Gene info: ID 501

Gene: ALDH7A1

GENE ID: 501

Synonyms: ATQ1|EPD|PDE

Description: aldehyde dehydrogenase 7 family member A1

Gene type: protein-coding

Location: 5q23.2

dbXrefs: Ensembl:ENSG00000164904 MIM:107323 Vega:OTTHUMG00000128942 UniprotKB:P49419

RefSeq: NG_008600.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.846e-1 (AD) 9.046e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ALDH6A1	0.919
ACAA2	0.918
ALDH9A1	0.905
HSDL2	0.898
PON2	0.889
HADHB	0.888
BDH2	0.883
GLUD1	0.881
RAB31	0.88
ADD3	0.879

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.487
OR4F5	-0.484
OSBPL10	-0.422
AGMAT	-0.413
PAQR9	-0.411
CACNA1F	-0.411
MIP	-0.408
MUM1L1	-0.407
IL12RB2	-0.404
FAM160A1	-0.404

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB11638	Artenimol	Small Molecule	71939-50-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C006718	1,12-benzoperylene	"1,12-benzoperylene results in increased expression of ALDH7A1 mRNA"	26377693
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ALDH7A1 mRNA"	22496397
C066841	2,3,7,8-tetrabromodibenzo-4-dioxin	"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ALDH7A1 protein"	27604104
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ALDH7A1 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ALDH7A1 mRNA"	21346803
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of ALDH7A1 mRNA"	18648102
C027576	4-hydroxy-2-nonenal	ALDH7A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal	21338592
C027576	4-hydroxy-2-nonenal	ALDH7A1 protein results in increased metabolism of 4-hydroxy-2-nonenal	21338592
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ALDH7A1 mRNA	19038236
D000079	Acetaldehyde	[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH7A1 mRNA	22285649
D000082	Acetaminophen	Acetaminophen results in decreased expression of ALDH7A1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of ALDH7A1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of ALDH7A1 protein	16538041
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ALDH7A1 gene	27153756
C000061	allysine	ALDH7A1 protein results in increased oxidation of allysine	21185811
C000061	allysine	allysine binds to ALDH7A1 protein	21185811
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of ALDH7A1 mRNA	28522335
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ALDH7A1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of ALDH7A1 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ALDH7A1 mRNA	26705709
D001379	Azathioprine	Azathioprine results in decreased expression of ALDH7A1 mRNA	22623647
C547126	AZM551248	AZM551248 results in decreased expression of ALDH7A1 mRNA	22323515
C038328	BEP protocol	BEP protocol results in increased expression of ALDH7A1 mRNA	18987330\|2320077
C004541	biochanin A	biochanin A results in decreased expression of ALDH7A1 mRNA	12111696
C006780	bisphenol A	bisphenol A results in decreased expression of ALDH7A1 mRNA	28196854
C006780	bisphenol A	bisphenol A affects the expression of ALDH7A1 mRNA	25181051
C013418	bromfenacoum	bromfenacoum results in increased expression of ALDH7A1 protein	28903499
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of ALDH7A1 mRNA	17998271
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of ALDH7A1 mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in decreased expression of ALDH7A1 mRNA	26079696
C584509	C646 compound	C646 compound results in increased expression of ALDH7A1 mRNA	26191083
D002104	Cadmium	Cadmium results in decreased expression of ALDH7A1 mRNA	24084258
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of ALDH7A1 protein	24874008
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ALDH7A1 mRNA	26472689
C100187	chloropicrin	chloropicrin results in decreased expression of ALDH7A1 mRNA	28476498
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of ALDH7A1 mRNA	20691718
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALDH7A1 gene	20938992
D002994	Clofibrate	Clofibrate results in decreased expression of ALDH7A1 mRNA	17585979
D002995	Clofibric Acid	Clofibric Acid results in increased expression of ALDH7A1 mRNA	17998271
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ALDH7A1 mRNA	19376846
D009243	NAD	NAD promotes the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]	21296058
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of ALDH7A1 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ALDH7A1 mRNA	19549813
D003407	Creosote	Creosote results in increased expression of ALDH7A1 mRNA	19389177
D016572	Cyclosporine	Cyclosporine results in decreased expression of ALDH7A1 mRNA	20106945\|2163298
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of ALDH7A1 mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of ALDH7A1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of ALDH7A1 mRNA	27392435
C000944	dicrotophos	dicrotophos results in decreased expression of ALDH7A1 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of ALDH7A1 mRNA	26924002
D004026	Dieldrin	Dieldrin results in decreased expression of ALDH7A1 mRNA	23041725
C039060	dihydroartemisinin	dihydroartemisinin analog binds to ALDH7A1 protein	26340163
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of ALDH7A1 mRNA	26924002
C019357	dioscin	dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein]	24146112
C019357	dioscin	dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein]	24146112
D004229	Dithiothreitol	Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]	21296058
D004317	Doxorubicin	ALDH7A1 protein affects the susceptibility to Doxorubicin	16217747
D000431	Ethanol	dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein]	24146112
D000431	Ethanol	Ethanol results in decreased expression of ALDH7A1 protein	24146112
D000431	Ethanol	dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein]	24146112
D000431	Ethanol	Ethanol results in decreased expression of ALDH7A1 protein	24146112
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ALDH7A1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ALDH7A1 mRNA	17557909
D005480	Flurbiprofen	Flurbiprofen results in decreased expression of ALDH7A1 mRNA	16949054
D005485	Flutamide	Flutamide results in decreased expression of ALDH7A1 mRNA	24793618
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALDH7A1 gene	20938992
C039281	furan	furan results in decreased expression of ALDH7A1 mRNA	26194646
D005839	Gentamicins	Gentamicins results in decreased expression of ALDH7A1 mRNA	22061828
