Gene: OXT

5020
OT|OT-NPI|OXT-NPI
oxytocin/neurophysin I prepropeptide
protein-coding
20p13
Ensembl:ENSG00000101405 MIM:167050 Vega:OTTHUMG00000031724 UniprotKB:P01178
NC_000020.11
PubMed
0   ANCO-SNPs
CD|ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.872e-2 (AD)  8.529e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AVP0.952
OTP0.925
LHX50.921
FOXB10.92
HMX20.919
HCRT0.918
SIM10.901
C22orf420.899
NTS0.898
SIX60.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RGS5-0.354
LZTS1-0.351
MGLL-0.349
CYTH3-0.341
SHANK3-0.322
ANKS1A-0.315
SLC38A11-0.314
MLLT6-0.311
DDN-0.311
KCNH3-0.311

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00107OxytocinBiotechDrug50-56-6ApprovedTarget
ID Drug Name Action PubMed
C42256513beta-methyl 19-nor-steroid13beta-methyl 19-nor-steroid inhibits the reaction [OXT protein results in increased secretion of Dinoprost]16797624
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of [OXT protein binds to and results in increased activity of OXTR protein]"12955084
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of OXT mRNA"19383538
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [OXT protein binds to and results in increased activity of OXTR protein]12955084
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [LHB protein results in increased secretion of OXT protein]"16780177
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of OXT mRNA"19383538
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased secretion of OXT protein"16780177|1696709
C0140242,4,5,2',4',5'-hexachlorobiphenyl"Genistein inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased secretion of OXT protein]"16967098
C0140242,4,5,2',4',5'-hexachlorobiphenyl"Mifepristone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased secretion of OXT protein]"16967098
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of OXT mRNA"20206263
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the reaction [LHB protein results in increased secretion of OXT protein]"16780177
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl results in increased expression of OXT mRNA"19383538|2063357
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl results in increased secretion of OXT protein"16780177|1696709
C0284513,4,3',4'-tetrachlorobiphenyl"Genistein inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased secretion of OXT protein]"16967098
C0284513,4,3',4'-tetrachlorobiphenyl"Mifepristone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased secretion of OXT protein]"16967098
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the reaction [LHB protein results in increased secretion of OXT protein]"16780177
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of OXT mRNA"19383538
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of OXT protein"16780177|1696709
C0230353,4,5,3',4'-pentachlorobiphenyl"Genistein inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of OXT protein]"16967098
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of OXT mRNA23664861
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of OXT mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of OXT mRNA]17585979
D000255Adenosine TriphosphateAdenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]11102496
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased secretion of OXT protein11102496
D000255Adenosine Triphosphate"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein]"11102496
D000255Adenosine Triphosphate"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]"11102496
D000420AlbuterolAlbuterol results in decreased susceptibility to OXT protein8680739
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [HTR2A protein results in increased secretion of OXT protein]"19304867
D000643Ammonium ChlorideAmmonium Chloride affects the expression of OXT mRNA16483693
D016718Arachidonic AcidArachidonic Acid promotes the reaction [OXT protein results in increased secretion of Dinoprost]16254031
C028617aroclor 1248aroclor 1248 results in increased expression of OXT mRNA19383538
C028617aroclor 1248aroclor 1248 results in increased secretion of OXT protein16967098
C047046atosiban[atosiban results in decreased activity of OXTR protein] inhibits the reaction [OXT protein results in decreased susceptibility to Methamphetamine]18092152
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OXT mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of OXT mRNA21839799
D004958EstradiolESR2 affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA]12834440
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA12834440
D004958Estradiol[Estradiol co-treated with OXT protein] results in increased expression of SLC5A5 mRNA16954431
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in increased expression of OXT mRNA26945725
D004958EstradiolEstradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form]22265196
D004958EstradiolEstradiol results in increased expression of OXT mRNA17010207|1740080
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in increased expression of OXT mRNA]17400809
C006780bisphenol Abisphenol A results in decreased expression of OXT mRNA22707478
C006780bisphenol Abisphenol A affects the expression of OXT mRNA27571134
