Gene: DUOX2

50506
LNOX2|NOXEF2|P138-TOX|TDH6|THOX2
dual oxidase 2
protein-coding
15q21.1
Ensembl:ENSG00000140279 MIM:606759 Vega:OTTHUMG00000131355 UniprotKB:Q9NRD8
NG_009447.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.374e-1 (AD)  5.862e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DUOXA10.704
DIO10.69
TFF30.584
FOXE10.583
KRT70.581
BAZ1A0.579
CCL140.574
NUAK20.568
DUOXA20.564
TG0.564

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLX1-0.378
LYPD6-0.374
ABCD2-0.366
SLC7A4-0.358
C9orf24-0.354
B9D1-0.352
SMKR1-0.351
MARCH4-0.35
CRH-0.349
DBH-0.349

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DUOX2 mRNA"20816883
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUOX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUOX2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of DUOX2 mRNA22230336
D020106AcrylamideAcrylamide affects the expression of DUOX2 mRNA28959563
D000242Cyclic AMPCyclic AMP results in increased expression of DUOX2 mRNA10601291
D016604Aflatoxin B1Aflatoxin B1 affects the expression of DUOX2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DUOX2 mRNA21632981
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DUOX2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DUOX2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of DUOX2 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of DUOX2 gene25435355
D004958EstradiolEstradiol results in decreased expression of DUOX2 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of DUOX2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of DUOX2 gene28505145
D002248Carbon MonoxideCarbon Monoxide results in decreased expression of DUOX2 protein29223502
D002248Carbon MonoxideCarbon Monoxide results in increased expression of DUOX2 mRNA29223502
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUOX2 mRNA28954213
D003300CopperCopper deficiency results in increased expression of DUOX2 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of DUOX2 mRNA26577399
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of DUOX2 mRNA28659758
D003676DeferoxamineDeferoxamine inhibits the reaction [Particulate Matter results in increased expression of DUOX2 mRNA]21703343
D004041Dietary FatsDietary Fats results in increased expression of DUOX2 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of DUOX2 mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of DUOX2 mRNA21658437
C118739entinostatentinostat results in increased expression of DUOX2 mRNA27188386
C039281furanfuran results in increased expression of DUOX2 mRNA27387713
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of DUOX2 gene28505145
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX2 mRNA28433809
C051890irinotecanirinotecan affects the expression of DUOX2 mRNA20097248
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUOX2 mRNA28954213
D015122MercaptopurineMercaptopurine results in increased expression of DUOX2 mRNA23358152
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of DUOX2 mRNA22108045|2517754
D019810Sodium AzideSodium Azide inhibits the reaction [IFNG protein results in increased activity of DUOX2 protein]16970942
D009532NickelNickel results in increased expression of DUOX2 mRNA25583101
C029341oxophenylarsineoxophenylarsine affects the folding of DUOX2 protein10601291
D010269Paraquat[Quercetin co-treated with Paraquat] results in increased expression of DUOX2 mRNA22996356
D052638Particulate MatterDeferoxamine inhibits the reaction [Particulate Matter results in increased expression of DUOX2 mRNA]21703343
D052638Particulate MatterParticulate Matter results in increased expression of DUOX2 mRNA21703343
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of DUOX2 mRNA28659758
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUOX2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DUOX2 mRNA26272509
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX2 mRNA28433809
D011441PropylthiouracilPropylthiouracil results in increased expression of DUOX2 mRNA24780913
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of DUOX2 mRNA28659758
D011794Quercetin[Quercetin co-treated with Paraquat] results in increased expression of DUOX2 mRNA22996356
D011794QuercetinQuercetin results in increased expression of DUOX2 mRNA22996356
C541923sandostatinLARsandostatinLAR results in increased expression of DUOX2 mRNA17210224
C017947sodium arsenitesodium arsenite affects the methylation of DUOX2 gene28589171
D053260SootSoot results in increased expression of DUOX2 mRNA21914721
D013974ThyroxineThyroxine results in decreased expression of DUOX2 protein17332529
D014638VanadatesVanadates promotes the reaction [IFNG protein results in increased expression of DUOX2 mRNA]29031483
D014638VanadatesVanadates promotes the reaction [IL4 protein results in increased expression of DUOX2 mRNA]29031483

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004601peroxidase activity-IEA-  
GO:0005509calcium ion binding-IDA15972824  
GO:0016174NAD(P)H oxidase activity-IDA15972824  
GO:0016174NAD(P)H oxidase activity-IMP21565790  
GO:0016174NAD(P)H oxidase activity-TAS-  
GO:0020037heme binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006590thyroid hormone generation-IEA-  
GO:0006590thyroid hormone generation-TAS-  
GO:0006979response to oxidative stress-IEA-  
GO:0009566fertilization-IEA-  
GO:0009615response to virus-IDA16111680  
GO:0019221cytokine-mediated signaling pathway-IDA16111680  
GO:0019221cytokine-mediated signaling pathway-ISS-  
GO:0030282bone mineralization-IEA-  
GO:0030878thyroid gland development-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0042335cuticle development-ISS-  
GO:0042446hormone biosynthetic process-IEA-  
GO:0042744hydrogen peroxide catabolic process-IEA-  
GO:0048839inner ear development-IEA-  
GO:0048855adenohypophysis morphogenesis-IEA-  
GO:0050665hydrogen peroxide biosynthetic process-IEA-  
GO:0051591response to cAMP-IDA15062544  
GO:0051591response to cAMP-ISS-  
GO:0055114oxidation-reduction process-TAS10601291  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-209776Amine-derived hormonesTAS
R-HSA-209968Thyroxine biosynthesisTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24180474NADPH oxidases in vascular pathology. (2014 Jun 10)Konior AAntioxid Redox Signal
29616282A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells. (2018 Jun)Yi GInflamm Res
26839536DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon. (2016)Qi RGastroenterol Res Pract
18177232Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease. (2008 Apr)Nagai KAntioxid Redox Signal