Gene: FURIN

5045
FUR|PACE|PCSK3|SPC1
furin, paired basic amino acid cleaving enzyme
protein-coding
15q26.1
Ensembl:ENSG00000140564 MIM:136950 Vega:OTTHUMG00000149831 UniprotKB:P09958
NC_000015.10
PubMed
0   ANCO-SNPs
OD|ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.538e-1 (AD)  5.467e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00207731chr15:91416118FURIN3.600e-17Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAF70.896
CSNK1D0.888
BRD40.887
TNFAIP10.881
SRF0.879
ERGIC10.879
PPARD0.877
E2F40.875
TMEM2140.873
ZNF5980.87

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.679
OR4F29-0.636
C5orf64-0.298
PDE11A-0.298
CTNNA3-0.281
TNFRSF13B-0.259
KLRC2-0.259
SH2D1A-0.244
C9orf92-0.227
TRPV5-0.221

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03600Capric acidSmall Molecule334-48-5ExperimentalTarget
DB04951PirfenidoneSmall Molecule53179-13-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FURIN mRNA"19114083
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of FURIN mRNA"17547211
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of FURIN mRNA"12376462
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FURIN mRNA"18648102
C0524109-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine"9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of FURIN mRNA"25633564
D000082AcetaminophenAcetaminophen results in increased expression of FURIN mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of FURIN mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of FURIN mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FURIN gene27153756
C430898AGN 194204AGN 194204 results in decreased expression of FURIN mRNA16339527
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of FURIN mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FURIN mRNA16483693
D001058ApomorphineApomorphine results in decreased expression of FURIN mRNA25633564
D001151ArsenicArsenic affects the methylation of FURIN gene25304211
D001241AspirinAspirin results in decreased expression of FURIN mRNA15928584
D001280AtrazineAtrazine results in increased expression of FURIN mRNA25929836
C080985batimastatbatimastat results in decreased activity of FURIN protein15632106
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FURIN mRNA22316170
C006780bisphenol Abisphenol A affects the expression of FURIN mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of FURIN mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of FURIN mRNA26191083
D002104CadmiumCadmium results in decreased expression of FURIN mRNA24614234
D002118CalciumCalcium affects the expression of FURIN mRNA15913539
D002273CarcinogensCarcinogens results in increased expression of FURIN mRNA16316942
D002857ChromiumChromium results in decreased expression of FURIN mRNA17547211
C018021cobaltous chloridecobaltous chloride results in decreased expression of FURIN mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of FURIN mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of FURIN mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of FURIN mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FURIN mRNA21266533
D002945CisplatinCisplatin results in decreased expression of FURIN mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of FURIN mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of FURIN mRNA"12376462
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of FURIN mRNA17547211
C104705dopamine quinonedopamine quinone results in decreased activity of FURIN protein21540292
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FURIN mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FURIN mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of FURIN mRNA18035473
D005485FlutamideFlutamide results in decreased expression of FURIN mRNA24136188
D005944GlucosamineGlucosamine results in decreased cleavage of FURIN protein alternative form19909832
D005944GlucosamineGlucosamine results in decreased glycosylation of and results in decreased activity of FURIN protein19909832
C492448ICG 001ICG 001 results in decreased expression of FURIN mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FURIN mRNA25613284
C119620kenpaullonekenpaullone results in decreased expression of FURIN mRNA25633564
D008628MercuryMercury results in decreased expression of FURIN mRNA17547211
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of FURIN mRNA12710931
C523799MRK 003FURIN results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FURIN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FURIN mRNA"25554681
C022838nickel chloridenickel chloride results in decreased expression of FURIN mRNA17547211
D009638NorepinephrineNorepinephrine results in decreased activity of FURIN protein21540292
D017239PaclitaxelFURIN mRNA results in decreased susceptibility to Paclitaxel16322897
D010795Phthalic AcidsPhthalic Acids results in decreased expression of FURIN mRNA21061450
D011192Potassium DichromatePotassium Dichromate results in decreased expression of FURIN mRNA17547211
D012110ReserpineReserpine results in increased activity of FURIN protein21540292
C028632rutecarpinerutecarpine results in decreased expression of FURIN mRNA25633564
D012715Sesame OilSesame Oil results in increased expression of FURIN mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FURIN mRNA25895662
D012834SilverSilver results in increased expression of FURIN mRNA27131904
