Gene: PAH

5053
PH|PKU|PKU1
phenylalanine hydroxylase
protein-coding
12q23.2
Ensembl:ENSG00000171759 MIM:612349 Vega:OTTHUMG00000169966 UniprotKB:P00439
NG_008690.2
PubMed
ND|AD
216   
8.358e-1 (AD)  8.906e-1 (ND)   (Frontal_Cortex)
9.609e-1 (AD)  5.912e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACSL60.671
CTNNA20.626
HAPLN10.621
C1orf210.619
TMOD20.617
F80.617
ERBB40.615
NREP0.614
VIP0.612
SLC6A10.611

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BEST3-0.415
TGFB3-0.411
ANXA2R-0.409
TBX19-0.408
LOXL2-0.404
ANGPT2-0.394
DTHD1-0.389
SPINK8-0.386
IGF2BP2-0.386
CHI3L2-0.384

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00120L-PhenylalanineSmall Molecule63-91-2Approved|Investigational|NutraceuticalTarget
DB00360SapropterinSmall Molecule62989-33-7Approved|InvestigationalTarget
DB00368NorepinephrineSmall Molecule51-41-2ApprovedTarget
DB00668EpinephrineSmall Molecule51-43-4ApprovedTarget
DB02562Quinonoid 7,8-TetrahydrobiopterinSmall Molecule79647-29-3ExperimentalTarget
DB03673Beta(2-Thienyl)AlanineSmall MoleculeExperimentalTarget
DB04400L-erythro-7,8-dihydrobiopterinSmall Molecule6779-87-9ExperimentalTarget
DB04419D-norleucineSmall Molecule327-56-0ExperimentalTarget
DB06262DroxidopaSmall Molecule23651-95-8Approved|InvestigationalTarget
DB06778Cupric sulfateSmall Molecule7758-98-7ApprovedEnzyme
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of PAH mRNA"22579512
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of PAH protein22527513
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PAH mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of PAH mRNA"21724226
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of PAH mRNA"20406850
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PAH mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAH mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PAH mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of PAH mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of PAH mRNA17562736
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of PAH protein25499718
D000082AcetaminophenAcetaminophen results in increased expression of PAH protein16538041
D000108AcetylcarnitineAcetylcarnitine results in decreased expression of PAH mRNA19555370
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PAH protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PAH mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PAH gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PAH mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of PAH protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of PAH protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PAH mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PAH mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PAH mRNA"19446018
C005948astaxanthineastaxanthine results in decreased expression of PAH mRNA19555370
D001379AzathioprineAzathioprine results in decreased expression of PAH mRNA22623647
D001507BeclomethasoneBeclomethasone results in increased expression of PAH mRNA23656298
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of PAH mRNA22579512
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of PAH mRNA19737606
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of PAH mRNA22579512
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PAH mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PAH mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PAH mRNA"26238291
D004958EstradiolEstradiol results in decreased expression of PAH mRNA20106945
C006780bisphenol Abisphenol A results in increased expression of PAH mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of PAH mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of PAH mRNA25181051
D002104CadmiumCadmium results in increased expression of PAH mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PAH protein21667247
D002233CarbocysteinePAH protein results in increased oxidation of Carbocysteine19367645
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PAH mRNA17084009|2733941
D002251Carbon TetrachlorideCYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of PAH mRNA]17084009
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased activity of PAH protein16139311
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PAH mRNA16178884
D002251Carbon Tetrachloride[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of PAH protein25303780
C031180chrysenechrysene results in decreased expression of PAH mRNA22579512
C019304ciprofibrateciprofibrate results in decreased expression of PAH mRNA12771043
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PAH mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of PAH mRNA24386269
C024989coenzyme Q10coenzyme Q10 results in decreased expression of PAH mRNA19555370
D019327Copper SulfateCopper Sulfate results in decreased expression of PAH mRNA19549813
D003474CurcuminCurcumin results in decreased expression of PAH mRNA19555370
D016572CyclosporineCyclosporine results in decreased expression of PAH mRNA20106945|2163298
C010902decabromobiphenyl etherdecabromobiphenyl ether analog results in increased expression of PAH mRNA26854739
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PAH mRNA26924002
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PAH mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of PAH mRNA19467301
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PAH mRNA21527772
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PAH mRNA12771043
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PAH mRNA17602206
