Gene info: ID 5054

Gene: SERPINE1

GENE ID: 5054

Synonyms: PAI|PAI-1|PAI1|PLANH1

Description: serpin family E member 1

Gene type: protein-coding

Location: 7q22.1

dbXrefs: Ensembl:ENSG00000106366 MIM:173360 Vega:OTTHUMG00000157107 UniprotKB:P05121

RefSeq: NG_013213.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.192e-1 (AD) 5.800e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FOSL1	0.821
TNFRSF12A	0.818
ITGA5	0.783
GPRC5A	0.771
EMP1	0.768
PLAUR	0.763
CLCF1	0.762
ADM	0.76
NFKB2	0.755
ITPRIP	0.753

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MARCH4	-0.483
MYADML2	-0.479
NEUROD6	-0.479
KBTBD7	-0.476
SLC7A4	-0.476
LHX6	-0.464
KCNQ4	-0.462
CDK5R2	-0.461
KCNB2	-0.46
SLITRK5	-0.459

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00009	Alteplase	BiotechDrug	105857-23-6	Approved	Target
DB00013	Urokinase	BiotechDrug	9039-53-6	Approved\|Investigational\|Withdrawn	Target
DB00015	Reteplase	BiotechDrug	133652-38-7	Approved\|Investigational	Target
DB00029	Anistreplase	BiotechDrug	81669-57-0	Approved	Target
DB00031	Tenecteplase	BiotechDrug	191588-94-0	Approved	Target
DB00055	Drotrecogin alfa	BiotechDrug	98530-76-8	Approved\|Investigational\|Withdrawn	Target
DB00197	Troglitazone	Small Molecule	97322-87-7	Investigational\|Withdrawn	Target
DB05254	Fibrinolysin	BiotechDrug	9004-09-5	Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C025205	1,10-phenanthroline	"1,10-phenanthroline results in increased expression of SERPINE1 mRNA"	19502547
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of SERPINE1 mRNA"	26377693
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]"	18278065
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]"	18278065
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]"	18278065
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]"	18278065
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]"	18278065
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]"	18278065
C448659	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]	27224288
C105351	1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene	"1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased expression of SERPINE1 protein"	18424783
C105351	1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene	"HIF1A protein promotes the reaction [1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased expression of SERPINE1 protein]"	18424783
C032668	1-nitropyrene	1-nitropyrene results in increased expression of SERPINE1 mRNA	19041380
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of SERPINE1 mRNA	25827057
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SERPINE1 mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SERPINE1 mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SERPINE1 mRNA"	20566336
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of SERPINE1 mRNA"	21920950
C501339	2-(2,6-diisopropylphenyl)-5-hydroxy-1H-isoindole-1,3-dione	"2-(2,6-diisopropylphenyl)-5-hydroxy-1H-isoindole-1,3-dione results in decreased expression of SERPINE1"	21788198
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]	16458614
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	16458614
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]	14534369
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]	14534369
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]	14534369
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [AGT protein modified form results in increased expression of SERPINE1 mRNA]	12409145
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	12409145
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]	12409145
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SERPINE1 mRNA]	12409145
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]"	18278065
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]"	18278065
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]"	18278065
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]"	18278065
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of SERPINE1 mRNA"	25710175
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of SERPINE1 mRNA"	22016648
C457499	2-chloro-5-nitrobenzanilide	"2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]"	18278065
C457499	2-chloro-5-nitrobenzanilide	"2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]"	18278065
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]	18278065
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]	18278065
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased expression of SERPINE1 mRNA	23727623
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased expression of SERPINE1 protein	23727623
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl affects the expression of SERPINE1 mRNA"	21703328
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA"	28973532
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 protein]"	28973532
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINE1 mRNA"	28163111
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINE1 protein"	28163111\|2897353
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of SERPINE1 protein"	29216392
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SERPINE1 mRNA"	28163111
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINE1 mRNA"	19692669
C106572	3-iodo-2-propynylbutylcarbamate	3-iodo-2-propynylbutylcarbamate affects the expression of SERPINE1	21788198
C047368	3-methylquercetin	3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]	27151496
C047368	3-methylquercetin	3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]	27151496
C047368	3-methylquercetin	NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]	27151496
C047368	3-methylquercetin	3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 protein]	27151496
C047368	3-methylquercetin	3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]	27151496
C047368	3-methylquercetin	3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]	27151496
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of SERPINE1 mRNA]"	22286157
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [INHBA protein results in increased expression of SERPINE1 mRNA]"	22286157
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]"	22286157
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
C108123	4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine	"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]"	15913578
C108123	4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine	"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]"	15913578
C026729	4-aminophenol	4-aminophenol results in increased expression of SERPINE1 mRNA	23558518
C097470	4'-methoxychalcone	4'-methoxychalcone analog inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	28528971
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] affects the expression of SERPINE1 mRNA"	25790727
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] results in decreased expression of SERPINE1 mRNA"	25790727
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of SERPINE1 mRNA"	26238291
C048324	abamectin	abamectin affects the expression of SERPINE1	21788198
D000082	Acetaminophen	Acetaminophen results in increased expression of SERPINE1 mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of SERPINE1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of SERPINE1 mRNA	11264010\|1846933
D000082	Acetaminophen	Acetaminophen results in increased expression of SERPINE1 protein	17654741\|2231919
D000082	Acetaminophen	caffeic acid inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein]	27720869
D000082	Acetaminophen	cobra venom factor inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein]	22319198
D000082	Acetaminophen	SERPINE1 protein affects the reaction [Acetaminophen results in increased expression of CCND1 mRNA]	18469330
D000082	Acetaminophen	SERPINE1 protein affects the reaction [Acetaminophen results in increased expression of CDKN1A mRNA]	18469330
D000082	Acetaminophen	SERPINE1 protein affects the reaction [Acetaminophen results in increased expression of PCNA protein]	18469330
D000082	Acetaminophen	SERPINE1 protein affects the susceptibility to Acetaminophen	22507835
D000082	Acetaminophen	SERPINE1 protein results in decreased susceptibility to Acetaminophen	18469330
C056165	acetovanillone	acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	22414048
D000171	Acrolein	Acrolein results in increased expression of SERPINE1 mRNA	18515264
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of SERPINE1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SERPINE1 mRNA	21632981\|2164198
D016604	Aflatoxin B1	[Zearalenone co-treated with Aflatoxin B1] results in increased expression of SERPINE1 mRNA	28965971
C412373	AG 1879	AG 1879 inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]	15913578
C000188	alachlor	alachlor affects the expression of SERPINE1	21788198
D000450	Aldosterone	[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA	18682491
D000450	Aldosterone	[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein	18682491
D000450	Aldosterone	Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]	18682491
D000450	Aldosterone	Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]	18682491
D000450	Aldosterone	[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]	18682491
D000450	Aldosterone	[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]	18682491
D000450	Aldosterone	eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]	18682491
D000450	Aldosterone	eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]	18682491
C103303	alitretinoin	alitretinoin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]	16192631
C103303	alitretinoin	alitretinoin results in decreased expression of SERPINE1 protein	9012633
D013196	Dihydrotestosterone	bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]]	16317058
D013196	Dihydrotestosterone	Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]	16317058
D013196	Dihydrotestosterone	Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	16317058
D000499	Allylamine	Allylamine results in increased expression of SERPINE1 mRNA	23558518
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SERPINE1 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of SERPINE1 mRNA"	22863853
D000936	Antigen-Antibody Complex	Antigen-Antibody Complex results in increased expression of SERPINE1 mRNA	25451590
D000936	Antigen-Antibody Complex	shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of SERPINE1 mRNA]	25451590
D001115	Arecoline	Arecoline results in increased expression of SERPINE1 protein	26908192
D001115	Arecoline	Arecoline results in increased expression of SERPINE1 protein	26908192
D001115	Arecoline	pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of SERPINE1 protein]	26908192
D034341	Aristolochic Acids	Aristolochic Acids results in increased expression of SERPINE1 mRNA	19717638
C026987	aroclor 1260	[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] affects the expression of SERPINE1 mRNA	28163111
D001149	Arsenates	[Atrazine co-treated with Arsenates] results in increased expression of SERPINE1 mRNA	18585445
D001151	Arsenic	Arsenic results in decreased expression of SERPINE1 mRNA	11134558
D001151	Arsenic	Arsenic results in increased expression of SERPINE1 mRNA	19945496
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]	24762191
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of SERPINE1 mRNA	17530438
C006632	arsenic trioxide	arsenic trioxide results in increased expression of SERPINE1 mRNA	26705709
C015001	arsenite	arsenite results in increased activity of SERPINE1 protein	11864708
C015001	arsenite	arsenite results in increased expression of SERPINE1 mRNA	11864708
C015001	arsenite	arsenite affects the expression of SERPINE1 mRNA	15738583
C015001	arsenite	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SERPINE1 mRNA	15894712
C015001	arsenite	arsenite results in decreased expression of SERPINE1 mRNA	15894712
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in decreased expression of SERPINE1 protein"	20855422
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of SERPINE1 mRNA"	17975199\|1868714
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of SERPINE1 mRNA"	23917077
D001205	Ascorbic Acid	Ascorbic Acid promotes the reaction [Vitamin E inhibits the reaction [Endosulfan results in increased activity of SERPINE1 protein]]	21804306
D000069059	Atorvastatin Calcium	Atorvastatin Calcium inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]	21122807
D001280	Atrazine	[Atrazine co-treated with Arsenates] results in increased expression of SERPINE1 mRNA	18585445
D001280	Atrazine	Atrazine results in increased expression of SERPINE1 mRNA	18585445
C017037	aurin	aurin results in increased expression of SERPINE1 mRNA	25477506
C072763	azamethiphos	azamethiphos affects the expression of SERPINE1	21788198
D001379	Azathioprine	Azathioprine results in increased expression of SERPINE1 mRNA	22623647
C010038	azelaic acid	azelaic acid results in increased expression of and results in increased secretion of SERPINE1 protein	8635147
C010038	azelaic acid	azelaic acid results in increased expression of SERPINE1 mRNA	8635147
C547126	AZM551248	AZM551248 results in increased expression of SERPINE1 mRNA	22323515
C024986	barium chloride	barium chloride results in increased secretion of SERPINE1 protein	21596853
C044946	benazepril	benazepril results in decreased expression of SERPINE1 mRNA	15339989
C044946	benazepril	benazepril results in decreased expression of SERPINE1 protein	15339989
C044946	benazepril	FR 173657 inhibits the reaction [benazepril results in decreased expression of SERPINE1 mRNA]	15339989
C044946	benazepril	benazepril inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]	15322501
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SERPINE1 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SERPINE1 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of SERPINE1 mRNA	26377693
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of SERPINE1 mRNA	19737606
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of SERPINE1 mRNA	22687991
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SERPINE1 mRNA	18164116\|2004503
D019324	beta-Naphthoflavone	isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SERPINE1 mRNA]	20045035
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of SERPINE1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SERPINE1 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of SERPINE1 mRNA]	15034205
D001564	Benzo(a)pyrene	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SERPINE1 mRNA	15894712
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SERPINE1 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SERPINE1 mRNA	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SERPINE1 mRNA	15034205\|2156981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SERPINE1 mRNA	22300585
D004958	Estradiol	[Estradiol co-treated with norethindrone acetate] results in decreased expression of SERPINE1 protein	17393018
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINE1 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of SERPINE1 mRNA	19619570\|2010694
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of SERPINE1 mRNA	17404688
D004958	Estradiol	Estradiol results in increased expression of SERPINE1 mRNA	20838740
D001629	Bezafibrate	Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]	11292061
D001629	Bezafibrate	Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein]	11292061
D001629	Bezafibrate	Bezafibrate results in increased activity of SERPINE1 protein	9678787
D001629	Bezafibrate	Bezafibrate results in increased expression of SERPINE1 mRNA	10364093
D001629	Bezafibrate	Bezafibrate results in increased secretion of SERPINE1 protein	10364093
D001629	Bezafibrate	Bezafibrate results in decreased expression of SERPINE1 protein	9012633
D001629	Bezafibrate	Bezafibrate promotes the reaction [PPARA protein binds to SERPINE1 promoter]	20400680
D001629	Bezafibrate	Bezafibrate results in increased expression of SERPINE1 mRNA	17118139\|2040068
D001629	Bezafibrate	CLOCK protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]	20400680
D001629	Bezafibrate	[CLOCK protein binds to ARNTL protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]	20400680
D001629	Bezafibrate	PPARA protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]	20400680
D001629	Bezafibrate	PPARA protein inhibits the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]	20854792
D001629	Bezafibrate	[CLOCK protein binds to ARNTL protein] promotes the reaction [[PPARA protein binds to RXRA protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]]	20400680
D001629	Bezafibrate	[PPARA protein binds to RXRA protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]	20400680
C053541	bicalutamide	bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]]	16317058
D001663	Bilirubin	Bilirubin results in increased expression of SERPINE1 mRNA	20196124
C018465	bioallethrin	bioallethrin affects the expression of SERPINE1	21788198
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of SERPINE1 mRNA	27685785
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [AGT protein modified form results in increased expression of SERPINE1 mRNA]	12409145
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	12409145
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]	12409145
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SERPINE1 mRNA]	12409145
C006780	bisphenol A	bisphenol A results in decreased expression of SERPINE1 mRNA	27685785\|2927551
C006780	bisphenol A	bisphenol A results in increased expression of SERPINE1 mRNA	25181051
C006780	bisphenol A	bisphenol A affects the expression of SERPINE1	21788198
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SERPINE1 mRNA	28628672
C074619	bivalirudin	bivalirudin inhibits the reaction [F2 protein results in increased expression of SERPINE1 mRNA]	9125671\|9579636
C074619	bivalirudin	bivalirudin inhibits the reaction [F2 protein results in increased expression of SERPINE1 protein]	9579636
C074619	bivalirudin	bivalirudin inhibits the reaction [F2 protein results in increased secretion of SERPINE1 protein]	9125671
D001761	Bleomycin	Bleomycin results in increased expression of SERPINE1 protein	29175452
D000069286	Bortezomib	Bortezomib results in increased expression of SERPINE1 mRNA	20830808
D001966	Bromine	Bromine results in increased expression of SERPINE1 mRNA	21391292
D015124	8-Bromo Cyclic Adenosine Monophosphate	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of SERPINE1 mRNA	16997883
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [F2 protein results in increased expression of SERPINE1 protein]	9579636
D002066	Busulfan	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of SERPINE1 mRNA]"	22286157
D002066	Busulfan	Busulfan results in increased expression of SERPINE1 mRNA	22286157
D002066	Busulfan	Busulfan results in increased expression of SERPINE1 protein	22286157
C487162	butafenacil	butafenacil affects the expression of SERPINE1	21788198
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of SERPINE1 mRNA	23939143
C006852	butralin	butralin affects the expression of SERPINE1	21788198
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene inhibits the reaction [LPA protein results in decreased expression of SERPINE1 protein]	10856522
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene inhibits the reaction [LPA protein results in increased expression of SERPINE1 protein]	10856522
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of SERPINE1 mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in increased expression of SERPINE1 mRNA	26079696
D020148	Butyric Acid	Butyric Acid results in decreased activity of SERPINE1 protein	23378038
D020148	Butyric Acid	Butyric Acid results in increased expression of SERPINE1 mRNA	12800193
C584509	C646 compound	C646 compound results in increased expression of SERPINE1 mRNA	26191083
D002104	Cadmium	Cadmium results in decreased expression of SERPINE1 mRNA	22562489
D002104	Cadmium	Cadmium results in increased expression of SERPINE1 mRNA	21172416
D002104	Cadmium	Cadmium results in increased expression of SERPINE1 mRNA	22666406
D019256	Cadmium Chloride	[MT1 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased expression of SERPINE1 mRNA	23921151
D019256	Cadmium Chloride	[MT2 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased expression of SERPINE1 mRNA	23921151
C058667	cadmium selenide	[cadmium selenide co-treated with zinc sulfide] results in decreased expression of SERPINE1 mRNA	22342292
C040048	caffeic acid	caffeic acid inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein]	27720869
D002118	Calcium	Calcium results in increased stability of SERPINE1 protein	21280127\|2128012
D002185	Cannabidiol	Cannabidiol results in decreased expression of SERPINE1 mRNA	20668920
D002185	Cannabidiol	Cannabidiol results in decreased secretion of SERPINE1 protein	20668920
D002185	Cannabidiol	CNR1 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein]	20668920
D002185	Cannabidiol	CNR2 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein]	20668920
D002185	Cannabidiol	SERPINE1 protein results in increased susceptibility to Cannabidiol	20668920
D002185	Cannabidiol	TRPV1 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein]	20668920
D000074262	Canola Oil	Canola Oil metabolite results in decreased expression of SERPINE1 mRNA	27363782
C070646	CAP18 lipopolysaccharide-binding protein	CAP18 lipopolysaccharide-binding protein inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 mRNA]	21731756
D002211	Capsaicin	Capsaicin results in decreased expression of SERPINE1 mRNA	21310942
D002220	Carbamazepine	Carbamazepine affects the expression of SERPINE1 mRNA	24752500\|2597931
D002235	Carbofuran	Carbofuran results in increased expression of SERPINE1 mRNA	20211217
D002251	Carbon Tetrachloride	3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 protein]	27151496
D002251	Carbon Tetrachloride	ABCB11 inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA]]	28505368
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SERPINE1 mRNA	25566828\|2733941
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SERPINE1 protein	27151496
D002251	Carbon Tetrachloride	NR1H4 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA]	28505368
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of SERPINE1 mRNA	16239168
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SERPINE1 mRNA	12445421
D002251	Carbon Tetrachloride	pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA]	12445421
D002258	Carbonyl Cyanide m-Chlorophenyl Hydrazone	[Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased abundance of Superoxides] inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	11050244
D002259	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of SERPINE1 mRNA	16039398
D002392	Catechin	Catechin results in decreased expression of SERPINE1 mRNA	17379280
D002392	Catechin	pyrazolanthrone inhibits the reaction [Catechin results in decreased expression of SERPINE1 mRNA]	17379280
D002392	Catechin	U 0126 inhibits the reaction [Catechin results in decreased expression of SERPINE1 mRNA]	17379280
D002518	Ceramides	Ceramides affects the secretion of SERPINE1 protein	11107162
D002518	Ceramides	[Daunorubicin results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein	11107162
D002518	Ceramides	[N-acetylsphingosine results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein	11107162
D002518	Ceramides	[TNF protein affects the abundance of Ceramides] which results in increased secretion of SERPINE1 protein	11107162
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of SERPINE1 mRNA	21224055
D002635	Chenodeoxycholic Acid	EGR1 promotes the reaction [Chenodeoxycholic Acid results in increased expression of SERPINE1 mRNA]	21224055
D002713	Chlorine	Chlorine results in increased expression of SERPINE1 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of SERPINE1 mRNA	18636392
D002725	Chloroform	Chloroform results in increased expression of SERPINE1 mRNA	23558518
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of SERPINE1 mRNA	26272509
C100187	chloropicrin	chloropicrin affects the expression of SERPINE1 mRNA	26352163
C100187	chloropicrin	chloropicrin results in decreased expression of SERPINE1 mRNA	28476498
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased activity of SERPINE1 protein"	16971767
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of SERPINE1 mRNA"	16971767
D002791	Cholesterol, Dietary	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased activity of SERPINE1 protein]"	16971767
D002791	Cholesterol, Dietary	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of SERPINE1 mRNA]"	16971767
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SERPINE1 mRNA	27344345
D002794	Choline	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA"	28973532
D002794	Choline	"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 protein]"	28973532
D002794	Choline	Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]	19593819
D002794	Choline	"[Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SERPINE1 mRNA"	28163111
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] affects the expression of SERPINE1 mRNA	28163111
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SERPINE1 mRNA	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA	19593819
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 protein	19593819\|2897353
D002794	Choline	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]]	19593819
D002794	Choline	pirinixic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]	19593819
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SERPINE1 mRNA	27858113
C418118	CI 1044	CI 1044 results in increased expression of SERPINE1 mRNA	17569694
C039671	ciglitazone	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of SERPINE1 mRNA	16197558
C039671	ciglitazone	[ciglitazone binds to PPARG protein] which results in increased expression of SERPINE1 mRNA	16197558
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of SERPINE1 mRNA	19000754
D002994	Clofibrate	Clofibrate results in decreased expression of SERPINE1 protein	9012633
D002994	Clofibrate	Clofibrate results in increased expression of SERPINE1 mRNA	23811191
D002995	Clofibric Acid	Clofibric Acid results in increased expression of SERPINE1 mRNA	10364093
D002995	Clofibric Acid	Clofibric Acid results in increased secretion of SERPINE1 protein	10364093
D003033	Coal Tar	Coal Tar results in decreased expression of SERPINE1 mRNA	27858113
D003035	Cobalt	Cobalt results in decreased stability of SERPINE1 protein	21280127\|2128012
D003035	Cobalt	VTN protein inhibits the reaction [Cobalt results in decreased stability of SERPINE1 protein]	21280127\|2128012
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SERPINE1 mRNA	18344023\|2510016
C018021	cobaltous chloride	sauchinone inhibits the reaction [cobaltous chloride results in increased expression of SERPINE1 mRNA]	27871897
C016310	cobra venom factor	cobra venom factor inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein]	22319198
D003078	Colchicine	Colchicine results in increased expression of SERPINE1 mRNA	20624997
D005576	Colforsin	Colforsin inhibits the reaction [F2 protein results in increased expression of SERPINE1 protein]	9579636
D003300	Copper	Copper binds to and results in decreased stability of SERPINE1 protein	21280128
D003300	Copper	Copper results in decreased stability of SERPINE1 protein	21280127
D003300	Copper	[Copper results in increased oxidation of LPA protein] which results in increased secretion of SERPINE1 protein	11681624
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of SERPINE1 mRNA	20971185
D003300	Copper	VTN protein inhibits the reaction [Copper results in decreased stability of SERPINE1 protein]	21280127\|2128012
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SERPINE1 mRNA	16283523
C030973	cupric oxide	cupric oxide results in increased expression of SERPINE1 mRNA	20171267
C030973	cupric oxide	cupric oxide results in increased expression of SERPINE1 protein	20171267
C030973	cupric oxide	SB 203580 inhibits the reaction [cupric oxide results in increased expression of SERPINE1 mRNA]	20171267
D003474	Curcumin	Curcumin results in increased expression of SERPINE1 mRNA	15713895
C465366	cyazofamid	cyazofamid affects the expression of SERPINE1	21788198
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA]	11007951
D003513	Cycloheximide	Cycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA]	12111005
D003513	Cycloheximide	Cycloheximide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]	9798919
D003513	Cycloheximide	Cycloheximide promotes the reaction [FGF2 protein results in increased expression of SERPINE1 mRNA]	9798919
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of SERPINE1 mRNA	23558518
D016572	Cyclosporine	Cyclosporine results in decreased expression of SERPINE1 mRNA	22147139
D016572	Cyclosporine	Cyclosporine results in increased expression of SERPINE1 mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine results in decreased expression of SERPINE1 mRNA	19770486
D016572	Cyclosporine	Cyclosporine results in increased expression of SERPINE1 mRNA	27585667
D016572	Cyclosporine	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of SERPINE1 mRNA]	27585667
D016572	Cyclosporine	TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of SERPINE1 mRNA]	27585667
D016572	Cyclosporine	Cyclosporine results in increased expression of SERPINE1 mRNA	21865292\|2758566
C521634	Dahuang Zhechong pill	Dahuang Zhechong pill results in decreased expression of SERPINE1 mRNA	18471418
C515055	darinaparsin	darinaparsin results in increased expression of SERPINE1 mRNA	22535156
D003630	Daunorubicin	Daunorubicin results in decreased expression of SERPINE1 mRNA	11336794
D003630	Daunorubicin	Daunorubicin results in decreased expression of SERPINE1 protein	11336794
D003630	Daunorubicin	[Daunorubicin results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein	11107162
D003630	Daunorubicin	fumonisin B1 inhibits the reaction [Daunorubicin results in decreased expression of SERPINE1 protein]	11336794
D003630	Daunorubicin	Daunorubicin results in decreased secretion of SERPINE1 protein	11107162
C012864	dazomet	dazomet affects the expression of SERPINE1	21788198
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of SERPINE1 mRNA	23914054
C014347	decitabine	decitabine results in increased expression of SERPINE1 mRNA	16367923
D013759	Dronabinol	Dronabinol results in increased expression of SERPINE1 mRNA	16039398
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased expression of SERPINE1 mRNA	21224055
D003840	Deoxycholic Acid	EGR1 promotes the reaction [Deoxycholic Acid results in increased expression of SERPINE1 mRNA]	21224055
D003907	Dexamethasone	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of SERPINE1 mRNA	16997883
D003907	Dexamethasone	Dexamethasone results in increased expression of SERPINE1 mRNA	21524281
D003907	Dexamethasone	Dexamethasone results in increased secretion of SERPINE1 protein	21524281
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SERPINE1 mRNA	28628672
D003907	Dexamethasone	[Simvastatin co-treated with Dexamethasone] results in increased secretion of SERPINE1 protein	21524281
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SERPINE1 mRNA	16054899
D003907	Dexamethasone	Dexamethasone inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 mRNA]	21731756
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SERPINE1 mRNA]	16054899
D003907	Dexamethasone	Dexamethasone promotes the reaction [IL1B protein results in increased expression of SERPINE1 protein]	15963473
D003907	Dexamethasone	Dexamethasone results in increased expression of SERPINE1 protein	3127913
D003974	Diatrizoate Meglumine	CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of SERPINE1 protein]	23335628
D003974	Diatrizoate Meglumine	[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of SERPINE1 protein	23335628
C000912	diazoxon	diazoxon affects the expression of SERPINE1	21788198
C023614	dibenzofuran	dibenzofuran analog results in increased expression of SERPINE1 mRNA	20566336
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of SERPINE1 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of SERPINE1 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of SERPINE1 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of SERPINE1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of SERPINE1 mRNA	21532991
D002945	Cisplatin	Cisplatin affects the expression of SERPINE1 mRNA	21151649
D002945	Cisplatin	Cisplatin results in decreased expression of SERPINE1 mRNA	22023808
D004008	Diclofenac	Diclofenac affects the expression of SERPINE1 mRNA	24752500
D004008	Diclofenac	Diclofenac results in increased expression of SERPINE1 mRNA	26934552
D004008	Diclofenac	"Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SERPINE1 mRNA]"	23939143
C000944	dicrotophos	dicrotophos results in increased expression of SERPINE1 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in decreased expression of SERPINE1 mRNA	26924002
C023635	dienogest	[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of SERPINE1 protein	15288212
D004041	Dietary Fats	Dietary Fats results in decreased expression of SERPINE1 mRNA	25016146
D004041	Dietary Fats	[Dietary Fats co-treated with resveratrol] results in increased expression of SERPINE1 mRNA	21852083
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of SERPINE1 mRNA	27614199
D004052	Diethylnitrosamine	AHR protein inhibits the reaction [Diethylnitrosamine results in increased expression of SERPINE1 mRNA]	19996281
D004052	Diethylnitrosamine	Diethylnitrosamine affects the expression of SERPINE1 mRNA	21159647
D004052	Diethylnitrosamine	Diethylnitrosamine affects the expression of SERPINE1 protein	21159647
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of SERPINE1 mRNA	18282651\|1999628
D004052	Diethylnitrosamine	RB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of SERPINE1 mRNA]	18282651
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SERPINE1 mRNA	18164116\|2004503
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SERPINE1 mRNA	23830814
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of SERPINE1 mRNA	18253720
D004052	Diethylnitrosamine	isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SERPINE1 mRNA]	20045035
C031394	difenzoquat	difenzoquat affects the expression of SERPINE1	21788198
C076154	dimethomorph	dimethomorph affects the expression of SERPINE1	21788198
C024629	dimethyl phthalate	dimethyl phthalate results in decreased expression of SERPINE1 mRNA	26924002
C049346	diniconazole	diniconazole affects the expression of SERPINE1	21788198
C058064	dinitrophenyl-human serum albumin conjugate	dinitrophenyl-human serum albumin conjugate results in increased expression of SERPINE1 mRNA	15961275
D004178	Diquat	Diquat results in increased expression of SERPINE1 mRNA	21172416
D004298	Dopamine	SERPINE1 protein inhibits the reaction [Morphine results in increased secretion of Dopamine]	16619846
D004317	Doxorubicin	Doxorubicin results in decreased expression of SERPINE1 mRNA	16705698
D004317	Doxorubicin	Doxorubicin results in increased expression of SERPINE1 mRNA	15870702
D004317	Doxorubicin	SERPINE1 protein affects the susceptibility to Doxorubicin	16217747
D004317	Doxorubicin	Doxorubicin results in increased expression of SERPINE1 mRNA	21040762\|2589636
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of SERPINE1 mRNA	21040762
D004317	Doxorubicin	Doxorubicin results in increased expression of SERPINE1 mRNA	20211217\|2355851
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of SERPINE1 mRNA"	23811387
C098320	efavirenz	efavirenz results in increased secretion of SERPINE1 protein	21619898
D015118	Eicosapentaenoic Acid	[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]	22169119
C035276	eicosapentaenoic acid ethyl ester	eicosapentaenoic acid ethyl ester results in decreased expression of SERPINE1 protein	14614217
C108024	emamectin benzoate	emamectin benzoate affects the expression of SERPINE1	21788198
D004642	Emodin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]	14534369
D004642	Emodin	Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]	14534369
D004642	Emodin	Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]	14534369
D004656	Enalapril	Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]	18682491
D004656	Enalapril	Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]	18682491
D004656	Enalapril	Enalapril results in decreased expression of SERPINE1 mRNA	18682491
D004656	Enalapril	Enalapril results in decreased expression of SERPINE1 protein	18682491
D004656	Enalapril	[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]	18682491
D004656	Enalapril	[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]	18682491
D004656	Enalapril	[eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA	18682491
D004656	Enalapril	[eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein	18682491
D015773	Enalaprilat	Enalaprilat results in decreased expression of SERPINE1 mRNA	21795644
D004726	Endosulfan	Ascorbic Acid promotes the reaction [Vitamin E inhibits the reaction [Endosulfan results in increased activity of SERPINE1 protein]]	21804306
D004726	Endosulfan	Endosulfan results in increased activity of SERPINE1 protein	21804306
D004726	Endosulfan	Vitamin E inhibits the reaction [Endosulfan results in increased activity of SERPINE1 protein]	21804306
C017435	enilconazole	enilconazole affects the expression of SERPINE1	21788198
C118739	entinostat	entinostat results in increased expression of SERPINE1 mRNA	26272509\|2718838
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
D004837	Epinephrine	Epinephrine results in increased expression of SERPINE1 mRNA	15850565
C414690	eplerenone	[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]	18682491
C414690	eplerenone	[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]	18682491
C414690	eplerenone	[eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA	18682491
C414690	eplerenone	[eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein	18682491
C414690	eplerenone	eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]	18682491
C414690	eplerenone	eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]	18682491
C414690	eplerenone	eplerenone results in decreased expression of SERPINE1 mRNA	18682491
C414690	eplerenone	eplerenone results in decreased expression of SERPINE1 protein	18682491
C454300	estradiol valerate-dienogest	[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased expression of SERPINE1 protein	15288212
D004966	Estrogens, Conjugated (USP)	"Estrogens, Conjugated (USP) results in decreased expression of SERPINE1 protein"	15850603
D004997	Ethinyl Estradiol	[Ethinyl Estradiol binds to Norethindrone] which results in decreased expression of SERPINE1 protein	14561536
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of SERPINE1 protein	15288212
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased expression of SERPINE1 protein	15288212
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Gestodene] results in increased activity of SERPINE1 protein	15504374
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased activity of SERPINE1 protein	14981370
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of SERPINE1 protein	15157790\|1528821
C442659	ethinyl estradiol-desogestrel combination	ethinyl estradiol-desogestrel combination results in decreased activity of SERPINE1 protein	14981370
C507035	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of SERPINE1 mRNA]	27585667
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of SERPINE1 mRNA	23649840
C508136	etoxazole	etoxazole affects the expression of SERPINE1	21788198
D015025	Zearalenone	[Zearalenone co-treated with Aflatoxin B1] results in increased expression of SERPINE1 mRNA	28965971
D015738	Famotidine	Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein]	16401727
D011345	Fenofibrate	Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]	19593819
D011345	Fenofibrate	Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]	19593819
D011345	Fenofibrate	Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]	19593819
D011345	Fenofibrate	Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]	19593819
D011345	Fenofibrate	Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]	19593819
D011345	Fenofibrate	Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]	19593819
D011345	Fenofibrate	NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]]	19593819
D011345	Fenofibrate	Fenofibrate affects the expression of SERPINE1 mRNA	20801182
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of SERPINE1 mRNA	18253720
C006012	fenofibric acid	[fenofibric acid binds to PPARA protein] which results in increased expression of SERPINE1 mRNA	16197558
C006012	fenofibric acid	fenofibric acid results in decreased expression of SERPINE1 mRNA	10364093
C006012	fenofibric acid	fenofibric acid results in decreased secretion of SERPINE1 protein	10364093
C052034	fenoxycarb	fenoxycarb affects the expression of SERPINE1	21788198
C415144	fenpyroximate	fenpyroximate affects the expression of SERPINE1	21788198
D005290	Ferric Compounds	Ferric Compounds results in decreased expression of SERPINE1 mRNA	24035972
D005411	Flame Retardants	Flame Retardants results in increased expression of SERPINE1 mRNA	26808241
C550006	fluoxastrobin	fluoxastrobin affects the expression of SERPINE1	21788198
D005485	Flutamide	Flutamide results in increased expression of SERPINE1 mRNA	24793618
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SERPINE1 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of SERPINE1 mRNA	23649840\|2766457
D017328	Fosinopril	Fosinopril results in decreased expression of SERPINE1 mRNA	21051829
D017328	Fosinopril	Fosinopril results in decreased expression of SERPINE1 protein	21051829
D017328	Fosinopril	[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA	21051829
D017328	Fosinopril	[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein	21051829
C105311	FR 173657	FR 173657 inhibits the reaction [benazepril results in decreased expression of SERPINE1 mRNA]	15339989
D005632	Fructose	Atorvastatin Calcium inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]	21122807
D005632	Fructose	Fructose results in increased expression of SERPINE1 mRNA	21122807\|2301613
D005632	Fructose	Fructose results in increased expression of SERPINE1 protein	23016136\|2510815
D005632	Fructose	Fructose results in increased secretion of SERPINE1 protein	19165636
D005632	Fructose	Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]	25108154
D005632	Fructose	Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]	23016136
D005632	Fructose	Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]	23016136
D005632	Fructose	resveratrol inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]	25108154
D037741	Fullerenes	Fullerenes analog results in increased expression of SERPINE1 mRNA	22342292
C056933	fumonisin B1	fumonisin B1 inhibits the reaction [Daunorubicin results in decreased expression of SERPINE1 protein]	11336794
D005688	Galactosamine	Galactosamine results in increased expression of SERPINE1 mRNA	11779202
C001277	geldanamycin	geldanamycin results in increased expression of SERPINE1 mRNA	26705709
D015248	Gemfibrozil	Gemfibrozil results in decreased expression of SERPINE1 mRNA	10364093
D015248	Gemfibrozil	Gemfibrozil results in decreased secretion of SERPINE1 protein	10364093
D015248	Gemfibrozil	Gemfibrozil results in increased activity of SERPINE1 protein	9678787
D015248	Gemfibrozil	Gemfibrozil results in decreased expression of SERPINE1 mRNA	9012633
D015248	Gemfibrozil	Gemfibrozil results in decreased expression of SERPINE1 protein	9012633
D015248	Gemfibrozil	Ro 31-8220 inhibits the reaction [Gemfibrozil results in decreased expression of SERPINE1 mRNA]	9012633
D019833	Genistein	Genistein inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]	14534369
D019833	Genistein	Genistein promotes the reaction [troglitazone inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]	14534369
D019833	Genistein	Genistein results in decreased expression of SERPINE1 mRNA	22228119
D019833	Genistein	Genistein results in increased expression of SERPINE1 mRNA	20838740
D005839	Gentamicins	CTF1 protein inhibits the reaction [[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of SERPINE1 protein]	23335628
D005839	Gentamicins	[Diatrizoate Meglumine co-treated with Gentamicins] results in increased expression of SERPINE1 protein	23335628
C033273	Gestodene	[Ethinyl Estradiol co-treated with Gestodene] results in increased activity of SERPINE1 protein	15504374
D005947	Glucose	[[Glucose results in increased chemical synthesis of Superoxides] which results in increased glycosylation of SP1 protein] which results in increased expression of SERPINE1	11050244
D005947	Glucose	Glucose results in increased secretion of SERPINE1 protein	16320596
D005947	Glucose	Indomethacin inhibits the reaction [Glucose results in increased secretion of SERPINE1 protein]	16320596
D005947	Glucose	SOD2 protein inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	11050244
D005947	Glucose	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	12409145
D005947	Glucose	[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA	18682491
D005947	Glucose	[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein	18682491
D005947	Glucose	bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	12409145
D005947	Glucose	Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]	18682491
D005947	Glucose	Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]	18682491
D005947	Glucose	[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]	18682491
D005947	Glucose	[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]	18682491
D005947	Glucose	eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]	18682491
D005947	Glucose	eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]	18682491
D005947	Glucose	Glucose results in increased expression of SERPINE1 mRNA	12409145
D005947	Glucose	UCP1 protein inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	11050244
D005947	Glucose	[Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased abundance of Superoxides] inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	11050244
D005947	Glucose	Glucose promotes the reaction [SP1 protein results in increased expression of SERPINE1 mRNA]	11050244
D005947	Glucose	Glucose results in increased expression of SERPINE1 mRNA	11050244
D005947	Glucose	[manganese(III)-tetrakis(4-benzoic acid)porphyrin results in decreased abundance of Superoxides] inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	11050244
D005947	Glucose	[Thenoyltrifluoroacetone results in decreased abundance of Superoxides] inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	11050244
C081021	Go 6976	Go 6976 inhibits the reaction [NGF protein results in increased expression of SERPINE1 mRNA]	23825664
C081021	Go 6976	Go 6976 inhibits the reaction [NGF protein results in increased expression of SERPINE1 protein]	23825664
C508665	gold (III) porphyrin 1a	gold (III) porphyrin 1a results in decreased expression of SERPINE1 mRNA	16206274
D006145	Guanethidine	Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]	15850565
C425931	GW 501516	[GW 501516 binds to PPARD protein] which results in increased expression of SERPINE1 mRNA	16197558
D055768	Halogenated Diphenyl Ethers	Halogenated Diphenyl Ethers results in increased expression of SERPINE1 mRNA	26808241
D006493	Heparin	Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]	16401727
D006493	Heparin	Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein]	16401727
C000625835	HFPO2 compound	HFPO2 compound results in increased expression of SERPINE1 mRNA	27553808
C000625836	HFPO4 compound	HFPO4 compound results in increased expression of SERPINE1 mRNA	27553808
C005499	honokiol	honokiol affects the expression of SERPINE1 mRNA	21265825
C005499	honokiol	honokiol inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]	21265825
D006830	Hydralazine	Hydralazine results in decreased expression of SERPINE1 mRNA	23415681
D006830	Hydralazine	[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA	11318962
D006830	Hydralazine	[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein	11318962
D006851	Hydrochloric Acid	SERPINE1 protein affects the susceptibility to Hydrochloric Acid	19060228
D006852	Hydrochlorothiazide	[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA	11318962
D006852	Hydrochlorothiazide	[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein	11318962
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SERPINE1 protein	19401454
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SERPINE1 mRNA	17620961
D006861	Hydrogen Peroxide	telmisartan inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]	17620961
D006861	Hydrogen Peroxide	tempol inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]	17620961
D006861	Hydrogen Peroxide	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]	12409145
D006861	Hydrogen Peroxide	bisindolylmaleimide I inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]	12409145
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SERPINE1 mRNA	12409145
D017665	Hydroxyl Radical	[[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein	11681624
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of SERPINE1 mRNA	19376150
C492448	ICG 001	ICG 001 results in increased expression of SERPINE1 mRNA	26191083
C474021	indirubin-3'-monoxime	[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SERPINE1 mRNA	18958680
D007213	Indomethacin	Indomethacin inhibits the reaction [Glucose results in increased secretion of SERPINE1 protein]	16320596
D007213	Indomethacin	Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of SERPINE1 protein]	16320596
D007213	Indomethacin	Indomethacin results in increased expression of SERPINE1 mRNA	16984733
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SERPINE1 mRNA	28628672
C401104	indoxacarb	indoxacarb affects the expression of SERPINE1	21788198
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SERPINE1 mRNA	25613284
D015759	Ionomycin	Ionomycin results in increased expression of SERPINE1 mRNA	15961275
C081309	irbesartan	irbesartan inhibits the reaction [ALB protein results in increased expression of SERPINE1 mRNA]	20214630
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of SERPINE1 mRNA	16997883
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SERPINE1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SERPINE1 mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SERPINE1 mRNA]	16054899
D007545	Isoproterenol	Isoproterenol results in decreased expression of SERPINE1 protein	24286936
D007545	Isoproterenol	Isoproterenol results in increased expression of SERPINE1 mRNA	20211217\|2355851
C016527	isoquercitrin	isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SERPINE1 mRNA]	20045035
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of SERPINE1 mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of SERPINE1 protein	17337753
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SERPINE1 mRNA	25961927\|2675264
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SERPINE1 mRNA	26644586
C410337	K 7174	K 7174 results in increased expression of SERPINE1 mRNA	24086573
D007608	Kainic Acid	Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]	15850565
D007608	Kainic Acid	Kainic Acid results in increased expression of SERPINE1 mRNA	15850565
D007608	Kainic Acid	Mecamylamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]	15850565
D007608	Kainic Acid	Phentolamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]	15850565
C067713	lactacystin	lactacystin inhibits the reaction [tin protoporphyrin IX inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]]	18344023
C055370	lactofen	lactofen affects the expression of SERPINE1	21788198
C008261	lead acetate	lead acetate results in increased expression of SERPINE1 mRNA	27562236
C045463	leflunomide	leflunomide results in increased expression of SERPINE1 mRNA	28988120
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SERPINE1 mRNA"	18930950
C482199	lipopolysaccharide, E coli O55-B5	"Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SERPINE1 mRNA]"	23939143
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of SERPINE1 mRNA"	23939143
D008070	Lipopolysaccharides	bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]]	16317058
D008070	Lipopolysaccharides	Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]	16317058
D008070	Lipopolysaccharides	Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of SERPINE1 protein]	16320596
D008070	Lipopolysaccharides	Lipopolysaccharides affects the expression of SERPINE1 mRNA	28070326
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINE1 mRNA	16317058\|9102164
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINE1 protein	9102164
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased secretion of SERPINE1 protein	16320596\|1751319
D008070	Lipopolysaccharides	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]	9102164
D008070	Lipopolysaccharides	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]	9102164
D008070	Lipopolysaccharides	Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of SERPINE1 mRNA]	28070326
D008070	Lipopolysaccharides	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of SERPINE1 mRNA	22777745
D008070	Lipopolysaccharides	CAP18 lipopolysaccharide-binding protein inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 mRNA]	21731756
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 mRNA]	21731756
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINE1 mRNA	22169119\|2589032
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINE1 protein	19367693\|9102164
D008070	Lipopolysaccharides	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]	9102164
D008070	Lipopolysaccharides	[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]	22169119
D008070	Lipopolysaccharides	SERPINE1 protein results in increased susceptibility to [trovafloxacin co-treated with Lipopolysaccharides]	19367693
D008070	Lipopolysaccharides	[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 mRNA	21731756
D008070	Lipopolysaccharides	trovafloxacin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]	19367693
D008070	Lipopolysaccharides	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]	27224288
D008070	Lipopolysaccharides	Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]	16401727
D008070	Lipopolysaccharides	Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein]	16401727
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SERPINE1 mRNA	16401727
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINE1 mRNA	11779202\|1641532
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINE1 protein	17698507\|2722428
D008070	Lipopolysaccharides	Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]	17698507
D008070	Lipopolysaccharides	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]	16415329
D008070	Lipopolysaccharides	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]	17698507
D019808	Losartan	AGTR1A protein affects the reaction [Losartan inhibits the reaction [AGT protein alternative form results in increased expression of SERPINE1 mRNA]]	17429342
D019808	Losartan	Losartan inhibits the reaction [AGT protein alternative form results in increased expression of SERPINE1 mRNA]	17429342
C520284	Ly-364947	Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA]	25566828
D008274	Magnesium	Magnesium results in increased stability of SERPINE1 protein	21280127\|2128012
D015636	Magnesium Chloride	Magnesium Chloride affects the reaction [Nickel binds to SERPINE1 protein]	21280128
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SERPINE1 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SERPINE1 mRNA	26378955
D008344	Maneb	Maneb affects the expression of SERPINE1	21788198
D008345	Manganese	Manganese results in increased stability of SERPINE1 protein	21280127\|2128012
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	[manganese(III)-tetrakis(4-benzoic acid)porphyrin results in decreased abundance of Superoxides] inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	11050244
C013592	mangiferin	mangiferin inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]	19706694
D008464	Mecamylamine	Mecamylamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]	15850565
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of SERPINE1 mRNA	20843944
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of SERPINE1 protein	16011840
C042720	mercuric bromide	mercuric bromide results in increased expression of SERPINE1 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of SERPINE1 mRNA	11817102
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of SERPINE1 protein	14620542
D008627	Mercuric Chloride	Tacrolimus inhibits the reaction [Mercuric Chloride results in increased expression of SERPINE1 protein]	14620542
D009921	Metaproterenol	Metaproterenol results in increased expression of SERPINE1 mRNA	23558518
D008687	Metformin	Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]	25108154
D008694	Methamphetamine	Methamphetamine results in increased expression of SERPINE1 mRNA	12766323
D008701	Methapyrilene	Methapyrilene results in increased expression of SERPINE1 mRNA	28935588
D008713	Methimazole	Methimazole results in increased expression of SERPINE1 mRNA	22504374
D008715	Methionine	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA"	28973532
D008715	Methionine	"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 protein]"	28973532
D008715	Methionine	Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]	19593819
D008715	Methionine	"[Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SERPINE1 mRNA"	28163111
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] affects the expression of SERPINE1 mRNA	28163111
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SERPINE1 mRNA	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA	19593819
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 protein	19593819\|2897353
D008715	Methionine	NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]]	19593819
D008715	Methionine	pirinixic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]	19593819
D008731	Methoxychlor	Methoxychlor affects the expression of SERPINE1	21788198
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of SERPINE1 mRNA	16619036
C028912	methylene bis(thiocyanate)	methylene bis(thiocyanate) affects the expression of SERPINE1	21788198
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SERPINE1 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of SERPINE1 mRNA	23649840
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in increased expression of SERPINE1 mRNA	15120970
D015741	Metribolone	Metribolone results in increased secretion of SERPINE1 protein	20711410
D015735	Mifepristone	Mifepristone results in decreased expression of SERPINE1 mRNA	17584828
D015735	Mifepristone	Mifepristone promotes the reaction [IL1B protein results in increased expression of SERPINE1 protein]	15963473
D015735	Mifepristone	Mifepristone results in decreased expression of SERPINE1 mRNA	25972201
D016685	Mitomycin	SERPINE1 protein affects the susceptibility to Mitomycin	16217747
D008942	Mitoxantrone	Mitoxantrone results in increased expression of SERPINE1 mRNA	23558518
D016686	Monocrotaline	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA	21224054
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of SERPINE1 mRNA	19945496
C517284	monomethyl phthalate	monomethyl phthalate results in decreased expression of SERPINE1 mRNA	26924002
D009020	Morphine	SERPINE1 protein inhibits the reaction [Morphine results in increased secretion of Dopamine]	16619846
C500085	muraglitazar	muraglitazar results in increased expression of SERPINE1 mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in increased expression of SERPINE1 mRNA	27617619
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SERPINE1 mRNA"	29244179
C064769	N-acetylsphingosine	[N-acetylsphingosine results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein	11107162
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of SERPINE1 mRNA"	25790727
D037742	Nanotubes, Carbon	"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] affects the expression of SERPINE1 mRNA"	25790727
D037742	Nanotubes, Carbon	"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] results in decreased expression of SERPINE1 mRNA"	25790727
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SERPINE1 protein"	25790727
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of SERPINE1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of SERPINE1 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SERPINE1 mRNA"	25554681
C031721	naphthalene	naphthalene results in increased expression of SERPINE1 mRNA	18978301
D009281	Naphthalenes	Naphthalenes results in increased expression of SERPINE1 protein	17337753
D009285	Naphthoquinones	Naphthoquinones results in increased expression of SERPINE1 mRNA	23811387
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SERPINE1 mRNA	27344345
D015058	1-Naphthylisothiocyanate	SERPINE1 gene mutant form results in increased susceptibility to 1-Naphthylisothiocyanate	24633426
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of SERPINE1 mRNA	23558518
C005273	naringenin	naringenin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	22709785
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of SERPINE1 mRNA	19812364
D009525	Niacin	Niacin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]	16916501
D009525	Niacin	Niacin results in decreased expression of SERPINE1 protein	19420110
D009532	Nickel	HIF1A protein promotes the reaction [Nickel results in increased expression of SERPINE1 mRNA]	11504687
D009532	Nickel	Magnesium Chloride affects the reaction [Nickel binds to SERPINE1 protein]	21280128
D009532	Nickel	Nickel binds to and results in decreased stability of SERPINE1 protein	21280128
D009532	Nickel	Nickel results in decreased stability of SERPINE1 protein	21280127
D009532	Nickel	Nickel results in increased expression of SERPINE1 mRNA	11504687\|2476865
D009532	Nickel	U 0126 inhibits the reaction [Nickel results in increased expression of SERPINE1 mRNA]	11504687
D009532	Nickel	VTN protein inhibits the reaction [Nickel results in decreased stability of SERPINE1 protein]	21280127\|2128012
C022838	nickel chloride	nickel chloride affects the expression of SERPINE1 mRNA	22110744
C017557	nickel subsulfide	nickel subsulfide results in increased expression of SERPINE1 mRNA	11504688
C029938	nickel sulfate	nickel sulfate results in increased expression of SERPINE1 mRNA	16100012
D009534	Niclosamide	Niclosamide affects the expression of SERPINE1	21788198
D009538	Nicotine	Nicotine results in increased expression of SERPINE1 mRNA	11166759
D009538	Nicotine	Nicotine results in increased secretion of SERPINE1 protein	21596853
C010615	Nonidet P-40	Nonidet P-40 results in decreased expression of SERPINE1 mRNA	26552463
D009638	Norepinephrine	Norepinephrine results in increased expression of SERPINE1 mRNA	17429342
D009640	Norethindrone	[Ethinyl Estradiol binds to Norethindrone] which results in decreased expression of SERPINE1 protein	14561536
C024262	norethindrone acetate	[Estradiol co-treated with norethindrone acetate] results in decreased expression of SERPINE1 protein	17393018
D016912	Levonorgestrel	[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased activity of SERPINE1 protein	14981370
D016912	Levonorgestrel	[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of SERPINE1 protein	15157790\|1528821
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]	9102164
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]	9102164
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]	16458614
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	16458614
C072936	notoginsenoside R1	notoginsenoside R1 results in decreased activity of SERPINE1 protein	8018658
C072936	notoginsenoside R1	notoginsenoside R1 results in increased expression of [PLAT protein binds to SERPINE1 protein]	8018658
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]	9102164
C570897	NSC668394	NSC668394 results in increased expression of SERPINE1 mRNA	27137931
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of SERPINE1 mRNA	20971185
C516519	NuvaRing	NuvaRing results in decreased expression of SERPINE1 protein	15157790
C464660	obeticholic acid	obeticholic acid results in decreased expression of SERPINE1 mRNA	27939613
C025589	ochratoxin A	ochratoxin A results in increased expression of SERPINE1 mRNA	19717638
D019787	Linoleic Acid	Linoleic Acid results in increased expression of SERPINE1 mRNA	17374693
D019301	Oleic Acid	Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]	11292061
D019301	Oleic Acid	Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein]	11292061
D019301	Oleic Acid	[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA	11292061
D019301	Oleic Acid	[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein	11292061
D019301	Oleic Acid	troglitazone promotes the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]	11292061
D019301	Oleic Acid	troglitazone promotes the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein]	11292061
D000068557	Olmesartan Medoxomil	Olmesartan Medoxomil results in decreased expression of SERPINE1 mRNA	18501344
C002771	Omite	Omite affects the expression of SERPINE1	21788198
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of SERPINE1 mRNA	25729387
D010100	Oxygen	APEX1 protein inhibits the reaction [RAC1 protein inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]]	12719791
D010100	Oxygen	APEX1 protein promotes the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]	12719791
D010100	Oxygen	Oxygen deficiency results in increased expression of SERPINE1 mRNA	12719791\|1867937
D010100	Oxygen	Oxygen deficiency results in increased expression of SERPINE1 protein	12719791
D010100	Oxygen	pyrrolidine dithiocarbamic acid inhibits the reaction [RAC1 protein inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]]	12719791
D010100	Oxygen	pyrrolidine dithiocarbamic acid promotes the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]	12719791
D010100	Oxygen	RAC1 protein inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]	12719791
D010100	Oxygen	RAC1 protein inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 protein]	12719791
D010100	Oxygen	Oxygen deficiency results in increased expression of SERPINE1 mRNA	23539316
D010100	Oxygen	Oxygen deficiency results in increased expression of SERPINE1 protein	24657099
D010100	Oxygen	"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]"	15913578
D010100	Oxygen	AG 1879 inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]	15913578
D010100	Oxygen	Oxygen deficiency results in increased expression of SERPINE1 mRNA	15913578
D010100	Oxygen	Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]	15913578
D010100	Oxygen	"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]"	15913578
D010100	Oxygen	Oxygen deficiency results in increased expression of SERPINE1 mRNA	15913578
D010118	Oxytetracycline	Oxytetracycline affects the expression of SERPINE1	21788198
D010126	Ozone	Ozone results in increased expression of SERPINE1 mRNA	27206323
D010126	Ozone	Ozone results in increased expression of SERPINE1 mRNA	19555225
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of SERPINE1 mRNA	18636392
D010126	Ozone	Ozone results in increased expression of SERPINE1 mRNA	20980218
D017239	Paclitaxel	SERPINE1 protein affects the susceptibility to Paclitaxel	16217747
C500026	palbociclib	palbociclib results in increased expression of SERPINE1 mRNA	22869556
D019308	Palmitic Acid	Palmitic Acid results in increased expression of SERPINE1 mRNA	17658692
D010269	Paraquat	Paraquat results in increased expression of SERPINE1 mRNA	20883675
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] affects the expression of SERPINE1 mRNA	17715259
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] results in decreased expression of SERPINE1 protein	17715259
D052638	Particulate Matter	Particulate Matter results in increased expression of SERPINE1 mRNA	21494547\|2170821
D052638	Particulate Matter	Particulate Matter results in increased expression of SERPINE1 protein	21494547
D052638	Particulate Matter	TNF protein promotes the reaction [Particulate Matter results in increased expression of SERPINE1 mRNA]	21494547
D052638	Particulate Matter	TNF protein promotes the reaction [Particulate Matter results in increased expression of SERPINE1 protein]	21494547
D052638	Particulate Matter	Particulate Matter analog inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1]	16180011
D052638	Particulate Matter	Particulate Matter analog inhibits the reaction [TNF protein results in increased expression of SERPINE1]	16180011
D052638	Particulate Matter	Particulate Matter analog results in decreased expression of SERPINE1	16180011
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of SERPINE1 mRNA	18593933
D010431	Pentoxifylline	Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]	17698507
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of SERPINE1 mRNA	19429403
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of SERPINE1 mRNA	20936131
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SERPINE1 mRNA	25868421
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of SERPINE1 mRNA	27614199
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of SERPINE1 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SERPINE1 mRNA	18467677\|2093613
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of SERPINE1 mRNA]	18467677\|2093613
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of SERPINE1 mRNA	17097637
D010575	Pesticides	Pesticides results in increased secretion of SERPINE1 protein	25463530
D010575	Pesticides	PON1 protein polymorphism affects the reaction [Pesticides results in increased secretion of SERPINE1 protein]	25463530
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of SERPINE1 mRNA	26678675
D010634	Phenobarbital	Phenobarbital results in decreased expression of SERPINE1 mRNA	19270015
D010646	Phentolamine	Phentolamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]	15850565
D010656	Phenylephrine	Phenylephrine results in increased expression of SERPINE1 mRNA	15850565
D010656	Phenylephrine	Phenylephrine results in increased expression of SERPINE1 mRNA	15808835
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SERPINE1 mRNA	26272509
D010672	Phenytoin	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA	21224054
D010705	Phosgene	Phosgene affects the expression of SERPINE1 mRNA	16300373
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] affects the expression of SERPINE1 mRNA	17715259
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] results in decreased expression of SERPINE1 protein	17715259
C004479	pimagedine	pimagedine inhibits the reaction [LPA protein modified form results in increased expression of SERPINE1 protein]	10856522
C004479	pimagedine	pimagedine results in increased expression of SERPINE1 mRNA	18380797
C060836	pioglitazone	pioglitazone results in increased expression of SERPINE1 mRNA	21757225
C060836	pioglitazone	pioglitazone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SERPINE1 mRNA]	16598202
C093844	pirfenidone	pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA]	12445421
C006253	pirinixic acid	pirinixic acid results in increased expression of SERPINE1 mRNA	10364093
C006253	pirinixic acid	pirinixic acid results in increased secretion of SERPINE1 protein	10364093
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SERPINE1 mRNA	19710929
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in increased expression of SERPINE1 mRNA	20813756
C006253	pirinixic acid	pirinixic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]	19593819
C006253	pirinixic acid	pirinixic acid results in increased expression of SERPINE1 mRNA	17118139\|2081375
D010936	Plant Extracts	Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of SERPINE1 mRNA]	28070326
D010936	Plant Extracts	Plant Extracts results in decreased expression of SERPINE1 mRNA	22144737
D010936	Plant Extracts	Plant Extracts inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]	19706694
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of SERPINE1 mRNA	24583197
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of SERPINE1 protein	29175452
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of SERPINE1 mRNA	27989595
C008971	polymarcine	polymarcine affects the expression of SERPINE1	21788198
D011189	Potassium Chloride	Potassium Chloride results in increased secretion of SERPINE1 protein	21596853
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of SERPINE1 protein	23718831
C045362	prochloraz	prochloraz affects the expression of SERPINE1	21788198
C479581	procyanidin B3	[procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]	22169119
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of SERPINE1 mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of SERPINE1 mRNA	17404688\|2086464
D011374	Progesterone	Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]	23016136
D011374	Progesterone	Progesterone inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]	23016136
D011372	Progestins	Progestins results in increased expression of SERPINE1	16011840
C005556	propionaldehyde	propionaldehyde results in increased expression of SERPINE1 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of SERPINE1 mRNA	22504374
C010313	pseudocumene	pseudocumene results in increased expression of SERPINE1 protein	17337753
D011692	Puromycin Aminonucleoside	pioglitazone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SERPINE1 mRNA]	16598202
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of SERPINE1 mRNA	16598202
C572726	pycnidione	pycnidione results in increased expression of SERPINE1 protein	22450442
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of SERPINE1 mRNA	27029645
C513428	pyrachlostrobin	pyrachlostrobin affects the expression of SERPINE1	21788198
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Catechin results in decreased expression of SERPINE1 mRNA]	17379280
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Quercetin results in decreased expression of SERPINE1 mRNA]	17379280
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Valproic Acid results in decreased activity of and results in decreased secretion of SERPINE1 protein]	23378038
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of SERPINE1 protein]	26908192
C428725	pyridaben	pyridaben affects the expression of SERPINE1	21788198
C010423	pyrithione zinc	pyrithione zinc results in decreased expression of SERPINE1 mRNA	21424779
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [RAC1 protein inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]]	12719791
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [RAC1 protein results in decreased expression of SERPINE1 mRNA]	12719791
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid promotes the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]	12719791
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid results in increased expression of SERPINE1 mRNA	12719791
C528580	qishen yiqi	qishen yiqi inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]	27636716
C528580	qishen yiqi	qishen yiqi inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]	27636716
D011794	Quercetin	pyrazolanthrone inhibits the reaction [Quercetin results in decreased expression of SERPINE1 mRNA]	17379280
D011794	Quercetin	Quercetin results in decreased expression of SERPINE1 mRNA	17379280
D011794	Quercetin	Quercetin results in increased expression of SERPINE1 mRNA	21632981
D011794	Quercetin	U 0126 inhibits the reaction [Quercetin results in decreased expression of SERPINE1 mRNA]	17379280
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of SERPINE1 mRNA	21632981
C470613	quinoxyfen	quinoxyfen affects the expression of SERPINE1	21788198
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SERPINE1 mRNA	19059307
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of SERPINE1 protein	15850603
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of SERPINE1 protein	16277677
D011899	Ranitidine	Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]	16401727
D011899	Ranitidine	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SERPINE1 mRNA	16401727
D011899	Ranitidine	Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]	17698507
D011899	Ranitidine	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]	16415329
D011899	Ranitidine	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]	17698507
D012110	Reserpine	[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA	11318962
D012110	Reserpine	[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein	11318962
C100036	resmethrin	resmethrin affects the expression of SERPINE1	21788198
C059514	resveratrol	LPIN1 affects the reaction [resveratrol inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]]	27345520
C059514	resveratrol	resveratrol affects the secretion of SERPINE1 protein	24802182
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of SERPINE1 mRNA]	20531350
C059514	resveratrol	resveratrol inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]	27345520
C059514	resveratrol	resveratrol inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]	27345520
C059514	resveratrol	resveratrol results in decreased expression of SERPINE1 mRNA	23819014
C059514	resveratrol	resveratrol results in decreased expression of SERPINE1 protein	23224687\|2381901
C059514	resveratrol	resveratrol results in increased expression of SERPINE1 mRNA	15280659
C059514	resveratrol	resveratrol results in increased expression of SERPINE1 protein	23437203
C059514	resveratrol	resveratrol inhibits the reaction [stearic acid results in increased expression of SERPINE1 mRNA]	17374693
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	17967414
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]	17967414
C059514	resveratrol	resveratrol inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]	25108154
C059514	resveratrol	[Dietary Fats co-treated with resveratrol] results in increased expression of SERPINE1 mRNA	21852083
D015474	Isotretinoin	Isotretinoin results in decreased expression of SERPINE1 mRNA	15972972
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINE1 mRNA	21127053
D012293	Rifampin	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA	21224054
C089032	rimonabant	rimonabant results in decreased expression of SERPINE1 protein	17882151
C064758	Ro 31-8220	Ro 31-8220 inhibits the reaction [Gemfibrozil results in decreased expression of SERPINE1 mRNA]	9012633
C064758	Ro 31-8220	Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SERPINE1 mRNA]	9012633
C089730	rosiglitazone	rosiglitazone inhibits the reaction and results in increased secretion of INS protein inhibits the reaction and results in increased secretion of SERPINE1 protein	12940867
C089730	rosiglitazone	rosiglitazone results in decreased expression of SERPINE1 mRNA	10364093
C089730	rosiglitazone	rosiglitazone results in decreased expression of SERPINE1 protein	17932317
C089730	rosiglitazone	rosiglitazone results in decreased secretion of SERPINE1 protein	10364093\|1294086
C089730	rosiglitazone	rosiglitazone results in increased expression of SERPINE1 mRNA	21757225
C089730	rosiglitazone	ADIPOQ affects the reaction [rosiglitazone results in decreased expression of SERPINE1 protein]	17932317
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SERPINE1 mRNA	16054899
C089730	rosiglitazone	rosiglitazone results in decreased expression of SERPINE1 protein	17932317
C089730	rosiglitazone	rosiglitazone results in increased expression of SERPINE1 mRNA	21757225
C089730	rosiglitazone	rosiglitazone results in increased expression of SERPINE1 protein	21757225
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SERPINE1 mRNA]	16054899
C089730	rosiglitazone	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]"	18278065
C089730	rosiglitazone	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]"	18278065
C089730	rosiglitazone	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]	18278065
C089730	rosiglitazone	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]	18278065
C089730	rosiglitazone	rosiglitazone inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]	18278065
C089730	rosiglitazone	rosiglitazone inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]	18278065
C089730	rosiglitazone	rosiglitazone results in increased expression of SERPINE1 mRNA	21515302
C041376	rosmarinic acid	rosmarinic acid results in decreased expression of SERPINE1 mRNA	26804033
C041376	rosmarinic acid	rosmarinic acid results in decreased expression of SERPINE1 mRNA	26804033
D012402	Rotenone	Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]	15913578
D012402	Rotenone	Rotenone results in increased expression of SERPINE1 mRNA	27900601
C000589029	RU24858	RU24858 promotes the reaction [IL1B protein results in increased expression of SERPINE1 protein]	15963473
C085917	RU 43044	RU 43044 promotes the reaction [IL1B protein results in increased expression of SERPINE1 protein]	15963473
D012504	Saralasin	Saralasin inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]	11244025
C410958	sauchinone	sauchinone inhibits the reaction [cobaltous chloride results in increased expression of SERPINE1 mRNA]	27871897
C410958	sauchinone	sauchinone inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]	25451574
C093642	SB 203580	SB 203580 inhibits the reaction [cupric oxide results in increased expression of SERPINE1 mRNA]	20171267
C410733	scriptaid	scriptaid affects the expression of SERPINE1 mRNA	18813790
C430918	SEA 0400	SEA 0400 results in decreased expression of SERPINE1 mRNA	15215644
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of SERPINE1 mRNA"	23917077
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of SERPINE1 mRNA"	23917077
D022641	Shiga Toxin 2	CAP18 lipopolysaccharide-binding protein inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 mRNA]	21731756
D022641	Shiga Toxin 2	Dexamethasone inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 mRNA]	21731756
D022641	Shiga Toxin 2	[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 mRNA	21731756
C016101	shikonin	shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of SERPINE1 mRNA]	25451590
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of SERPINE1 protein	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of SERPINE1 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SERPINE1 mRNA	19073995\|2322117
D012834	Silver	Silver results in decreased expression of SERPINE1 mRNA	22342292
D012834	Silver	Silver results in increased expression of SERPINE1 mRNA	26014281\|2895954
D019821	Simvastatin	Simvastatin results in decreased expression of SERPINE1 mRNA	16375908
D019821	Simvastatin	[Simvastatin co-treated with Dexamethasone] results in increased secretion of SERPINE1 protein	21524281
D019821	Simvastatin	Simvastatin results in decreased activity of SERPINE1 protein	17513194
D019821	Simvastatin	Simvastatin results in decreased expression of SERPINE1 mRNA	17513194\|2152428
D019821	Simvastatin	Simvastatin results in decreased expression of SERPINE1 protein	16375908
D019821	Simvastatin	Simvastatin results in decreased secretion of SERPINE1 protein	21524281
D019821	Simvastatin	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased activity of SERPINE1 protein]"	16971767
D019821	Simvastatin	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of SERPINE1 mRNA]"	16971767
D019821	Simvastatin	Simvastatin results in decreased expression of SERPINE1 mRNA	16414398
D020123	Sirolimus	Sirolimus inhibits the reaction [TP73 protein results in decreased expression of SERPINE1 mRNA]	21245298
D012906	Smoke	Smoke analog results in increased expression of SERPINE1 mRNA	20079143
D012906	Smoke	Smoke analog results in increased expression of SERPINE1 protein	20079143
C009277	sodium arsenate	sodium arsenate results in increased expression of SERPINE1 mRNA	23922661
C017947	sodium arsenite	sodium arsenite results in increased expression of SERPINE1 mRNA	26535918
C017947	sodium arsenite	sodium arsenite affects the expression of SERPINE1 mRNA	16507464
C017947	sodium arsenite	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SERPINE1 mRNA	16368122
C017947	sodium arsenite	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SERPINE1 protein	16368122
C017947	sodium arsenite	sodium arsenite results in decreased expression of SERPINE1 mRNA	16014739
C017947	sodium arsenite	sodium arsenite results in increased expression of SERPINE1 protein	16507464
D012999	Soman	Soman results in increased expression of SERPINE1 mRNA	19281266
D053260	Soot	Soot results in increased expression of SERPINE1 mRNA	26551751
C508135	spirodiclofen	spirodiclofen affects the expression of SERPINE1	21788198
D013148	Spironolactone	Spironolactone results in decreased expression of SERPINE1 protein	12424430
C031183	stearic acid	resveratrol inhibits the reaction [stearic acid results in increased expression of SERPINE1 mRNA]	17374693
C031183	stearic acid	stearic acid results in increased expression of SERPINE1 mRNA	17374693
D013311	Streptozocin	SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SERPINE1]	22744176
D013311	Streptozocin	SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]	21778425
D013311	Streptozocin	Streptozocin promotes the reaction [MAP3K5 protein results in increased expression of SERPINE1 protein]	16731828
D013311	Streptozocin	Streptozocin results in increased expression of SERPINE1	22744176
D013311	Streptozocin	Streptozocin results in increased expression of SERPINE1 mRNA	21778425
D013311	Streptozocin	Streptozocin results in increased expression of SERPINE1 protein	16731828\|2496769
D013311	Streptozocin	sulforafan inhibits the reaction [Streptozocin results in increased expression of SERPINE1 protein]	24967692
D013311	Streptozocin	benazepril inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]	15322501
D013311	Streptozocin	Streptozocin results in increased expression of SERPINE1 mRNA	15322501\|1697371
D013311	Streptozocin	Streptozocin results in increased expression of SERPINE1 protein	15322501\|1936905
D013311	Streptozocin	Trientine inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]	16973718
D013311	Streptozocin	Zinc inhibits the reaction [Streptozocin results in increased expression of SERPINE1 protein]	19369054
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SERPINE1 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SERPINE1 mRNA	26378955
D013453	Sulfonylurea Compounds	Sulfonylurea Compounds results in decreased expression of SERPINE1 protein	17932317
C016766	sulforafan	sulforafan inhibits the reaction [Streptozocin results in increased expression of SERPINE1 protein]	24967692
C025462	sulindac sulfide	sulindac sulfide results in increased expression of SERPINE1 mRNA	15897233
D013481	Superoxides	[[Glucose results in increased chemical synthesis of Superoxides] which results in increased glycosylation of SP1 protein] which results in increased expression of SERPINE1	11050244
D013481	Superoxides	[[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein	11681624
D013481	Superoxides	[Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased abundance of Superoxides] inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	11050244
D013481	Superoxides	[manganese(III)-tetrakis(4-benzoic acid)porphyrin results in decreased abundance of Superoxides] inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	11050244
D013481	Superoxides	[Thenoyltrifluoroacetone results in decreased abundance of Superoxides] inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	11050244
D016559	Tacrolimus	Tacrolimus inhibits the reaction [Mercuric Chloride results in increased expression of SERPINE1 protein]	14620542
D016559	Tacrolimus	Tacrolimus inhibits the reaction [NGF protein results in increased expression of SERPINE1 mRNA]	23825664
D016559	Tacrolimus	Tacrolimus inhibits the reaction [NGF protein results in increased expression of SERPINE1 protein]	23825664
D016559	Tacrolimus	Tacrolimus results in increased expression of SERPINE1 mRNA	21865292\|9422427
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in increased expression of SERPINE1 mRNA	19059307
D013629	Tamoxifen	Tamoxifen results in decreased expression of SERPINE1 protein	15850603
D013656	Taurocholic Acid	NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased expression of SERPINE1 mRNA]	28505368
C084178	telmisartan	telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]	17620961
C084178	telmisartan	telmisartan inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]	17620961
C084178	telmisartan	telmisartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]	19706694
C001803	tempol	tempol inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]	17620961
C001803	tempol	tempol inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]	17620961
C501413	tesaglitazar	tesaglitazar results in increased expression of SERPINE1 mRNA	21515302
D013739	Testosterone	Testosterone results in decreased expression of SERPINE1 mRNA	22138414
D013739	Testosterone	Testosterone results in increased expression of SERPINE1 mRNA	15788153
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of SERPINE1 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA]	11007951
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINE1 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SERPINE1 mRNA	22298810\|2257421
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA	11007951\|1148935
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA]	12111005\|2211307
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 protein]	12111005
D013749	Tetrachlorodibenzodioxin	ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA]	12111005
D013749	Tetrachlorodibenzodioxin	ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 protein]	12111005
D013749	Tetrachlorodibenzodioxin	Cycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA]	12111005
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SERPINE1 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of SERPINE1 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SERPINE1 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SERPINE1 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to SERPINE1 enhancer] which results in increased expression of SERPINE1 mRNA]	22113079\|2211307
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SERPINE1 promoter]	21889950
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA	12111005\|1216731
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SERPINE1 protein	12111005
D013749	Tetrachlorodibenzodioxin	CGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 protein]	12128104
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA	19692669\|2121527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SERPINE1 protein	12128104
C005806	tetrachloroisophthalonitrile	tetrachloroisophthalonitrile affects the expression of SERPINE1	21788198
D013755	Tetradecanoylphorbol Acetate	[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SERPINE1 mRNA	18958680
D013755	Tetradecanoylphorbol Acetate	Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SERPINE1 mRNA]	9012633
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SERPINE1 mRNA	9012633
D013755	Tetradecanoylphorbol Acetate	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SERPINE1 mRNA	16368122
D013755	Tetradecanoylphorbol Acetate	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SERPINE1 protein	16368122
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SERPINE1 mRNA	25613284
D013755	Tetradecanoylphorbol Acetate	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SERPINE1 mRNA]	12409145
D013755	Tetradecanoylphorbol Acetate	bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SERPINE1 mRNA]	12409145
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SERPINE1 mRNA	12409145
C009424	tetramethrin	tetramethrin affects the expression of SERPINE1	21788198
D013792	Thalidomide	Thalidomide results in increased expression of SERPINE1	21788198
D013804	Thenoyltrifluoroacetone	[Thenoyltrifluoroacetone results in decreased abundance of Superoxides] inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	11050244
D013849	Thimerosal	Thimerosal results in increased expression of SERPINE1 mRNA	16870260
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SERPINE1 mRNA	23830814
D013853	Thioacetamide	Thioacetamide results in increased expression of SERPINE1 mRNA	23558518
C027971	thiodicarb	thiodicarb affects the expression of SERPINE1	21788198
D013893	Thiram	Thiram affects the expression of SERPINE1	21788198
C027385	tibolone	tibolone metabolite results in increased expression of SERPINE1 protein	16011840
C027385	tibolone	tibolone results in increased expression of SERPINE1 protein	16011840
C032628	tin protoporphyrin IX	lactacystin inhibits the reaction [tin protoporphyrin IX inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]]	18344023
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]	18344023
C009495	titanium dioxide	titanium dioxide affects the expression of SERPINE1 mRNA	19695317
C009495	titanium dioxide	titanium dioxide results in increased expression of SERPINE1 mRNA	22342292
C009495	titanium dioxide	titanium dioxide results in increased expression of SERPINE1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SERPINE1 mRNA	15289447\|2811129
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of and results in increased secretion of SERPINE1 protein	27818348
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of SERPINE1 protein	27793746
D019772	Topotecan	SERPINE1 protein affects the susceptibility to Topotecan	16217747
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of SERPINE1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of SERPINE1 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of SERPINE1 mRNA"	19682533
C032910	triadimefon	triadimefon results in decreased expression of SERPINE1 mRNA	26705709
D014223	Triamterene	Triamterene results in increased expression of SERPINE1 mRNA	23558518
D014241	Trichloroethylene	PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of SERPINE1 mRNA]	15363585
D014241	Trichloroethylene	Trichloroethylene affects the expression of SERPINE1 mRNA	21135412
D014241	Trichloroethylene	Trichloroethylene results in increased expression of SERPINE1 mRNA	28973375
C012589	trichostatin A	trichostatin A results in increased expression of SERPINE1 mRNA	26705709
C012589	trichostatin A	trichostatin A results in decreased expression of SERPINE1 mRNA	15901671
D014266	Trientine	Trientine inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]	16973718
C467051	trifloxystrobin	trifloxystrobin affects the expression of SERPINE1	21788198
C053549	triflumizol	triflumizol affects the expression of SERPINE1	21788198
C009954	trilostane	trilostane inhibits the reaction [GNRH1 protein results in increased expression of SERPINE1 mRNA]	17332517
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of SERPINE1 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SERPINE1 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of SERPINE1 mRNA	29024780
C057693	troglitazone	Genistein promotes the reaction [troglitazone inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]	14534369
C057693	troglitazone	troglitazone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	14534369
C057693	troglitazone	troglitazone inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]	14534369
C057693	troglitazone	troglitazone promotes the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]	11292061
C057693	troglitazone	troglitazone promotes the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein]	11292061
C057693	troglitazone	troglitazone results in decreased expression of SERPINE1 mRNA	10768100\|1963173
C057693	troglitazone	troglitazone results in decreased secretion of SERPINE1 protein	10768100
C057693	troglitazone	troglitazone results in increased expression of SERPINE1 mRNA	19140230\|1963173
C057693	troglitazone	[troglitazone binds to and results in increased activity of PPARG mRNA] which results in decreased expression of SERPINE1 mRNA	11318962
C057693	troglitazone	[troglitazone binds to and results in increased activity of PPARG mRNA] which results in decreased expression of SERPINE1 protein	11318962
C057693	troglitazone	[troglitazone binds to and results in increased activity of TGFB1 mRNA] which results in decreased expression of SERPINE1 mRNA	11318962
C057693	troglitazone	[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA	11318962
C057693	troglitazone	[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein	11318962
C057693	troglitazone	troglitazone results in decreased expression of SERPINE1 mRNA	11318962
C057693	troglitazone	troglitazone results in decreased expression of SERPINE1 protein	11318962
C057693	troglitazone	troglitazone results in increased expression of SERPINE1 mRNA	21515302
C080163	trovafloxacin	SERPINE1 protein results in increased susceptibility to [trovafloxacin co-treated with Lipopolysaccharides]	19367693
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SERPINE1 mRNA"	18930950
C080163	trovafloxacin	trovafloxacin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]	19367693
D020032	Tyrphostins	Tyrphostins inhibits the reaction [EGF protein results in increased expression of SERPINE1 mRNA]	9012633
C113580	U 0126	U 0126 inhibits the reaction [Catechin results in decreased expression of SERPINE1 mRNA]	17379280
C113580	U 0126	U 0126 inhibits the reaction [Nickel results in increased expression of SERPINE1 mRNA]	11504687
C113580	U 0126	U 0126 inhibits the reaction [Quercetin results in decreased expression of SERPINE1 mRNA]	17379280
C113580	U 0126	U 0126 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]	16458614
C113580	U 0126	U 0126 inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	16458614
C022884	undecane	undecane results in increased expression of SERPINE1 protein	17337753
C073339	usnic acid	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of SERPINE1 mRNA	22777745
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of SERPINE1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of SERPINE1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of SERPINE1 mRNA	23179753\|2493525
D014635	Valproic Acid	SERPINE1 gene mutant form results in increased susceptibility to Valproic Acid	23378038
D014635	Valproic Acid	pyrazolanthrone inhibits the reaction [Valproic Acid results in decreased activity of and results in decreased secretion of SERPINE1 protein]	23378038
D014635	Valproic Acid	SERPINE1 protein inhibits the reaction [Valproic Acid results in increased activity of PLAT protein]	23378038
D014635	Valproic Acid	SERPINE1 protein results in decreased susceptibility to Valproic Acid	23378038
D014635	Valproic Acid	Valproic Acid results in decreased activity of and results in decreased secretion of SERPINE1 protein	23378038
D014635	Valproic Acid	[Valproic Acid results in decreased activity of SERPINE1 protein] which results in increased activity of PLAT protein	23378038
D014635	Valproic Acid	Valproic Acid results in decreased expression of SERPINE1 mRNA	15901671
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in increased secretion of SERPINE1 protein]	11244025
D000068756	Valsartan	[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA	21051829
D000068756	Valsartan	[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein	21051829
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]	11244025
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]	11244025
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 protein]	11244025
D000068756	Valsartan	Valsartan results in decreased expression of SERPINE1 mRNA	21051829
D000068756	Valsartan	Valsartan results in decreased expression of SERPINE1 protein	21051829
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SERPINE1 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions analog inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1]	16180011
D001335	Vehicle Emissions	Vehicle Emissions analog inhibits the reaction [TNF protein results in increased expression of SERPINE1]	16180011
D001335	Vehicle Emissions	Vehicle Emissions analog results in decreased expression of SERPINE1	16180011
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of SERPINE1 mRNA	20980218
D014747	Vinblastine	SERPINE1 protein affects the susceptibility to Vinblastine	16217747
D014747	Vinblastine	Vinblastine results in increased expression of SERPINE1 mRNA	20624997
C025643	vinclozolin	vinclozolin results in decreased expression of SERPINE1 mRNA	23034163
D014750	Vincristine	SERPINE1 gene SNP results in increased susceptibility to Vincristine	21245421
D014750	Vincristine	Vincristine results in increased expression of SERPINE1 mRNA	20624997
C029297	vinylidene chloride	vinylidene chloride results in increased expression of SERPINE1 mRNA	26682919
D014807	Vitamin D	Vitamin D results in decreased expression of SERPINE1	25488441
D002762	Cholecalciferol	Cholecalciferol results in increased expression of SERPINE1 mRNA	17170073
D014810	Vitamin E	Ascorbic Acid promotes the reaction [Vitamin E inhibits the reaction [Endosulfan results in increased activity of SERPINE1 protein]]	21804306
D014810	Vitamin E	Vitamin E inhibits the reaction [Endosulfan results in increased activity of SERPINE1 protein]	21804306
C121611	VIVIT peptide	VIVIT peptide inhibits the reaction [NGF protein results in increased expression of SERPINE1 protein]	23825664
C009687	wortmannin	wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]	16458614
C009687	wortmannin	wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]	16458614
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of SERPINE1 mRNA	18593933
D015032	Zinc	Zinc inhibits the reaction [Streptozocin results in increased expression of SERPINE1 protein]	19369054
D017967	Zinc Compounds	Zinc Compounds results in decreased expression of SERPINE1 mRNA	24035972
C031238	zinc sulfide	[cadmium selenide co-treated with zinc sulfide] results in decreased expression of SERPINE1 mRNA	22342292
C451427	zoxamide	zoxamide affects the expression of SERPINE1	21788198

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IPI	2503541 8508955 8626514 12114510 15853774
GO:0004867	serine-type endopeptidase inhibitor activity	-	IBA	21873635
GO:0004867	serine-type endopeptidase inhibitor activity	-	IDA	1695900 8508955
GO:0004867	serine-type endopeptidase inhibitor activity	-	TAS	-
GO:0005102	signaling receptor binding	-	IPI	8626514
GO:0005515	protein binding	-	IPI	16272158 25416956 28296156

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001300	chronological cell aging	-	IEP	18974388
GO:0001525	angiogenesis	-	IEP	11866539
GO:0002576	platelet degranulation	-	TAS	-
GO:0007623	circadian rhythm	-	TAS	-
GO:0010469	regulation of signaling receptor activity	-	IDA	8837777
GO:0010757	negative regulation of plasminogen activation	-	IDA	8508955
GO:0010757	negative regulation of plasminogen activation	-	IMP	18835034 19855083
GO:0010951	negative regulation of endopeptidase activity	-	IBA	21873635
GO:0010951	negative regulation of endopeptidase activity	-	IDA	1695900
GO:0014912	negative regulation of smooth muscle cell migration	-	IDA	8837777
GO:0030194	positive regulation of blood coagulation	-	IMP	9207454
GO:0030195	negative regulation of blood coagulation	-	IC	1695900
GO:0030198	extracellular matrix organization	-	TAS	-
GO:0030336	negative regulation of cell migration	-	IDA	10902815
GO:0032757	positive regulation of interleukin-8 production	-	IMP	19916862
GO:0033629	negative regulation of cell adhesion mediated by integrin	-	IDA	8837777
GO:0035491	positive regulation of leukotriene production involved in inflammatory response	-	IMP	19916862
GO:0042730	fibrinolysis	-	TAS	-
GO:0045766	positive regulation of angiogenesis	-	IMP	18835034
GO:0045944	positive regulation of transcription by RNA polymerase II	-	TAS	-
GO:0048260	positive regulation of receptor-mediated endocytosis	-	IDA	8626514
GO:0050729	positive regulation of inflammatory response	-	IGI	17032919
GO:0050829	defense response to Gram-negative bacterium	-	IGI	17032919
GO:0051918	negative regulation of fibrinolysis	-	IDA	2503541
GO:0061044	negative regulation of vascular wound healing	-	IGI	9386191
GO:0061045	negative regulation of wound healing	-	IC	8837777
GO:0071222	cellular response to lipopolysaccharide	-	IMP	19916862
GO:0071277	cellular response to calcium ion	-	HEP	21237226
GO:0090026	positive regulation of monocyte chemotaxis	-	IMP	19916862
GO:0090399	replicative senescence	-	IMP	16862142
GO:0097187	dentinogenesis	-	IDA	27046084
GO:1901331	positive regulation of odontoblast differentiation	-	IDA	27046084
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	IMP	18835034
GO:2000098	negative regulation of smooth muscle cell-matrix adhesion	-	IDA	8837777
GO:2000352	negative regulation of endothelial cell apoptotic process	-	IMP	18835034

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IDA	9386191
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	1695900 18835034
GO:0005886	plasma membrane	-	TAS	-
GO:0031093	platelet alpha granule lumen	-	TAS	-
GO:0062023	collagen-containing extracellular matrix	-	HDA	23979707
GO:0062023	collagen-containing extracellular matrix	-	IDA	1632457
GO:0070062	extracellular exosome	-	IDA	21276792

KEGG ID	KEGG Term
hsa04115	p53 signaling pathway
hsa04610	Complement and coagulation cascades
hsa05142	Chagas disease (American trypanosomiasis)

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114608	Platelet degranulation	TAS
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	TAS
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-170834	Signaling by TGF-beta Receptor Complex	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	TAS
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	TAS
R-HSA-3000178	ECM proteoglycans	TAS
R-HSA-400253	Circadian Clock	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-75205	Dissolution of Fibrin Clot	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	TAS
R-HSA-9006936	Signaling by TGF-beta family members	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17656673	Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study. (2007 Oct)	Morange PE	Arterioscler Thromb Vasc Biol
22982001	Association between variations in coagulation system genes and carotid plaque. (2012 Dec 15)	Della-Morte D	J Neurol Sci
17036337	Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation. (2006 Nov 15)	Carmichael SL	Am J Med Genet A
28296937	Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)	Lin E	PLoS One
25775950	Association between SNPs in Serpin gene family and risk of esophageal squamous cell carcinoma. (2015 Aug)	Meng H	Tumour Biol
17683517	The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics. (2008 Jan)	Lao O	Ann Hum Genet