Gene: PRDX1

5052
MSP23|NKEF-A|NKEFA|PAG|PAGA|PAGB|PRX1|PRXI|TDPX2
peroxiredoxin 1
protein-coding
1p34.1
Ensembl:ENSG00000117450 MIM:176763 Vega:OTTHUMG00000007738 UniprotKB:Q06830
NC_000001.11
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.672e-1 (AD)  2.418e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06070002chr1:45986120PRDX12.940e-8Maternal smoking in pregnancy27040690
cg06070002chr1:45986120PRDX14.460e-10Maternal smoking in pregnancy27040690
cg06070002chr1:45986120PRDX11.600e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DAD10.95
GABARAP0.944
HMGN30.942
SRP140.925
SNAPIN0.913
SPCS20.912
SRP90.907
TXN20.903
GSTP10.901
POLR2G0.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.865
OR4F29-0.845
TMEM89-0.158
FER1L6-0.138
OR6C74-0.132
CLEC6A-0.128
PCDHAC1-0.121
DCC-0.118
HCRTR1-0.116
LINC00989-0.115

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
DB09221PolaprezincSmall Molecule107667-60-7Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] which results in increased expression of PRDX1 mRNA"22495766
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PRDX1 mRNA"28903501
C4656642-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PRDX1 mRNA"26808241
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of PRDX1 protein"27604104
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of PRDX1 mRNA"22016648
C5396122-acetylamino-3-(4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl)propionic acid2-acetylamino-3-(4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl)propionic acid results in increased oxidation of PRDX1 protein28461233
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of PRDX1 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of PRDX1 mRNA]28655636
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of PRDX1 mRNA17961207
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of PRDX1 mRNA16014739
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PRDX1 protein26194647
C0263083,4-dihydrocoumarin"3,4-dihydrocoumarin results in increased expression of PRDX1 mRNA"22016648
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole affects the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]11796722
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDX1 mRNA"27188386
C0046584-chloroaniline4-chloroaniline results in increased expression of PRDX1 mRNA17961207
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal analog binds to PRDX118232660
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of PRDX1 mRNA19191707
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in decreased expression of PRDX1 mRNA15135645
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDX1 mRNA"27188386
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PRDX1 protein"24455688
C0671348-oxo-7-hydrodeoxyguanosinePRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of 8-oxo-7-hydrodeoxyguanosine]27517622
D000082AcetaminophenAcetaminophen affects the expression of PRDX1 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of PRDX1 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of PRDX1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of PRDX1 protein22939915
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of PRDX1 protein25499718
D000082Acetaminophendioscin inhibits the reaction [Acetaminophen results in decreased expression of PRDX1 protein]22939915
D000171AcroleinAcrolein results in increased oxidation of PRDX1 protein19135121
D020106AcrylamideAcrylamide results in increased expression of PRDX1 mRNA17961207
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of PRDX1 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog affects the expression of PRDX1 protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of PRDX1 protein26597043
D000638AmiodaroneAmiodarone affects the expression of PRDX1 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRDX1 mRNA16483693
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Herbicides results in decreased expression of PRDX1 mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX1 mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [triclopyr results in increased expression of PRDX1 mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide results in increased expression of PRDX1 mRNA"21318024
D001151ArsenicArsenic affects the methylation of PRDX1 gene25304211
D001151ArsenicArsenic results in increased expression of PRDX1 mRNA19945496
C006632arsenic trioxidearsenic trioxide results in increased expression of PRDX1 mRNA17961207
C006632arsenic trioxidearsenic trioxide results in increased expression of PRDX1 mRNA26976014
C006632arsenic trioxidearsenic trioxide results in increased expression of PRDX1 mRNA20458559
D018053ArsenitesArsenites analog binds to PRDX1 protein19874836
D001194AsbestosAsbestos results in increased expression of PRDX1 protein22537621
D017636Asbestos, Amphibole"Asbestos, Amphibole affects the expression of PRDX1 protein"20855422
