Gene: P2RX4

5025
P2X4|P2X4R
purinergic receptor P2X 4
protein-coding
12q24.31
Ensembl:ENSG00000135124 MIM:600846 Vega:OTTHUMG00000169155 UniprotKB:Q99571
NC_000012.12
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.506e-1 (AD)  6.154e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADPGK0.785
TINF20.779
RNPEP0.769
GNL20.762
AKAP17A0.759
CREG10.752
RPS6KB20.75
QARS0.748
DCAF150.746
EDEM20.746

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.518
OR4F29-0.499
RAX2-0.252
MTRNR2L6-0.249
MIA-0.236
BTBD8-0.232
EPPIN-0.21
MTRNR2L9-0.204
GYS2-0.2
PRDM14-0.189

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09119Eslicarbazepine acetateSmall Molecule236395-14-5ApprovedTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of P2RX4 mRNA"22698814
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of P2RX4 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of P2RX4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of P2RX4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of P2RX4 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of P2RX4 mRNA17562736
D000255Adenosine Triphosphate[resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 mRNA24149798
D000255Adenosine Triphosphate[resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 protein24149798
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased activity of P2RX4 protein21638035
D000255Adenosine TriphosphateIvermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]21638035
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased activity of P2RX4 protein10737610|1562918
D000255Adenosine Triphosphate[Cadmium co-treated with Zinc] promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]15629187
D000255Adenosine TriphosphateCadmium promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]10737610|1562918
D000255Adenosine TriphosphateCobalt promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]15629187
D000255Adenosine TriphosphateCopper inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]10737610|1562918
D000255Adenosine TriphosphateCopper inhibits the reaction [Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]]10737610
D000255Adenosine Triphosphate[Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]15629187
D000255Adenosine TriphosphateMercury inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]10737610|1562918
D000255Adenosine TriphosphateZinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]10737610|1562918
D000393Air PollutantsAir Pollutants analog results in decreased expression of P2RX4 mRNA21757418
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of P2RX4 mRNA24449571
D001151ArsenicArsenic affects the methylation of P2RX4 gene25304211
C547126AZM551248AZM551248 results in increased expression of P2RX4 mRNA22323515
D001554BenzeneBenzene results in increased expression of P2RX4 mRNA19162166
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of P2RX4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of P2RX4 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of P2RX4 mRNA21839799
D004958EstradiolEstradiol promotes the reaction [P2RX4 protein binds to ESR1 protein]27156127
D004958EstradiolEstradiol results in decreased expression of P2RX4 mRNA21185374
C006780bisphenol Abisphenol A results in increased expression of P2RX4 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of P2RX4 mRNA25181051
D002104CadmiumCadmium results in increased expression of P2RX4 mRNA24376830
D002104Cadmium[Cadmium co-treated with Zinc] promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]15629187
D002104CadmiumCadmium promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]10737610|1562918
D019256Cadmium ChlorideCadmium Chloride results in increased expression of P2RX4 mRNA26472689
D003035CobaltCobalt promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]15629187
C018021cobaltous chloridecobaltous chloride results in decreased expression of P2RX4 mRNA24386269
D003300CopperCopper inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]10737610|1562918
D003300CopperCopper inhibits the reaction [Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]]10737610
D003300Copper[Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]15629187
D016572CyclosporineCyclosporine results in increased expression of P2RX4 mRNA22147139
C093628cyproconazolecyproconazole results in increased expression of P2RX4 mRNA22334560
D002945CisplatinCisplatin results in increased expression of P2RX4 mRNA27594783
D002945CisplatinCisplatin results in increased expression of P2RX4 mRNA21151649
D004008DiclofenacDiclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX4 protein]25450234
