Gene info: ID 5033

Gene: P4HA1

GENE ID: 5033

Synonyms: P4HA

Description: prolyl 4-hydroxylase subunit alpha 1

Gene type: protein-coding

Location: 10q22.1

dbXrefs: Ensembl:ENSG00000122884 MIM:176710 Vega:OTTHUMG00000018449 UniprotKB:P13674

RefSeq: NC_000010.11

Retrived from: SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.964e-1 (AD) 3.713e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs7085141	chr10:73017023 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs16930262	chr10:73007937 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABHD3	0.854
BAG3	0.814
PLOD2	0.796
CASP7	0.793
HSPB1	0.787
SNAP23	0.782
NFE2L2	0.781
MKNK2	0.768
CSF1	0.763
PLEKHF2	0.759

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NUDT18	-0.476
SLC7A4	-0.473
BFSP1	-0.458
ZSCAN1	-0.454
PPEF1	-0.438
TPBGL	-0.434
CYP4A11	-0.428
MYOZ3	-0.425
AARD	-0.425
F7	-0.424

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00126	Vitamin C	Small Molecule	50-81-7	Approved\|Nutraceutical	Target
DB00139	Succinic acid	Small Molecule	110-15-6	Approved\|Nutraceutical	Target
DB00172	L-Proline	Small Molecule	147-85-3	Approved\|Nutraceutical	Target
DB01275	Hydralazine	Small Molecule	86-54-4	Approved	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of P4HA1 mRNA"	19162173
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of P4HA1 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of P4HA1 mRNA"	20406850
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of P4HA1 mRNA"	21346803
D000082	Acetaminophen	Acetaminophen results in decreased expression of P4HA1 mRNA	25704631
D000082	Acetaminophen	Acetaminophen affects the expression of P4HA1 mRNA	17562736
C106812	adefovir dipivoxil	adefovir dipivoxil results in decreased expression of P4HA1 mRNA	25596134
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of P4HA1 protein	20106945
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of P4HA1 mRNA	28522335
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of P4HA1 mRNA	16483693
D001151	Arsenic	Arsenic results in decreased expression of P4HA1 mRNA	19654921
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of P4HA1 mRNA	15725085
C547126	AZM551248	AZM551248 results in increased expression of P4HA1 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of P4HA1 mRNA	21632981
C006780	bisphenol A	bisphenol A results in increased expression of P4HA1 protein	24909818
C006780	bisphenol A	bisphenol A affects the expression of P4HA1 mRNA	25181051
C025703	bleomycetin	bleomycetin results in increased expression of P4HA1 mRNA	21040473
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased expression of P4HA1 mRNA	15878706
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of P4HA1 mRNA	15336504
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of P4HA1 mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of P4HA1 promoter	22457795
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of P4HA1 mRNA	25596134
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of P4HA1 mRNA	21356183
C059262	cidofovir	cidofovir results in decreased expression of P4HA1 mRNA	25596134
D004002	Clodronic Acid	Clodronic Acid results in decreased expression of P4HA1 mRNA	25596134
C018021	cobaltous chloride	cobaltous chloride results in increased expression of P4HA1 mRNA	19376846\|2220211
C018021	cobaltous chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of P4HA1 mRNA]	22202117
C018021	cobaltous chloride	cobaltous chloride results in increased expression of P4HA1 mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of P4HA1 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of P4HA1 mRNA	20106945\|2163298
C526360	dechlorane plus	dechlorane plus results in increased expression of P4HA1 mRNA	22913625
D003676	Deferoxamine	Deferoxamine results in decreased expression of P4HA1 protein	19515424
D003676	Deferoxamine	ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of P4HA1 protein]	19515424
D003703	Demecolcine	Demecolcine results in decreased expression of P4HA1 mRNA	23649840
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of P4HA1 mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of P4HA1 mRNA	25596134
C000944	dicrotophos	dicrotophos results in decreased expression of P4HA1 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of P4HA1 mRNA	18042831\|2501614
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of P4HA1 mRNA	19638242
D004237	Diuron	Diuron results in decreased expression of P4HA1 mRNA	21551480
D004317	Doxorubicin	Doxorubicin affects the expression of P4HA1 protein	29385562
D011345	Fenofibrate	Fenofibrate affects the expression of P4HA1 mRNA	25596134
C013531	ferric ammonium citrate	ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of P4HA1 protein]	19515424
D005557	Formaldehyde	Formaldehyde results in decreased expression of P4HA1 mRNA	23649840
D005947	Glucose	Glucose deficiency results in increased expression of P4HA1 protein	22314686
D007069	Ifosfamide	Ifosfamide results in decreased expression of P4HA1 mRNA	25596134
D007501	Iron	Iron deficiency results in increased expression of P4HA1 mRNA	16629162
C005056	isoascorbic acid	isoascorbic acid results in increased expression of P4HA1 mRNA	11852233
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of P4HA1 mRNA	24796395
D007649	Ketamine	Ketamine results in decreased expression of P4HA1 mRNA	20080153
C045463	leflunomide	leflunomide results in increased expression of P4HA1 mRNA	24136188
D001556	Lindane	Lindane results in decreased expression of P4HA1 mRNA	17785943
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of P4HA1 mRNA	16415329
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of P4HA1 mRNA	16507785