C006780bisphenol Abisphenol A results in decreased expression of OXT mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of OXT mRNA17010207|2366486
C057368BRL 37344[BRL 37344 binds to and results in increased activity of ADRB3 protein] which results in decreased activity of OXT protein17632099
C057368BRL 37344[ICI 118551 binds to and results in decreased activity of ADRB2 protein] affects the reaction [[BRL 37344 binds to and results in increased activity of ADRB3 protein] which results in decreased activity of OXT protein]17632099
D020148Butyric AcidButyric Acid results in increased expression of OXT mRNA22687346
D002118CalciumOXT protein promotes the reaction [TRPC3 protein results in increased transport of Calcium]12700192
D002118Calcium[Thapsigargin results in increased transport of Calcium] which results in increased secretion of OXT protein22028774
D002118CalciumOXT protein results in increased abundance of Calcium16997130
D002118CalciumOXT protein results in increased transport of Calcium21370738
D002118CalciumProgesterone affects the reaction [OXT protein results in increased abundance of Calcium]16997130
D002118CalciumProgesterone inhibits the reaction [OXT protein results in increased transport of Calcium]21370738
D002118Calcium[KB 5-21 binds to and results in decreased activity of OXTR protein] inhibits the reaction [[OXT protein binds to OXTR protein] which results in increased abundance of Calcium]11181528
D002118Calcium[OXT protein binds to OXTR protein] which results in increased abundance of Calcium11181528
D002118CalciumOXT protein results in increased transport of Calcium3742162
D004390ChlorpyrifosChlorpyrifos results in decreased expression of OXT mRNA25889763
D004390ChlorpyrifosChlorpyrifos results in increased expression of OXT protein19165396
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of OXT mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of OXT mRNA]17585979
D003024ClozapineOXT protein affects the susceptibility to Clozapine20196918
D003024ClozapineClozapine results in decreased susceptibility to OXT protein16005055
D005576ColforsinBMP6 protein inhibits the reaction [Colforsin results in increased expression of OXT mRNA]18936084
D003375CoumestrolCoumestrol results in increased expression of OXT mRNA21656645
D003375CoumestrolCoumestrol results in increased secretion of OXT protein16967098|2165664
D019806CromakalimCromakalim results in decreased susceptibility to OXT protein2444298|8680739
D019806CromakalimProcaine inhibits the reaction [Cromakalim results in decreased susceptibility to OXT protein]2444298
D0150842,4-Dichlorophenoxyacetic Acid"2,4-Dichlorophenoxyacetic Acid results in decreased secretion of OXT protein"20122984
C004742daidzeindaidzein results in increased secretion of OXT protein16967098
D003634DDTDDT results in increased expression of OXT mRNA19383538|2063357
D003634DDTDDT results in increased secretion of OXT protein modified form27894940
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of OXT mRNA23914054
D013759DronabinolDronabinol results in decreased expression of OXT mRNA16513365
D013759DronabinolDronabinol results in decreased expression of OXT protein alternative form16513365
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of OXT mRNA19383538|2063357
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased secretion of OXT protein modified form27894940
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of OXT mRNA17010207
D004110DiltiazemDiltiazem results in decreased susceptibility to OXT protein3742162
D004967EstrogensEstrogens results in increased expression of OXT protein16554389
D000431EthanolEthanol results in increased expression of OXT mRNA23342055
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of OXT mRNA27571134
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of OXT mRNA15834898|1735126
D005419FlavonoidsFlavonoids results in increased expression of OXT mRNA18035473
D005444FlunarizineFlunarizine results in decreased susceptibility to OXT protein2339153|2806374
D005473FluoxetineFluoxetine results in decreased expression of OXT mRNA17033635
C070081fulvestrantfulvestrant results in increased expression of OXT mRNA15842231
D019833Genistein"Genistein inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased secretion of OXT protein]"16967098
D019833Genistein"Genistein inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased secretion of OXT protein]"16967098
D019833Genistein"Genistein inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of OXT protein]"16967098
D019833GenisteinGenistein results in increased secretion of OXT protein16967098
D006152Cyclic GMP[OXT protein affects the activity of OXTR protein] which results in increased abundance of Cyclic GMP9874809
D006152Cyclic GMPOXT protein promotes the reaction [Nitric Oxide results in increased abundance of Cyclic GMP]9874809
D006152Cyclic GMPOXT protein promotes the reaction [NPPA protein results in increased secretion of Cyclic GMP]9874809
D012701SerotoninOXT protein results in increased secretion of Serotonin19228979
D006854HydrocortisoneOXT protein affects the abundance of Hydrocortisone16554389
