Gene: P2RX7

5027
P2X7
purinergic receptor P2X 7
protein-coding
12q24.31
Ensembl:ENSG00000089041 MIM:602566 Vega:OTTHUMG00000169153 UniprotKB:Q99572
NG_011471.2
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.428e-1 (AD)  3.797e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATM0.828
ZBTB260.783
ZNF3970.783
STAG30.779
TCP11L20.776
PEAK10.773
MSH60.771
SLC22A230.77
ZC3H11A0.766
HSD17B10.761

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNNT1-0.346
PRSS27-0.345
HES5-0.334
PLA2G5-0.325
ENDOU-0.324
CACNG1-0.302
S100A14-0.3
HPDL-0.297
PNMT-0.297
HKDC1-0.288

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of P2RX7 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of P2RX7 mRNA"23146750
C0171992',3'-dialdehyde ATP"2',3'-dialdehyde ATP binds to and results in decreased activity of P2RX7 protein"15258577|1591464
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of P2RX7 mRNA"20713471
C5236683-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein]"27466191
C5236683-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]"21638035
C5236683-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine results in decreased activity of P2RX7 protein"27466191
C5236683-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine binds to and results in decreased activity of P2RX7 protein"21638035
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased import of Calcium21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK1 protein21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK3 protein21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased secretion of IL1B protein21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased secretion of IL2 protein21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateBerberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateKN 62 inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateKN 62 inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased import of Calcium]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateKN 62 inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK1 protein]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateKN 62 inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK3 protein]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateKN 62 inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased secretion of IL2 protein]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateprotoberberine analog inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateprotoberberine analog inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased import of Calcium]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateprotoberberine analog inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK1 protein]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateprotoberberine analog inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK3 protein]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateprotoberberine analog inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased secretion of IL1B protein]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateprotoberberine analog inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased secretion of IL2 protein]21320518
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein]"27466191
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein27466191
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased expression of P2RX7 protein26522449
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateazetidine analog inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased expression of P2RX7 protein]26522449
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateP2RX7 gene mutant form results in decreased susceptibility to 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate17728465|2410173
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphateP2RX7 protein affects the susceptibility to 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate12873706
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate binds to and results in increased activity of P2RX7 protein15914640|1772846
D000082AcetaminophenAcetaminophen results in increased expression of P2RX7 mRNA29067470
C022571adenosine 5'-O-(3-thiotriphosphate)P2RX7 protein affects the susceptibility to adenosine 5'-O-(3-thiotriphosphate)12873706
D000255Adenosine Triphosphate[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA24149798
D000255Adenosine Triphosphate[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein24149798
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased activity of P2RX7 protein19023039
D000255Adenosine TriphosphateP2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein]11003599
D000255Adenosine TriphosphateP2RX7 protein affects the reaction [Adenosine Triphosphate results in increased transport of Barium]11003599
D000255Adenosine Triphosphateresveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA]24149798
D000255Adenosine Triphosphateresveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein]24149798
D000255Adenosine Triphosphate"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]"21638035