D012999SomanSoman results in increased expression of FURIN mRNA19281266
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of FURIN mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FURIN mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FURIN mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FURIN mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FURIN mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of FURIN mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of FURIN mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI14744861  
GO:0004175endopeptidase activity-IDA9242664  17010968  
GO:0004175endopeptidase activity-TAS-  
GO:0004252serine-type endopeptidase activity-IDA8615794  10567353  
GO:0004252serine-type endopeptidase activity-IMP9130696  11799113  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0004867serine-type endopeptidase inhibitor activity-IDA10567353  
GO:0005515protein binding-IPI23829672  25543063  
GO:0008233peptidase activity-IDA10526337  15082773  15606899  17938254  
GO:0042277peptide binding-IDA8940009  
GO:0046872metal ion binding-IEA-  
GO:0048406nerve growth factor binding-IDA8615794  
GO ID GO Term Qualifier Evidence PubMed
GO:0006465signal peptide processing-IDA16912035  
GO:0006465signal peptide processing-TAS-  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS-  
GO:0008283cell proliferation-IMP15899807  
GO:0009966regulation of signal transduction-IEA-  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0016485protein processing-IDA9242664  10526337  10567353  14744861  15606899  17938254  
GO:0016485protein processing-IMP15899807  
GO:0016486peptide hormone processing-IDA9242664  
GO:0019058viral life cycle-IEP8940009  
GO:0019082viral protein processing-TAS-  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0030198extracellular matrix organization-TAS-  
GO:0030574collagen catabolic process-TAS-  
GO:0031638zymogen activation-IMP9130696  11799113  
GO:0032804negative regulation of low-density lipoprotein particle receptor catabolic process-IDA16912035  
GO:0032902nerve growth factor production-IDA8615794  
GO:0032904negative regulation of nerve growth factor productionNOTIDA10567353  
GO:0032911negative regulation of transforming growth factor beta1 production-IMP15899807  
GO:0032940secretion by cell-IDA8615794  
GO:0042176regulation of protein catabolic process-IMP15899807  
GO:0043043peptide biosynthetic process-IDA8262946  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045714regulation of low-density lipoprotein particle receptor biosynthetic process-IEA-  
GO:0051004regulation of lipoprotein lipase activity-TAS-  
GO:0051044positive regulation of membrane protein ectodomain proteolysis-IC17010968  
GO:0052548regulation of endopeptidase activity-IDA14744861  
GO:0070268cornification-TAS-  
GO:0090472dibasic protein processing-IMP11799113  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IMP9130696  11799113  
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular spaceNOTIDA10567353  
GO:0005783endoplasmic reticulum-IGI17938254  
GO:0005796Golgi lumen-TAS-  
GO:0005802trans-Golgi network-IDA14744861  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IDA16537537  
GO:0010008endosome membrane-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0030140trans-Golgi network transport vesicle-IDA15078902  
GO:0045121membrane raft-IDA17010968  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1181150Signaling by NODALIEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1442490Collagen degradationTAS
R-HSA-1442490Collagen degradationIEA
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1566948Elastic fibre formationTAS
R-HSA-157118Signaling by NOTCHTAS
R-HSA-1592389Activation of Matrix MetalloproteinasesTAS
R-HSA-159782Removal of aminoterminal propeptides from gamma-carboxylated proteinsTAS
R-HSA-159854Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162587HIV Life CycleTAS
R-HSA-162599Late Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationTAS
R-HSA-1643685DiseaseTAS
R-HSA-166520Signaling by NTRKsTAS
R-HSA-167060NGF processingTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-171286Synthesis and processing of ENV and VPUTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-175474Assembly Of The HIV VirionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-1912420Pre-NOTCH Processing in GolgiTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-2173789TGF-beta receptor signaling activates SMADsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5210891Uptake and function of anthrax toxinsTAS
R-HSA-5339562Uptake and actions of bacterial toxinsTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS
R-HSA-8963889Assembly of active LPL and LIPC lipase complexesTAS
R-HSA-8963899Plasma lipoprotein remodelingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9036866Expression and Processing of NeurotrophinsTAS
R-HSA-977225Amyloid fiber formationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28776309Morphine Withdrawal Increases Brain-Derived Neurotrophic Factor Precursor. (2017 Oct)Bachis ANeurotox Res
26405538Association of FURIN and ZPR1 polymorphisms with metabolic syndrome. (2015 Sep)Ueyama CBiomed Rep
27367528Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients. (2016)Amari YPLoS One