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"[Vasotocin analog binds to and results in decreased activity of AVPR1A protein] inhibits the reaction [OXT protein affects the activity of 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]"1399968
C026777ICI 118551[ICI 118551 binds to and results in decreased activity of ADRB2 protein] affects the reaction [[BRL 37344 binds to and results in increased activity of ADRB3 protein] which results in decreased activity of OXT protein]17632099
C026777ICI 118551[ICI 118551 binds to and results in decreased activity of ADRB2 protein] affects the reaction [[Ritodrine binds to and results in increased activity of ADRB2 protein] which results in decreased activity of OXT protein]17632099
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of OXT mRNA25613284
D014668Vasotocin"[Vasotocin analog binds to and results in decreased activity of AVPR1A protein] inhibits the reaction [OXT protein affects the activity of 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]"1399968
D014668VasotocinVasotocin analog results in decreased activity of OXT protein16005055|2767126
D014668VasotocinVasotocin analog results in decreased susceptibility to OXT protein16005055
C094211JTP 4819JTP 4819 results in decreased degradation of OXT protein modified form7562510
C055830KB 5-21[KB 5-21 binds to and results in decreased activity of OXTR protein] inhibits the reaction [[OXT protein binds to OXTR protein] which results in increased abundance of Calcium]11181528
D008094LithiumLithium results in increased expression of OXT mRNA11739594
D008094LithiumLithium results in increased secretion of OXT protein11739594
D008694MethamphetamineMethamphetamine affects the expression of OXT mRNA19564919
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] affects the expression of OXT mRNA19564919
D008694Methamphetamine[atosiban results in decreased activity of OXTR protein] inhibits the reaction [OXT protein results in decreased susceptibility to Methamphetamine]18092152
D008694MethamphetamineOXT protein results in decreased susceptibility to Methamphetamine18092152
D008751Methylene BlueMethylene Blue results in decreased susceptibility to OXT protein7870289
D008803MianserinMianserin results in decreased susceptibility to OXT protein8001637
D015735Mifepristone"Mifepristone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased secretion of OXT protein]"16967098
D015735Mifepristone"Mifepristone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased secretion of OXT protein]"16967098
D015735MifepristoneMifepristone inhibits the reaction [OXT protein binds to OXTR protein]16797624
D015735MifepristoneMifepristone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]16797624
D009020Morphine[Morphine affects the activity of OPRM1 protein] which results in decreased susceptibility to OXT protein9151298
D009020MorphineMorphine inhibits the reaction [OXT protein results in increased abundance of Nitrates]9151298
D009020MorphineMorphine inhibits the reaction [OXT protein results in increased abundance of Nitrites]9151298
D009020MorphineMorphine results in decreased susceptibility to OXT protein1315136
D009020MorphineNaloxone inhibits the reaction [Morphine inhibits the reaction [OXT protein results in increased abundance of Nitrates]]9151298
D009020MorphineNaloxone inhibits the reaction [Morphine inhibits the reaction [OXT protein results in increased abundance of Nitrites]]9151298
D009020MorphineNaloxone inhibits the reaction [Morphine results in decreased susceptibility to OXT protein]1315136
C568376MT19c compoundMT19c compound results in decreased expression of OXT mRNA21781307
D009270NaloxoneNaloxone inhibits the reaction [Morphine inhibits the reaction [OXT protein results in increased abundance of Nitrates]]9151298
D009270NaloxoneNaloxone inhibits the reaction [Morphine inhibits the reaction [OXT protein results in increased abundance of Nitrites]]9151298
D009270NaloxoneNaloxone inhibits the reaction [Morphine results in decreased susceptibility to OXT protein]1315136
D009529NicardipineNicardipine results in decreased susceptibility to OXT protein2339153|2806374
D009543NifedipineNifedipine results in decreased susceptibility to OXT protein2339153|2806374|
D009553NimodipineNimodipine results in decreased susceptibility to OXT protein2339153|2806374
D009566NitratesMorphine inhibits the reaction [OXT protein results in increased abundance of Nitrates]9151298
D009566NitratesNaloxone inhibits the reaction [Morphine inhibits the reaction [OXT protein results in increased abundance of Nitrates]]9151298
D009566NitratesOXT protein affects the abundance of Nitrates9874809
D009566NitratesOXT protein results in increased abundance of Nitrates9151298
D009569Nitric OxideOXT protein promotes the reaction [Nitric Oxide results in increased abundance of Cyclic GMP]9874809
D009573NitritesMorphine inhibits the reaction [OXT protein results in increased abundance of Nitrites]9151298
D009573NitritesNaloxone inhibits the reaction [Morphine inhibits the reaction [OXT protein results in increased abundance of Nitrites]]9151298
D009573NitritesOXT protein results in increased abundance of Nitrites9151298