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of PRDX1 protein"20855422
D001205Ascorbic Acid[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PRDX1 mRNA18544905
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]16964424
D001280AtrazineAtrazine results in decreased expression of PRDX1 mRNA22378314
D001280AtrazineAtrazine results in increased expression of PRDX1 protein25275270
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of PRDX1 mRNA23656968
C041512benzo(b)fluorene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of PRDX1 mRNA22120849
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of PRDX1 mRNA15240111
D053119Benzophenanthridines[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of PRDX1 mRNA22120849
D053119BenzophenanthridinesBenzophenanthridines analog results in increased expression of PRDX1 mRNA22120849
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRDX1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRDX1 protein17292933
D001564Benzo(a)pyreneQuercetin inhibits the reaction [Benzo(a)pyrene results in increased expression of PRDX1 protein]17292933
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRDX1 mRNA15034205|2222880
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PRDX1 mRNA20061341
D004958EstradiolEstradiol affects the expression of PRDX1 mRNA22574217
D001622BetaineBetaine inhibits the reaction [Copper deficiency results in decreased expression of PRDX1 protein]25150618
C006780bisphenol Abisphenol A affects the expression of PRDX1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PRDX1 protein20189630
C006780bisphenol Abisphenol A results in decreased expression of PRDX1 protein24909818
C006780bisphenol Abisphenol A results in increased expression of PRDX1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PRDX1 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of PRDX1 protein22174045
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of PRDX1 mRNA15707499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PRDX1 mRNA28212397
D020122tert-ButylhydroperoxideOleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PRDX1 protein]20100471
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PRDX1 protein20100471
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PRDX1 protein11295360
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased activity of PRDX1 protein16880205
D020122tert-ButylhydroperoxidePRDX1 protein results in decreased susceptibility to tert-Butylhydroperoxide19041905
D002104CadmiumCadmium affects the reaction [Tetrachlorodibenzodioxin affects the expression of PRDX1 protein]29107029
D002104CadmiumCadmium results in increased expression of PRDX1 mRNA28212397
D002104CadmiumCadmium results in increased expression of PRDX1 protein16440303
D002104CadmiumCadmium results in increased oxidation of PRDX1 protein24077948
D002104CadmiumCadmium results in decreased expression of PRDX1 mRNA23851056
D002104CadmiumCadmium results in increased expression of PRDX1 mRNA17327700
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRDX1 mRNA17961207|2317448
D019256Cadmium ChlorideNFE2L2A mutant form inhibits the reaction [Cadmium Chloride results in increased expression of PRDX1 mRNA]23174481
D019256Cadmium Chloridesulforafan promotes the reaction [Cadmium Chloride results in increased expression of PRDX1 mRNA]23174481
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRDX1 mRNA26976014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRDX1 mRNA26525392
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRDX1 protein16440303
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRDX1 mRNA20061341|2267778
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRDX1 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRDX1 mRNA17327700
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRDX1 protein21699967
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRDX1 mRNA26976014
D002211CapsaicinCapsaicin inhibits the reaction [Dietary Fats results in increased expression of PRDX1 protein]20359164
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PRDX1 mRNA25471833
D002251Carbon TetrachlorideQuercetin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PRDX1 mRNA]25471833
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PRDX1 mRNA16309569
D002251Carbon Tetrachloride[Olive Oil analog co-treated with Carbon Tetrachloride] results in increased expression of PRDX1 protein25303780
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PRDX1 mRNA24763279
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PRDX1 mRNA28954213
C026690cerous chloridecerous chloride results in decreased expression of PRDX1 mRNA28954213
C016300chloramine-Tchloramine-T results in increased expression of PRDX1 protein24213014
D007631ChlordeconeChlordecone results in decreased expression of PRDX1 protein19666090
