins	didemnins inhibits the reaction [PRL protein results in increased activity of OTC protein]	3097147
C030051	didemnins	didemnins inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
C030051	didemnins	didemnins inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D004041	Dietary Fats	Dietary Fats results in decreased expression of OTC mRNA	25016146
D004052	Diethylnitrosamine	[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of OTC protein	20935162
D007980	Levodopa	[OTC protein modified form co-treated with PINK1 gene mutant form] results in decreased susceptibility to Levodopa	24161480
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of OTC mRNA	26159488
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of OTC mRNA	17522070
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of OTC mRNA	17108234
D005001	Ethionine	Ethionine affects the expression of OTC mRNA	19483382
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of OTC mRNA	28189721
D005485	Flutamide	Flutamide results in decreased expression of OTC mRNA	24136188
C039281	furan	furan binds to OTC protein	22240984
D005897	Glafenine	Glafenine results in decreased expression of OTC mRNA	24136188
D005998	Glycine	OTC gene mutant form affects the metabolism of Glycine	3091026
D005998	Glycine	Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Glycine]	3091026
D006072	Gossypol	Gossypol inhibits the reaction [PRL protein results in increased activity of OTC protein]	3097147
D006072	Gossypol	Gossypol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D012701	Serotonin	OTC gene mutant form affects the metabolism of Serotonin	3374991
D012701	Serotonin	Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]	3374991
D006897	Hydroxyindoleacetic Acid	OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid	3374991
D006897	Hydroxyindoleacetic Acid	Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]	3374991
D007213	Indomethacin	Indomethacin promotes the reaction [PRL protein results in increased activity of OTC protein]	3097147
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of OTC mRNA	25613284
C067713	lactacystin	lactacystin inhibits the reaction [Oxygen results in decreased metabolism of OTC protein]	11161710
C067713	lactacystin	lactacystin results in decreased metabolism of OTC protein	11161710
C008261	lead acetate	lead acetate results in increased expression of OTC mRNA	22609695
C008261	lead acetate	lead acetate results in decreased expression of OTC mRNA	11578147
D008070	Lipopolysaccharides	Lipopolysaccharides affects the expression of OTC protein	16741687
D009637	Masoprocol	Masoprocol promotes the reaction [PRL protein results in increased activity of OTC protein]	3097147
D009270	Naloxone	Naloxone results in decreased expression of OTC mRNA	17522070
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of OTC mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of OTC mRNA"	25620056
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of OTC mRNA	17522070
C051752	nefazodone	nefazodone results in decreased expression of OTC mRNA	24136188
C012655	nimesulide	nimesulide results in decreased expression of OTC mRNA	24136188
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of OTC protein	19716841
D009853	Omeprazole	Omeprazole affects the expression of OTC mRNA	19483382
D010100	Oxygen	lactacystin inhibits the reaction [Oxygen results in decreased metabolism of OTC protein]	11161710
D010100	Oxygen	Oxygen results in decreased metabolism of OTC protein	11161710
C016030	pantogab	pantogab results in decreased expression of OTC mRNA	17379144
D010269	Paraquat	Paraquat results in decreased import of OTC protein	11161710
D010269	Paraquat	Paraquat results in decreased metabolism of OTC protein	11161710
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of OTC mRNA	21723365
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of OTC mRNA	19162173\|2172336
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of OTC protein	20452409
D010634	Phenobarbital	Phenobarbital affects the expression of OTC mRNA	19159669
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of OTC mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of OTC mRNA	19482888
D010634	Phenobarbital	[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of OTC protein	20935162
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of OTC mRNA	19710929
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in decreased expression of OTC mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of OTC mRNA	16807375\|2005976
C006253	pirinixic acid	pirinixic acid results in decreased expression of OTC protein	16807375
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of OTC mRNA]	20059764
C006253	pirinixic acid	pirinixic acid affects the expression of OTC mRNA	19483382
C015586	propiverine	propiverine binds to OTC protein	29273565
C004765	propylene dichloride	propylene dichloride results in increased activity of OTC protein	2744274
D011441	Propylthiouracil	Propylthiouracil affects the expression of OTC mRNA	19483382
D011794	Quercetin	Quercetin inhibits the reaction [PRL protein results in increased activity of OTC protein]	3097147
D011794	Quercetin	Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D011796	Quinacrine	Quinacrine inhibits the reaction [PRL protein results in increased activity of OTC protein]	3097147
D011796	Quinacrine	Quinacrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D011802	Quinidine	Quinidine results in decreased expression of OTC mRNA	17522070
C089730	rosiglitazone	rosiglitazone results in decreased expression of OTC mRNA	25572481
D020160	Sodium Benzoate	Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]	3374991
D020160	Sodium Benzoate	Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Glycine]	3091026
D020160	Sodium Benzoate	Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]	3374991
D020160	Sodium Benzoate	Sodium Benzoate affects the reaction [OTC gene mutant form results in increased abundance of Ammonium Compounds]	3374991
C016104	sodium bichromate	sodium bichromate results in decreased expression of OTC mRNA	25993096
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of OTC mRNA	15885361