C024629dimethyl phthalatedimethyl phthalate affects the expression of PAH mRNA26924002
C118739entinostatentinostat results in increased expression of PAH mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAH mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PAH mRNA17606305
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PAH protein20227414
D005033EthylmaleimideEthylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein]19367645
D005485FlutamideFlutamide results in decreased expression of PAH mRNA19299419|2479361
D005897GlafenineGlafenine results in decreased expression of PAH mRNA24136188
C004312glycidolglycidol results in decreased expression of PAH mRNA24915197
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of PAH mRNA22467014
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of PAH mRNA"22579512
C410337K 7174K 7174 results in decreased expression of PAH mRNA24086573
D048628KetolidesKetolides analog results in decreased expression of PAH mRNA24967691
C011890kojic acidkojic acid results in decreased expression of PAH mRNA16595896
C015329lycopenelycopene results in decreased expression of PAH mRNA19555370
D008244LysophosphatidylcholinesLysophosphatidylcholines results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein]19367645
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of PAH mRNA22579512
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PAH mRNA23103053
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of PAH mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PAH mRNA26011545
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of PAH mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PAH mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PAH mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PAH mRNA"25620056
C031721naphthalenenaphthalene results in decreased expression of PAH mRNA22579512
D009532NickelNickel results in increased expression of PAH mRNA24084258
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of PAH protein19716841
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of PAH mRNA19793540
D000069463Olive Oil[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of PAH protein25303780
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PAH mRNA25868421
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of PAH mRNA17097637
C069276peroxovanadateperoxovanadate inhibits the reaction [Streptozocin results in increased activity of PAH protein]11055810
C069276peroxovanadateperoxovanadate inhibits the reaction [Streptozocin results in increased expression of PAH mRNA]11055810
C031181phenanthrenephenanthrene results in decreased expression of PAH mRNA22579512
D010634PhenobarbitalPhenobarbital results in decreased expression of PAH protein19952500
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of PAH mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of PAH mRNA16221962|2081375
C006253pirinixic acidpirinixic acid results in decreased expression of PAH mRNA17164430
D011192Potassium DichromatePotassium Dichromate results in increased expression of PAH mRNA23608068
C045950propiconazolepropiconazole results in increased metabolism of PAH protein19714882
D011794QuercetinQuercetin results in decreased expression of PAH mRNA21632981
C059514resveratrolresveratrol results in decreased expression of PAH mRNA19555370
C089730rosiglitazonerosiglitazone results in decreased expression of PAH mRNA21515302
C008425S-methylcysteinePAH protein results in increased oxidation of S-methylcysteine19367645
C009277sodium arsenatesodium arsenate results in decreased expression of PAH mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of PAH gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of PAH mRNA24612858
C016104sodium bichromatesodium bichromate affects the expression of PAH mRNA22110744
D013311Streptozocinperoxovanadate inhibits the reaction [Streptozocin results in increased activity of PAH protein]11055810
D013311Streptozocinperoxovanadate inhibits the reaction [Streptozocin results in increased expression of PAH mRNA]11055810
D013311StreptozocinStreptozocin results in increased activity of PAH protein11055810
D013311StreptozocinStreptozocin results in increased expression of PAH mRNA11055810
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of PAH mRNA22467014
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of PAH mRNA15885361
C001803tempoltempol results in decreased expression of PAH mRNA19555370
C501413tesaglitazartesaglitazar results in decreased expression of PAH mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PAH mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PAH mRNA26854739
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PAH mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PAH mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of PAH mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PAH promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PAH mRNA18796159|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PAH mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PAH mRNA21215274|2172422
D013752TetracyclineTetracycline results in decreased expression of PAH mRNA24489787
C582340tetradecabromodiphenoxybenzenetetradecabromodiphenoxybenzene analog results in increased expression of PAH mRNA26854739
D008063Thioctic AcidThioctic Acid results in decreased expression of PAH mRNA19555370
C009495titanium dioxidetitanium dioxide results in increased expression of PAH mRNA23557971
D014212TretinoinTretinoin results in decreased expression of PAH mRNA18230668
D014241TrichloroethyleneTrichloroethylene results in increased expression of PAH mRNA19254012
C012589trichostatin Atrichostatin A results in decreased expression of PAH mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PAH mRNA"26179874
D014520UrethaneUrethane results in decreased expression of PAH mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of PAH mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of PAH mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of PAH mRNA28001369
D014640VancomycinVancomycin results in increased expression of PAH mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PAH gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004505phenylalanine 4-monooxygenase activity-EXP9642259  
GO:0004505phenylalanine 4-monooxygenase activity-IDA20667834  
GO:0005506iron ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006559L-phenylalanine catabolic process-IEA-  
GO:0006559L-phenylalanine catabolic process-TAS-  
GO:0008652cellular amino acid biosynthetic process-TAS3856322  
GO:0042136neurotransmitter biosynthetic process-NAS2872999  
GO:0042423catecholamine biosynthetic process-NAS2872999  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00360Phenylalanine metabolism
hsa00400Phenylalanine, tyrosine and tryptophan biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-2160456PhenylketonuriaTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-71182Phenylalanine and tyrosine catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22467358Neighborhood socioeconomic status modifies the association between individual smoking status and PAH-DNA adduct levels in prostate tissue. (2012 Jun)Rundle AEnviron Mol Mutagen
22809837BPDE-like DNA adduct level in oral tissue may act as a risk biomarker of oral cancer. (2013 Jan)Chuang CYArch Oral Biol
25227798Synergistic increase of oxidative stress and tumor markers in PAH-exposed workers. (2014)Gao MLAsian Pac J Cancer Prev
10511262Urinary 1-hydroxypyrene and other PAH metabolites as biomarkers of exposure to environmental PAH in air particulate matter. (1999 Sep 5)Strickland PToxicol Lett
10698483Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms. (2000 Feb)Whyatt RMCancer Epidemiol Biomarkers Prev
26082767Polycyclic aromatic hydrocarbons and cytochrome P450 in HIV pathogenesis. (2015)Rao PSFront Microbiol
23885040Mitochondrial DNA copy number and exposure to polycyclic aromatic hydrocarbons. (2013 Oct)Pavanello SCancer Epidemiol Biomarkers Prev
8143603Measurement of chromosomal aberrations, sister chromatid exchange, hprt mutations, and DNA adducts in peripheral lymphocytes of human populations at increased risk for cancer. (1993 Oct)Jacobson-Kram DEnviron Health Perspect
15093273Impact of phase I or phase II enzyme polymorphisms on lymphocyte DNA adducts in subjects exposed to urban air pollution and environmental tobacco smoke. (2004 Apr 1)Georgiadis PToxicol Lett
14740720Polycyclic aromatic hydrocarbons in indoor and outdoor environments and factors affecting their concentrations. (2004 Jan 1)Ohura TEnviron Sci Technol
22172412RASSF1A hypermethylation is associated with aflatoxin B1 and polycyclic aromatic hydrocarbon exposure in hepatocellular carcinoma. (2012 Sep)Feng YHepatogastroenterology
19836015Association of urinary polycyclic aromatic hydrocarbons and serum C-reactive protein. (2010 Jan)Everett CJEnviron Res
15471096Occupational exposure to polycyclic aromatic hydrocarbons suppresses constitutive expression of CYP1B1 on the transcript level in human leukocytes. (2004 Sep)Lemm FInt J Hyg Environ Health
24260161Parental smoking and risk of childhood brain tumors by functional polymorphisms in polycyclic aromatic hydrocarbon metabolism genes. (2013)Barrington-Trimis JLPLoS One
10806302Immunohistochemical analysis of polycyclic aromatic hydrocarbon-DNA adducts in breast tumor tissue. (2000 Jun 30)Santella RMCancer Lett
24266295Polymorphisms of genes involved in polycyclic aromatic hydrocarbons' biotransformation and atherosclerosis. (2013)Marinkovic NBiochem Med (Zagreb)
7732197[Mortality due to bronchopulmonary cancers in workers of 2 foundries]. (1995)Moulin JJRev Epidemiol Sante Publique
10511265Variations in urinary 1-hydroxypyrene glucuronide in relation to smoking and the modification effects of GSTM1 and GSTT1. (1999 Sep 5)Hong YCToxicol Lett
19860743Effect of gene-environment Interactions on mental development in African American, Dominican, and Caucasian mothers and newborns. (2010 Jan)Wang SAnn Hum Genet
21359563Urinary metabolites of polycyclic aromatic hydrocarbons in workers exposed to vapours and aerosols of bitumen. (2011 Jun)Pesch BArch Toxicol
21359562Modulation of urinary polycyclic aromatic hydrocarbon metabolites by enzyme polymorphisms in workers of the German Human Bitumen Study. (2011 Jun)Rihs HPArch Toxicol
16922636Cytochrome P450 interactions in human cancers: new aspects considering CYP1B1. (2005 Aug)Roos PHExpert Opin Drug Metab Toxicol
11883753Exposure to genotoxins present in ambient air in Bangkok, Thailand--particle associated polycyclic aromatic hydrocarbons and biomarkers. (2002 Mar 15)Ruchirawa MSci Total Environ
20356378Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters. (2010 Mar 31)Wang TRespir Res
15572290Genotoxicity of tobacco smoke and tobacco smoke condensate: a review. (2004 Nov)DeMarini DMMutat Res
29149738Associations of urinary polycyclic aromatic hydrocarbon metabolites with fractional exhaled nitric oxide and exhaled carbon monoxide: A cross-sectional study. (2018 Mar 15)Zhou YSci Total Environ
29412867Urinary 1-hydroxypyrene and smoking are determinants of LINE-1 and AhRR promoter methylation in coke oven workers. (2018 Feb)Yang JMutat Res
16404638Decreasing urinary PAH metabolites and 7-methylguanine after smoking cessation. (2006 Aug)Ichiba MInt Arch Occup Environ Health
16323636[Effects of oxidative DNA damage induced by polycyclic aromatic hydrocarbons and genetic polymorphism of the paraoxonase-1 (PON1) gene on lung cancer]. (2005 Aug)Lee CHJ Prev Med Public Health
9646044Relationship between ambient air pollution and DNA damage in Polish mothers and newborns. (1998 Jun)Whyatt RMEnviron Health Perspect
12686493Determination of polycyclic aromatic hydrocarbons in urine of coke oven workers by headspace solid phase microextraction and gas chromatography-mass spectrometry. (2003 May 6)Waidyanatha SChem Biol Interact
11219854Monooxygenase, epoxide hydrolase, and glutathione-S-transferase activities in human lung. Variation between groups of bronchogenic carcinoma and non-cancer patients and interindividual differences. (1980)Oesch FCarcinogenesis
22626472Exposure to polycyclic aromatic hydrocarbons and serum inflammatory markers of cardiovascular disease. (2012 Aug)Clark JD 3rdEnviron Res
11859435The effect of relevant genotypes on PAH exposure-related biomarkers. (2002 Jan-Feb)Kuljukka-Rabb TJ Expo Anal Environ Epidemiol
24092628N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: results from the EPIC cohort. (2013 Nov)Pesch BCancer Epidemiol Biomarkers Prev
11238174Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke. (2001 Mar)Hainaut PCarcinogenesis
12919719Susceptibility and exposure biomarkers in people exposed to PAHs from diesel exhaust. (2003 Sep 15)Adonis MToxicol Lett
10817119Occupational risk factors for urothelial carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter Urothelial and Renal Cancer. (2000 Apr)Pesch BInt J Epidemiol
8692233Comparative synchronous fluorescence spectrophotometry and 32P-postlabeling analysis of PAH-DNA adducts in human lung and the relationship to TP53 mutations. (1996 Jul 5)Andreassen AMutat Res
8895986Cytochrome P-450 and acetyltransferase expression as biomarkers of carcinogen-DNA adduct levels and human cancer susceptibility. (1996)Badawi AFProg Clin Biol Res
18067928Genetic polymorphisms in cytochrome P4501B1 and susceptibility to head and neck cancer. (2008 Mar 1)Singh APMutat Res
27565807Significant interactions between maternal PAH exposure and single nucleotide polymorphisms in candidate genes on B[ a ]P-DNA adducts in a cohort of non-smoking Polish mothers and newborns. (2016 Nov 1)Iyer SCarcinogenesis
24977008Remodeling of rat pulmonary artery induced by chronic smoking exposure. (2014 Jun)Zhao LJ Thorac Dis
19892797Shorter telomere length in peripheral blood lymphocytes of workers exposed to polycyclic aromatic hydrocarbons. (2010 Feb)Pavanello SCarcinogenesis
21081473Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia. (2011 Feb)Wang HCarcinogenesis
19644882Independent association of anti-beta(2)-glycoprotein I antibodies with macrovascular disease and mortality in scleroderma patients. (2009 Aug)Boin FArthritis Rheum
15061915[A study on the inherited susceptibility of chromosomal damage in peripheral blood lymphocytes among coke oven workers]. (2004 Mar)Leng SGZhonghua Yu Fang Yi Xue Za Zhi
15584438[Individual susceptibility to occupational carcinogens: the evidence from biomonitoring and molecular epidemiology studies]. (2004 Oct-Dec)Pavanello SG Ital Med Lav Ergon
20064791Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumors. (2010 Apr)Mordukhovich IEnviron Health Perspect
22837862Leptin levels predict survival in pulmonary arterial hypertension. (2012 Apr-Jun)Tonelli ARPulm Circ
15001535DNA adducts in tumour, normal peripheral lung and bronchus, and peripheral blood lymphocytes from smoking and non-smoking lung cancer patients: correlations between tissues and detection by 32P-postlabelling and immunoassay. (2004 Jul)Gyorffy ECarcinogenesis
12376472Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study. (2002 Oct)Perera FPCarcinogenesis
26544069Effect of Simvastatin on 5-HT and 5-HTT in a Rat Model of Pulmonary Artery Hypertension. (2015)Jiang XCell Physiol Biochem
26671626Sources of polycyclic aromatic hydrocarbons are associated with gene-specific promoter methylation in women with breast cancer. (2016 Feb)White AJEnviron Res
23314068Polycyclic aromatic hydrocarbons (PAHs) as determinants of various anthropometric measures of birth outcome. (2013 Feb 1)Al-Saleh ISci Total Environ
25410918[Correlation between submaximal exercise measurements and peak oxygen uptake in patients with pulmonary arterial hypertension]. (2014 Aug 26)Shi XZhonghua Yi Xue Za Zhi
27626030Blood Levels of Monoamine Precursors and Smoking in Patients with Schizophrenia. (2016)Mathai AJFront Public Health
19722178Occupational exposure to polycyclic aromatic hydrocarbons influenced neither the frequency nor the spectrum of FGFR3 mutations in bladder urothelial carcinoma. (2010 Jan)Bakkar AAMol Carcinog
10330311Cytochrome P450 CYP1A1 enzyme activity and DNA adducts in placenta of women environmentally exposed to organochlorines. (1999 May)Lagueux JEnviron Res
17429172Urinary 1-hydroxypyrene level relative to vehicle exhaust exposure mediated by metabolic enzyme polymorphisms. (2007 Mar)Chuang CYJ Occup Health
9488590Urinary excretion of 1-hydroxypyrene as a marker for exposure to urban air levels of polycyclic aromatic hydrocarbons. (1998 Feb)Merlo FCancer Epidemiol Biomarkers Prev
24084248The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes. (2013 Dec 12)Molina EMutat Res
164064203-Hydroxybenzo[a]pyrene in the urine of smokers and non-smokers. (2006 Apr 10)Lafontaine MToxicol Lett
14646292Urinary PAH metabolites influenced by genetic polymorphisms of GSTM1 in male hospital incinerator workers. (2003 May)Lee KHJ Occup Health
14646291Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations. (2003 May)Kim YDJ Occup Health
29713476Relationship between residence characteristics and polycyclic aromatic hydrocarbon exposure in housewives: second Korean National Environmental Health Survey (2012-2014). (2018)Park HGAnn Occup Environ Med
12714181On the origin of G --> T transversions in lung cancer. (2003 May 15)Pfeifer GPMutat Res
9855010A study of multiple biomarkers in coke oven workers--a cross-sectional study in China. (1998 Nov)Pan GCarcinogenesis
18409824[Urinary 1-naphthol in the general population of Umbria]. (2007 Jul-Sep)Gambelunghe AG Ital Med Lav Ergon
16438934Human endothelial progenitors constitute targets for environmental atherogenic polycyclic aromatic hydrocarbons. (2006 Mar 17)van Grevenynghe JBiochem Biophys Res Commun
11956619Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer. (2002 May-Jun)Chen CYOncol Rep
27434868Periostin mediates cigarette smoke extract-induced proliferation and migration in pulmonary arterial smooth muscle cells. (2016 Oct)Wang XDBiomed Pharmacother
15301869Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung. (2004 Sep)Berge GLung Cancer
18940956Urinary 1-hydroxypyrene and malondialdehyde in male workers in Chinese restaurants. (2008 Nov)Pan CHOccup Environ Med
27129092Benzopyrene, a major polyaromatic hydrocarbon in smoke fume, mobilizes Langerhans cells and polarizes Th2/17 responses in epicutaneous protein sensitization through the aryl hydrocarbon receptor. (2016 Jul)Hong CHInt Immunopharmacol
10521679The frequency of illegitimate TCRbeta/gamma gene recombination in human lymphocytes: influence of age, environmental exposure and cytostatic treatment, and correlation with frequencies of t(14;18) and hprt mutation. (1999 Aug 18)Meydan DMutat Res
27741445Polycyclic aromatic hydrocarbons and postmenopausal breast cancer: An evaluation of effect measure modification by body mass index and weight change. (2017 Jan)Niehoff NEnviron Res
11455387Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. (2001 Aug)Matikainen TNat Genet
8547829Decline of DNA damage and other biomarkers in peripheral blood following smoking cessation. (1995 Sep)Mooney LACancer Epidemiol Biomarkers Prev
16978913Determinants of anti-benzo[a]pyrene diol epoxide-DNA adduct formation in lymphomonocytes of the general population. (2006 Dec 10)Pavanello SMutat Res
19930591Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. (2009 Nov 21)Andersen VBMC Cancer
17493640Biomarkers of air pollution exposure--a study of policemen in Prague. (2007 Nov 1)Topinka JMutat Res
29722794DNA-methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons. (2018 May 2)Alhamdow ACarcinogenesis
11531009Immunoperoxidase detection of polycyclic aromatic hydrocarbon-DNA adducts in breast tissue sections. (2001)Motykiewicz GCancer Detect Prev
10224318Increased urinary excretion of 8-oxo-2'-deoxyguanosine, a biomarker of oxidative DNA damage, in urban bus drivers. (1999 Apr 26)Loft SMutat Res
23972896Polycyclic aromatic hydrocarbon biomarkers and serum markers of inflammation. A positive association that is more evident in men. (2013 Oct)Alshaarawy OEnviron Res
16752224IGHMBP2 Thr671Ala polymorphism might be a modifier for the effects of cigarette smoking and PAH-DNA adducts to breast cancer risk. (2006 Sep)Shen JBreast Cancer Res Treat
7955090Polycyclic aromatic hydrocarbon-DNA adducts in smokers and their relationship to micronutrient levels and the glutathione-S-transferase M1 genotype. (1994 Nov)Grinberg-Funes RACarcinogenesis
16001207Dermal and bronchial symptoms in children: are they caused by PAH containing parquet glue or by passive smoking? (2005 Sep)Heudorf UInt Arch Occup Environ Health
17896209PAH-DNA adducts in a Chinese population: relationship to PAH exposure, smoking and polymorphisms of metabolic and DNA repair genes. (2008 Feb)Hu YBiomarkers
11317712Internal exposure to PAHs of children and adults living in homes with parquet flooring containing high levels of PAHs in the parquet glue. (2001 Mar)Heudorf UInt Arch Occup Environ Health
28215083Development of a Zeolite Filter for Removing Polycyclic Aromatic Hydrocarbons (PAHs) from Smoke and Smoked Ingredients while Retaining the Smoky Flavor. (2018 Mar 14)Parker JKJ Agric Food Chem
6511802Aryl hydrocarbon hydroxylase induction levels in patients with malignant tumors associated with smoking. (1984)Korsgaard RJ Cancer Res Clin Oncol
20178811Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: possible involvement of angiotensin-converting enzyme-2. (2010 May 15)Han SXToxicol Appl Pharmacol
22674470Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation. (2012 Sep)Wang JJ Pharmacol Exp Ther
6496065Arylhydrocarbonhydroxylase inducibility and smoking habits in patients with laryngeal carcinomas. (1984 Sep-Oct)Korsgaard RActa Otolaryngol
20198579Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran. (2010 Feb 9)Marjani HAGenet Mol Res
16830233Embryonic loss due to exposure to polycyclic aromatic hydrocarbons is mediated by Bax. (2006 Aug)Detmar JApoptosis
11355291Urinary monohydroxylated phenanthrenes and hydroxypyrene--the effects of smoking habits and changes induced by smoking on monooxygenase-mediated metabolism. (2001 Apr)Heudorf UInt Arch Occup Environ Health
28095286The Relations between Polycyclic Aromatic Hydrocarbons Exposure and 1-OHP Levels as a Biomarker of the Exposure. (2016 Dec)Kloslova ZCent Eur J Public Health
7515516Exposure of bus and taxi drivers to urban air pollutants as measured by DNA and protein adducts. (1994 Jun)Hemminki KToxicol Lett
10797280Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers. (2000 Jun 1)Piipari RInt J Cancer
24761888Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons. (2014)Gao MAsian Pac J Cancer Prev
2793238Bladder cancer and occupational exposure to polycyclic aromatic hydrocarbons. (1989 Oct 15)Bonassi SInt J Cancer
7788860Expression of cytochrome P450 and microsomal epoxide hydrolase in cervical and oral epithelial cells immortalized by human papillomavirus type 16 E6/E7 genes. (1995 Jun)Farin FMCarcinogenesis
22028322Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers. (2011 Nov 1)Yuan JMCancer Res
8001254Carcinogen-DNA adducts and gene mutation in foundry workers with low-level exposure to polycyclic aromatic hydrocarbons. (1994 Dec)Perera FPCarcinogenesis
10491856[Role of metabolic polymorphisms in lung carcinogenesis]. (1999 Apr)Kiyohara CNihon Koshu Eisei Zasshi
7581496Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans. (1995)Bartsch HPharmacogenetics
19440493PAH-DNA adducts, cigarette smoking, GST polymorphisms, and breast cancer risk. (2009 Apr)McCarty KMEnviron Health Perspect
14729580Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk. (2004 Jun)Hung RJCarcinogenesis
12827334Detection of 1-hydroxypyrene in urine by direct fluorometric analysis on a solid sorbing phase. Validation and application of the method to biological monitoring of PAH-exposed persons. (2003 Jul)Lamotte MAnal Bioanal Chem
16484233Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids. (2006 Aug)Tsuji PACarcinogenesis
29730800Ambient air emissions of polycyclic aromatic hydrocarbons and female breast cancer incidence in US. (2018 May 5)Stults WPMed Oncol
19307479Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia. (2009 Apr 7)Grunig ECirculation
20951464Sex differences in susceptibility to PAHs is an intrinsic property of human lung adenocarcinoma cells. (2011 Mar)Uppstad HLung Cancer
8711952Determination of polycyclic aromatic hydrocarbons in smoked fishery products from different smoking kilns. (1996 Jun)Karl HZ Lebensm Unters Forsch
14993811Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor. (2004 Mar)Tamaki ABiol Pharm Bull
10571654Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers. (1999)Bartsch HCancer Detect Prev
19225966Increased levels of oxidative DNA damage attributable to cooking-oil fumes exposure among cooks. (2009 Jul)Ke YInhal Toxicol
1554617Interaction of smoking, uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers. (1992 Mar)Sherson DBr J Ind Med
24148823Urinary metabolites of a polycyclic aromatic hydrocarbon and volatile organic compounds in relation to lung cancer development in lifelong never smokers in the Shanghai Cohort Study. (2014 Feb)Yuan JMCarcinogenesis
23899393Influence of GSTM1 and NAT2 genotypes on the relationship between personal exposure to PAH and biomarkers of internal dose. (1998)Costa DJBiomarkers
11535249Impact of metabolic genotypes on levels of biomarkers of genotoxic exposure. (2001 Oct 1)Schoket BMutat Res
23902352Profile of urinary phenanthrene metabolites in smokers and non-smokers. (1999)Jacob JBiomarkers
11815259Influence of GSTM1 genotype on association between aromatic DNA adducts and urinary PAH metabolites in incineration workers. (2002 Feb 15)Lee JMutat Res
9855008Associations between both genetic and environmental biomarkers and lung cancer: evidence of a greater risk of lung cancer in women smokers. (1998 Nov)Tang DLCarcinogenesis
21193517Seasonal variations in the levels of PAH-DNA adducts in young adults living in Mexico City. (2011 May)Garcia-Suastegui WAMutagenesis
18053706Xeroderma pigmentosum complementation group C genotypes/diplotypes play no independent or interaction role with polycyclic aromatic hydrocarbons-DNA adducts for breast cancer risk. (2008 Mar)Shen JEur J Cancer
11037803Relation between inducibility of CYP1A1, GSTM1 and lung cancer in a French population. (2000 Oct)Stucker IPharmacogenetics
15856074Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult females. (2005 Nov)Shantakumar SJ Expo Anal Environ Epidemiol
9054627Aromatic DNA adducts in foundry workers in relation to exposure, life style and CYP1A1 and glutathione transferase M1 genotype. (1997 Feb)Hemminki KCarcinogenesis
9067549Contribution of genetic and nutritional factors to DNA damage in heavy smokers. (1997 Mar)Mooney LACarcinogenesis
29263183Urinary Concentrations of Polycyclic Aromatic Hydrocarbon Metabolites in Mate Drinkers in Rio Grande do Sul, Brazil. (2018 Mar)Lopes ABCancer Epidemiol Biomarkers Prev
25795458Activation of renin-angiotensin-aldosterone system (RAAS) in the lung of smoking-induced pulmonary arterial hypertension (PAH) rats. (2015 Jun)Yuan YMJ Renin Angiotensin Aldosterone Syst
21245046Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA. (2011 May)Guza RNucleic Acids Res
15090466Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients. (2004 Sep)Shi QCarcinogenesis
11418090Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1. (2001 Jul)van Delft JHAnn Occup Hyg
10839488Analysis of aromatic DNA adducts in laryngeal biopsies. (2000)Banaszewski JEur Arch Otorhinolaryngol
29518434Pharmacokinetics of [(14)C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. (2018 May)Hummel JMFood Chem Toxicol
7586163Mutation spectrum of cigarette smoke condensate in Salmonella: comparison to mutations in smoking-associated tumors. (1995 Oct)DeMarini DMCarcinogenesis
20040932Determinants of polycyclic aromatic hydrocarbon levels in house dust. (2011 Mar-Apr)Whitehead TJ Expo Sci Environ Epidemiol
16365018Longitudinal study of urinary phenanthrene metabolite ratios: effect of smoking on the diol epoxide pathway. (2005 Dec)Hecht SSCancer Epidemiol Biomarkers Prev
2356563Factors associated with human exposures to polycyclic aromatic hydrocarbons. (1990 Mar)Lioy PJToxicol Ind Health
19602500Investigation of PAH biomarkers in the urine of workers exposed to hot asphalt. (2009 Aug)Sobus JRAnn Occup Hyg
7690887B- and T-lymphocyte micronuclei in chimney sweeps with respect to genetic polymorphism for CYP1A1 and GST1 (class Mu). (1993 Oct)Carstensen UMutat Res
12807751Genetic effects on urinary 1-hydroxypyrene levels in a Korean population. (2003 Jun)Yang MCarcinogenesis
14706514Urinary 1-hydroxypyrene and mutagenicity in bus drivers and mail carriers exposed to urban air pollution in Denmark. (2004 Jan 10)Hansen AMMutat Res
9820667A molecular epidemiology study in women from Upper Silesia, Poland. (1998 Aug)Motykiewicz GToxicol Lett
12685737Sources and patterns of polycyclic aromatic hydrocarbons pollution in kitchen air, China. (2003 Feb)Zhu LChemosphere
17412371PAH-DNA adducts in environmentally exposed population in relation to metabolic and DNA repair gene polymorphisms. (2007 Jul 1)Binkova BMutat Res
10607731Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism. (2000 Jan)Rojas MCarcinogenesis
10350438Molecular and genetic damage from environmental tobacco smoke in young children. (1999 May)Tang DCancer Epidemiol Biomarkers Prev
21046075A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of phenolic polycyclic aromatic hydrocarbons (OH-PAH) in urine of non-smokers and smokers. (2011 Jan)Ramsauer BAnal Bioanal Chem
12398325Cytochrome P450 1B1 mRNA levels in peripheral blood cells and exposure to polycyclic aromatic hydrocarbons in Chinese coke oven workers. (2002 Sep 16)Hanaoka TSci Total Environ
22063352Polycyclic aromatic hydrocarbons (PAHs) in different types of smoked meat products from Serbia. (2008 Oct)Djinovic JMeat Sci
9744534Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 induction and genotype. (1998 Aug)Whyatt RMCarcinogenesis
19317515Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers. (2009 Apr)Carmella SGChem Res Toxicol
17548691Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race. (2007 Jun)Nock NLCancer Epidemiol Biomarkers Prev
27765036Short-term markers of DNA damage among roofers who work with hot asphalt. (2016 Oct 20)Serdar BEnviron Health
9539972Determination of HPRT mutant frequency and molecular analysis of T-lymphocyte mutants derived from coke-oven workers. (1998 Jan 30)Zanesi NMutat Res
16406813Effect of urban traffic, individual habits, and genetic polymorphisms on background urinary 1-hydroxypyrene excretion. (2007 Jan)Cocco PAnn Epidemiol
19690180Aryl hydrocarbon receptor expression is associated with a family history of upper gastrointestinal tract cancer in a high-risk population exposed to aromatic hydrocarbons. (2009 Sep)Roth MJCancer Epidemiol Biomarkers Prev
12107641Cytochrome P450 1B1, a new keystone in gene-environment interactions related to human head and neck cancer? (2002 Jun)Thier RArch Toxicol
8640907Environmental air pollution and DNA adducts in Copenhagen bus drivers--effect of GSTM1 and NAT2 genotypes on adduct levels. (1996 May)Nielsen PSCarcinogenesis
12375734Detection of DNA adducts in developing CD4+ CD8+ thymocytes and splenocytes following in utero exposure to benzo[a]pyrene. (2002 Aug)Rodriguez JWImmunopharmacol Immunotoxicol
12872524Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes. (2003 Jun)Thier RInt J Hyg Environ Health
26756918Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population. (2016 Jul)Zhu XEnviron Health Perspect
3698208Mutagenic activity and polycyclic aromatic hydrocarbon levels in urine of humans exposed to therapeutical coal tar. (1986 May)Clonfero ECarcinogenesis
12727806Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells. (2003 Apr)Feng ZCarcinogenesis
22655262Exposure to Polycyclic Aromatic Hydrocarbons Among Never Smokers in Golestan Province, Iran, an Area of High Incidence of Esophageal Cancer - a Cross-Sectional Study with Repeated Measurement of Urinary 1-OHPG in Two Seasons. (2012)Islami FFront Oncol
9167058Interactive effects of polycyclic aromatic hydrocarbons and iron oxides particles. Epidemiological and fundamental aspects. (1996)Haguenoer JMCent Eur J Public Health
25156607The interaction of APEX1 variant with polycyclic aromatic hydrocarbons on increasing chromosome damage and lung cancer risk among male Chinese. (2015 Jun)Li XMol Carcinog
16557573Sex differences in risk of lung cancer: Expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts. (2006 Aug 15)Mollerup SInt J Cancer
10095126Influence of metabolic genotype GSTM1 on levels of urinary mutagens in patients treated topically with coal tar. (1999 Mar 15)Gabbani GMutat Res
12379456On the origin of p53 G:C --> T:A transversions in lung cancers. (2002 Oct 31)Rodin SNMutat Res
24179391Urinary 1-hydroxypyrene as a biomarker to carcinogenic polycyclic aromatic hydrocarbon exposure. (2012)Ifegwu CBiomark Cancer
25411724Mouth-level intake of benzo[a]pyrene from reduced nicotine cigarettes. (2014 Nov 18)Ding YSInt J Environ Res Public Health
18559983Fetal growth restriction triggered by polycyclic aromatic hydrocarbons is associated with altered placental vasculature and AhR-dependent changes in cell death. (2008 Aug)Detmar JAm J Physiol Endocrinol Metab
27452439Dichotomous effects of aryl hydrocarbon receptor (AHR) activation on human fetoplacental endothelial cell function. (2016 Aug)Palatnik APlacenta
15598760Polymorphism in the DNA repair gene XPD, polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, and breast cancer risk. (2004 Dec)Terry MBCancer Epidemiol Biomarkers Prev
11323399Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations. (2001 May)Nan HMCarcinogenesis
11948486Polycyclic aromatic hydrocarbon-DNA adducts in liver tissues of hepatocellular carcinoma patients and controls. (2002 May 1)Chen SYInt J Cancer
23393797[Biological monitoring of PAH exposure among asphalt workers]. (2011 Jul-Sep)Campo LG Ital Med Lav Ergon
24177223Significant interactions between maternal PAH exposure and haplotypes in candidate genes on B[a]P-DNA adducts in a NYC cohort of non-smoking African-American and Dominican mothers and newborns. (2014 Jan)Iyer SCarcinogenesis
10753202CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure. (2000 Apr)Alexandrie AKCarcinogenesis
29800768Short-term effects of airport-associated ultrafine particle exposure on lung function and inflammation in adults with asthma. (2018 May 22)Habre REnviron Int
16646259[Assessment of occupational exposure to PAH in coke-oven workers of Taranto steel plant through biological monitoring]. (2005 Sep-Dec)Bisceglia LEpidemiol Prev
12379884Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. (2002 Oct 21)Pfeifer GPOncogene
16084535Effect of genetic polymorphisms of MnSOD and MPO on the relationship between PAH exposure and oxidative DNA damage. (2006 Jan 29)Park SYMutat Res
14673870Sources of polycyclic aromatic hydrocarbon exposure in non-occupationally exposed Koreans. (2003)Yang MEnviron Mol Mutagen
24307569Maternal genetic polymorphisms of phase II metabolic enzymes and the risk of fetal neural tube defects. (2014 Jan)Wang LBirth Defects Res A Clin Mol Teratol
11189784[Biomarkers of gentotoxic risk and metabolic polymorphism]. (2000 Sep-Oct)Pavanello SMed Lav
21321788N-nitrosamines are associated with shorter telomere length. (2011 Jul)Li HScand J Work Environ Health
21126447[Association of cooking oil fumes exposure and oxidative DNA damage among occupational exposed populations]. (2010 Aug)Ke YBZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
15917149Occupational exposure to polycyclic aromatic hydrocarbons in German industries: association between exogenous exposure and urinary metabolites and its modulation by enzyme polymorphisms. (2005 Jul 4)Rihs HPToxicol Lett
11641039Effects of genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 on the urinary levels of 1-hydroxypyrene and 2-naphthol in aircraft maintenance workers. (2001 Sep 15)Lee CYToxicol Lett
17624591Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York. (2008 Mar)Gaudet MMBreast Cancer Res Treat
10882891Immunoperoxidase detection of 4-aminobiphenyl- and polycyclic aromatic hydrocarbons-DNA adducts in induced sputum of smokers and non-smokers. (2000 Jul 10)Besaratinia AMutat Res
10026994Impact of adduct determination on the assessment of cancer susceptibility. (1998)Bartsch HRecent Results Cancer Res
9498898Aromatic amines and cancer. (1997 May)Vineis PCancer Causes Control
10635992Influence of GSTM1, GSTT1, GSTP1, and EPHX gene polymorphisms on DNA adduct level and HPRT mutant frequency in coke-oven workers. (1999 Dec 17)Viezzer CMutat Res
8761425GSTM1 and NAT2 genotypes and urinary mutagens in coke oven workers. (1996 Aug)Gabbani GCarcinogenesis
22103900Microsomal epoxide hydrolase polymorphisms, cigarette smoking and prostate cancer risk in the Slovak population. (2012)Sivonova MKNeoplasma
21184614Immediate consequences of cigarette smoking: rapid formation of polycyclic aromatic hydrocarbon diol epoxides. (2011 Feb 18)Zhong YChem Res Toxicol
12775499A cross-sectional study of polycyclic aromatic hydrocarbon-DNA adducts and polymorphism of glutathione S-transferases among heavy smokers by race/ethnicity. (2003 Mar-Apr)Weiserbs KFBiomarkers
15122594GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population. (2004 Jul 1)Hung RJInt J Cancer
3730301Respiratory cancer in Danish bakers: a 10 year cohort study. (1986 Aug)Tuchsen FBr J Ind Med
28181029Smoking modify the effects of polycyclic aromatic hydrocarbons exposure on oxidative damage to DNA in coke oven workers. (2017 Jul)Yang JInt Arch Occup Environ Health
10408872Cytochrome P450 1A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers. (1999 May)Yu MWBr J Cancer
12507920CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation. (2002 Dec)Alexandrov KCarcinogenesis
11921189Characterization of a major aromatic DNA adduct detected in human breast tissues. (2002)Li DEnviron Mol Mutagen
11600727Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes. (2001 Nov)Zhang JOccup Environ Med
12972061Multiple biomarkers study in painters in a shipyard in Korea. (2003 Sep 9)Lee KHMutat Res
16675419Elevated levels of urinary 8-hydroxy-2 -deoxyguanosine, lymphocytic micronuclei, and serum glutathione S-transferase in workers exposed to coke oven emissions. (2006 May)Liu ALEnviron Health Perspect
29272778Urinary trans-anti-7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene as the most relevant biomarker for assessing carcinogenic polycyclic aromatic hydrocarbons exposure. (2018 Mar)Barbeau DEnviron Int