Gene info: ID 5021

Gene: OXTR

GENE ID: 5021

Synonyms: OT-R

Description: oxytocin receptor

Gene type: protein-coding

Location: 3p25.3

dbXrefs: Ensembl:ENSG00000180914 MIM:167055 Vega:OTTHUMG00000090537 UniprotKB:P30559

RefSeq: NC_000003.12

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 4

Sherlock p-value : NA (AD) 5.362e-1 (ND) (Frontal_Cortex)

Pascal p-value : 2.810e-2 (AD) 7.664e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs17049541	chr3:8778715 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs237899	chr3:8766829 (GRCh38.p7)	G>A / G>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC44A3	0.701
TRAF3IP2	0.695
MGST1	0.685
TMBIM1	0.684
TMPRSS3	0.673
OSBPL11	0.671
NQO1	0.667
TNFRSF1A	0.658
LIMK2	0.653
RFX4	0.645

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PPEF1	-0.446
NEUROD6	-0.43
ABCC12	-0.423
VIT	-0.414
NXPH2	-0.413
CASC15	-0.402
DUSP27	-0.399
LHX6	-0.397
AGMAT	-0.395
PTCHD4	-0.394

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00107	Oxytocin	BiotechDrug	50-56-6	Approved	Target
DB01282	Carbetocin	Small Molecule	37025-55-1	Approved\|Investigational	Target
DB13929	Relcovaptan	Small Molecule	150375-75-0	Investigational	Target