C025256nonylphenolnonylphenol results in increased expression of OXT mRNA17010207
D009640NorethindroneNorethindrone results in decreased susceptibility to OXT protein5784655
C474055octylphenoloctylphenol results in increased expression of OXT mRNA17010207
D0173718-Hydroxy-2-(di-n-propylamino)tetralin[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form22265196
D0173718-Hydroxy-2-(di-n-propylamino)tetralinEstradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form]22265196
C064578oxytocin, Pen(1)-(4-MePhe)(2)-Thr(4)-Orn(8)-"oxytocin, Pen(1)-(4-MePhe)(2)-Thr(4)-Orn(8)- analog results in decreased activity of OXT protein"2780415
C064578oxytocin, Pen(1)-(4-MePhe)(2)-Thr(4)-Orn(8)-"oxytocin, Pen(1)-(4-MePhe)(2)-Thr(4)-Orn(8)- results in decreased activity of OXT protein"2767126
C064578oxytocin, Pen(1)-(4-MePhe)(2)-Thr(4)-Orn(8)-"oxytocin, Pen(1)-(4-MePhe)(2)-Thr(4)-Orn(8)- results in decreased susceptibility to OXT protein"2767126
D017239PaclitaxelPaclitaxel analog results in increased expression of OXT mRNA15585946
D017239PaclitaxelPaclitaxel results in increased expression of OXT mRNA15585946
D037342Pertussis ToxinPertussis Toxin results in decreased activity of [OXT protein binds to and results in increased activity of OXTR protein]12955084
D015232DinoprostoneOXT protein results in increased abundance of Dinoprostone21370738
D015232DinoprostoneOXT protein results in increased secretion of Dinoprostone16997130
D015232DinoprostoneProgesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprostone]16997130
D010656PhenylephrineAdenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]11102496
D010656PhenylephrinePhenylephrine results in increased secretion of OXT protein15149956
D010656Phenylephrine"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]"11102496
D010716PhosphatidylinositolsProgesterone inhibits the reaction [OXT protein results in increased abundance of Phosphatidylinositols]16254031
D010936Plant ExtractsPlant Extracts results in decreased expression of OXT mRNA23557933
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in increased expression of OXT mRNA26945725
D011224PrazosinPrazosin results in increased expression of OXT protein1791990
D011343ProcaineProcaine inhibits the reaction [Cromakalim results in decreased susceptibility to OXT protein]2444298
D011374ProgesteroneESR2 affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA]12834440
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA12834440
D011374ProgesteroneProgesterone inhibits the reaction [OXT protein binds to OXTR protein]16254031|1762952
D011374ProgesteroneProgesterone inhibits the reaction [OXT protein results in increased abundance of Phosphatidylinositols]16254031
D011374ProgesteroneProgesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]16254031
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in increased expression of OXT mRNA]17400809
D011374ProgesteroneProgesterone affects the reaction [OXT protein results in increased abundance of Calcium]16997130
D011374ProgesteroneProgesterone inhibits the reaction [OXT protein results in increased abundance of Dinoprost]21370738
D011374ProgesteroneProgesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]16997130
D011374ProgesteroneProgesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprostone]16997130
D011374ProgesteroneProgesterone inhibits the reaction [OXT protein results in increased transport of Calcium]21370738
D015237Dinoprost13beta-methyl 19-nor-steroid inhibits the reaction [OXT protein results in increased secretion of Dinoprost]16797624
D015237DinoprostMifepristone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]16797624
D015237DinoprostOXT protein results in increased secretion of Dinoprost16797624
D015237DinoprostArachidonic Acid promotes the reaction [OXT protein results in increased secretion of Dinoprost]16254031
D015237DinoprostProgesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]16254031
D015237DinoprostOXT protein results in increased abundance of Dinoprost21370738
D015237DinoprostOXT protein results in increased secretion of Dinoprost16997130
D015237DinoprostProgesterone inhibits the reaction [OXT protein results in increased abundance of Dinoprost]21370738
D015237DinoprostProgesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]16997130
C428725pyridabenpyridaben results in decreased expression of OXT mRNA22563483
C077792pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein]"11102496
C077792pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]"11102496
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of OXT mRNA15842231
D016713RitanserinRitanserin results in decreased susceptibility to OXT protein8001637
D012312Ritodrine[ICI 118551 binds to and results in decreased activity of ADRB2 protein] affects the reaction [[Ritodrine binds to and results in increased activity of ADRB2 protein] which results in decreased activity of OXT protein]17632099
D012312Ritodrine[Ritodrine binds to and results in increased activity of ADRB2 protein] which results in decreased activity of OXT protein17632099
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] affects the expression of OXT mRNA19564919
C534628SCH 23390SCH 23390 affects the expression of OXT mRNA19564919
