Gene: RRM2B

50484
MTDPS8A|MTDPS8B|P53R2
ribonucleotide reductase regulatory TP53 inducible subunit M2B
protein-coding
8q22.3
Ensembl:ENSG00000048392 MIM:604712 Vega:OTTHUMG00000164776 UniprotKB:Q7LG56
NG_016617.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.457e-1 (AD)  8.946e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMF10.91
VPS37A0.908
SUZ120.907
RAB180.904
ABCE10.904
CHMP2B0.902
KPNA30.901
NUDT210.901
SLC30A50.897
SGPP10.897

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.598
OR4F29-0.567
MTRNR2L6-0.316
MTRNR2L10-0.31
MTRNR2L9-0.288
MMP23B-0.274
RSPO1-0.254
MTRNR2L1-0.251
CSAG1-0.249
MTRNR2L3-0.243

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00242CladribineSmall Molecule4291-63-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of RRM2B mRNA25596134
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of RRM2B mRNA"21704725
C0247092,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone"2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to RRM2B protein"16533022
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RRM2B mRNA"21704725
C0292162-amino-3-methylimidazo(4,5-f)quinoline"2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of RRM2B mRNA"21704725
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of RRM2B protein26194647
C0781573-aminopyridine-2-carboxaldehyde thiosemicarbazone[Cisplatin co-treated with 3-aminopyridine-2-carboxaldehyde thiosemicarbazone] results in increased expression of RRM2B protein20954859
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RRM2B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RRM2B mRNA"27188386
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of RRM2B mRNA"28073004
D000082AcetaminophenAcetaminophen results in increased expression of RRM2B mRNA22230336
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of RRM2B mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RRM2B mRNA]17585979
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of RRM2B mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RRM2B protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RRM2B mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RRM2B mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RRM2B mRNA23630614
D006710HomocysteineHomocysteine results in decreased expression of RRM2B mRNA17326132
D001151ArsenicArsenic results in decreased expression of RRM2B mRNA19654921
D001374AzacitidineAzacitidine results in increased expression of RRM2B mRNA19010910
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of RRM2B mRNA21873647
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of RRM2B mRNA21704725
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RRM2B mRNA20064835|2010694
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RRM2B mRNA"20382639|2859349
C006780bisphenol Abisphenol A affects the expression of RRM2B mRNA21786754
D000069286BortezomibBortezomib results in increased expression of RRM2B mRNA20977926
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RRM2B mRNA25596134
D002220CarbamazepineCarbamazepine affects the expression of RRM2B mRNA25979313
D002701ChloramphenicolChloramphenicol results in increased expression of RRM2B mRNA21704725
C004656chloroacetaldehydechloroacetaldehyde affects the expression of RRM2B mRNA25596134
C059262cidofovircidofovir results in decreased expression of RRM2B mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of RRM2B mRNA25596134
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of RRM2B mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RRM2B mRNA]17585979
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of RRM2B mRNA21878529
D003520CyclophosphamideCyclophosphamide metabolite results in increased expression of RRM2B mRNA21704725
D016572CyclosporineCyclosporine results in increased expression of RRM2B mRNA20106945|2559613
C014347decitabinedecitabine results in increased expression of RRM2B mRNA19010910
C014347decitabinedecitabine results in increased expression of RRM2B protein19010910
C014347decitabineTP53 protein affects the reaction [decitabine results in increased expression of RRM2B mRNA]19010910
D003703DemecolcineDemecolcine results in increased expression of RRM2B mRNA23649840
D002945Cisplatin[Cisplatin co-treated with 3-aminopyridine-2-carboxaldehyde thiosemicarbazone] results in increased expression of RRM2B protein20954859
D002945CisplatinCisplatin results in decreased expression of RRM2B mRNA25596134
D002945CisplatinCisplatin results in increased expression of RRM2B mRNA21704725|2545074
D002945CisplatinCisplatin results in increased expression of RRM2B protein21875941
D002945CisplatinTP53 affects the reaction [Cisplatin results in increased expression of RRM2B protein]21875941
D002945CisplatinCisplatin results in increased expression of RRM2B mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of RRM2B mRNA28302478
C020283diethanolaminediethanolamine results in increased expression of RRM2B mRNA21704725
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of RRM2B mRNA20886546
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene metabolite results in increased expression of RRM2B mRNA"21704725
D004128DimethylnitrosamineDimethylnitrosamine metabolite results in increased expression of RRM2B mRNA21704725
C024629dimethyl phthalatedimethyl phthalate affects the expression of RRM2B mRNA26924002
D004317DoxorubicinDoxorubicin affects the expression of RRM2B mRNA25529476
D004317DoxorubicinDoxorubicin results in increased expression of RRM2B mRNA21704725
C100264enniatinsenniatins results in decreased expression of RRM2B mRNA27163883