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased activity of P2RX7 protein19023039|2163803
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased expression of P2RX7 protein26522449
D000255Adenosine Triphosphateazetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of P2RX7 protein]26522449
D000255Adenosine Triphosphatecoomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]21638035
D000255Adenosine TriphosphateP2RX7 gene mutant form results in decreased susceptibility to Adenosine Triphosphate17728465|2410173
D000255Adenosine TriphosphateP2RX7 protein results in increased susceptibility to Adenosine Triphosphate23565201
D000255Adenosine Triphosphate"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]"21638035
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased activity of P2RX7 protein19023039
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased activity of P2RX7 protein21320518
D000255Adenosine Triphosphate[Adenosine Triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK1 protein21320518
D000255Adenosine Triphosphate[Adenosine Triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK3 protein21320518
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of P2RX7 mRNA27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of P2RX7 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin affects the expression of P2RX7 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of P2RX7 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of P2RX7 mRNA24449571
D047310ApigeninApigenin inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein]25935278
C082735azetidineazetidine analog inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased expression of P2RX7 protein]26522449
C082735azetidineazetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of P2RX7 protein]26522449
D001464BariumP2RX7 protein affects the reaction [Adenosine Triphosphate results in increased transport of Barium]11003599
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of P2RX7 mRNA27858113
D001554BenzeneBenzene results in increased expression of P2RX7 mRNA19162166
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of P2RX7 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of P2RX7 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of P2RX7 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of P2RX7 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of P2RX7 protein26657896
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of P2RX7 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of P2RX7 mRNA20713471
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of P2RX7 mRNA19770486|2156981
D001599BerberineBerberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein]21320518
C006780bisphenol Abisphenol A results in decreased expression of P2RX7 mRNA25181051
D002118Calcium[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased import of Calcium21320518
D002118CalciumKN 62 inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased import of Calcium]21320518
D002118Calciumprotoberberine analog inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased import of Calcium]21320518
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of P2RX7 mRNA17484886
D002351Carrageenan"[(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) binds to and results in decreased activity of P2RX7 protein] which results in decreased susceptibility to Carrageenan"16982702
C054133casticincasticin results in increased expression of P2RX7 mRNA28444820
C562356CE 224,535"CE 224,535 binds to and results in decreased activity of P2RX7 protein"21320518
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of P2RX7 mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of P2RX7 mRNA27858113
D003033Coal TarCoal Tar results in increased expression of P2RX7 mRNA27858113
C004692coomassie Brilliant Bluecoomassie Brilliant Blue binds to and results in decreased activity of P2RX7 protein23583883
C004692coomassie Brilliant Bluecoomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]21638035
C004692coomassie Brilliant Bluecoomassie Brilliant Blue results in decreased activity of P2RX7 protein27466191
C004692coomassie Brilliant Bluecoomassie Brilliant Blue binds to and results in decreased activity of P2RX7 protein15914640|1966662
D016572CyclosporineCyclosporine results in increased expression of P2RX7 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of P2RX7 mRNA21266533
D002945CisplatinCisplatin results in increased expression of P2RX7 mRNA21151649
D002945CisplatinCisplatin results in increased expression of P2RX7 protein25308879
D004008DiclofenacDiclofenac results in increased expression of P2RX7 mRNA26934552
D004008DiclofenacDiclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein]25935278
D004026DieldrinDieldrin results in increased expression of P2RX7 mRNA23041725
C014476diethyl maleatediethyl maleate results in decreased expression of P2RX7 mRNA21161181
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of P2RX7 mRNA17942915|2453584
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of P2RX7 mRNA]17942915
D004317DoxorubicinDoxorubicin affects the expression of P2RX717402594