D006861	Hydrogen Peroxide	ALDH7A1 protein results in decreased susceptibility to Hydrogen Peroxide	21338592
D006861	Hydrogen Peroxide	Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]	21296058
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased activity of ALDH7A1 protein	21296058
D006861	Hydrogen Peroxide	Mercaptoethanol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]	21296058
D006861	Hydrogen Peroxide	NAD promotes the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]	21296058
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of ALDH7A1 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of ALDH7A1 mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of ALDH7A1 mRNA	24086573
C008261	lead acetate	lead acetate results in increased expression of ALDH7A1 mRNA	21829687
D008623	Mercaptoethanol	Mercaptoethanol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]	21296058
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALDH7A1 gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ALDH7A1 mRNA	23103053
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ALDH7A1 mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of ALDH7A1 protein	26558463
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of ALDH7A1 protein	26558463
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of ALDH7A1 mRNA	29191790
C406082	monomethylarsonous acid	[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of ALDH7A1 promoter	18448484
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of ALDH7A1 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ALDH7A1 mRNA"	25554681\|2562005
C010463	n-hexanal	ALDH7A1 protein results in decreased susceptibility to n-hexanal	21338592
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of ALDH7A1 protein	19716841
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of ALDH7A1 mRNA	20971185
C025589	ochratoxin A	ochratoxin A results in decreased acetylation of ALDH7A1 promoter	29098329
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of ALDH7A1 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of ALDH7A1 mRNA	25729387
C046012	pentanal	pentanal results in decreased expression of ALDH7A1 mRNA	26079696
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ALDH7A1 protein	22609092
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ALDH7A1 protein	26879310
D010695	Phlorhizin	Phlorhizin results in decreased expression of ALDH7A1 mRNA	22538082
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ALDH7A1 mRNA	19710929
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of ALDH7A1 mRNA	23608068
C015586	propiverine	propiverine binds to ALDH7A1 protein	29273565
D011763	Pyrrolizidine Alkaloids	Pyrrolizidine Alkaloids results in decreased expression of ALDH7A1 mRNA	26100227
D011794	Quercetin	Quercetin results in increased expression of ALDH7A1 mRNA	21565894
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of ALDH7A1 mRNA	25351596
C017947	sodium arsenite	[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of ALDH7A1 promoter	18448484
D012999	Soman	Soman results in increased expression of ALDH7A1 mRNA	19281266
D013629	Tamoxifen	Tamoxifen affects the expression of ALDH7A1 mRNA	17555576
D013739	Testosterone	Testosterone results in decreased expression of ALDH7A1 mRNA	20403060
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH7A1 mRNA]	22496397
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of ALDH7A1 mRNA	22496397
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ALDH7A1 mRNA	22496397
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ALDH7A1 mRNA	16267337
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ALDH7A1 mRNA	18796159
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of ALDH7A1 protein	22609517
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of ALDH7A1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of ALDH7A1 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of ALDH7A1 mRNA	21934132
C057693	troglitazone	troglitazone results in increased expression of ALDH7A1 protein	18495193
D014415	Tunicamycin	Tunicamycin results in decreased expression of ALDH7A1 mRNA	22378314
D014635	Valproic Acid	Valproic Acid results in decreased expression of ALDH7A1 mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ALDH7A1 gene	29154799
D014640	Vancomycin	Vancomycin results in increased expression of ALDH7A1 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of ALDH7A1 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004029	aldehyde dehydrogenase (NAD) activity	-	ISS	-
GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	-	EXP	16491085
GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	21988832
GO:0008802	betaine-aldehyde dehydrogenase activity	-	TAS	-
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	-	IBA	21873635
GO:0043878	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006081	cellular aldehyde metabolic process	-	ISS	-
GO:0006554	lysine catabolic process	-	TAS	-
GO:0007605	sensory perception of sound	-	TAS	9417906
GO:0019285	glycine betaine biosynthetic process from choline	-	IEA	-
GO:0042426	choline catabolic process	-	TAS	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005739	mitochondrion	-	IDA	-
GO:0005759	mitochondrial matrix	-	TAS	-
GO:0005829	cytosol	-	IDA	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa00010	Glycolysis / Gluconeogenesis
hsa00053	Ascorbate and aldarate metabolism
hsa00071	Fatty acid degradation
hsa00260	Glycine, serine and threonine metabolism
hsa00280	Valine, leucine and isoleucine degradation
hsa00300	Lysine biosynthesis
hsa00310	Lysine degradation
hsa00330	Arginine and proline metabolism
hsa00340	Histidine metabolism
hsa00380	Tryptophan metabolism
hsa00410	beta-Alanine metabolism
hsa00561	Glycerolipid metabolism
hsa00620	Pyruvate metabolism
hsa00640	Propanoate metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-6788656	Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	TAS
R-HSA-6798163	Choline catabolism	TAS
R-HSA-71064	Lysine catabolism	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19038236	Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2009 Feb 12)	Prokopczyk B	Chem Biol Interact
25803269	Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner. (2015 Jun)	Filis P	J Clin Endocrinol Metab
25073604	Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways. (2014 Nov)	Zhang H	Hum Genet