Gene: P2RY2

5029
HP2U|P2RU1|P2U|P2U1|P2UR|P2Y2|P2Y2R
purinergic receptor P2Y2
protein-coding
11q13.4
Ensembl:ENSG00000175591 MIM:600041 Vega:OTTHUMG00000167966 UniprotKB:P41231
NC_000011.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.028e-1 (AD)  6.739e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7111814chr11:73224780 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMILIN10.74
FGF110.728
NEK60.728
PALLD0.71
LRP100.709
FAM198A0.705
SH3BP20.705
TMEM176A0.704
LIMK20.703
TEAD30.703

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF860-0.507
MYOZ3-0.507
SLC7A4-0.506
PPEF1-0.506
SLC8A3-0.503
CASC15-0.485
BFSP1-0.485
SMIM18-0.483
PTPRR-0.481
ABCC12-0.477

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04786SuraminSmall Molecule145-63-1Approved|InvestigationalTarget
DB04983DenufosolSmall Molecule211448-85-0InvestigationalTarget
DB05390INS 316Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of P2RY2 mRNA"26377693
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of P2RY2 mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of P2RY2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of P2RY2 mRNA"21346803
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of P2RY2 mRNA14610520
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of P2RY2 mRNA19191707
C038699acetophenone[acetophenone co-treated with OLFR151 co-treated with GNAO1 co-treated with P2RY2] results in increased phosphorylation of MAPK1 protein17472961
C038699acetophenone[acetophenone co-treated with OLFR151 co-treated with GNAO1 co-treated with P2RY2] results in increased phosphorylation of MAPK3 protein17472961
C038699acetophenonePertussis Toxin inhibits the reaction [[acetophenone co-treated with OLFR151 co-treated with P2RY2] results in increased phosphorylation of MAPK1 protein]17472961
C038699acetophenonePertussis Toxin inhibits the reaction [[acetophenone co-treated with OLFR151 co-treated with P2RY2] results in increased phosphorylation of MAPK3 protein]17472961
D000242Cyclic AMP"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP]"10604969
D000242Cyclic AMP[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP10604969
D000255Adenosine Triphosphate[Adenosine Triphosphate binds to and affects the activity of P2RY2 protein] which affects the secretion of Chlorides18322271
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased activity of P2RY2 protein11527950
D000255Adenosine Triphosphate[Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Calcium11527950
D000255Adenosine TriphosphateAdenosine Triphosphate affects the activity of P2RY2 protein15243297
D000255Adenosine Triphosphate[Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased uptake of Calcium17003265
D000447AldehydesAldehydes results in increased expression of P2RY2 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of P2RY2 mRNA16483693
D016718Arachidonic Acid"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]"10604969
D016718Arachidonic Acid[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid10604969
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of P2RY2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of P2RY2 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of P2RY2 mRNA22228805|2373587
C006780bisphenol Abisphenol A results in decreased methylation of P2RY2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of P2RY2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of P2RY2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the expression of P2RY2 mRNA22110744
D002118Calcium[Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Calcium11527950
D002118CalciumP2RY2 protein affects the susceptibility to Calcium18343036
D002118Calcium[Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased uptake of Calcium17003265
D002118CalciumGo 6976 promotes the reaction [P2RY2 protein results in increased uptake of Calcium]17003265
D002118CalciumTetradecanoylphorbol Acetate inhibits the reaction [P2RY2 protein results in increased uptake of Calcium]17003265
D002118Calcium[denufosol tetrasodium affects the activity of P2RY2 protein] which results in increased secretion of Calcium22514656
D002118Calcium[[denufosol tetrasodium affects the activity of P2RY2 protein] which results in increased secretion of Calcium] affects the reaction [CFTR protein mutant form affects the transport of Calcium]22514656
D002211CapsaicinKNG1 protein alternative form affects the reaction [P2RY2 protein affects the susceptibility to Capsaicin]18343036
D002211CapsaicinP2RY2 protein affects the susceptibility to Capsaicin18343036
D002712Chlorides[Adenosine Triphosphate binds to and affects the activity of P2RY2 protein] which affects the secretion of Chlorides18322271
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of P2RY2 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of P2RY2 mRNA23052192
C018021cobaltous chloridecobaltous chloride results in increased expression of P2RY2 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of P2RY2 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in decreased expression of P2RY2 mRNA17403535
C465279denufosol tetrasodiumdenufosol tetrasodium affects the activity of P2RY2 protein22514656
C465279denufosol tetrasodium[denufosol tetrasodium affects the activity of P2RY2 protein] which results in increased secretion of Calcium22514656
C465279denufosol tetrasodium[[denufosol tetrasodium affects the activity of P2RY2 protein] which results in increased secretion of Calcium] affects the reaction [CFTR protein mutant form affects the transport of Calcium]22514656
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of P2RY2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of P2RY2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of P2RY2 mRNA27594783
D002945CisplatinCisplatin results in increased expression of P2RY2 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of P2RY2 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of P2RY2 mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of P2RY2 mRNA12875902|1600243
C024629dimethyl phthalatedimethyl phthalate affects the expression of P2RY2 mRNA26924002
C403315diquafosoldiquafosol binds to and results in increased activity of P2RY2 protein21528910
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of P2RY2 mRNA17347304
C540355fenamidonefenamidone results in increased expression of P2RY2 mRNA27029645
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of P2RY2 mRNA17347304
D005419FlavonoidsFlavonoids results in increased expression of P2RY2 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of P2RY2 gene20938992