ID	Drug Name	Action	PubMed
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of [OXT protein binds to and results in increased activity of OXTR protein]"	12955084
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [OXT protein binds to and results in increased activity of OXTR protein]	12955084
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of OXTR mRNA"	19167446
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of OXTR mRNA	23664861
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of OXTR protein	23664861
D000336	Aerosols	[[Ozone results in increased oxidation of Particulate Matter] which results in increased chemical synthesis of Aerosols] which results in decreased expression of OXTR mRNA	25361045
D000336	Aerosols	[[Ozone results in increased oxidation of Vehicle Emissions] which results in increased chemical synthesis of Aerosols] which results in decreased expression of OXTR mRNA	25361045
D000393	Air Pollutants	Air Pollutants analog results in increased expression of OXTR mRNA	21757418
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of OXTR mRNA	16483693
C032739	aroclor 1221	aroclor 1221 results in decreased expression of OXTR mRNA	26620572
C015001	arsenite	arsenite results in increased methylation of OXTR promoter	23974009
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in decreased expression of OXTR mRNA"	20831825
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of OXTR mRNA"	20831825
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of OXTR mRNA"	18687144\|2535159
C047046	atosiban	atosiban binds to and results in decreased activity of OXTR protein	10440088\|1937157
C047046	atosiban	atosiban results in decreased activity of OXTR protein	18092152
C047046	atosiban	[atosiban results in decreased activity of OXTR protein] inhibits the reaction [OXT protein results in decreased susceptibility to Methamphetamine]	18092152
D001374	Azacitidine	Azacitidine results in decreased expression of OXTR mRNA	21245298
C547126	AZM551248	AZM551248 results in decreased expression of OXTR mRNA	22323515
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of OXTR mRNA"	20382639
D004958	Estradiol	EGF protein inhibits the reaction [Estradiol results in decreased expression of OXTR mRNA]	24758408
D004958	Estradiol	Estradiol results in decreased expression of OXTR mRNA	19167446\|2475840
D004958	Estradiol	Estradiol results in increased expression of OXTR mRNA	19484750
D004958	Estradiol	Estradiol results in increased expression of OXTR mRNA	23664861
D004958	Estradiol	Estradiol results in increased expression of OXTR protein	23664861
D001640	Bicuculline	"Bicuculline inhibits the reaction [oxytocin, Thr(4)-Gly(7)- results in increased activity of OXTR protein]"	11069593
C006780	bisphenol A	bisphenol A results in decreased expression of OXTR mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of OXTR mRNA	21980460
C006780	bisphenol A	bisphenol A results in decreased expression of OXTR mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of OXTR mRNA	23664861\|2909715
C018475	butyraldehyde	butyraldehyde results in increased expression of OXTR mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of OXTR mRNA	24982889
D002118	Calcium	[KB 5-21 binds to and results in decreased activity of OXTR protein] inhibits the reaction [[OXT protein binds to OXTR protein] which results in increased abundance of Calcium]	11181528
D002118	Calcium	[OXT protein binds to OXTR protein] which results in increased abundance of Calcium	11181528
D002220	Carbamazepine	Carbamazepine affects the expression of OXTR mRNA	25979313
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of OXTR mRNA	20682304
D003042	Cocaine	Cocaine affects the expression of OXTR protein	15380831
D003042	Cocaine	"Cocaine affects the reaction [vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 binds to OXTR protein]"	15380831
D019327	Copper Sulfate	Copper Sulfate results in increased expression of OXTR mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of OXTR mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of OXTR mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of OXTR mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of OXTR mRNA	27989131
C014347	decitabine	decitabine inhibits the reaction [Smoke results in decreased expression of OXTR mRNA]	21095227
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of OXTR mRNA	27392435
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of OXTR mRNA	26033743
D002117	Calcitriol	Calcitriol results in decreased expression of OXTR mRNA	26485663
D002117	Calcitriol	Calcitriol results in increased expression of OXTR mRNA	16002434
D004317	Doxorubicin	OXTR protein results in decreased susceptibility to Doxorubicin	11313874
D004967	Estrogens	ESR1 affects the reaction [Estrogens results in increased expression of OXTR mRNA]	9579693
D004967	Estrogens	Estrogens results in increased expression of OXTR mRNA	9579693
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased activity of OXTR protein	12834913
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of OXTR mRNA	15834898\|2909715
D005419	Flavonoids	Flavonoids results in increased expression of OXTR mRNA	18035473
D005473	Fluoxetine	"Fluoxetine affects the reaction [vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 binds to OXTR protein]"	15380831
D005473	Fluoxetine	Fluoxetine results in increased expression of OXTR protein	15380831
C001277	geldanamycin	geldanamycin results in increased expression of OXTR mRNA	26705709
D019833	Genistein	Genistein results in decreased expression of OXTR mRNA	22228119
D006152	Cyclic GMP	[OXT protein affects the activity of OXTR protein] which results in increased abundance of Cyclic GMP	9874809
D017313	Fenretinide	Fenretinide results in decreased expression of OXTR mRNA	28973697
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of OXTR mRNA	27392435
C055830	KB 5-21	KB 5-21 binds to and results in decreased activity of OXTR protein	11181528
C055830	KB 5-21	[KB 5-21 binds to and results in decreased activity of OXTR protein] inhibits the reaction [[OXT protein binds to OXTR protein] which results in increased abundance of Calcium]	11181528
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of OXTR mRNA	12057914
C569869	malondialdehyde-low density lipoprotein, human	"malondialdehyde-low density lipoprotein, human results in increased expression of OXTR mRNA"	29104011
C569869	malondialdehyde-low density lipoprotein, human	"malondialdehyde-low density lipoprotein, human results in increased expression of OXTR protein"	29104011
C065757	meloxicam	meloxicam results in increased expression of OXTR mRNA	21270428
D008694	Methamphetamine	[atosiban results in decreased activity of OXTR protein] inhibits the reaction [OXT protein results in decreased susceptibility to Methamphetamine]	18092152
D008731	Methoxychlor	Methoxychlor results in decreased expression of OXTR protein	16307867
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of OXTR mRNA	28001369
D015735	Mifepristone	Mifepristone inhibits the reaction [OXT protein binds to OXTR protein]	16797624
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of OXTR mRNA	22401849
D010121	Oxytocin	Oxytocin analog binds to and results in decreased activity of OXTR protein	9502799
C045427	oxytocin, Thr(4)-Gly(7)-	"Bicuculline inhibits the reaction [oxytocin, Thr(4)-Gly(7)- results in increased activity of OXTR protein]"	11069593
C045427	oxytocin, Thr(4)-Gly(7)-	"oxytocin, Thr(4)-Gly(7)- binds to and results in increased activity of OXTR protein"	9502799
C045427	oxytocin, Thr(4)-Gly(7)-	"oxytocin, Thr(4)-Gly(7)- results in increased activity of OXTR protein"	11069593
D010126	Ozone	[[Ozone results in increased oxidation of Particulate Matter] which results in increased chemical synthesis of Aerosols] which results in decreased expression of OXTR mRNA	25361045
D010126	Ozone	[[Ozone results in increased oxidation of Vehicle Emissions] which results in increased chemical synthesis of Aerosols] which results in decreased expression of OXTR mRNA	25361045
D052638	Particulate Matter	[[Ozone results in increased oxidation of Particulate Matter] which results in increased chemical synthesis of Aerosols] which results in decreased expression of OXTR mRNA	25361045
D037342	Pertussis Toxin	Pertussis Toxin results in decreased activity of [OXT protein binds to and results in increased activity of OXTR protein]	12955084
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of OXTR mRNA	26678675
D016226	Phosphorus, Dietary	"Phosphorus, Dietary affects the expression of OXTR mRNA"	16311027
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of OXTR mRNA	19710929
D028321	Plant Preparations	Plant Preparations results in increased expression of OXTR mRNA	26945725
D059808	Polyphenols	Polyphenols results in decreased expression of OXTR mRNA	16293270
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of OXTR mRNA	22714537
D011374	Progesterone	Progesterone results in decreased expression of OXTR mRNA	18070364
D011374	Progesterone	Progesterone inhibits the reaction [OXT protein binds to OXTR protein]	16254031\|1762952
D011374	Progesterone	Progesterone affects the expression of OXTR	17765941
D011794	Quercetin	Quercetin results in increased expression of OXTR mRNA	21632981
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of OXTR mRNA	19167446
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of OXTR mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of OXTR mRNA	25351596
D012906	Smoke	decitabine inhibits the reaction [Smoke results in decreased expression of OXTR mRNA]	21095227
C017947	sodium arsenite	sodium arsenite results in increased methylation of OXTR gene	25199682
D013629	Tamoxifen	Tamoxifen results in increased activity of OXTR protein	12834913
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of OXTR mRNA	20044593
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of OXTR mRNA	20044593
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of OXTR mRNA	26232522
D014212	Tretinoin	Tretinoin results in increased expression of OXTR mRNA	21934132
C012589	trichostatin A	trichostatin A results in increased expression of OXTR mRNA	24935251\|2670570
C101044	tyrphostin AG 1478	[tyrphostin AG 1478 results in decreased activity of EGFR protein] results in decreased activity of [OXT protein binds to and results in increased activity of OXTR protein]	12955084
D014635	Valproic Acid	Valproic Acid results in decreased expression of OXTR mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of OXTR mRNA	23179753
C076093	vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2	"Cocaine affects the reaction [vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 binds to OXTR protein]"	15380831
C076093	vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2	"Fluoxetine affects the reaction [vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 binds to OXTR protein]"	15380831
C076093	vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2	"vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 binds to OXTR protein"	15380831
D001335	Vehicle Emissions	[[Ozone results in increased oxidation of Vehicle Emissions] which results in increased chemical synthesis of Aerosols] which results in decreased expression of OXTR mRNA	25361045

