Gene: NOX3

50508
GP91-3|MOX-2
NADPH oxidase 3
protein-coding
6q25.3
Ensembl:ENSG00000074771 MIM:607105 Vega:OTTHUMG00000015883 UniprotKB:Q9HBY0
NG_011995.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.000e-2 (AD)  8.279e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCGB1D20.466
COLCA10.462
GINS20.444
HKDC10.425
NOTCH2NL0.424
C1orf1410.416
CUBN0.411
CC2D2A0.407
CCL250.403
F110.4

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM43A-0.306
CCKAR-0.276
CREB3L1-0.273
ALPL-0.268
OTOA-0.249
DUOXA2-0.247
PLEKHA8P1-0.242
KCNG2-0.23
SSTR2-0.227
GNA15-0.224

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester results in decreased activity of NOX3 protein"20712533
C006780bisphenol Abisphenol A results in decreased expression of NOX3 mRNA25181051
D002211CapsaicinNOX3 mutant form inhibits the reaction [Capsaicin results in increased abundance of Reactive Oxygen Species]20712533
D002211CapsaicinCapsaicin results in increased expression of NOX3 mRNA20712533
D002211CapsaicinCapsaicin results in increased expression of NOX3 protein20712533
D002211CapsaicinNOX3 mutant form inhibits the reaction [Capsaicin results in increased expression of NOS2 mRNA]20712533
D002211CapsaicinNOX3 mutant form inhibits the reaction [Capsaicin results in increased expression of NOS2 protein]20712533
D002211CapsaicinNOX3 mutant form inhibits the reaction [Capsaicin results in increased expression of NOX3 mRNA]20712533|2071253
D002211CapsaicinNOX3 mutant form inhibits the reaction [Capsaicin results in increased expression of NOX3 protein]20712533|2071253
D002211CapsaicinNOX3 mutant form inhibits the reaction [Capsaicin results in increased expression of PTGS2 mRNA]20712533
D002211CapsaicinNOX3 mutant form inhibits the reaction [Capsaicin results in increased expression of PTGS2 protein]20712533
D002211CapsaicinNOX3 mutant form inhibits the reaction [Capsaicin results in increased expression of TNF mRNA]20712533
D002211CapsaicinNOX3 mutant form inhibits the reaction [Capsaicin results in increased expression of TNF protein]20712533
D002211CapsaicinSTAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of NOX3 mRNA]20712533
D002211CapsaicinSTAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of NOX3 protein]20712533
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of NOX3 protein21742780
C031291diphenyliodoniumdiphenyliodonium results in decreased activity of NOX3 protein20712533
D004726EndosulfanEndosulfan results in increased expression of NOX3 mRNA25199686
D019800PhenolPhenol results in increased expression of NOX3 mRNA16785328
D011374ProgesteroneProgesterone results in decreased expression of NOX3 mRNA18070364
D017382Reactive Oxygen SpeciesNOX3 mutant form inhibits the reaction [Capsaicin results in increased abundance of Reactive Oxygen Species]20712533
D017382Reactive Oxygen SpeciesNOX3 results in increased abundance of Reactive Oxygen Species20712533
C059514resveratrolresveratrol results in decreased expression of and results in decreased activity of NOX3 protein20675566
C059514resveratrol[resveratrol results in decreased expression of and results in decreased activity of NOX3 protein] which results in decreased abundance of Superoxides20675566
C059514resveratrolresveratrol results in decreased expression of NOX3 mRNA20675566
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NOX3 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in increased expression of NOX3 mRNA27862939
D013481Superoxides[resveratrol results in decreased expression of and results in decreased activity of NOX3 protein] which results in decreased abundance of Superoxides20675566
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NOX3 mRNA21570461
D014212TretinoinTretinoin results in decreased expression of NOX3 mRNA23724009

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016175superoxide-generating NADPH oxidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001659temperature homeostasis-IEA-  
GO:0009590detection of gravity-IEA-  
GO:0042554superoxide anion generation-IEA-  
GO:0048840otolith development-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0043020NADPH oxidase complex-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04380Osteoclast differentiation
hsa04670Leukocyte transendothelial migration
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5668599RHO GTPases Activate NADPH OxidasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24180474NADPH oxidases in vascular pathology. (2014 Jun 10)Konior AAntioxid Redox Signal
22879519The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis. (2013 Oct)Tyler ADGut
27980621Analysis of gene expression to predict dynamics of future hypertension incidence in type 2 diabetic patients. (2016)Radkowski PBMC Proc