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDX1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of PRDX1 mRNA26272509
C100187chloropicrinchloropicrin results in increased expression of PRDX1 mRNA26352163
D002746ChlorpromazineChlorpromazine affects the expression of PRDX1 mRNA25064622
C074702chromium hexavalent ionchromium hexavalent ion results in increased oxidation of PRDX1 protein19703554
C018021cobaltous chloridecobaltous chloride results in increased expression of PRDX1 mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of PRDX1 protein22339908
D003300CopperBetaine inhibits the reaction [Copper deficiency results in decreased expression of PRDX1 protein]25150618
D003300CopperCopper deficiency results in decreased expression of PRDX1 protein25150618
D003300CopperPRDX1 protein binds to Copper14534351|1535973
D003300CopperCopper analog results in increased expression of PRDX1 protein23882024
D003300CopperCopper results in increased expression of PRDX1 protein23882024
C007164cumene hydroperoxidecumene hydroperoxide results in increased expression of PRDX1 protein11295360
C007164cumene hydroperoxidePRDX1 protein results in decreased susceptibility to cumene hydroperoxide19041905
C029892cupric chloridecupric chloride results in increased expression of PRDX1 protein21641295
C029892cupric chloridecupric chloride results in increased expression of PRDX1 mRNA17211630
C030973cupric oxidecupric oxide analog results in increased expression of PRDX1 protein23882024
D016572CyclosporineCyclosporine affects the expression of PRDX1 mRNA25064622
D003609DactinomycinDactinomycin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]11796722
D003609DactinomycinDactinomycin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRDX1 mRNA28659758
C049098diallyl phthalatediallyl phthalate results in increased expression of PRDX1 protein20189630
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of PRDX1 mRNA"25908611
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PRDX1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PRDX1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PRDX1 protein25450742
D002945CisplatinCisplatin results in increased expression of PRDX1 protein22023808
C000944dicrotophosdicrotophos results in decreased expression of PRDX1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PRDX1 mRNA26924002
D004041Dietary FatsCapsaicin inhibits the reaction [Dietary Fats results in increased expression of PRDX1 protein]20359164
D004041Dietary FatsDietary Fats results in increased expression of PRDX1 protein20359164
D004052Diethylnitrosamine[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PRDX1 mRNA18544905
C039060dihydroartemisinindihydroartemisinin analog binds to PRDX1 protein26340163
D002117CalcitriolCalcitriol results in decreased expression of PRDX1 mRNA12875902
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of PRDX1 mRNA27638505
C024629dimethyl phthalatedimethyl phthalate results in increased expression of PRDX1 mRNA26924002
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the oxidation of PRDX1 protein18789312
C019357dioscindioscin inhibits the reaction [Acetaminophen results in decreased expression of PRDX1 protein]22939915
D004178DiquatDiquat results in increased expression of PRDX1 mRNA16962985
D004237DiuronDiuron results in increased expression of PRDX1 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of PRDX1 mRNA21463615|2201664
D004317DoxorubicinDoxorubicin results in increased expression of PRDX1 protein21463615
D004317DoxorubicinMT1 affects the reaction [Doxorubicin results in increased expression of PRDX1 mRNA]21463615
D004317DoxorubicinMT1 affects the reaction [Doxorubicin results in increased expression of PRDX1 protein]21463615
D004317DoxorubicinMT2 affects the reaction [Doxorubicin results in increased expression of PRDX1 mRNA]21463615
D004317DoxorubicinMT2 affects the reaction [Doxorubicin results in increased expression of PRDX1 protein]21463615
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of PRDX1 mRNA25187966
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of PRDX1 mRNA24534155
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of PRDX1 mRNA20064776
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PRDX1 protein23301498
D000431EthanolEthanol results in increased expression of PRDX1 protein20621659
D000431EthanolEthanol results in decreased expression of PRDX1 protein23200777
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PRDX1 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PRDX1 mRNA15576828|1617478
D005015EthoxyquinEthoxyquin results in increased expression of PRDX1 protein16880205
D005015Ethoxyquin[Ethoxyquin results in increased expression of PRDX1 protein] which results in increased phosphorylation of MAPK14 protein16880205
D018120FinasterideFinasteride results in increased expression of PRDX1 mRNA24136188
C082360fipronilfipronil results in increased expression of PRDX1 mRNA23962444