C501413	tesaglitazar	tesaglitazar results in decreased expression of OTC mRNA	21515302
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of OTC mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of OTC mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of OTC mRNA	16960034
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of OTC mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of OTC mRNA	16960034\|1879615
D013752	Tetracycline	Tetracycline results in decreased expression of OTC mRNA	24489787
D013752	Tetracycline	Tetracycline results in decreased expression of OTC mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of OTC mRNA	25613284
D013755	Tetradecanoylphorbol Acetate	[Calcimycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [PRL protein results in increased activity of OTC protein]	3097147
D013755	Tetradecanoylphorbol Acetate	Calcimycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D013755	Tetradecanoylphorbol Acetate	Cyclosporine inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
D013755	Tetradecanoylphorbol Acetate	Cyclosporine inhibits the reaction [Calcimycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]]	3097147
D013755	Tetradecanoylphorbol Acetate	Cyclosporine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
D013755	Tetradecanoylphorbol Acetate	Cyclosporine promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D013755	Tetradecanoylphorbol Acetate	didemnins inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
D013755	Tetradecanoylphorbol Acetate	didemnins inhibits the reaction [Calcimycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]]	3097147
D013755	Tetradecanoylphorbol Acetate	didemnins inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [PRL protein results in increased activity of OTC protein]]	3097147
D013755	Tetradecanoylphorbol Acetate	didemnins inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D013755	Tetradecanoylphorbol Acetate	Gossypol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D013755	Tetradecanoylphorbol Acetate	Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D013755	Tetradecanoylphorbol Acetate	Quinacrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein]	3097147
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [PRL protein results in increased activity of OTC protein]	3097147
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of OTC protein	3097147
D013806	Theophylline	Theophylline results in decreased expression of OTC mRNA	17522070
D013853	Thioacetamide	Thioacetamide affects the expression of OTC mRNA	19483382
D013974	Thyroxine	Thyroxine results in increased expression of OTC mRNA	17403546
C057693	troglitazone	troglitazone results in decreased expression of OTC mRNA	25572481
C057693	troglitazone	troglitazone results in increased expression of OTC protein	18495193
C057693	troglitazone	troglitazone results in decreased expression of OTC protein	21315101
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of OTC mRNA	15885361
C406224	valdecoxib	valdecoxib results in decreased expression of OTC mRNA	24136188
D014635	Valproic Acid	OTC affects the susceptibility to Valproic Acid	10227223\|9598692
D014635	Valproic Acid	Valproic Acid results in decreased expression of OTC mRNA	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of OTC gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004585	ornithine carbamoyltransferase activity	-	EXP	6372096
GO:0004585	ornithine carbamoyltransferase activity	-	IBA	21873635
GO:0004585	ornithine carbamoyltransferase activity	-	IDA	2556444 8112735
GO:0005543	phospholipid binding	-	IEA	-
GO:0016597	amino acid binding	-	IEA	-
GO:0042301	phosphate ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000050	urea cycle	-	IDA	2556444
GO:0000050	urea cycle	-	IEA	-
GO:0000050	urea cycle	-	TAS	-
GO:0001889	liver development	-	IEA	-
GO:0006593	ornithine catabolic process	-	IDA	2556444 8112735
GO:0007494	midgut development	-	IEA	-
GO:0010043	response to zinc ion	-	IEA	-
GO:0019240	citrulline biosynthetic process	-	IDA	2556444 8112735
GO:0032868	response to insulin	-	IEA	-
GO:0042450	arginine biosynthetic process via ornithine	-	IBA	21873635
GO:0055081	anion homeostasis	-	IEA	-
GO:0070207	protein homotrimerization	-	IEA	-
GO:0070781	response to biotin	-	IEA	-
GO:0097272	ammonia homeostasis	-	IMP	2556444 2575934

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IBA	21873635
GO:0005739	mitochondrion	-	IDA	3472484 6372096
GO:0005743	mitochondrial inner membrane	-	IEA	-
GO:0005759	mitochondrial matrix	-	NAS	6372096
GO:0005759	mitochondrial matrix	-	TAS	-
GO:0043231	intracellular membrane-bounded organelle	-	IBA	21873635

KEGG ID	KEGG Term
hsa00330	Arginine and proline metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1268020	Mitochondrial protein import	IEA
R-HSA-1268020	Mitochondrial protein import	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-351202	Metabolism of polyamines	TAS
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-70635	Urea cycle	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16096879	Effects of alendronate and calcitonin on bone mineral density in postmenopausal osteoporotic women. An observational study. (2005 Jun)	Hejdova M	Pharm World Sci
26410779	Protecting the BBB endothelium against cigarette smoke-induced oxidative stress using popular antioxidants: Are they really beneficial? (2015 Nov 19)	Kaisar MA	Brain Res
23520400	Association of placenta organotin concentrations with congenital cryptorchidism and reproductive hormone levels in 280 newborn boys from Denmark and Finland. (2013 Jun)	Rantakokko P	Hum Reprod
7831424	The discriminative stimulus properties of legal, over-the-counter stimulants administered singly and in binary and ternary combinations. (1993)	Gauvin DV	Psychopharmacology (Berl)
21069519	Prescribed-drug utilization and polypharmacy in a general population in Greece: association with sociodemographic, health needs, health-services utilization, and lifestyle factors. (2011 Feb)	Pappa E	Eur J Clin Pharmacol
11387540	Variations in treatment benefits influence smoking cessation: results of a randomised controlled trial. (2001 Jun)	Schauffler HH	Tob Control