Gene: P4HA1

5033
P4HA
prolyl 4-hydroxylase subunit alpha 1
protein-coding
10q22.1
Ensembl:ENSG00000122884 MIM:176710 Vega:OTTHUMG00000018449 UniprotKB:P13674
NC_000010.11
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.964e-1 (AD)  3.713e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7085141chr10:73017023 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs16930262chr10:73007937 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABHD30.854
BAG30.814
PLOD20.796
CASP70.793
HSPB10.787
SNAP230.782
NFE2L20.781
MKNK20.768
CSF10.763
PLEKHF20.759

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUDT18-0.476
SLC7A4-0.473
BFSP1-0.458
ZSCAN1-0.454
PPEF1-0.438
TPBGL-0.434
CYP4A11-0.428
MYOZ3-0.425
AARD-0.425
F7-0.424

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00126Vitamin CSmall Molecule50-81-7Approved|NutraceuticalTarget
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTarget
DB00172L-ProlineSmall Molecule147-85-3Approved|NutraceuticalTarget
DB01275HydralazineSmall Molecule86-54-4ApprovedTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of P4HA1 mRNA"19162173
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of P4HA1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of P4HA1 mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of P4HA1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of P4HA1 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of P4HA1 mRNA17562736
C106812adefovir dipivoxiladefovir dipivoxil results in decreased expression of P4HA1 mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 affects the expression of P4HA1 protein20106945
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of P4HA1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of P4HA1 mRNA16483693
D001151ArsenicArsenic results in decreased expression of P4HA1 mRNA19654921
C006632arsenic trioxidearsenic trioxide results in decreased expression of P4HA1 mRNA15725085
C547126AZM551248AZM551248 results in increased expression of P4HA1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of P4HA1 mRNA21632981
C006780bisphenol Abisphenol A results in increased expression of P4HA1 protein24909818
C006780bisphenol Abisphenol A affects the expression of P4HA1 mRNA25181051
C025703bleomycetinbleomycetin results in increased expression of P4HA1 mRNA21040473
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of P4HA1 mRNA15878706
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of P4HA1 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of P4HA1 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of P4HA1 promoter22457795
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of P4HA1 mRNA25596134
D004390ChlorpyrifosChlorpyrifos results in increased expression of P4HA1 mRNA21356183
C059262cidofovircidofovir results in decreased expression of P4HA1 mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of P4HA1 mRNA25596134
C018021cobaltous chloridecobaltous chloride results in increased expression of P4HA1 mRNA19376846|2220211
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of P4HA1 mRNA]22202117
C018021cobaltous chloridecobaltous chloride results in increased expression of P4HA1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of P4HA1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of P4HA1 mRNA20106945|2163298
C526360dechlorane plusdechlorane plus results in increased expression of P4HA1 mRNA22913625
D003676DeferoxamineDeferoxamine results in decreased expression of P4HA1 protein19515424
D003676Deferoxamineferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of P4HA1 protein]19515424
D003703DemecolcineDemecolcine results in decreased expression of P4HA1 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of P4HA1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of P4HA1 mRNA25596134
C000944dicrotophosdicrotophos results in decreased expression of P4HA1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of P4HA1 mRNA18042831|2501614
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of P4HA1 mRNA19638242
D004237DiuronDiuron results in decreased expression of P4HA1 mRNA21551480
D004317DoxorubicinDoxorubicin affects the expression of P4HA1 protein29385562
D011345FenofibrateFenofibrate affects the expression of P4HA1 mRNA25596134
C013531ferric ammonium citrateferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of P4HA1 protein]19515424
D005557FormaldehydeFormaldehyde results in decreased expression of P4HA1 mRNA23649840
D005947GlucoseGlucose deficiency results in increased expression of P4HA1 protein22314686
D007069IfosfamideIfosfamide results in decreased expression of P4HA1 mRNA25596134
D007501IronIron deficiency results in increased expression of P4HA1 mRNA16629162
C005056isoascorbic acidisoascorbic acid results in increased expression of P4HA1 mRNA11852233
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of P4HA1 mRNA24796395
D007649KetamineKetamine results in decreased expression of P4HA1 mRNA20080153
C045463leflunomideleflunomide results in increased expression of P4HA1 mRNA24136188
D001556LindaneLindane results in decreased expression of P4HA1 mRNA17785943
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of P4HA1 mRNA16415329