D005419FlavonoidsFlavonoids results in decreased expression of PRDX1 mRNA18035473
D005485FlutamideFlutamide results in increased expression of PRDX1 mRNA24136188
C039281furanfuran binds to PRDX1 protein22240984
C039281furanfuran results in increased expression of PRDX1 mRNA15120968
C039281furanfuran results in increased methylation of PRDX1 gene22079235
D019833GenisteinGenistein results in decreased expression of PRDX1 mRNA24967385
D005839GentamicinsGentamicins results in decreased expression of PRDX1 protein22061828
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of PRDX1 mRNA22634610
D006046GoldGold analog results in decreased expression of PRDX1 protein24780912
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PRDX1 mRNA24763279
D006540Herbicides"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Herbicides results in decreased expression of PRDX1 mRNA]"21318024
D006540HerbicidesHerbicides results in decreased expression of PRDX1 mRNA21318024
D006540HerbicidesHerbicides results in increased expression of PRDX1 mRNA21318024
D006820Hyaluronic AcidHyaluronic Acid analog affects the expression of PRDX1 protein23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PRDX1 mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PRDX1 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PRDX1 mRNA18598687
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PRDX1 protein18598687
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PRDX1 protein11295360
D006861Hydrogen Peroxide(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate inhibits the reaction [Hydrogen Peroxide results in decreased expression of PRDX1 mRNA]18598687
D006861Hydrogen Peroxide(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate inhibits the reaction [Hydrogen Peroxide results in decreased expression of PRDX1 protein]18598687
D006861Hydrogen PeroxidePRDX1 protein results in decreased susceptibility to Hydrogen Peroxide11469800
D006861Hydrogen PeroxidePRDX1 protein promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK14 protein]16880205
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PRDX1 protein23178681
D006861Hydrogen PeroxidePRDX1 protein results in decreased susceptibility to Hydrogen Peroxide19041905
C031927hydroquinonehydroquinone results in increased expression of PRDX1 mRNA15452088
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of PRDX1 mRNA19376150
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PRDX1 mRNA27392435
C410337K 7174K 7174 results in decreased expression of PRDX1 mRNA24086573
C011890kojic acid[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PRDX1 mRNA18544905
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PRDX1 mRNA28954213
D007854LeadLead affects the expression of PRDX1 mRNA28903495
C008261lead acetatelead acetate results in decreased expression of PRDX1 mRNA21829687
C029891lead chloridelead chloride results in increased expression of PRDX1 mRNA17961207
C017461lead nitratelead nitrate results in increased expression of PRDX1 mRNA26976014
C052901lemongrass oillemongrass oil affects the expression of PRDX1 mRNA25976427
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PRDX1 mRNA19339665
D008070Lipopolysaccharidesmethyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of PRDX1 mRNA]19339665
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PRDX1 mRNA25613284
D008344Maneb[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of PRDX1 mRNA21402726
C042720mercuric bromidemercuric bromide results in increased expression of PRDX1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDX1 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of PRDX1 mRNA26976014
D008627Mercuric ChlorideMercuric Chloride results in increased expression of PRDX1 mRNA26976014
D008713MethimazoleMethimazole results in increased expression of PRDX1 mRNA20144635
D008727MethotrexateMethotrexate results in increased expression of PRDX1 mRNA21678067
D008748MethylcholanthreneMethylcholanthrene results in increased expression of PRDX1 mRNA18804290
C008435methyldithiocarbamatemethyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of PRDX1 mRNA]19339665
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PRDX1 mRNA17961207|2018165
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PRDX1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PRDX1 mRNA20061341
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PRDX1 mRNA26976014
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PRDX1 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PRDX1 protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PRDX1 protein20600802
D015741MetriboloneMetribolone affects the splicing of PRDX1 mRNA17010196
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PRDX1 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of PRDX1 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PRDX1 protein"22157353
