Gene: PEBP1

5037
HCNP|HCNPpp|HEL-210|HEL-S-34|HEL-S-96|PBP|PEBP|PEBP-1|RKIP
phosphatidylethanolamine binding protein 1
protein-coding
12q24.23
Ensembl:ENSG00000089220 MIM:604591 Vega:OTTHUMG00000168860 UniprotKB:P30086
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
9.208e-1 (AD)  6.521e-1 (ND)   (Frontal_Cortex)
8.589e-1 (AD)  4.817e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHMP4B0.97
COPS60.965
CALM20.964
MRFAP10.964
OAZ20.963
CFL10.962
GAPDH0.962
NGRN0.96
YWHAE0.96
PARK70.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.898
OR4F29-0.893
MTRNR2L6-0.262
KCNJ15-0.257
C2orf83-0.251
MTRNR2L9-0.245
SIX1-0.243
SLAMF6-0.24
C8orf74-0.236
KLRB1-0.235

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of PEBP1 mRNA"19162173
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in decreased phosphorylation of PEBP1 protein"27026707
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of PEBP1 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of PEBP1 mRNA"20702594
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PEBP1 mRNA"12376462
C5444715-hydroxythalidomide5-hydroxythalidomide binds to PEBP1 protein27464947
C5444715-hydroxythalidomide5-hydroxythalidomide binds to PEBP1 protein27464947
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PEBP1 protein"24455688
D000082AcetaminophenAcetaminophen results in decreased expression of PEBP1 mRNA25704631|2906747
D000082AcetaminophenAcetaminophen affects the expression of PEBP1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PEBP1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PEBP1 mRNA]17585979
D000242Cyclic AMPPEBP1 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]26670611
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PEBP1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PEBP1 mRNA27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of PEBP1 protein26072098
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PEBP1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PEBP1 mRNA24449571
D001205Ascorbic AcidAscorbic Acid results in increased expression of PEBP1 mRNA19224539
D001205Ascorbic AcidAscorbic Acid results in increased expression of PEBP1 protein19224539
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PEBP1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PEBP1 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PEBP1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PEBP1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PEBP1 protein20719421
D001564Benzo(a)pyrene[Cadmium Chloride co-treated with Benzo(a)pyrene] results in decreased expression of PEBP1 protein20719421
C006780bisphenol Abisphenol A results in increased expression of PEBP1 mRNA25181051
C032036bromobenzenebromobenzene metabolite binds to PEBP1 protein17305373
C584509C646 compoundC646 compound results in decreased expression of PEBP1 mRNA26191083
D002104CadmiumCadmium results in increased expression of PEBP1 mRNA23256528
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PEBP1 mRNA19031917
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PEBP1 protein21699967
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PEBP1 mRNA21297351
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PEBP1 protein21699967
D019256Cadmium Chloride[Cadmium Chloride co-treated with Benzo(a)pyrene] results in decreased expression of PEBP1 protein20719421
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PEBP1 protein20719421
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PEBP1 protein12629582
C100187chloropicrinchloropicrin results in increased expression of PEBP1 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PEBP1 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PEBP1 mRNA27858113
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PEBP1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PEBP1 mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PEBP1 mRNA17602206
D003033Coal TarCoal Tar results in decreased expression of PEBP1 mRNA27858113
D003042CocaineCocaine affects the expression of PEBP1 protein19393250
D003042CocaineCocaine affects the expression of PEBP1 mRNA20187946
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PEBP1 mRNA20971185
D003300CopperPEBP1 protein binds to Copper15359738
D019327Copper SulfateCopper Sulfate results in decreased expression of PEBP1 mRNA19549813
C009160cyclonitecyclonite results in increased expression of PEBP1 mRNA25559034
D016572CyclosporineCyclosporine results in decreased expression of PEBP1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of PEBP1 mRNA21865292
C017160cypermethrincypermethrin results in increased expression of PEBP1 protein21561882
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PEBP1 mRNA]27941970
D003907DexamethasonePEBP1 protein results in decreased susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]26670611
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PEBP1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PEBP1 mRNA17379624|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PEBP1 protein17379624
C552234didymindidymin results in increased expression of PEBP1 protein27899290
C552234didyminlocostatin inhibits the reaction [didymin results in increased expression of PEBP1 protein]27899290
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PEBP1 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PEBP1 mRNA]17942915
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PEBP1 mRNA17602206
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PEBP1 mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PEBP1 mRNA"12376462
D007980LevodopaLevodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein]23562983
D004317DoxorubicinDoxorubicin results in increased oxidation of PEBP1 protein28818578
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PEBP1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PEBP1 mRNA12655037|1755790
C024565ethylene dichlorideethylene dichloride results in decreased expression of PEBP1 mRNA28189721
D005230Fatty Acids, Nonesterified"PEBP1 protein results in increased abundance of Fatty Acids, Nonesterified"26670611
D005485FlutamideFlutamide results in increased expression of PEBP1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PEBP1 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of PEBP1 mRNA19167457
D005947GlucoseGlucose deficiency results in increased expression of PEBP1 protein22314686
D005947GlucoseGlucose deficiency results in increased secretion of PEBP1 protein24802182
C492448ICG 001ICG 001 results in decreased expression of PEBP1 mRNA26191083
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of PEBP1 mRNA"26377693
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PEBP1 mRNA25613284
D0150561-Methyl-3-isobutylxanthinePEBP1 protein results in decreased susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]26670611
D007545IsoproterenolPEBP1 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]26670611
C410337K 7174K 7174 results in decreased expression of PEBP1 mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of PEBP1 mRNA16807920
D008094LithiumLithium results in increased expression of PEBP1 protein18296634
C529490locostatinlocostatin inhibits the reaction [didymin results in increased expression of PEBP1 protein]27899290
D008344ManebLevodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein]23562983
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein23562983
D008694MethamphetamineMethamphetamine results in increased expression of PEBP1 protein19826936
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PEBP1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PEBP1 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of PEBP1 mRNA12710931
D008777MethyltestosteroneMethyltestosterone results in decreased expression of PEBP1 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PEBP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PEBP1 mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of PEBP1 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of PEBP1 protein19716841
C025256nonylphenolnonylphenol results in increased expression of PEBP1 protein19260726
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PEBP1 mRNA20971185
D010269ParaquatLevodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein]23562983
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein23562983
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PEBP1 protein19954255
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of PEBP1 protein19854247
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of PEBP1 mRNA19854247
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PEBP1 protein22609092
D010634PhenobarbitalPhenobarbital results in increased expression of PEBP1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of PEBP1 mRNA19162173
D010795Phthalic AcidsPhthalic Acids results in decreased expression of PEBP1 mRNA15728792
C006253pirinixic acidpirinixic acid results in increased expression of PEBP1 mRNA17426115
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in increased expression of PEBP1 protein19059321
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PEBP1 protein18563748
D011374ProgesteroneProgesterone results in increased expression of PEBP1 mRNA19690047
D011794QuercetinQuercetin results in increased expression of PEBP1 protein17292933
C059514resveratrolresveratrol affects the secretion of PEBP1 protein24802182
C059514resveratrolresveratrol results in decreased expression of PEBP1 protein25505154
D012822Silicon DioxideSilicon Dioxide results in increased expression of PEBP1 mRNA23623845
C017947sodium arsenitesodium arsenite results in decreased expression of PEBP1 mRNA27255443
C017947sodium arsenitesodium arsenite results in decreased expression of PEBP1 protein27255443
C016104sodium bichromatesodium bichromate results in decreased expression of PEBP1 protein20600800
D012969Sodium FluorideSodium Fluoride results in decreased expression of PEBP1 mRNA21340527
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of PEBP1 mRNA16214533
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PEBP1 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEBP1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PEBP1 mRNA20702594|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PEBP1 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PEBP1 mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEBP1 mRNA9653055
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PEBP1 protein15822908
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PEBP1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PEBP1 mRNA20133372
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PEBP1 gene27618143
D014280TriglyceridesPEBP1 protein results in increased abundance of Triglycerides26670611
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PEBP1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PEBP1 mRNA29024780
D014415TunicamycinTunicamycin results in decreased expression of PEBP1 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of PEBP1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PEBP1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of PEBP1 protein20616205
D014810Vitamin EVitamin E results in increased expression of PEBP1 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of PEBP1 protein20543569
D015215ZidovudineZidovudine results in decreased expression of PEBP1 mRNA16894629