D004837EpinephrineEpinephrine results in decreased activity of P2RX7 protein15459114
D004996EthidiumP2RX7 gene polymorphism results in decreased transport of Ethidium16263709
D004996EthidiumP2RX7 protein results in increased transport of Ethidium16263709
D005047EtoposideEtoposide results in increased expression of P2RX7 mRNA25270620
D005492Folic AcidFolic Acid results in decreased expression of P2RX7 mRNA25006883
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of P2RX7 mRNA20938992
D005620Freund's AdjuvantApigenin inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein]25935278
D005620Freund's AdjuvantDiclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein]25935278
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of P2RX7 protein25935278
D005620Freund's Adjuvant"[(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) binds to and results in decreased activity of P2RX7 protein] which results in decreased susceptibility to Freund's Adjuvant"16982702
C039281furanfuran results in decreased expression of P2RX7 mRNA25539665|2738771
C546771gardiquimodgardiquimod results in increased expression of P2RX7 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of P2RX7 mRNA]28003376
D019833GenisteinGenistein results in increased expression of P2RX7 mRNA22553218
D005947GlucoseGlucose results in increased expression of P2RX7 mRNA21832250
D017313FenretinideFenretinide results in increased expression of P2RX7 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of P2RX7 mRNA25613284
D007501IronIron deficiency results in increased expression of P2RX7 mRNA20368581
D007657Ketone BodiesKetone Bodies results in decreased expression of P2RX7 mRNA16807920
C063302KN 62KN 62 analog binds to and results in decreased activity of P2RX7 protein12672232
C063302KN 62KN 62 binds to and results in decreased activity of P2RX7 protein12672232
C063302KN 62KN 62 inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein]21320518
C063302KN 62KN 62 inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased import of Calcium]21320518
C063302KN 62KN 62 inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK1 protein]21320518
C063302KN 62KN 62 inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK3 protein]21320518
C063302KN 62KN 62 inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased secretion of IL2 protein]21320518
C063302KN 62KN 62 binds to and results in decreased activity of P2RX7 protein21320518
C008261lead acetatelead acetate results in increased expression of P2RX7 mRNA22641619|2647846
C008261lead acetatelead acetate results in increased expression of P2RX7 protein20932874|2647846
D008070Lipopolysaccharides[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA24149798
D008070Lipopolysaccharides[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein24149798
D008070Lipopolysaccharidesresveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA]24149798
D008070Lipopolysaccharidesresveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein]24149798
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of P2RX7 mRNA alternative form26068648
D008555MelittenMelitten results in increased activity of P2RX7 protein22613720
D008555MelittenP2RX7 protein results in increased susceptibility to Melitten22613720
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of P2RX7 mRNA23872137
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of P2RX7 mRNA20938992
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of P2RX7 mRNA23519560
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of P2RX7 mRNA20713471
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of P2RX7 mRNA"19285098
C059539midostaurinmidostaurin results in decreased expression of P2RX7 mRNA20980353
C515928(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide)"(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) binds to and results in decreased activity of P2RX7 protein"16982702
C515928(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide)"[(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) binds to and results in decreased activity of P2RX7 protein] which results in decreased secretion of IL1B protein"16982702
C515928(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide)"[(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) binds to and results in decreased activity of P2RX7 protein] which results in decreased susceptibility to Carrageenan"16982702
C515928(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide)"[(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) binds to and results in decreased activity of P2RX7 protein] which results in decreased susceptibility to Freund's Adjuvant"16982702
C515928(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide)"[(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) binds to and results in decreased activity of P2RX7 protein] which results in decreased susceptibility to Vincristine"16982702
D019829NevirapineNevirapine results in decreased expression of P2RX7 mRNA23947594
D009532NickelNickel results in decreased expression of P2RX7 mRNA23195993
D019301Oleic Acid[Oleic Acid co-treated with Palmitic Acid] results in increased expression of P2RX7 mRNA25348860