C031721naphthalenenaphthalene results in increased reduction of PRDX1 protein19843705
C005273naringeninnaringenin results in decreased expression of PRDX1 mRNA27838343
C005273naringeninnaringenin results in decreased expression of PRDX1 protein27838343
C017096n-butoxyethanoln-butoxyethanol results in increased expression of PRDX1 mRNA19812364
C498045NCX 4040NCX 4040 results in increased expression of PRDX1 mRNA20188076
C051752nefazodonenefazodone results in increased expression of PRDX1 mRNA24136188
D009532NickelNickel results in decreased expression of PRDX1 mRNA23195993
C022838nickel chloridenickel chloride results in increased expression of PRDX1 mRNA24612858
C012655nimesulidenimesulide results in increased expression of PRDX1 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of PRDX1 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of PRDX1 protein19716841
C025256nonylphenolnonylphenol results in increased expression of PRDX1 protein16054331
C510003nordynordy results in decreased expression of PRDX1 protein18232056
C423264(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate inhibits the reaction [Hydrogen Peroxide results in decreased expression of PRDX1 mRNA]18598687
C423264(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate inhibits the reaction [Hydrogen Peroxide results in decreased expression of PRDX1 protein]18598687
C474958O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate"PRDX1 protein affects the susceptibility to O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate"20962031
C464660obeticholic acidobeticholic acid results in decreased expression of PRDX1 mRNA27939613
C025589ochratoxin Aochratoxin A results in decreased expression of PRDX1 mRNA14994279
D009828Oleanolic AcidOleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PRDX1 protein]20100471
D000069463Olive Oil[Olive Oil analog co-treated with Carbon Tetrachloride] results in increased expression of PRDX1 protein25303780
C029341oxophenylarsineoxophenylarsine binds to PRDX1 protein12519079
D010100OxygenOxygen results in increased expression of PRDX1 mRNA22911455
C530734p-aminophenylarsine oxidep-aminophenylarsine oxide binds to PRDX1 protein22422341
D010269ParaquatParaquat affects the expression of PRDX1 mRNA25064622
D010269ParaquatParaquat results in increased expression of PRDX1 mRNA22996356
D010269ParaquatParaquat results in increased expression of PRDX1 protein modified form11697128
D010269ParaquatParaquat results in increased oxidation of PRDX1 protein21402726
D010269Paraquat[Quercetin co-treated with Paraquat] results in increased expression of PRDX1 mRNA22996356
D010269ParaquatParaquat results in decreased expression of PRDX1 mRNA17215068
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of PRDX1 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of PRDX1 mRNA15046786|2865563
D052638Particulate MatterParticulate Matter results in increased expression of PRDX1 mRNA17987463
D052638Particulate MatterParticulate Matter analog results in increased expression of PRDX1 mRNA12011483|1269990
D010416PentachlorophenolPentachlorophenol results in increased expression of PRDX1 mRNA23892564
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRDX1 mRNA28659758
D010634PhenobarbitalPhenobarbital results in increased expression of PRDX1 mRNA16510358
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDX1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PRDX1 mRNA26272509
D010695PhlorhizinPhlorhizin results in increased expression of PRDX1 mRNA22538082
D010846Picloram"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX1 mRNA]"21318024
D010846PicloramPicloram results in decreased expression of PRDX1 mRNA21318024
D011192Potassium DichromatePotassium Dichromate results in increased expression of PRDX1 mRNA11678601|1833204
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PRDX1 mRNA19162173
C035988procymidoneprocymidone results in decreased expression of PRDX1 mRNA15686871
C015586propiverinepropiverine binds to PRDX1 protein29273565
D054328Proton Pump InhibitorsProton Pump Inhibitors results in increased expression of PRDX1 mRNA25626140
C010313pseudocumenepseudocumene results in decreased expression of PRDX1 protein17337753
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRDX1 mRNA28659758
C010423pyrithione zincpyrithione zinc results in increased expression of PRDX1 mRNA21424779
D011748PyrogallolPyrogallol results in increased expression of PRDX1 mRNA20362636
D011791QuartzQuartz results in increased expression of PRDX1 mRNA27917503
D011794Quercetin[Quercetin co-treated with Paraquat] results in increased expression of PRDX1 mRNA22996356
D011794QuercetinQuercetin inhibits the reaction [Benzo(a)pyrene results in increased expression of PRDX1 protein]17292933
D011794QuercetinQuercetin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PRDX1 mRNA]25471833
D017382Reactive Oxygen SpeciesPRDX1 protein results in decreased abundance of Reactive Oxygen Species27517622