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in increased expression of P4HA1 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of P4HA1 mRNA	19564919
D008727	Methotrexate	Methotrexate affects the expression of P4HA1 mRNA	18502557
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of P4HA1 mRNA	23179753\|2718838
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of P4HA1 mRNA	17475336
D008942	Mitoxantrone	P4HA1 protein affects the susceptibility to Mitoxantrone	16217747
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of P4HA1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of P4HA1 mRNA"	25554681
C022838	nickel chloride	nickel chloride results in increased expression of P4HA1 mRNA	21455298
C022838	nickel chloride	nickel chloride affects the expression of P4HA1 mRNA	22110744
D009569	Nitric Oxide	Nitric Oxide deficiency results in decreased expression of P4HA1 mRNA	15878706
C030110	oxaliplatin	oxaliplatin results in decreased expression of P4HA1 mRNA	17762391
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of P4HA1 mRNA	25729387
D010100	Oxygen	HIF1A mutant form inhibits the reaction [Oxygen deficiency results in increased expression of P4HA1 mRNA]	23423382
D010100	Oxygen	Oxygen deficiency results in increased expression of P4HA1 mRNA	20042640\|2342338
D010100	Oxygen	Oxygen deficiency results in increased expression of P4HA1 mRNA	20880076
D010126	Ozone	Ozone results in increased expression of P4HA1 mRNA	21543283
D000073878	Palm Oil	Palm Oil results in decreased expression of P4HA1 mRNA	18042831
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of P4HA1 mRNA	27614199
D010634	Phenobarbital	Phenobarbital affects the expression of P4HA1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of P4HA1 mRNA	19162173
D010656	Phenylephrine	Phenylephrine results in increased expression of P4HA1 mRNA	18158353
C006253	pirinixic acid	pirinixic acid results in increased expression of P4HA1 mRNA	18301758
D010936	Plant Extracts	Plant Extracts results in increased expression of P4HA1 mRNA	23557933
C045950	propiconazole	propiconazole results in increased expression of P4HA1 mRNA	21278054
D011794	Quercetin	Quercetin results in decreased expression of P4HA1 mRNA	21632981
D011899	Ranitidine	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of P4HA1 mRNA	16415329
C089730	rosiglitazone	rosiglitazone results in increased expression of P4HA1 mRNA	25596134
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in increased expression of P4HA1 mRNA	19564919
C002979	selenomethylselenocysteine	selenomethylselenocysteine results in increased expression of P4HA1 mRNA	18514395
C078903	seocalcitol	seocalcitol results in increased expression of P4HA1 mRNA	12040012
C017947	sodium arsenite	sodium arsenite affects the expression of P4HA1 mRNA	19590694
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of P4HA1 protein	28918527
D018038	Sodium Selenite	Sodium Selenite results in increased expression of P4HA1 mRNA	18514395
D013629	Tamoxifen	Tamoxifen affects the expression of P4HA1 mRNA	20937368
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of P4HA1 mRNA	16443690\|1849575
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of P4HA1 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of P4HA1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of P4HA1 mRNA]	15667827
D013849	Thimerosal	Thimerosal results in decreased expression of P4HA1 mRNA	27188386
C009495	titanium dioxide	titanium dioxide results in increased expression of P4HA1 mRNA	23131501\|2340900
C066340	tolcapone	tolcapone binds to P4HA1 protein	19783845
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of P4HA1 mRNA	25729387
C011559	tributyltin	tributyltin results in decreased expression of P4HA1 mRNA	27614199
C406224	valdecoxib	valdecoxib results in increased expression of P4HA1 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of P4HA1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of P4HA1 mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in decreased methylation of P4HA1 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of P4HA1 mRNA	19165385
D014750	Vincristine	Vincristine results in decreased expression of P4HA1 mRNA	23649840
C111237	vorinostat	vorinostat results in decreased expression of P4HA1 mRNA	27188386
D015032	Zinc	Zinc deficiency results in increased expression of P4HA1 mRNA	12672911
C016837	zinc chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of P4HA1 mRNA]	22202117
C088658	zoledronic acid	zoledronic acid results in increased expression of P4HA1 mRNA	25596134

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004656	procollagen-proline 4-dioxygenase activity	CONTRIBUTES_TO	IBA	21873635
GO:0004656	procollagen-proline 4-dioxygenase activity	-	IEA	-
GO:0005506	iron ion binding	-	IEA	-
GO:0005515	protein binding	-	IPI	17500595
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	-	IEA	-
GO:0031418	L-ascorbic acid binding	-	IEA	-
GO:0042802	identical protein binding	-	IPI	24207127

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	-	IBA	21873635
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	-	IEA	-
GO:0030199	collagen fibril organization	-	IEA	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IDA	-
GO:0005783	endoplasmic reticulum	-	IBA	21873635
GO:0005783	endoplasmic reticulum	-	IDA	-
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0016222	procollagen-proline 4-dioxygenase complex	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-

KEGG ID	KEGG Term
hsa00330	Arginine and proline metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474290	Collagen formation	TAS
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal