Gene: OTX2

5015
CPHD6|MCOPS5
orthodenticle homeobox 2
protein-coding
14q22.3
Ensembl:ENSG00000165588 MIM:600037 Vega:OTTHUMG00000152338 UniprotKB:P32243
NG_008204.1
PubMed
0   ANCO-SNPs
CD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.784e-1 (AD)  4.702e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIM10.812
UNCX0.806
PAGE40.806
SIX60.804
LHX90.801
HMX30.8
CCDC1400.784
ELSPBP10.777
LHX50.775
FOXB10.775

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOHLH1-0.349
ANKRD24-0.337
MGLL-0.331
NXPH3-0.328
CABP1-0.323
SCRT1-0.323
COL5A3-0.313
MOXD1-0.31
TNNT2-0.31
ANO8-0.307

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of OTX2 mRNA16788091
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of OTX2 mRNA"9006080
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"bexarotene inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of OTX2 mRNA]"9006080
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of OTX2 mRNA22634333
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of OTX2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of OTX2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of OTX2 mRNA16483693
C015001arsenitearsenite results in increased methylation of OTX2 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of OTX2 mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OTX2 mRNA21839799
C095105bexarotene"bexarotene inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of OTX2 mRNA]"9006080
C006780bisphenol Abisphenol A results in increased expression of OTX2 mRNA25181051
D002104CadmiumCadmium results in increased expression of OTX2 mRNA24482418
D019256Cadmium ChlorideCadmium Chloride affects the expression of OTX2 mRNA18974090
D002220CarbamazepineCarbamazepine affects the expression of OTX2 mRNA25979313
C473710Chir 98014Chir 98014 results in decreased expression of OTX2 mRNA22723015
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OTX2 gene20938992
D003300CopperCopper results in decreased expression of OTX2 mRNA26293553
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of OTX2 mRNA26033743
D003300CopperCopper deficiency results in increased expression of OTX2 mRNA26033743
D003471CuprizoneCuprizone results in increased expression of OTX2 mRNA26577399
D003976DiazinonDiazinon affects the localization of OTX2 protein18224450
D003976DiazinonDiazinon results in decreased expression of OTX2 mRNA29108742
D004026DieldrinDieldrin results in decreased expression of OTX2 mRNA28385952
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of OTX2 mRNA26033743
C061365flusilazoleflusilazole affects the expression of OTX2 mRNA22634333
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OTX2 gene20938992
D006046GoldGold analog results in decreased expression of OTX2 mRNA23549158
D007608Kainic AcidKainic Acid results in decreased expression of OTX2 mRNA19700661
C008261lead acetatelead acetate affects the expression of OTX2 mRNA21864555
C008261lead acetatelead acetate results in decreased expression of OTX2 mRNA22641619
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OTX2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of OTX2 mRNA28001369
C020771methylmercury hydroxidemethylmercury hydroxide results in increased expression of OTX2 mRNA20493249
D0156551-Methyl-4-phenylpyridiniumOTX2 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium20573704
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
D010416PentachlorophenolPentachlorophenol results in decreased expression of OTX2 mRNA24642059
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of OTX2 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of OTX2 mRNA23557933
C513428pyrachlostrobinpyrachlostrobin results in increased expression of OTX2 mRNA27029645
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of OTX2 mRNA21427059
D012834SilverSilver results in decreased expression of OTX2 mRNA26551752
C017947sodium arsenitesodium arsenite affects the methylation of OTX2 gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of OTX2 mRNA24058054
D014212TretinoinTretinoin results in decreased expression of OTX2 mRNA21934132
D014212TretinoinTretinoin affects the expression of OTX2 mRNA16211290
D014212TretinoinTretinoin results in decreased expression of OTX2 mRNA16788091|2142705
D014212TretinoinTretinoin results in decreased expression of OTX2 mRNA20488242
C011559tributyltintributyltin results in increased expression of OTX2 mRNA21683754
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of OTX2 mRNA22723015|2493525
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTX2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of OTX2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of OTX2 mRNA22723015|2317975
D014635Valproic AcidValproic Acid results in decreased expression of OTX2 mRNA19136453|2054688
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of OTX2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA12559959  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA12559959  20530484  
GO:0005515protein binding-IPI20530484  
GO:0008190eukaryotic initiation factor 4E binding-TAS15705863  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007411axon guidance-IDA16267555  
GO:0008589regulation of smoothened signaling pathway-TAS15705863  
GO:0030900forebrain development-TAS15705863  
GO:0030901midbrain development-TAS15705863  
GO:0040019positive regulation of embryonic development-ISS-  
GO:0040036regulation of fibroblast growth factor receptor signaling pathway-TAS15705863  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12559959  20530484  
GO:0065003protein-containing complex assembly-IDA20530484  
GO:0071542dopaminergic neuron differentiation-IGI19951692  
GO:0071542dopaminergic neuron differentiation-TAS24431302  
GO:0090009primitive streak formation-ISS-  
GO:2000543positive regulation of gastrulation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA24399192  
GO:0030426growth cone-IDA16267555  
GO:0032991protein-containing complex-IDA20530484  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24802313New insights into septo-optic dysplasia. (2014)Saranac LPril (Makedon Akad Nauk Umet Odd Med Nauki)