D017382Reactive Oxygen SpeciesPRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of Reactive Oxygen Species]27517622
D017382Reactive Oxygen SpeciesPRDX1 protein results in decreased abundance of Reactive Oxygen Species27517622
C059514resveratrolresveratrol affects the secretion of PRDX1 protein24802182
C447880retene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of PRDX1 mRNA22120849
D012176RetinoidsRetinoids results in decreased expression of PRDX1 protein28886987
D012402RotenoneRotenone results in decreased expression of PRDX1 mRNA22016648
C085746rottlerinrottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]11796722
C085746rottlerinrottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
D012822Silicon DioxideSilicon Dioxide analog results in increased secretion of PRDX1 protein25895662
C024711siomycin Asiomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of PRDX1 protein]27517622
C009277sodium arsenate2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
C009277sodium arsenate4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole affects the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]11796722
C009277sodium arsenate4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
C009277sodium arsenateDactinomycin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]11796722
C009277sodium arsenateDactinomycin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
C009277sodium arsenaterottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]11796722
C009277sodium arsenaterottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
C009277sodium arsenateSB 203580 inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
C009277sodium arsenatesodium arsenate results in increased expression of PRDX1 mRNA11796722|1274506
C009277sodium arsenatesodium arsenate results in increased expression of PRDX1 protein11796722
C009277sodium arsenateStaurosporine inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
C017947sodium arseniteNFE2L2A protein affects the reaction [sodium arsenite results in increased expression of PRDX1 mRNA]27306194
C017947sodium arsenitesodium arsenite results in increased expression of PRDX1 mRNA27306194
C017947sodium arsenite[sodium arsenite co-treated with sodium arsenite deficiency] results in increased methylation of PRDX1 promoter28336213
C017947sodium arsenitesodium arsenite deficiency inhibits the reaction [sodium arsenite results in decreased expression of PRDX1 mRNA]28336213
C017947sodium arsenitesodium arsenite results in decreased expression of PRDX1 mRNA28336213
C017947sodium arsenitesodium arsenite results in increased expression of PRDX1 mRNA28229933
C017947sodium arsenitesodium arsenite results in increased expression of PRDX1 protein15899475
C017947sodium arsenitesodium arsenite results in increased methylation of PRDX1 promoter28336213
C017947sodium arsenitesodium arsenite results in increased expression of PRDX1 mRNA16322246
C016104sodium bichromatesodium bichromate results in increased expression of PRDX1 mRNA24612858
C016104sodium bichromatesodium bichromate results in increased expression of PRDX1 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of PRDX1 mRNA22561333
D012969Sodium FluorideSodium Fluoride results in decreased expression of PRDX1 protein28918527
D012969Sodium FluorideSodium Fluoride results in increased expression of PRDX1 mRNA21340527
D018038Sodium SeleniteSodium Selenite results in increased expression of PRDX1 mRNA18175754
D053260SootSoot results in increased expression of PRDX1 mRNA21914721
D019311StaurosporineStaurosporine inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]11796722
D013311StreptozocinPRDX4 protein inhibits the reaction [Streptozocin results in decreased expression of PRDX1 mRNA]20446767
D013311StreptozocinStreptozocin results in decreased expression of PRDX1 mRNA20446767
D020058StyreneStyrene results in increased expression of PRDX1 mRNA17654243
D012460SulfasalazineSulfasalazine results in increased expression of PRDX1 mRNA22016648
D012460SulfasalazineSulfasalazine results in increased expression of PRDX1 mRNA16141653
C016766sulforafansulforafan promotes the reaction [Cadmium Chloride results in increased expression of PRDX1 mRNA]23174481
C016766sulforafansulforafan results in increased expression of PRDX1 mRNA23174481|2730619
D013467SulindacSulindac results in increased expression of PRDX1 mRNA24136188
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of PRDX1 mRNA20189893
D013749TetrachlorodibenzodioxinCadmium affects the reaction [Tetrachlorodibenzodioxin affects the expression of PRDX1 protein]29107029
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRDX1 protein29107029
D013749Tetrachlorodibenzodioxin[NFE2L2 gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of PRDX1 mRNA21846477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRDX1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRDX1 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRDX1 mRNA15034205|1559103