D019301Oleic Acid[Oleic Acid co-treated with Palmitic Acid] results in increased expression of P2RX7 protein25348860
D019301Oleic Acidresveratrol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of P2RX7 mRNA]25348860
D019301Oleic Acidresveratrol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of P2RX7 protein]25348860
D019308Palmitic Acid[Oleic Acid co-treated with Palmitic Acid] results in increased expression of P2RX7 mRNA25348860
D019308Palmitic Acid[Oleic Acid co-treated with Palmitic Acid] results in increased expression of P2RX7 protein25348860
D019308Palmitic Acidresveratrol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of P2RX7 mRNA]25348860
D019308Palmitic Acidresveratrol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of P2RX7 protein]25348860
D010269ParaquatParaquat affects the expression of P2RX7 mRNA18198484
C004282periodate-oxidized adenosine 5'-triphosphateperiodate-oxidized adenosine 5'-triphosphate binds to and results in decreased activity of P2RX7 protein17728465
D010862PilocarpinePilocarpine results in increased expression of P2RX7 protein19138473
D011070Poly I-CPoly I-C results in decreased expression of P2RX7 protein23516405
D011070Poly I-CSuramin inhibits the reaction [Poly I-C results in decreased expression of P2RX7 protein]23516405
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of P2RX7 mRNA19162173
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of P2RX7 mRNA]28003376
C009090protoberberineprotoberberine analog inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein]21320518
C009090protoberberineprotoberberine analog inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased import of Calcium]21320518
C009090protoberberineprotoberberine analog inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK1 protein]21320518
C009090protoberberineprotoberberine analog inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased phosphorylation of MAPK3 protein]21320518
C009090protoberberineprotoberberine analog inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased secretion of IL1B protein]21320518
C009090protoberberineprotoberberine analog inhibits the reaction [[3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] which results in increased secretion of IL2 protein]21320518
C009090protoberberineprotoberberine analog binds to and results in decreased activity of P2RX7 protein21320518
C513428pyrachlostrobinpyrachlostrobin results in increased expression of P2RX7 mRNA27029645
C077792pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]"21638035
C077792pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid binds to and results in decreased activity of P2RX7 protein"15258577|2163803
C059514resveratrolresveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA]24149798
C059514resveratrolresveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein]24149798
C059514resveratrolresveratrol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of P2RX7 mRNA]25348860
C059514resveratrolresveratrol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of P2RX7 protein]25348860
C009250sevofluranesevoflurane affects the expression of P2RX7 mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of P2RX7 mRNA23806026
D012834SilverSilver results in increased expression of P2RX7 mRNA27131904
D013498SuraminSuramin inhibits the reaction [Poly I-C results in decreased expression of P2RX7 protein]23516405
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of P2RX7 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of P2RX7 mRNA21570461|2637764
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of P2RX7 mRNA23519560
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of P2RX7 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of P2RX7 mRNA29128614
C009495titanium dioxidetitanium dioxide results in increased expression of P2RX7 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of P2RX7 protein28646487
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of P2RX7 mRNA20133372
D014051Toluene 2,4-Diisocyanate"P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]"26072274
D014118Toxins, Biological"Toxins, Biological affects the expression of P2RX7 mRNA"19682533
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of P2RX7 mRNA23537331
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of P2RX7 gene25560391
D014750Vincristine"[(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) binds to and results in decreased activity of P2RX7 protein] which results in decreased susceptibility to Vincristine"16982702
C029297vinylidene chloridevinylidene chloride results in increased expression of P2RX7 mRNA26682919
D019287Zinc SulfateZinc Sulfate results in decreased expression of P2RX7 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001530lipopolysaccharide binding-ISS-  
GO:0001614purinergic nucleotide receptor activity-IBA21873635  
GO:0001614purinergic nucleotide receptor activity-IDA9038151  
GO:0004931extracellularly ATP-gated cation channel activity-IBA21873635  
GO:0004931extracellularly ATP-gated cation channel activity-IDA9038151  
GO:0004931extracellularly ATP-gated cation channel activity-TAS-  