C039281furanfuran results in decreased expression of P2RY2 mRNA26194646
C004312glycidolglycidol results in decreased expression of P2RY2 mRNA24915197
C081021Go 6976Go 6976 promotes the reaction [P2RY2 protein results in increased uptake of Calcium]17003265
D007052IbuprofenIbuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA]10496880
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of P2RY2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of P2RY2 mRNA27432991
D008694MethamphetamineMethamphetamine results in increased expression of P2RY2 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of P2RY2 gene20938992
C030957methylmercury IImethylmercury II results in decreased expression of P2RY2 mRNA17905399
C517284monomethyl phthalatemonomethyl phthalate affects the expression of P2RY2 mRNA26924002
C109860N-(3-oxododecanoyl)homoserine lactoneIbuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA]10496880
C109860N-(3-oxododecanoyl)homoserine lactoneN-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA10496880
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of P2RY2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of P2RY2 mRNA"25554681
C092312N-butyrylhomoserine lactoneN-butyrylhomoserine lactone results in decreased expression of P2RY2 mRNA10496880
D009532NickelNickel results in increased expression of P2RY2 mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of P2RY2 mRNA22110744
D010100OxygenOxygen deficiency results in decreased expression of P2RY2 mRNA26516004
D000073878Palm OilPalm Oil results in increased expression of P2RY2 mRNA18042831
C046012pentanalpentanal results in increased expression of P2RY2 mRNA26079696
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [[acetophenone co-treated with OLFR151 co-treated with P2RY2] results in increased phosphorylation of MAPK1 protein]17472961
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [[acetophenone co-treated with OLFR151 co-treated with P2RY2] results in increased phosphorylation of MAPK3 protein]17472961
C006253pirinixic acidpirinixic acid results in decreased expression of P2RY2 mRNA23811191
C006253pirinixic acidpirinixic acid results in decreased expression of P2RY2 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of P2RY2 mRNA24677778
D011070Poly I-CPoly I-C results in decreased expression of P2RY2 protein23516405
D011070Poly I-CSuramin inhibits the reaction [Poly I-C results in decreased expression of P2RY2 protein]23516405
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of P2RY2 mRNA19162173
C005556propionaldehydepropionaldehyde results in increased expression of P2RY2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of P2RY2 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of P2RY2 mRNA27029645
C077792pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]"10604969
C077792pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP]"10604969
D011794QuercetinQuercetin results in increased expression of P2RY2 mRNA15309432
C488333Ro 65-7199Ro 65-7199 results in increased expression of P2RY2 mRNA14610520
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of P2RY2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of P2RY2 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of P2RY2 mRNA22431001
C017947sodium arsenitesodium arsenite results in decreased expression of P2RY2 mRNA21357385|2320411
D053260SootSoot results in increased expression of P2RY2 mRNA22461453|2655175
D013498SuraminSuramin inhibits the reaction [Poly I-C results in decreased expression of P2RY2 protein]23516405
D013498SuraminSuramin results in decreased activity of P2RY2 protein15654852
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of P2RY2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of P2RY2 mRNA21570461
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of P2RY2 mRNA28973375
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [P2RY2 protein results in increased uptake of Calcium]17003265
C009495titanium dioxidetitanium dioxide results in increased expression of P2RY2 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of P2RY2 mRNA22363418
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of P2RY2 mRNA28111298
D014212TretinoinTretinoin results in increased expression of P2RY2 mRNA12875902
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of P2RY2 mRNA"26179874
C080163trovafloxacintrovafloxacin results in decreased expression of P2RY2 mRNA24136188
D017974Uranium CompoundsUranium Compounds results in increased expression of P2RY2 mRNA19654044
D014520UrethaneUrethane results in decreased expression of P2RY2 mRNA28818685
D014544Uridine Triphosphate"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]"10604969
D014544Uridine Triphosphate"pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP]"10604969
D014544Uridine TriphosphateUridine Triphosphate results in increased activity of P2RY2 protein10604969
D014544Uridine Triphosphate[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid10604969
D014544Uridine Triphosphate[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP10604969
D014544Uridine TriphosphateUridine Triphosphate binds to and results in increased activity of P2RY2 protein15654852
D014635Valproic AcidValproic Acid affects the expression of P2RY2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of P2RY2 mRNA23179753
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of P2RY2 mRNA16330358
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of P2RY2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of P2RY2 mRNA23034163
D015032ZincZinc deficiency results in decreased expression of P2RY2 mRNA12672911

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0038023signaling receptor activity-TAS7779087  
GO:0045028G-protein coupled purinergic nucleotide receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006873cellular ion homeostasis-TAS8159738  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0035589G-protein coupled purinergic nucleotide receptor signaling pathway-IEA-  
GO:0070257positive regulation of mucus secretion-IEA-  
GO:0097746regulation of blood vessel diameter-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8159738  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-417957P2Y receptorsTAS
R-HSA-418038Nucleotide-like (purinergic) receptorsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-5683826Surfactant metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17137217Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (2006 Aug)Kokubo YHypertens Res