D004026DieldrinDieldrin results in decreased expression of P2RX4 mRNA23153324
D004041Dietary FatsDietary Fats results in decreased expression of P2RX4 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of P2RX4 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of P2RX4 mRNA]17942915
C109476epoxiconazoleepoxiconazole results in increased expression of P2RX4 mRNA22334560
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of P2RX4 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of P2RX4 mRNA27664576
D005620Freund's AdjuvantDiclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX4 protein]25450234
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of P2RX4 protein25450234
D005620Freund's AdjuvantLuteolin inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX4 protein]25450234
D006533HeptachlorHeptachlor results in decreased expression of P2RX4 mRNA23153324
C492448ICG 001ICG 001 results in increased expression of P2RX4 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of P2RX4 mRNA25613284
D007559IvermectinIvermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]21638035
D007559IvermectinIvermectin results in increased activity of P2RX4 protein19560503
D007559IvermectinIvermectin results in increased activity of P2RX4 protein21402096|2163803
C544151jinfukangjinfukang results in increased expression of P2RX4 mRNA27392435
C410337K 7174K 7174 results in increased expression of P2RX4 mRNA24086573
C008261lead acetatelead acetate results in increased expression of P2RX4 mRNA26478469
C008261lead acetatelead acetate results in increased expression of P2RX4 protein26478469
D008070Lipopolysaccharides[resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 mRNA24149798
D008070Lipopolysaccharides[resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 protein24149798
D047311LuteolinLuteolin inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX4 protein]25450234
D008628Mercury[Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]15629187
D008628MercuryMercury inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]10737610|1562918
D008694MethamphetamineMethamphetamine results in decreased expression of P2RX4 mRNA19564919
D008701MethapyrileneMethapyrilene results in decreased expression of P2RX4 mRNA16393664
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of P2RX4 mRNA22776087
D009118MuscimolMuscimol results in increased expression of P2RX4 mRNA12941474
D009118MuscimolMuscimol results in increased expression of P2RX4 protein12941474
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of P2RX4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of P2RX4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of P2RX4 mRNA"25554681|2562005
D000073878Palm OilPalm Oil results in decreased expression of P2RX4 mRNA18042831
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of P2RX4 mRNA28973697
D010634PhenobarbitalPhenobarbital affects the expression of P2RX4 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of P2RX4 mRNA19270015
D010936Plant ExtractsPlant Extracts results in increased expression of P2RX4 mRNA23557933
C045950propiconazolepropiconazole results in increased expression of P2RX4 mRNA21278054|2233456
C059514resveratrol[resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 mRNA24149798
C059514resveratrol[resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 protein24149798
D012822Silicon DioxideSilicon Dioxide results in increased expression of P2RX4 mRNA21602193
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of P2RX4 mRNA25879800
C017947sodium arsenitesodium arsenite results in decreased expression of P2RX4 mRNA21357385
D018038Sodium SeleniteSodium Selenite results in decreased expression of P2RX4 mRNA18175754
D013739TestosteroneTestosterone results in increased expression of P2RX4 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of P2RX4 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of P2RX4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of P2RX4 mRNA]15667827
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of P2RX4 mRNA25613284
D014051Toluene 2,4-Diisocyanate"P2RX4 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]"26072274
C012589trichostatin Atrichostatin A results in decreased expression of P2RX4 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of P2RX4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of P2RX4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of P2RX4 mRNA23179753|2438349
D020888VigabatrinVigabatrin results in increased expression of P2RX4 mRNA12941474
