Gene: SYCP3

50511
COR1|RPRGL4|SCP3|SPGF4
synaptonemal complex protein 3
protein-coding
12q23.2
Ensembl:ENSG00000139351 MIM:604759 Vega:OTTHUMG00000150132 UniprotKB:Q8IZU3
NG_021181.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.485e-1 (AD)  8.231e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAM200.422
MAB21L10.419
TTC280.414
C9orf1310.412
ZNF7090.406
TMPPE0.395
PARD6G0.389
AVIL0.382
XKR60.379
PCDHGB30.377

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH2D1A-0.242
TSPAN8-0.238
AGMO-0.237
LILRA4-0.225
HMSD-0.219
CA14-0.216
CLCA4-0.216
OR4N2-0.215
SLCO1A2-0.213
S1PR5-0.212

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0212962-ethoxyethanol2-ethoxyethanol results in decreased expression of SYCP3 mRNA19643169
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SYCP3 mRNA]"19467301
D019342Acetic AcidAcetic Acid results in decreased expression of SYCP3 protein21296659
C096920AGN 193109AGN 193109 inhibits the reaction [Tretinoin results in increased expression of SYCP3 mRNA]16574651
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SYCP3 mRNA16483693
D001151ArsenicArsenic affects the methylation of SYCP3 gene25304211
D001280AtrazineAtrazine affects the expression of SYCP3 protein26518232
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SYCP3 mRNA20504355
D004958EstradiolEstradiol results in decreased expression of SYCP3 mRNA19484750
C006780bisphenol Abisphenol A affects the localization of SYCP3 mRNA22732146
C006780bisphenol Abisphenol A results in decreased expression of SYCP3 mRNA22187349
C006780bisphenol Abisphenol A affects the expression of SYCP3 mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of SYCP3 protein21296659
D004390ChlorpyrifosChlorpyrifos results in increased expression of SYCP3 mRNA20350560
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SYCP3 mRNA17602206
C030123coumarincoumarin results in decreased expression of SYCP3 mRNA18480146
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SYCP3 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of SYCP3 mRNA27392435
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SYCP3 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of SYCP3 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of SYCP3 mRNA19467301|2501614
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SYCP3 mRNA25975992
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SYCP3 protein25975992
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SYCP3 mRNA17602206
D015025ZearalenoneZearalenone results in decreased expression of SYCP3 mRNA24412631
D005419FlavonoidsFlavonoids results in decreased expression of SYCP3 mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of SYCP3 protein21296659
C551027GANT 61GANT 61 results in increased expression of SYCP3 mRNA22265815
D005839GentamicinsGentamicins results in decreased expression of SYCP3 mRNA22061828
C016517indole-3-carbinolindole-3-carbinol affects the expression of SYCP3 mRNA21396975
D007213IndomethacinIndomethacin results in increased expression of SYCP3 mRNA28201806
C544151jinfukangjinfukang results in decreased expression of SYCP3 mRNA27392435
D007654KetoconazoleKetoconazole results in increased expression of SYCP3 mRNA16574651
D008627Mercuric ChlorideMercuric Chloride affects the expression of SYCP3 mRNA20353558
D008727MethotrexateMethotrexate affects the expression of SYCP3 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SYCP3 mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SYCP3 mRNA29191790
D009532NickelNickel results in decreased expression of SYCP3 mRNA25583101
D010098OxycodoneOxycodone results in increased expression of SYCP3 mRNA23439660
D000073878Palm OilPalm Oil results in decreased expression of SYCP3 mRNA18042831
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of SYCP3 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of SYCP3 mRNA16221962|1830175
D059808PolyphenolsPolyphenols results in decreased expression of SYCP3 mRNA16293270
C043680ptaquilosideptaquiloside results in increased expression of SYCP3 mRNA23274088
C009277sodium arsenatesodium arsenate results in decreased expression of SYCP3 mRNA23922661
D013849ThimerosalThimerosal results in increased expression of SYCP3 mRNA24675092
D014212TretinoinAGN 193109 inhibits the reaction [Tretinoin results in increased expression of SYCP3 mRNA]16574651
D014212TretinoinTretinoin results in increased expression of SYCP3 mRNA16574651
D014212TretinoinTretinoin results in increased expression of SYCP3 protein21295132
D014241TrichloroethyleneTrichloroethylene results in increased expression of SYCP3 mRNA28973375
D014520UrethaneUrethane results in decreased expression of SYCP3 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007141male meiosis I-NAS15218256  
GO:0007283spermatogenesis-IBA21873635  
GO:0007286spermatid development-IBA21873635  
GO:0035093spermatogenesis, exchange of chromosomal proteins-IMP14643120  
GO:0051301cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000775chromosome, centromeric region-ISS-  
GO:0000795synaptonemal complex-IBA21873635  
GO:0000795synaptonemal complex-IDA9774970  
GO:0000800lateral element-ISS-  
GO:0005634nucleus-IDA22899867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26230583Differential Gene Expression in Colon Tissue Associated With Diet, Lifestyle, and Related Oxidative Stress. (2015)Slattery MLPLoS One