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RRM2B mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of RRM2B mRNA21704725
D005047EtoposideEtoposide results in increased expression of RRM2B mRNA21704725
D005054EugenolEugenol results in increased expression of RRM2B mRNA21704725
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of RRM2B mRNA21704725
D005472FluorouracilFluorouracil results in increased expression of RRM2B mRNA16557594|2170472
D005472FluorouracilRRM2B protein results in decreased susceptibility to Fluorouracil15890238
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of RRM2B mRNA]15016801
D005557FormaldehydeFormaldehyde results in increased expression of RRM2B mRNA23649840
D019833GenisteinGenistein results in increased expression of RRM2B mRNA18847459
D006918HydroxyureaHydroxyurea results in increased expression of RRM2B mRNA18647660
D007069IfosfamideIfosfamide results in decreased expression of RRM2B mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRM2B mRNA25613284
C017439isobutyraldehydeisobutyraldehyde results in increased expression of RRM2B mRNA21704725
C544151jinfukangjinfukang results in decreased expression of RRM2B mRNA27392435
D007854LeadLead affects the expression of RRM2B mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of RRM2B mRNA"24972896
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of RRM2B mRNA26378955
D008687MetforminMetformin results in increased expression of RRM2B mRNA25596134
D008727MethotrexateMethotrexate results in increased expression of RRM2B mRNA21678067
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RRM2B mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of RRM2B mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RRM2B mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RRM2B mRNA21704725|2364984
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RRM2B mRNA"26251327
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of RRM2B mRNA21704725
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of RRM2B mRNA24128854
C517284monomethyl phthalatemonomethyl phthalate affects the expression of RRM2B mRNA26924002
D009020MorphineMorphine results in increased expression of RRM2B mRNA21178816
D009151Mustard GasMustard Gas results in increased expression of RRM2B mRNA25102026
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of RRM2B mRNA19812364
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of RRM2B protein14587038
D010100OxygenOxygen deficiency results in decreased expression of RRM2B mRNA25596134
D017239PaclitaxelPaclitaxel results in increased expression of RRM2B mRNA21704725
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RRM2B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RRM2B mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of RRM2B mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of RRM2B mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of RRM2B protein23718831
C005556propionaldehydepropionaldehyde results in increased expression of RRM2B mRNA26079696
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in increased expression of RRM2B mRNA19010910
D011794QuercetinQuercetin results in increased expression of RRM2B mRNA21632981
C059514resveratrolresveratrol results in increased expression of RRM2B mRNA15767336|2634129
C009277sodium arsenatesodium arsenate results in increased expression of RRM2B mRNA21795629
C017947sodium arsenitesodium arsenite affects the expression of RRM2B mRNA29319823
C017947sodium arsenitesodium arsenite results in increased expression of RRM2B mRNA21704725
D018038Sodium SeleniteSodium Selenite results in increased expression of RRM2B mRNA24383545
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of RRM2B mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RRM2B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RRM2B mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRM2B mRNA25613284
D013893ThiramThiram results in increased expression of RRM2B mRNA20530235
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of RRM2B mRNA26898711
D014415TunicamycinTunicamycin results in increased expression of RRM2B mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of RRM2B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RRM2B mRNA19101580
C025643vinclozolinvinclozolin results in decreased expression of RRM2B mRNA23034163
C111237vorinostatvorinostat results in increased expression of RRM2B mRNA27188386
D015215ZidovudineZidovudine results in increased expression of RRM2B mRNA21704725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor-IBA21873635  
GO:0005515protein binding-IPI19015526  25416956  25910212  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001822kidney development-IEA-  
GO:0003014renal system process-IEA-  
GO:0006264mitochondrial DNA replication-IEA-  
GO:0006281DNA repair-IEA-  
GO:0006979response to oxidative stress-IEA-  
GO:0009200deoxyribonucleoside triphosphate metabolic process-IEA-  
GO:0009263deoxyribonucleotide biosynthetic process-IBA21873635  
GO:0014075response to amine-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:1902254negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00240Pyrimidine metabolism
hsa00480Glutathione metabolism
hsa01100Metabolic pathways
hsa04115p53 signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-499943Interconversion of nucleotide di- and triphosphatesTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26001082Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status. (2015)Mah VPLoS One