GO:0005102signaling receptor binding-ISS17785580  
GO:0005515protein binding-IPI12107182  25651887  
GO:0005524ATP binding-IC9038151  
GO:0035381ATP-gated ion channel activity-IBA21873635  
GO:0042803protein homodimerization activity-NAS17895406  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IEA-  
GO:0000902cell morphogenesis-IEA-  
GO:0001845phagolysosome assembly-IEA-  
GO:0001916positive regulation of T cell mediated cytotoxicity-IEA-  
GO:0002028regulation of sodium ion transport-ISS17785580  
GO:0006468protein phosphorylation-IEA-  
GO:0006509membrane protein ectodomain proteolysis-IEA-  
GO:0006649phospholipid transfer to membrane-IEA-  
GO:0006812cation transport-IBA21873635  
GO:0006900vesicle budding from membrane-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0007005mitochondrion organization-IEA-  
GO:0007166cell surface receptor signaling pathway-ISS-  
GO:0007596blood coagulation-TAS-  
GO:0009612response to mechanical stimulus-IEA-  
GO:0010043response to zinc ion-IEA-  
GO:0010524positive regulation of calcium ion transport into cytosol-IDA9038151  
GO:0010628positive regulation of gene expression-IMP22898868  
GO:0014049positive regulation of glutamate secretion-IEA-  
GO:0014054positive regulation of gamma-aminobutyric acid secretion-IEA-  
GO:0016079synaptic vesicle exocytosis-IEA-  
GO:0016485protein processing-IEA-  
GO:0017121phospholipid scrambling-IDA25651887  
GO:0019233sensory perception of pain-ISS-  
GO:0019835cytolysis-IEA-  
GO:0030163protein catabolic process-IEA-  
GO:0030501positive regulation of bone mineralization-ISS-  
GO:0031668cellular response to extracellular stimulus-IEA-  
GO:0032060bleb assembly-IDA12107182  
GO:0032060bleb assembly-ISS-  
GO:0032308positive regulation of prostaglandin secretion-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0032755positive regulation of interleukin-6 production-IEA-  
GO:0032963collagen metabolic process-IEA-  
GO:0033198response to ATP-IDA9038151  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034405response to fluid shear stress-IEA-  
GO:0034767positive regulation of ion transmembrane transport-IMP25651887  
GO:0035590purinergic nucleotide receptor signaling pathway-IMP25651887  
GO:0042098T cell proliferation-IEA-  
GO:0043029T cell homeostasis-IEA-  
GO:0043132NAD transport-IEA-  
GO:0043409negative regulation of MAPK cascade-ISS-  
GO:0045332phospholipid translocation-IEA-  
GO:0045779negative regulation of bone resorption-ISS-  
GO:0045794negative regulation of cell volume-IMP25651887  
GO:0045821positive regulation of glycolytic process-IMP22898868  
GO:0045919positive regulation of cytolysis-ISS-  
GO:0046513ceramide biosynthetic process-IEA-  
GO:0046931pore complex assembly-IDA9038151  
GO:0046931pore complex assembly-IMP25651887  
GO:0048705skeletal system morphogenesis-IEA-  
GO:0048873homeostasis of number of cells within a tissue-IEA-  
GO:0050717positive regulation of interleukin-1 alpha secretion-IEA-  
GO:0050718positive regulation of interleukin-1 beta secretion-IDA17036048  18089587  
GO:0050830defense response to Gram-positive bacterium-IEA-  
GO:0051209release of sequestered calcium ion into cytosol-IEA-  
GO:0051259protein complex oligomerization-IEA-  
GO:0051495positive regulation of cytoskeleton organization-ISS-  
GO:0051592response to calcium ion-IEA-  
GO:0051602response to electrical stimulus-IEA-  
GO:0051709regulation of killing of cells of other organism-NAS17785580  
GO:0051899membrane depolarization-IDA9038151  
GO:0051901positive regulation of mitochondrial depolarization-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0070230positive regulation of lymphocyte apoptotic process-IEA-  
GO:0071359cellular response to dsRNA-IEA-  
GO:0072593reactive oxygen species metabolic process-IEA-  
GO:0097190apoptotic signaling pathway-ISS-  
GO:0097191extrinsic apoptotic signaling pathway-IEA-  
GO:1904172positive regulation of bleb assembly-IMP25651887  
GO ID GO Term Qualifier Evidence PubMed
GO:0005639integral component of nuclear inner membrane-IBA21873635  
GO:0005737cytoplasm-ISS-  
GO:0005886plasma membrane-IDA12107182  
GO:0005886plasma membrane-ISS17785580  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IC9038151  
GO:0005911cell-cell junction-IEA-  
GO:0009897external side of plasma membrane-IEA-  
GO:0016020membrane-IDA17785580  
GO:0016021integral component of membrane-IBA21873635  
GO:0031594neuromuscular junction-IEA-  
GO:0032059bleb-ISS-  
GO:0043025neuronal cell body-IEA-  
GO:0098793presynapse-IEA-  
GO:0098794postsynapse-IEA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-139853Elevation of cytosolic Ca2+ levelsTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysTAS
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysIEA
R-HSA-418346Platelet homeostasisTAS
R-HSA-418360Platelet calcium homeostasisTAS
R-HSA-622312InflammasomesTAS
R-HSA-622312InflammasomesIEA
R-HSA-844456The NLRP3 inflammasomeTAS
R-HSA-844456The NLRP3 inflammasomeIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28737528Genetic variants of increased waist circumference in psychosis. (2017 Dec)Hukic DSPsychiatr Genet