D020888VigabatrinVigabatrin results in increased expression of P2RX4 protein12941474
C029297vinylidene chloridevinylidene chloride results in increased expression of P2RX4 mRNA26682919
D015032Zinc[Cadmium co-treated with Zinc] promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]15629187
D015032ZincCopper inhibits the reaction [Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]]10737610
D015032ZincZinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]10737610|1562918
C088658zoledronic acidzoledronic acid results in increased expression of P2RX4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001614purinergic nucleotide receptor activity-IBA21873635  
GO:0001614purinergic nucleotide receptor activity-IDA9016352  
GO:0001614purinergic nucleotide receptor activity-IMP11606481  
GO:0004931extracellularly ATP-gated cation channel activity-IBA21873635  
GO:0004931extracellularly ATP-gated cation channel activity-IDA9016352  10515189  
GO:0005102signaling receptor binding-ISS17785580  
GO:0005507copper ion binding-ISS12819199  
GO:0005515protein binding-IPI25416956  
GO:0005524ATP binding-IC11606481  
GO:0008270zinc ion binding-ISS12819199  
GO:0035381ATP-gated ion channel activity-IBA21873635  
GO:0042803protein homodimerization activity-NAS17895406  
GO:0045296cadherin binding-IPI12088286  
GO:0099604ligand-gated calcium channel activity-IDA9016352  
GO ID GO Term Qualifier Evidence PubMed
GO:0001894tissue homeostasis-NAS17264311  
GO:0002028regulation of sodium ion transport-ISS17785580  
GO:0006812cation transport-IBA21873635  
GO:0007165signal transduction-IDA9016352  
GO:0007596blood coagulation-TAS-  
GO:0008217regulation of blood pressure-IMP11606481  15130891  
GO:0010524positive regulation of calcium ion transport into cytosol-IDA10969036  
GO:0010524positive regulation of calcium ion transport into cytosol-IMP10899068  
GO:0010614negative regulation of cardiac muscle hypertrophy-IMP15130891  
GO:0019228neuronal action potential-IEA-  
GO:0019233sensory perception of pain-ISS14978347  
GO:0019722calcium-mediated signaling-IEA-  
GO:0032308positive regulation of prostaglandin secretion-NAS10899068  
GO:0033198response to ATP-IDA9016352  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IDA10515189  
GO:0034405response to fluid shear stress-IDA10969036  
GO:0035590purinergic nucleotide receptor signaling pathway-IMP11606481  
GO:0042118endothelial cell activation-TAS12088286  
GO:0043536positive regulation of blood vessel endothelial cell migration-IMP21106936  
GO:0045429positive regulation of nitric oxide biosynthetic process-NAS10899068  
GO:0050850positive regulation of calcium-mediated signaling-IDA10969036  
GO:0050850positive regulation of calcium-mediated signaling-IMP10899068  
GO:0051260protein homooligomerization-IEA-  
GO:0051899membrane depolarization-IDA9016352  
GO:0051928positive regulation of calcium ion transport-NAS15130891  
GO:0055117regulation of cardiac muscle contraction-IMP11606481  15130891  
GO:0055119relaxation of cardiac muscle-IMP11606481  15130891  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0070588calcium ion transmembrane transport-IDA9016352  
GO:0071294cellular response to zinc ion-ISS-  
GO:0071318cellular response to ATP-IDA10515189  
GO:0097190apoptotic signaling pathway-IDA17264311  
GO:2001028positive regulation of endothelial cell chemotaxis-IMP21106936  
GO ID GO Term Qualifier Evidence PubMed
GO:0005639integral component of nuclear inner membrane-IBA21873635  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005886plasma membrane-IDA23303206  
GO:0005886plasma membrane-ISS17785580  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IC11606481  
GO:0005887integral component of plasma membrane-IMP10515189  
GO:0005887integral component of plasma membrane-ISS-  
GO:0014069postsynaptic density-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IDA17785580  
GO:0016021integral component of membrane-IBA21873635  
GO:0030054cell junction-IDA12088286  
GO:0043025neuronal cell body-IEA-  
GO:0043195terminal bouton-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA12088286  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-139853Elevation of cytosolic Ca2+ levelsTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418360Platelet calcium homeostasisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21402096Pharmacologically targeting the P2rx4 gene on maintenance and reinstatement of alcohol self-administration in rats. (2011 Jun)Kosten TAPharmacol Biochem Behav
25009459P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders. (2014)Franklin KMFront Neurosci