D013752TetracyclineTetracycline affects the expression of PRDX1 mRNA25064622
D019284ThapsigarginThapsigargin results in decreased expression of PRDX1 protein24648495
D013853ThioacetamideThioacetamide affects the expression of PRDX1 mRNA25064622
C009495titanium dioxidetitanium dioxide results in decreased phosphorylation of PRDX1 protein21439344
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PRDX1 mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PRDX1 protein27189315
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PRDX1 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased metabolism of PRDX1 protein23396223
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PRDX1 protein22595367
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PRDX1 protein22609517
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PRDX1 protein27319396
D014212TretinoinTretinoin results in decreased expression of PRDX1 mRNA12875902|1605412
D014241TrichloroethyleneTrichloroethylene results in increased expression of PRDX1 mRNA19254012
C012589trichostatin Atrichostatin A results in increased expression of PRDX1 protein19294695
C032742triclopyr"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [triclopyr results in increased expression of PRDX1 mRNA]"21318024
C032742triclopyrtriclopyr results in increased expression of PRDX1 mRNA21318024
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PRDX1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PRDX1 mRNA19631733
D017974Uranium CompoundsUranium Compounds results in decreased expression of PRDX1 mRNA19654044
D014527Uric AcidUric Acid results in increased expression of PRDX1 protein23619996
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of PRDX1 mRNA18687751
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of PRDX1 protein18687751
D014635Valproic AcidValproic Acid affects the expression of PRDX1 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of PRDX1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid affects the expression of PRDX1 mRNA17292431
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of PRDX1 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of PRDX1 mRNA15046786|2865563
D001335Vehicle EmissionsVehicle Emissions results in increased expression of PRDX1 mRNA17987463
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of PRDX1 mRNA12011483|1269990
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of PRDX1 mRNA25423262
C025643vinclozolinvinclozolin results in decreased expression of PRDX1 mRNA15686871
C111237vorinostatvorinostat results in increased expression of PRDX1 protein17593366|2054356
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of PRDX1 mRNA"22055752
D015032ZincPRDX1 protein binds to Zinc14534351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0004601peroxidase activity-IDA11986303  
GO:0004601peroxidase activity-TAS-  
GO:0005515protein binding-IPI15105503  17909037  18172504  19369943  21044950  23386615  
GO:0008379thioredoxin peroxidase activity-EXP10514471  10751410  17519234  
GO:0008379thioredoxin peroxidase activity-IBA21873635  
GO:0008379thioredoxin peroxidase activity-IDA18606987  
GO:0042802identical protein binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS8089076  
GO:0001895retina homeostasis-HEP23580065  
GO:0006979response to oxidative stress-IBA21873635  
GO:0008283cell proliferation-IEA-  
GO:0019430removal of superoxide radicals-IEA-  
GO:0030101natural killer cell activation-IDA8462106  
GO:0032872regulation of stress-activated MAPK cascade-IEA-  
GO:0034101erythrocyte homeostasis-IEA-  
GO:0034599cellular response to oxidative stress-TAS-  
GO:0042267natural killer cell mediated cytotoxicity-IEA-  
GO:0042744hydrogen peroxide catabolic process-IBA21873635  
GO:0042744hydrogen peroxide catabolic process-IDA11986303  18606987  
GO:0045454cell redox homeostasis-IBA21873635  
GO:0045454cell redox homeostasis-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:1901222regulation of NIK/NF-kappaB signaling-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  23580065  
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IDA17603937  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA17603937  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0042470melanosome-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0070062extracellular exosome-HDA19199708  20458337  23533145  
KEGG ID KEGG Term
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3299685Detoxification of Reactive Oxygen SpeciesTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsIEA
R-HSA-8863678Neurodegenerative DiseasesIEA
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25524402Association between plasma selenium level and NRF2 target genes expression in humans. (2015 Apr)Reszka EJ Trace Elem Med Biol