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI17097642  21831839  
GO:0005524ATP binding-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0008429phosphatidylethanolamine binding-TAS7637590  
GO:0019899enzyme binding-IPI21831839  
GO:0019901protein kinase binding-IPI21831839  
GO:0051019mitogen-activated protein kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0000165MAPK cascade-TAS-  
GO:0001505regulation of neurotransmitter levels-IBA21873635  
GO:0002026regulation of the force of heart contraction-IBA21873635  
GO:0006979response to oxidative stress-IBA21873635  
GO:0007568aging-IBA21873635  
GO:0009408response to heat-IBA21873635  
GO:0009611response to wounding-IBA21873635  
GO:0009636response to toxic substance-IBA21873635  
GO:0010243response to organonitrogen compound-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0014823response to activity-IBA21873635  
GO:0021766hippocampus development-IBA21873635  
GO:0043409negative regulation of MAPK cascade-IBA21873635  
GO:0043950positive regulation of cAMP-mediated signaling-IBA21873635  
GO:0045471response to ethanol-IBA21873635  
GO:0045840positive regulation of mitotic nuclear division-IBA21873635  
GO:0048240sperm capacitation-IBA21873635  
GO:0051412response to corticosterone-IBA21873635  
GO:0051591response to cAMP-IBA21873635  
GO:0051592response to calcium ion-IBA21873635  
GO:0060409positive regulation of acetylcholine metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005634nucleus-HDA21630459  
GO:0005739mitochondrion-IBA21873635  
GO:0005741mitochondrial outer membrane-IBA21873635  
GO:0005794Golgi apparatus-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0008021synaptic vesicle-IBA21873635  
GO:0009986cell surface-IBA21873635  
GO:0043025neuronal cell body-IBA21873635  
GO:0043209myelin sheath-IBA21873635  
GO:0043679axon terminus-IBA21873635  
GO:0045177apical part of cell-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  19199708  20458337  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5675221Negative regulation of MAPK pathwayTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24198121Cigarette smoking exposure alters pebp1 DNA methylation and protein profile involved in MAPK signaling pathway in mice testis. (2013 Dec)Xu WBiol Reprod