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004930	G-protein coupled receptor activity	-	IBA	21873635
GO:0004990	oxytocin receptor activity	-	IBA	21873635
GO:0005000	vasopressin receptor activity	-	IBA	21873635
GO:0017046	peptide hormone binding	-	IEA	-
GO:0042277	peptide binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001967	suckling behavior	-	IEA	-
GO:0001975	response to amphetamine	-	IEA	-
GO:0001992	regulation of systemic arterial blood pressure by vasopressin	-	IBA	21873635
GO:0006936	muscle contraction	-	TAS	1313946
GO:0007166	cell surface receptor signaling pathway	-	TAS	1313946
GO:0007186	G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IEA	-
GO:0007507	heart development	-	IEA	-
GO:0007565	female pregnancy	-	IBA	21873635
GO:0007595	lactation	-	TAS	1313946
GO:0007613	memory	-	IEA	-
GO:0010701	positive regulation of norepinephrine secretion	-	IEA	-
GO:0021537	telencephalon development	-	IEA	-
GO:0030431	sleep	-	IEA	-
GO:0032230	positive regulation of synaptic transmission, GABAergic	-	IEA	-
GO:0032355	response to estradiol	-	IEA	-
GO:0032570	response to progesterone	-	IEA	-
GO:0032870	cellular response to hormone stimulus	-	IBA	21873635
GO:0034059	response to anoxia	-	IEA	-
GO:0034097	response to cytokine	-	IEA	-
GO:0035176	social behavior	-	IBA	21873635
GO:0042220	response to cocaine	-	IEA	-
GO:0042711	maternal behavior	-	IBA	21873635
GO:0042713	sperm ejaculation	-	IEA	-
GO:0042755	eating behavior	-	IEA	-
GO:0043434	response to peptide hormone	-	IEA	-
GO:0044849	estrous cycle	-	IEA	-
GO:0045777	positive regulation of blood pressure	-	IEA	-
GO:0045907	positive regulation of vasoconstriction	-	IBA	21873635
GO:0048565	digestive tract development	-	IEA	-
GO:0051965	positive regulation of synapse assembly	-	IEA	-
GO:0051968	positive regulation of synaptic transmission, glutamatergic	-	IEA	-
GO:0060137	maternal process involved in parturition	-	IEA	-
GO:0060406	positive regulation of penile erection	-	IEA	-
GO:0060455	negative regulation of gastric acid secretion	-	IEA	-
GO:0070371	ERK1 and ERK2 cascade	-	IEA	-
GO:0070474	positive regulation of uterine smooth muscle contraction	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005622	intracellular	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	10858434
GO:0005902	microvillus	-	IEA	-
GO:0005913	cell-cell adherens junction	-	IEA	-
GO:0016324	apical plasma membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-388479	Vasopressin-like receptors	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27818356	Association between oxytocin and receptor genetic polymorphisms and aggression in a northern Chinese Han population with alcohol dependence. (2017 Jan 1)	Yang L	Neurosci Lett
25449413	The oxytocin receptor impairs ethanol reward in mice. (2015 Feb)	Bahi A	Physiol Behav
24766650	Drug addiction and stress-response genetic variability: association study in African Americans. (2014 Jul)	Levran O	Ann Hum Genet
25450139	Preliminary evidence for the interaction of the oxytocin receptor gene (oxtr) and face processing in differentiating prenatal smoking patterns. (2015 Jan 1)	Massey SH	Neurosci Lett