D013629TamoxifenTamoxifen results in increased expression of OXT mRNA15842231
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of OXT mRNA25613284
D019284Thapsigargin[Thapsigargin results in increased transport of Calcium] which results in increased secretion of OXT protein22028774
D014118Toxins, Biological"Toxins, Biological affects the expression of OXT mRNA"19682533
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of OXT mRNA"26179874
C101044tyrphostin AG 1478[tyrphostin AG 1478 results in decreased activity of EGFR protein] results in decreased activity of [OXT protein binds to and results in increased activity of OXTR protein]12955084
D014635Valproic AcidValproic Acid results in increased expression of OXT mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of OXT mRNA17292431
C025043vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-"vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine- analog results in decreased activity of OXT protein"2780415
C025043vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-"vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine- results in decreased activity of OXT protein"2767126
C025043vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-"vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine- results in decreased susceptibility to OXT protein"2767126
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of OXT gene25487561
D014700VerapamilVerapamil results in decreased susceptibility to OXT protein2339153|2806374

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005185neurohypophyseal hormone activity-IEA-  
GO:0031855oxytocin receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001975response to amphetamine-IEA-  
GO:0002027regulation of heart rate-IEA-  
GO:0002125maternal aggressive behavior-IEA-  
GO:0007165signal transduction-TAS10218979  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007507heart development-IEA-  
GO:0007565female pregnancy-IEA-  
GO:0007613memory-IEA-  
GO:0007625grooming behavior-IEA-  
GO:0009744response to sucrose-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010701positive regulation of norepinephrine secretion-IEA-  
GO:0014823response to activity-IEA-  
GO:0030431sleep-IEA-  
GO:0032094response to food-IEA-  
GO:0032308positive regulation of prostaglandin secretion-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0032526response to retinoic acid-IEA-  
GO:0032570response to progesterone-IEA-  
GO:0034695response to prostaglandin E-IEA-  
GO:0035176social behavior-IEA-  
GO:0035811negative regulation of urine volume-IEA-  
GO:0035815positive regulation of renal sodium excretion-IEA-  
GO:0042220response to cocaine-IEA-  
GO:0042538hyperosmotic salinity response-IEA-  
GO:0042711maternal behavior-IEA-  
GO:0042713sperm ejaculation-IEA-  
GO:0042755eating behavior-IEA-  
GO:0042756drinking behavior-IEA-  
GO:0043434response to peptide hormone-IEA-  
GO:0045472response to ether-IEA-  
GO:0045776negative regulation of blood pressure-IEA-  
GO:0045777positive regulation of blood pressure-IEA-  
GO:0045778positive regulation of ossification-IEA-  
GO:0045925positive regulation of female receptivity-IEA-  
GO:0050806positive regulation of synaptic transmission-IEA-  
GO:0051384response to glucocorticoid-IEA-  
GO:0051591response to cAMP-IEA-  
GO:0051602response to electrical stimulus-IEA-  
GO:0051930regulation of sensory perception of pain-IEA-  
GO:0051965positive regulation of synapse assembly-IEA-  
GO:0060179male mating behavior-IEA-  
GO:0060406positive regulation of penile erection-IEA-  
GO:0060450positive regulation of hindgut contraction-IEA-  
GO:0060455negative regulation of gastric acid secretion-IEA-  
GO:0070474positive regulation of uterine smooth muscle contraction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0030141secretory granule-IEA-  
GO:0043195terminal bouton-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388479Vasopressin-like receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
3593487Effects of neurohypophyseal peptide hormones on alcohol dependence and withdrawal. (1987)Szabo GAlcohol Alcohol
29021442The Relationship between the Serum Oxytocin Levels, Disease Activity, the ADLs and the QOL in Patients with Rheumatoid Arthritis. (2017 Dec 1)Miwa YIntern Med
26810371Oxytocin inhibits ethanol consumption and ethanol-induced dopamine release in the nucleus accumbens. (2017 May)Peters STAddict Biol
29040351Oxytocin Genotype Moderates the Impact of Social Support on Psychiatric Distress in Alcohol-Dependent Patients. (2018 Jan 1)Love TMAlcohol Alcohol
27818356Association between oxytocin and receptor genetic polymorphisms and aggression in a northern Chinese Han population with alcohol dependence. (2017 Jan 1)Yang LNeurosci Lett
29657870Is the serum oxytocin level altered by treatment in rheumatoid arthritis patients complicated with depression? (2018 Mar)Miwa YEur J Rheumatol
9924746Oxytocin and addiction: a review. (1998 Nov)Kovacs GLPsychoneuroendocrinology
23126471Differential effects of baclofen and oxytocin on the increased ethanol consumption following chronic psychosocial stress in mice. (2013 Jan)Peters SAddict Biol