D008627Mercuric ChlorideMercuric Chloride results in increased expression of P4HA1 mRNA16507785
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of P4HA1 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of P4HA1 mRNA19564919
D008727MethotrexateMethotrexate affects the expression of P4HA1 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of P4HA1 mRNA23179753|2718838
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of P4HA1 mRNA17475336
D008942MitoxantroneP4HA1 protein affects the susceptibility to Mitoxantrone16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of P4HA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of P4HA1 mRNA"25554681
C022838nickel chloridenickel chloride results in increased expression of P4HA1 mRNA21455298
C022838nickel chloridenickel chloride affects the expression of P4HA1 mRNA22110744
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of P4HA1 mRNA15878706
C030110oxaliplatinoxaliplatin results in decreased expression of P4HA1 mRNA17762391
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of P4HA1 mRNA25729387
D010100OxygenHIF1A mutant form inhibits the reaction [Oxygen deficiency results in increased expression of P4HA1 mRNA]23423382
D010100OxygenOxygen deficiency results in increased expression of P4HA1 mRNA20042640|2342338
D010100OxygenOxygen deficiency results in increased expression of P4HA1 mRNA20880076
D010126OzoneOzone results in increased expression of P4HA1 mRNA21543283
D000073878Palm OilPalm Oil results in decreased expression of P4HA1 mRNA18042831
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of P4HA1 mRNA27614199
D010634PhenobarbitalPhenobarbital affects the expression of P4HA1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of P4HA1 mRNA19162173
D010656PhenylephrinePhenylephrine results in increased expression of P4HA1 mRNA18158353
C006253pirinixic acidpirinixic acid results in increased expression of P4HA1 mRNA18301758
D010936Plant ExtractsPlant Extracts results in increased expression of P4HA1 mRNA23557933
C045950propiconazolepropiconazole results in increased expression of P4HA1 mRNA21278054
D011794QuercetinQuercetin results in decreased expression of P4HA1 mRNA21632981
D011899Ranitidine[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of P4HA1 mRNA16415329
C089730rosiglitazonerosiglitazone results in increased expression of P4HA1 mRNA25596134
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of P4HA1 mRNA19564919
C002979selenomethylselenocysteineselenomethylselenocysteine results in increased expression of P4HA1 mRNA18514395
C078903seocalcitolseocalcitol results in increased expression of P4HA1 mRNA12040012
C017947sodium arsenitesodium arsenite affects the expression of P4HA1 mRNA19590694
D012969Sodium FluorideSodium Fluoride results in increased expression of P4HA1 protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of P4HA1 mRNA18514395
D013629TamoxifenTamoxifen affects the expression of P4HA1 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of P4HA1 mRNA16443690|1849575
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of P4HA1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of P4HA1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of P4HA1 mRNA]15667827
D013849ThimerosalThimerosal results in decreased expression of P4HA1 mRNA27188386
C009495titanium dioxidetitanium dioxide results in increased expression of P4HA1 mRNA23131501|2340900
C066340tolcaponetolcapone binds to P4HA1 protein19783845
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of P4HA1 mRNA25729387
C011559tributyltintributyltin results in decreased expression of P4HA1 mRNA27614199
C406224valdecoxibvaldecoxib results in increased expression of P4HA1 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of P4HA1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of P4HA1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of P4HA1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of P4HA1 mRNA19165385
D014750VincristineVincristine results in decreased expression of P4HA1 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of P4HA1 mRNA27188386
D015032ZincZinc deficiency results in increased expression of P4HA1 mRNA12672911
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of P4HA1 mRNA]22202117
C088658zoledronic acidzoledronic acid results in increased expression of P4HA1 mRNA25596134

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004656procollagen-proline 4-dioxygenase activityCONTRIBUTES_TOIBA21873635  
GO:0004656procollagen-proline 4-dioxygenase activity-IEA-  
GO:0005506iron ion binding-IEA-  
GO:0005515protein binding-IPI17500595  
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen-IEA-  
GO:0031418L-ascorbic acid binding-IEA-  
GO:0042802identical protein binding-IPI24207127  
GO ID GO Term Qualifier Evidence PubMed
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-proline-IBA21873635  
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-proline-IEA-  
GO:0030199collagen fibril organization-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016222procollagen-proline 4-dioxygenase complex-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal