Gene info: ID 5055

Gene: SERPINB2

GENE ID: 5055

Synonyms: HsT1201|PAI|PAI-2|PAI2|PLANH2

Description: serpin family B member 2

Gene type: protein-coding

Location: 18q21.33-q22.1

dbXrefs: Ensembl:ENSG00000197632 MIM:173390 Vega:OTTHUMG00000060592 UniprotKB:P05120

RefSeq: NC_000018.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.866e-1 (AD) 7.715e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLEKHS1	0.593
BEND4	0.587
ALDH1A2	0.587
DSG3	0.566
TNFSF18	0.556
SDC1	0.551
DYRK2	0.55
ENTPD7	0.543
MEX3B	0.543
FST	0.53

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MYOM1	-0.352
PLIN5	-0.331
HIF3A	-0.325
NRN1L	-0.319
SMOC1	-0.318
PAIP2B	-0.313
ARMC12	-0.313
SNX22	-0.311
PON1	-0.311
C10orf105	-0.306

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00013	Urokinase	BiotechDrug	9039-53-6	Approved\|Investigational\|Withdrawn	Target
DB00031	Tenecteplase	BiotechDrug	191588-94-0	Approved	Target
DB06245	Lanoteplase	BiotechDrug	171870-23-8	Investigational	Target

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of SERPINB2 mRNA	28329830
C051246	1-methylanthracene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of SERPINB2 mRNA]	28329830
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SERPINB2 mRNA"	23146750
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	23625689
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased expression of SERPINB2 mRNA	23625689
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINB2 mRNA"	22262711\|2314675
C023035	3,4,5,3',4'-pentachlorobiphenyl	"alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINB2 mRNA]"	22262711
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of SERPINB2 mRNA"	24172598
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in decreased expression of SERPINB2 mRNA"	24172598
C091768	3'-methoxy-4'-nitroflavone	3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB2 mRNA"	27188386
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in decreased expression of SERPINB2 mRNA	15982314
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of SERPINB2 mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of SERPINB2 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of SERPINB2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SERPINB2 mRNA	22100608
C412373	AG 1879	AG 1879 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of SERPINB2 mRNA"	23195993
C103303	alitretinoin	alitretinoin results in decreased expression of SERPINB2 mRNA	15982314
C011512	alpha-naphthoflavone	"alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINB2 mRNA]"	22262711
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	15075337\|2226271
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]]	15075337
C011512	alpha-naphthoflavone	alpha-naphthoflavone results in decreased expression of SERPINB2 mRNA	22262711
C011512	alpha-naphthoflavone	alpha-naphthoflavone results in increased expression of SERPINB2 mRNA	22262711
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SERPINB2 mRNA	16483693
D016718	Arachidonic Acid	Arachidonic Acid results in increased expression of SERPINB2 mRNA	18388244
C006632	arsenic trioxide	arsenic trioxide affects the expression of SERPINB2 protein	14619570
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of SERPINB2 mRNA"	25757056
D001205	Ascorbic Acid	Ascorbic Acid results in decreased expression of SERPINB2 mRNA	19197388
D001241	Aspirin	Aspirin results in decreased expression of SERPINB2 mRNA	15456535
D001554	Benzene	Benzene affects the expression of SERPINB2 mRNA	21147609
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SERPINB2 mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of SERPINB2 mRNA	22342234
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SERPINB2 mRNA"	20382639
C020711	beryllium sulfate	beryllium sulfate results in increased expression of SERPINB2 mRNA	16314022
D004958	Estradiol	Estradiol results in decreased expression of SERPINB2 mRNA	16298037
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of SERPINB2 mRNA	17404688
C006780	bisphenol A	bisphenol A results in increased expression of SERPINB2 mRNA	28079927
C006780	bisphenol A	bisphenol A results in increased expression of SERPINB2 mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of SERPINB2 mRNA	15336504
D002104	Cadmium	Cadmium results in decreased expression of SERPINB2 mRNA	24376830
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SERPINB2 mRNA	18560533
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SERPINB2 protein	24527689
D019256	Cadmium Chloride	TNF affects the reaction [Cadmium Chloride results in increased expression of SERPINB2 mRNA]	18560533
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SERPINB2 mRNA	20061341
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SERPINB2 mRNA	20360939
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of SERPINB2 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SERPINB2 mRNA	19549813
D003474	Curcumin	Curcumin results in increased expression of SERPINB2 mRNA	15713895
D000069439	Dasatinib	Dasatinib results in decreased expression of SERPINB2 mRNA	20579391
C014347	decitabine	decitabine results in increased expression of SERPINB2 mRNA	16367923
D013759	Dronabinol	Dronabinol results in decreased expression of SERPINB2 mRNA	18454173
D003703	Demecolcine	Demecolcine results in increased expression of SERPINB2 mRNA	23649840
D004041	Dietary Fats	[Dietary Fats co-treated with resveratrol] results in increased expression of SERPINB2 mRNA	21852083
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of SERPINB2 mRNA	26033743
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SERPINB2 mRNA	20360939
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SERPINB2 mRNA	15171707
D002117	Calcitriol	Calcitriol results in decreased expression of SERPINB2 mRNA	16002434
C472511	dimethylarsinous acid	dimethylarsinous acid results in increased expression of SERPINB2 mRNA	23876855
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SERPINB2 mRNA"	22485181
D004237	Diuron	Diuron metabolite results in increased expression of SERPINB2 mRNA	24172598
D004237	Diuron	Diuron metabolite results in decreased expression of SERPINB2 mRNA	24172598
D004317	Doxorubicin	SERPINB2 protein affects the susceptibility to Doxorubicin	16217747
D004391	Dust	Dust results in increased expression of SERPINB2 mRNA	17805423
C046770	EGTA acetoxymethyl ester	EGTA acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
D004656	Enalapril	Enalapril results in decreased expression of SERPINB2 mRNA	25037058
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of SERPINB2 mRNA	26159488
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of SERPINB2 mRNA	28329830
C007738	fluoranthene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of SERPINB2 mRNA]	28329830
D005472	Fluorouracil	Fluorouracil results in increased expression of SERPINB2 mRNA	16709241
D005492	Folic Acid	Folic Acid affects the expression of SERPINB2 mRNA	16361273
D005557	Formaldehyde	Formaldehyde results in decreased expression of SERPINB2 mRNA	28937961
D005557	Formaldehyde	Formaldehyde results in increased expression of SERPINB2 mRNA	20884683
C070081	fulvestrant	fulvestrant results in increased expression of SERPINB2 mRNA	16298037
D005944	Glucosamine	Glucosamine results in increased expression of SERPINB2 mRNA	17109745
D017313	Fenretinide	Fenretinide results in decreased expression of SERPINB2 mRNA	16671099
D007213	Indomethacin	Indomethacin inhibits the reaction [GNRH1 protein results in increased expression of SERPINB2 mRNA]	16514196
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SERPINB2 mRNA	25613284
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of SERPINB2 mRNA	17085751
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SERPINB2 mRNA	24796395
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINB2 mRNA	18289624
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINB2 protein	18289624
D008070	Lipopolysaccharides	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINB2 mRNA]	18289624
D008070	Lipopolysaccharides	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINB2 protein]	18289624
D008070	Lipopolysaccharides	AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of SERPINB2 mRNA]	22273745
D008070	Lipopolysaccharides	CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of SERPINB2 mRNA]]	22273745
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINB2 mRNA	12057914
D008070	Lipopolysaccharides	[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of SERPINB2 mRNA	22273745
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINB2 mRNA	25613284
D008154	Lucanthone	Lucanthone results in increased expression of SERPINB2 mRNA	21148553
D008345	Manganese	Manganese results in increased expression of SERPINB2 mRNA	26745496
C025340	manganese chloride	manganese chloride results in increased expression of SERPINB2 mRNA	26745496
D008558	Melphalan	Melphalan results in increased expression of SERPINB2 mRNA	22363485
D008713	Methimazole	Methimazole results in increased expression of SERPINB2 mRNA	22504374
C104810	methyl arachidonylfluorophosphonate	methyl arachidonylfluorophosphonate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SERPINB2 mRNA	20061341
D008917	Mirex	Mirex results in increased expression of SERPINB2 mRNA	23153324
D016685	Mitomycin	SERPINB2 protein affects the susceptibility to Mitomycin	16217747
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of SERPINB2 mRNA	23876855
D009151	Mustard Gas	Mustard Gas results in increased expression of SERPINB2 mRNA	25102026
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SERPINB2 mRNA"	25102311
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SERPINB2 mRNA"	24389112\|2510231
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of SERPINB2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SERPINB2 mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of SERPINB2 mRNA	23195993
C029938	nickel sulfate	nickel sulfate results in decreased expression of SERPINB2 mRNA	22714537
D009543	Nifedipine	Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of SERPINB2 mRNA	17616710
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of SERPINB2 mRNA	20971185
C558013	NSC 689534	NSC 689534 results in increased expression of SERPINB2 mRNA	20971185
C025589	ochratoxin A	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINB2 mRNA]	18289624
C025589	ochratoxin A	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINB2 protein]	18289624
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of SERPINB2 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of SERPINB2 mRNA	26516004
D010100	Oxygen	Oxygen deficiency results in increased expression of SERPINB2 mRNA	24236059
D010100	Oxygen	Oxygen deficiency results in increased expression of SERPINB2 mRNA	20880076
D017239	Paclitaxel	SERPINB2 protein affects the susceptibility to Paclitaxel	16217747
D052638	Particulate Matter	Particulate Matter results in increased expression of SERPINB2 mRNA	23085030\|2834120
D052638	Particulate Matter	Particulate Matter results in increased expression of SERPINB2 mRNA	28655636
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SERPINB2 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SERPINB2 mRNA	19710929
D059808	Polyphenols	Polyphenols results in decreased expression of SERPINB2 mRNA	16293270
D011137	Polystyrenes	Polystyrenes analog results in increased expression of SERPINB2 mRNA	25102311
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of SERPINB2 mRNA	17404688
D011374	Progesterone	Progesterone results in decreased expression of SERPINB2 mRNA	17404688\|2086464
D011441	Propylthiouracil	Propylthiouracil results in increased expression of SERPINB2 mRNA	22504374
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SERPINB2 mRNA]	12832416
D011794	Quercetin	Quercetin results in increased expression of SERPINB2 mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of SERPINB2 mRNA	16202921
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of SERPINB2 mRNA	16298037
C059514	resveratrol	[Dietary Fats co-treated with resveratrol] results in increased expression of SERPINB2 mRNA	21852083
D015474	Isotretinoin	Isotretinoin results in decreased expression of SERPINB2 mRNA	15982314
C093642	SB 203580	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of SERPINB2 mRNA]	28329830
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of SERPINB2 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SERPINB2 mRNA	22300531\|2535159
D012822	Silicon Dioxide	AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of SERPINB2 mRNA]	22273745
D012822	Silicon Dioxide	CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of SERPINB2 mRNA]]	22273745
D012822	Silicon Dioxide	[Silicon Dioxide co-treated with Lipopolysaccharides] results in increased expression of SERPINB2 mRNA	22273745
C017947	sodium arsenite	sodium arsenite results in increased expression of SERPINB2 mRNA	23876855
D018038	Sodium Selenite	Sodium Selenite results in increased expression of SERPINB2 mRNA	24383545
D012999	Soman	Soman results in increased expression of SERPINB2 mRNA	19281266
C061133	tamibarotene	tamibarotene results in decreased expression of SERPINB2 mRNA	15498508
D013629	Tamoxifen	Tamoxifen results in decreased expression of SERPINB2 mRNA	16298037
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of SERPINB2 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	2-aminoethoxydiphenyl borate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
D013749	Tetrachlorodibenzodioxin	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	23625689
D013749	Tetrachlorodibenzodioxin	3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
D013749	Tetrachlorodibenzodioxin	AG 1879 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
D013749	Tetrachlorodibenzodioxin	AHR gene SNP affects the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 protein]	25445724
D013749	Tetrachlorodibenzodioxin	alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	15075337\|2226271
D013749	Tetrachlorodibenzodioxin	alpha-naphthoflavone inhibits the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]]	15075337
D013749	Tetrachlorodibenzodioxin	EGTA acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of SERPINB2 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	methyl arachidonylfluorophosphonate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
D013749	Tetrachlorodibenzodioxin	Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	18388244
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of and results in increased stability of SERPINB2 mRNA	10198199
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA	11281733\|1507533
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SERPINB2 protein	25445724\|8631129
D013749	Tetrachlorodibenzodioxin	Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	15075337
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SERPINB2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SERPINB2 mRNA	22666406
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA	17035482\|1869160
D013749	Tetrachlorodibenzodioxin	CGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 protein]	12128104
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SERPINB2 protein	12128104
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SERPINB2 mRNA	8631129
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SERPINB2 protein	8631129
D013755	Tetradecanoylphorbol Acetate	SERPINB2 affects the susceptibility to Tetradecanoylphorbol Acetate	16044405
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate affects the expression of SERPINB2	16044405
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SERPINB2 mRNA	19945525
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SERPINB2 mRNA	25613284
D013792	Thalidomide	SERPINB2 gene SNP results in increased susceptibility to Thalidomide	21245421
D019284	Thapsigargin	Thapsigargin results in increased expression of SERPINB2 mRNA	19442820
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SERPINB2 mRNA	22363418
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SERPINB2 protein	27189315
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of SERPINB2 mRNA	27404394\|2786577
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of SERPINB2 mRNA	20133372
D019772	Topotecan	SERPINB2 protein affects the susceptibility to Topotecan	16217747
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of SERPINB2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of SERPINB2 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of SERPINB2 mRNA"	19682533
D014212	Tretinoin	alpha-naphthoflavone inhibits the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]]	15075337
D014212	Tretinoin	Tretinoin metabolite results in increased expression of SERPINB2 mRNA	15982314
D014212	Tretinoin	Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]	15075337
D014212	Tretinoin	Tretinoin results in decreased expression of SERPINB2 mRNA	15498508\|1598231
C009954	trilostane	trilostane inhibits the reaction [GNRH1 protein results in increased expression of SERPINB2 mRNA]	17332517
D017973	Tungsten Compounds	Tungsten Compounds results in increased expression of SERPINB2 mRNA	28666766
D014635	Valproic Acid	Valproic Acid results in decreased expression of SERPINB2 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of SERPINB2 mRNA	28001369
D014638	Vanadates	Vanadates results in increased expression of SERPINB2 mRNA	22714537
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of SERPINB2 mRNA	16330358
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of SERPINB2 mRNA	28655636
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of SERPINB2 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions analog results in increased expression of SERPINB2 mRNA	15541757
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of SERPINB2 mRNA	19465080
D014747	Vinblastine	SERPINB2 protein affects the susceptibility to Vinblastine	16217747
D014750	Vincristine	Vincristine results in increased expression of SERPINB2 mRNA	23649840
D002762	Cholecalciferol	Cholecalciferol results in increased expression of SERPINB2 mRNA	17170073
D015032	Zinc	Zinc results in decreased expression of SERPINB2 mRNA	18316168
D015032	Zinc	Zinc deficiency results in increased expression of SERPINB2 mRNA	16140947
D015032	Zinc	Zinc inhibits the reaction [Zinc deficiency results in increased expression of SERPINB2 mRNA]	16140947

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004867	serine-type endopeptidase inhibitor activity	-	IBA	21873635
GO:0004867	serine-type endopeptidase inhibitor activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0010951	negative regulation of endopeptidase activity	-	IBA	21873635
GO:0010951	negative regulation of endopeptidase activity	-	IEA	-
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	-
GO:0042060	wound healing	-	IEA	-
GO:0042730	fibrinolysis	-	TAS	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005737	cytoplasm	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-

KEGG ID	KEGG Term
hsa05146	Amoebiasis

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168256	Immune System	TAS
R-HSA-447115	Interleukin-12 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-75205	Dissolution of Fibrin Clot	TAS
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	TAS
R-HSA-9020591	Interleukin-12 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27189315	The human placental proteome is affected by maternal smoking. (2016 Aug)	Huuskonen P	Reprod Toxicol
25775950	Association between SNPs in Serpin gene family and risk of esophageal squamous cell carcinoma. (2015 Aug)	Meng H	Tumour Biol
17056606	Cigarette smoke-induced differential gene expression in blood cells from monozygotic twin pairs. (2007 Mar)	van Leeuwen DM	Carcinogenesis